Interaction of Hoechst 33258 and ethidium with histone1-DNA condensates.

abstract：:Specific folate receptors are abundantly overexpressed in chronically activated macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is formed using a large spacer like polyethylene glycol. He...

journal_title：Biomacromolecules

authors： Nogueira E,Mangialavori IC,Loureiro A,Azoia NG,Sárria MP,Nogueira P,Freitas J,Härmark J,Shimanovich U,Rollett A,Lacroix G,Bernardes GJ,Guebitz G,Hebert H,Moreira A,Carmo AM,Rossi JP,Gomes AC,Preto A,Cavaco-Paulo A

更新日期：2015-09-14 00:00:00

abstract：:A novel pH and temperature sensitive block copolymer was prepared by adding pH sensitive moiety to temperature sensitive block copolymer. This block copolymer solution showed a reversible sol-gel transition by a small pH change in the range of pH 7.4-8.0 and also by the temperature change in the region of body tempera...

journal_title：Biomacromolecules

authors： Shim WS,Yoo JS,Bae YH,Lee DS

更新日期：2005-11-01 00:00:00

abstract：:Stability of four dissimilar basic proteins (chymotrypsinogen A, ribonuclease A, cytochrome c, lysozyme) in the complex with four polyanions (heparin, poly(vinylsulfate), poly(4-styrene-sulfonate), Nafion) has been studied by differential scanning calorimetry. The polyanions were chosen because of their different char...

journal_title：Biomacromolecules

authors： Sedlák E,Fedunová D,Veselá V,Sedláková D,Antalík M

更新日期：2009-09-14 00:00:00

abstract：:The encapsulation of live cells with polymeric coat-ings is a versatile approach to modulate or control the response cells to their environment. The layer-by-layer (LbL) self-assembly of nonimmunogenic polyelectrolytes is employed here to attenuate or suppress the binding of antibodies to live red blood cells (RBCs) a...

journal_title：Biomacromolecules

authors： Mansouri S,Merhi Y,Winnik FM,Tabrizian M

更新日期：2011-03-14 00:00:00

abstract：:Bone fractures constitute a major cause of morbidity and mortality especially in the elderly. Complications associated with osteoporosis drugs and the age of the patient slow bone turnover and render such fractures difficult to heal. Increasing the speed of fracture repair by administration of a fracture-targeted bone...

journal_title：Biomacromolecules

authors： Low SA,Galliford CV,Yang J,Low PS,Kopeček J

更新日期：2015-10-12 00:00:00

abstract：:The inferior in vivo stability of micellar drugs has been a prime challenge for their application in targeted drug delivery. Here we report on novel galactose-decorated covalently cross-linked biodegradable micelles based on photo-cross-linkable poly(ethylene glycol)-b-poly(acryloyl carbonate)-b-poly(ε-caprolactone) (...

journal_title：Biomacromolecules

authors： Yang R,Meng F,Ma S,Huang F,Liu H,Zhong Z

更新日期：2011-08-08 00:00:00

abstract：:A series of structurally diverse polymers, containing either peptide or vinyl-derived backbones, was tested for ice recrystallization inhibition activity, which is commonly associated with antifreeze (glyco)proteins. It was revealed that only polymers bearing hydroxyl groups in the side chain could inhibit ice growth....

journal_title：Biomacromolecules

authors： Gibson MI,Barker CA,Spain SG,Albertin L,Cameron NR

更新日期：2009-02-09 00:00:00

abstract：:Chitosan possesses many characteristics of an ideal gene delivery system. However, the transfection efficiency of conventional chitosans is generally found to be low. In this study, we investigated the self-branching of chitosans as a strategy to improve its gene transfer properties without compromising its safety pro...

journal_title：Biomacromolecules

authors： Malmo J,Vårum KM,Strand SP

更新日期：2011-03-14 00:00:00

abstract：:Synthesis of novel zwitterionic block copolypeptides, poly(N-isopropylacrylamide)-block-poly(L-glutamic acid-co-L-lysine) [PNiPAM(n)(PLG(x)-co-PLLys(y))m , where n is the number-average degree of polymerization (DP(n)) of PNiPAM block, x and y are the mole fraction of glutamic acid and lysine residues, respectively, a...

