Effect of size, surface charge, and hydrophobicity of poly(amidoamine) dendrimers on their skin penetration.

abstract：:Cellulose nanocrystals (CNCs) are mechanically rigid, toxicologically benign, fiber-like nanoparticles. They can easily be extracted from renewable biosources and have attracted significant interest as reinforcing fillers in polymers. We here report the modification of CNCs with the 2-ureido-4[1H]pyrimidinone (UPy) mo...

journal_title：Biomacromolecules

authors： Natterodt JC,Sapkota J,Foster EJ,Weder C

更新日期：2017-02-13 00:00:00

abstract：:Oscillatory shear rheometry has been used to study the gelation of beta-lactoglobulin at ambient in 50% v/v trifluoroethanol (TFE)/pH 7 aqueous buffer and in 50% v/v ethanol (EtOH)/water at pH 2. In contrast to what was found on heating aqueous solutions at pH 2 (Part 2 of this series), a more expected "chemical gelat...

journal_title：Biomacromolecules

authors： Gosal WS,Clark AH,Ross-Murphy SB

更新日期：2004-11-01 00:00:00

abstract：:Chitin is a nitrogen-rich polysaccharide that is abundant in crustaceans, mollusks, insects, and fungi and is the second most abundant organic material found in nature next to cellulose. Chitosan, the N-deacetylated derivative of chitin, is environmentally friendly, nontoxic, biodegradable, and antibacterial. Fibrous ...

journal_title：Biomacromolecules

authors： Schiffman JD,Schauer CL

更新日期：2007-09-01 00:00:00

abstract：:We describe a facile method to amine functionalize and subsequently fluorescently label polymethacrylamides synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. RAFT-generated poly(N-(2-hydroxypropyl) methacrylamide-b-N-[3-(dimethylamino)propyl] methacrylamide) (poly(HPMA-b-DMAPMA)),...

journal_title：Biomacromolecules

authors： York AW,Scales CW,Huang F,McCormick CL

更新日期：2007-08-01 00:00:00

abstract：:As a biomaterial, silk presents unique features with a combination of excellent mechanical properties, biocompatibility, and biodegradability. The biodegradability aspects of silk biomaterials, especially with options to control the rate from short (days) to long (years) time frames in vivo, make this protein-based bi...

journal_title：Biomacromolecules

authors： Guo C,Li C,Kaplan DL

更新日期：2020-05-11 00:00:00

abstract：:Exendin-4 (EX4), a glucagon-like peptide-1 receptor (GLP-1R) agonist that regulates blood glucose levels, has been used in the management of type-2 diabetes mellitus. EX4 can be PEGylated to improve its antidiabetic effects by enhancing its stability and extending the circulation half-life. Here, to determine whether ...

journal_title：Biomacromolecules

authors： Lee W,Park EJ,Kwak S,Lee KC,Na DH,Bae JS

更新日期：2016-03-14 00:00:00

abstract：:Immobilizing zwitterionic molecules on material surfaces has been a promising strategy for creating antifouling surfaces. Herein, we show the ability to surface derivatize an allyl-ether-functionalized thermoplastic polyurethane (TPU) with a zwitterionic thiol in a radically induced thiol-ene reaction. The thermoplast...

journal_title：Biomacromolecules

authors： Nikam SP,Chen P,Nettleton K,Hsu YH,Becker ML

更新日期：2020-07-13 00:00:00

abstract：:The new combinations of monomers presented in this work were evaluated in order to create an elastic material for potential application in soft tissue engineering. Thermoplastic elastomers (TPE) of trimethylene carbonate (TMC) with L-lactide (LLA) and 1,5-dioxepan-2-one (DXO) have been synthesized using a cyclic five-...

journal_title：Biomacromolecules

authors： Andronova N,Albertsson AC

更新日期：2006-05-01 00:00:00

abstract：:Multicomponent poly(ethylene glycol) (PEG) brushes (i.e., ≥ 2 adjacent PEG brushes) can be used to engineer culture substrates with microscale, nonfouling regions decorated with covalently immobilized ligands that mediate biospecific interactions. However, synthesizing such brushes with orthogonal immobilization chemi...

journal_title：Biomacromolecules

authors： Sha J,Lippmann ES,McNulty J,Ma Y,Ashton RS

更新日期：2013-09-09 00:00:00

abstract：:G-quadruplex is a type of DNA secondary structure formed by specific guanine-rich sequences. Because of their enrichment in functional genomic regions and their biological significance, G-quadruplexes are recognized as significant drug targets for cancer and other diseases. Here, we tested the precipitation efficiency...

journal_title：Biomacromolecules

authors： Lin J,Yan YY,Ou TM,Tan JH,Huang SL,Li D,Huang ZS,Gu LQ

更新日期：2010-12-13 00:00:00

abstract：:In this paper we propose a detailed analysis of structural and morphological properties of two poly-L-lysine (PLL)-based transfection formulations, PLL/DNA and pegylated PLL (PLL-g-PEG)/DNA, by means of atomic force microscopy (AFM) and transmission electron microscopy (TEM). Comparing PLL-g-PEG/DNA with PLL/DNA polyp...

journal_title：Biomacromolecules

authors： Stanić V,Arntz Y,Richard D,Affolter C,Nguyen I,Crucifix C,Schultz P,Baehr C,Frisch B,Ogier J

更新日期：2008-07-01 00:00:00

abstract：:The time-dependent diffusion and mechanical properties of gelatin in solution, in the gel state, and during the sol/gel transition were determined using fluorescence recovery after photobleaching (FRAP) and rheology. The parameters in the experimental design were 2% w/w and 5% w/w gelatin concentration; 15, 20, and 25...

journal_title：Biomacromolecules

authors： Hagman J,Lorén N,Hermansson AM

更新日期：2010-12-13 00:00:00

abstract：:The remarkable diversity of the self-assembly behavior of PEG-peptides is reviewed, including self-assemblies formed by PEG-peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed. Additionally, applications in bionanotechnology a...

journal_title：Biomacromolecules

authors： Hamley IW

更新日期：2014-05-12 00:00:00

abstract：:Chimeric DNA containing parallel (ps) and antiparallel (aps) duplex elements as well as poly-dC tracts were designed and synthesized. Oligonucleotide duplexes with ps chain orientation containing reverse Watson-Crick dA-dT base pairs and short d(C)2 tails are stabilized under slightly acidic conditions by hemiprotonat...

journal_title：Biomacromolecules

authors： Mei H,Budow S,Seela F

更新日期：2012-12-10 00:00:00

abstract：:Molecular orientation distributions in the crystalline and amorphous regions of a biaxially oriented poly(L-lactic acid) film were analyzed fully by polarized Raman spectroscopy. Raman bands at 926 and 875 cm(-1) were chosen for the determination of the most probable molecular orientation distribution functions for th...

journal_title：Biomacromolecules

authors： Tanaka M,Young RJ

更新日期：2006-09-01 00:00:00

abstract：:In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...

journal_title：Biomacromolecules

authors： Peng Y,Wu P,Siesler HW

更新日期：2003-07-01 00:00:00

abstract：:Glycerol derivatives of cutin and suberin monomers were synthesized by acid catalysis. Their dispersion in an aqueous solution was examined by phase contrast microscopy, neutron scattering, and solid state NMR. It is shown that the phase behavior strongly depends on the nature of the derivatives forming either lumps o...

journal_title：Biomacromolecules

authors： Douliez JP,Barrault J,Jerome F,Heredia A,Navailles L,Nallet F

更新日期：2005-01-01 00:00:00

abstract：:The use of polyelectrolyte surface-modified Cowpea mosaic virus (CPMV) for the templated synthesis of narrowly dispersed gold nanoparticles is described. The cationic polyelectrolyte, poly(allylamine) hydrochloride (PAH), is electrostatically bound to the external surface of the virus capsid; the polyelectrolyte promo...

journal_title：Biomacromolecules

authors： Aljabali AA,Lomonossoff GP,Evans DJ

更新日期：2011-07-11 00:00:00

abstract：:To provide for prolonged, site-specific delivery of basic fibroblast growth factor (bFGF) to the grafted skin in a convenient manner, biodegradable chitosan-gelatin microspheres containing bFGF were fabricated and incorporated into a porous chitosan-gelatin scaffold in this study. The microspheres are an integral part...

journal_title：Biomacromolecules

authors： Liu H,Fan H,Cui Y,Chen Y,Yao K,Goh JC

更新日期：2007-05-01 00:00:00

abstract：:The interaction between positively charged poly(amido amine) (PAMAM) dendrimers of generation 4 and DNA has been investigated for two DNA lengths; 2000 basepairs (bp; L = 680 nm) and 4331 bp (L = 1472.5 nm) using a theoretical model by Schiessel for a semiflexible polyelectrolyte and hard spheres. The model was modifi...