journal_title：Biomacromolecules

authors： Li J,Wang T,Wu D,Zhang X,Yan J,Du S,Guo Y,Wang J,Zhang A

更新日期：2008-10-01 00:00:00

abstract：:Poly(3-(tert-butoxycarbonyl)-N-vinyl-2-pyrrolidone) has been synthesized and characterized by gel permeation chromatography, Fourier transform infrared spectroscopy, NMR spectroscopy, and thermal analysis. The polymer is a chemically amplified photoresist. Arrays of lines with 25 microm width and 25 microm spacing wer...

journal_title：Biomacromolecules

authors： He W,Gonsalves KE,Pickett JH,Halberstadt C

更新日期：2003-01-01 00:00:00

abstract：:New therapeutic strategies for the treatment of neoplastic pathologies and, in particular, metastasis processes are based on the inhibitory effect of angiogenic processes. The present article deals with the design, preparation, and application of new "polymer drugs" with a clear inhibitory effect of the activation of ...

journal_title：Biomacromolecules

authors： García-Fernández L,Aguilar MR,Fernández MM,Lozano RM,Giménez G,Valverde S,San Román J

更新日期：2010-07-12 00:00:00

abstract：:Oral delivery remains a challenge for poorly permeable hydrophilic macromolecules. Poly(amido amine) (PAMAM) dendrimers have shown potential for their possible oral delivery. Transepithelial transport of carboxyl-terminated G3.5 and amine-terminated G4 PAMAM dendrimers was assessed using isolated rat jejunal mucosae m...

journal_title：Biomacromolecules

authors： Hubbard D,Ghandehari H,Brayden DJ

更新日期：2014-08-11 00:00:00

abstract：:In tissue engineering, incorporation of bone morphogenetic protein-2 (BMP-2) into biomaterial scaffolds is an attractive strategy to stimulate bone repair. However, suboptimal release of BMP-2 remains a great concern, which may cause unfavorable bone formation as well as severe inflammation. In this study, genipin-cro...

journal_title：Biomacromolecules

authors： Zhang Q,Tan K,Zhang Y,Ye Z,Tan WS,Lang M

更新日期：2014-01-13 00:00:00

abstract：:Horseradish peroxidase-catalyzed polymerization of cardanol in aqueous organic solvent was investigated in the presence of a redox mediator. Cardanol is a phenol derivative from a renewable resource mainly having a C15 unsaturated hydrocarbon chain with mostly 1-3 double bonds at a meta position. Unlike soybean peroxi...

journal_title：Biomacromolecules

authors： Won K,Kim YH,An ES,Lee YS,Song BK

更新日期：2004-01-01 00:00:00

abstract：:Most biopolymers exist in a plasticized state, whether it is naturally with water or unnaturally with glycerol or other suitable polyol, to make a flexible material. We have found that the extent to which a biopolymer can be plasticized is dependent on its molecular and higher order structures outside of simply molecu...

journal_title：Biomacromolecules

authors： Athamneh AI,Griffin M,Whaley M,Barone JR

更新日期：2008-11-01 00:00:00

abstract：:Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...

journal_title：Biomacromolecules

authors： Manchineella S,Murugan NA,Govindaraju T

更新日期：2017-11-13 00:00:00

abstract：:A stepwise anticancer drug delivery system based on an injectable supramolecular hydrogel was presented. In this system, poly(ethylene glycol)-b-poly(acrylic acid) (PEG-b-PAA) block copolymer nanoparticles containing cisplatin were released by erosion of the hydrogels and then the cisplatin was released from the nanop...

journal_title：Biomacromolecules

authors： Zhu W,Li Y,Liu L,Chen Y,Wang C,Xi F

更新日期：2010-11-08 00:00:00

abstract：:Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stab...

journal_title：Biomacromolecules

authors： He H,Bai Y,Wang J,Deng Q,Zhu L,Meng F,Zhong Z,Yin L

更新日期：2015-04-13 00:00:00

abstract：:We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded ...

journal_title：Biomacromolecules

authors： Zhang H,Mardyani S,Chan WC,Kumacheva E

更新日期：2006-05-01 00:00:00

abstract：:A way to convert the volume change of a biochemo-mechanical gel into the change in liquid column length was developed. Our trial sensor device consisted of a small compartment for incorporating the gel, a flow channel with a filled dye solution, and a poly(dimethylsiloxane) (PDMS) diaphragm by which the gel and the dy...

journal_title：Biomacromolecules

authors： Suzuki H,Kumagai A,Ogawa K,Kokufuta E

更新日期：2004-03-01 00:00:00

abstract：:Hemicellulose-based hydrogels were prepared by radical polymerization of 2-hydroxyethyl methacrylate or poly(ethylene glycol) dimethacrylate with oligomeric hydrosoluble hemicellulose modified with well-defined amounts of methacrylic functions. The polymerization reaction was carried out in water at 40 degrees C using...

journal_title：Biomacromolecules

authors： Söderqvist Lindblad M,Albertsson AC,Ranucci E,Laus M,Giani E

更新日期：2005-03-01 00:00:00

abstract：:The barrier functions of the stratum corneum and the epidermal layers present a tremendous challenge in achieving effective transdermal delivery of drug molecules. Although a few reports have shown that poly(amidoamine) (PAMAM) dendrimers are effective skin-penetration enhancers, little is known regarding the fundamen...

journal_title：Biomacromolecules

authors： Yang Y,Sunoqrot S,Stowell C,Ji J,Lee CW,Kim JW,Khan SA,Hong S

更新日期：2012-07-09 00:00:00

abstract：:It is well-known that 3D in vitro cell cultures provide a much better model than 2D cell cultures for understanding the in vivo microenvironment of cells. However, significant technical challenges in handling and analyzing 3D cell cultures remain, which currently limits their widespread application. Herein, we demonst...

journal_title：Biomacromolecules

authors： Simon KA,Warren NJ,Mosadegh B,Mohammady MR,Whitesides GM,Armes SP

更新日期：2015-12-14 00:00:00

abstract：:Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction betwee...

journal_title：Biomacromolecules

authors： Kim K,Bae B,Kang YJ,Nam JM,Kang S,Ryu JH

更新日期：2013-10-14 00:00:00

abstract：:Molecular dynamics (MD) simulations have been applied to study the interactions between hydrophobic and hydrophilic faces of ordered cellulose chains and a single layer of graphene in explicit aqueous solvent. The hydrophobic cellulose face is predicted to form a stable complex with graphene. This interface remains so...

journal_title：Biomacromolecules

authors： Alqus R,Eichhorn SJ,Bryce RA

更新日期：2015-06-08 00:00:00

abstract：:This paper describes the synthesis and characterization of polymer-peptide conjugates to be used as infection-resistant coating for biomaterial implants and devices. Antiadhesive polymer brushes composed of block copolymer Pluronic F-127 (PF127) were functionalized with antimicrobial peptides (AMP), able to kill bacte...

journal_title：Biomacromolecules

authors： Muszanska AK,Rochford ET,Gruszka A,Bastian AA,Busscher HJ,Norde W,van der Mei HC,Herrmann A

更新日期：2014-06-09 00:00:00

abstract：:Thanks to chemical stabilization, aldehyde-assisted fractionation (AAF) of lignocellulosic biomass has recently emerged as a powerful tool for the production of largely uncondensed lignin. Depolymerization of AAF lignin via ether cleavage provides aromatic monomers at near theoretical yields based on ether cleavage an...

journal_title：Biomacromolecules

authors： Vendamme R,Behaghel de Bueren J,Gracia-Vitoria J,Isnard F,Mulunda MM,Ortiz P,Wadekar M,Vanbroekhoven K,Wegmann C,Buser R,Héroguel F,Luterbacher JS,Eevers W

更新日期：2020-10-12 00:00:00

abstract：:The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the degradation characteristics of the microspheres. To this end, an in-vitro degradation study was conducted. PLLA-microspheres with and without Ho...

journal_title：Biomacromolecules

authors： Zielhuis SW,Nijsen JF,Krijger GC,van het Schip AD,Hennink WE

更新日期：2006-07-01 00:00:00

abstract：:Candida antarctica Lipase B (CALB) was covalently immobilized onto epoxy-activated macroporous poly(methyl methacrylate) Amberzyme beads (235 microm particle size, 220 A pore size) and nanoparticles (nanoPSG, diameter 68 nm) with a poly(glycidyl methacrylate) outer region. Amberzyme beads allowed CALB loading up to 0....

journal_title：Biomacromolecules

authors： Chen B,Hu J,Miller EM,Xie W,Cai M,Gross RA

更新日期：2008-02-01 00:00:00

abstract：:Cartilage tissue engineering highly relies on the ability to store and transport chondrocytes in order to be clinically successful. Cryopreservation is a most reliable technology for chondrocyte storage, but it suffers from the intrinsic toxicity of current state-of-the-art cryoprotectant, dimethyl sulfoxide (DMSO). I...

journal_title：Biomacromolecules

authors： Liu M,Zhang X,Guo H,Zhu Y,Wen C,Sui X,Yang J,Zhang L

更新日期：2019-10-14 00:00:00