journal_title：Biomacromolecules

authors： Qamhieh K,Nylander T,Ainalem ML

更新日期：2009-07-13 00:00:00

abstract：:Photosensitive supramolecular micelles, a combination of intermolecular hydrogen bonds between complementary adenine (A) and uracil (U) groups and a blend of two types of supramolecular polymers, can stably self-assemble into structurally stable, spherical micelles in aqueous solution before and after photoirradiation...

journal_title：Biomacromolecules

authors： Abebe Alemayehu Y,Tewabe Gebeyehu B,Cheng CC

更新日期：2019-12-09 00:00:00

abstract：:Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...

journal_title：Biomacromolecules

authors： Manchineella S,Murugan NA,Govindaraju T

更新日期：2017-11-13 00:00:00

abstract：:Subunit vaccines can have excellent safety profiles, but their ability to give rise to robust immune responses is often compromised. For glycan-based vaccines, insufficient understanding of B and T cell epitope combinations that yield optimal immune activation hinders optimization. To determine which antigen features ...

journal_title：Biomacromolecules

authors： Bennett NR,Jarvis CM,Alam MM,Zwick DB,Olson JM,Nguyen HV,Johnson JA,Cook ME,Kiessling LL

更新日期：2019-12-09 00:00:00

abstract：:A series of poly(vinyl alcohol) amphiphilic derivatives have been prepared to obtain polymeric aggregates in aqueous phase holding thermodynamic instability. The aim was to evaluate their ability to interact with tumor cells eliciting selective cytotoxicity. The poly(vinyl alcohol) derivatives were prepared by partial...

journal_title：Biomacromolecules

authors： Orienti I,Zuccari G,Carosio R,Montaldo PG

更新日期：2005-09-01 00:00:00

abstract：:Hydrogels constructed from folded protein domains are of increasing interest as resilient and responsive biomaterials, but their optimization for applications requires time-consuming and costly molecular design. Here, we explore a complementary approach to control their properties by examining the influence of crossli...

journal_title：Biomacromolecules

authors： Aufderhorst-Roberts A,Hughes MDG,Hare A,Head DA,Kapur N,Brockwell DJ,Dougan L

更新日期：2020-10-12 00:00:00

abstract：:Chitosan is a well sought-after polysaccharide in biomedical applications and has been blended with various macromolecules to mitigate undesirable properties. However, the effects of blending on the unique antibacterial activity of chitosan as well as changes in fatigue and degradation properties are not well understo...

journal_title：Biomacromolecules

authors： Sarasam AR,Krishnaswamy RK,Madihally SV

更新日期：2006-04-01 00:00:00

abstract：:In this contribution, a hydrophobically modified polysaccharide derivative is synthesized in an eco-friendly solvent water by conjugation of benzylamine with the backbone of the biopolymer. Owing to the presence of aromatic moieties, the resulting water-soluble polysaccharide derivative self-assembles spontaneously an...

journal_title：Biomacromolecules

authors： Mohan T,Rathner R,Reishofer D,Koller M,Elschner T,Spirk S,Heinze T,Stana-Kleinschek K,Kargl R

更新日期：2015-08-10 00:00:00

abstract：:Positive strand RNA viruses replicate in specialized niches called membranous web within the cytoplasm of host cells. These virus replication organelles sequester viral proteins, RNA, and a variety of host factors within a fluid, amorphous matrix of clusters of endoplasmic reticulum (ER) derived vesicles. They are tho...

journal_title：Biomacromolecules

authors： Ho JCS,Steininger C,Hiew SH,Kim MC,Reimhult E,Miserez A,Cho N,Parikh AN,Liedberg B

更新日期：2019-04-08 00:00:00

abstract：:Recombinant spider silk proteins mimicking the properties of dragline silk proteins represent a class of materials that hold great potential for future high-performance applications. Here we explore the self-assembly behavior of a recombinantly produced spider silk protein based on the dragline silk of the Araneus di...

journal_title：Biomacromolecules

authors： Young SL,Gupta M,Hanske C,Fery A,Scheibel T,Tsukruk VV

更新日期：2012-10-08 00:00:00

abstract：:A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...

journal_title：Biomacromolecules

authors： Charlot A,Heyraud A,Guenot P,Rinaudo M,Auzély-Velty R

更新日期：2006-03-01 00:00:00