Inhibition of ice crystal growth by synthetic glycopolymers: implications for the rational design of antifreeze glycoprotein mimics.

Abstract:

:A series of structurally diverse polymers, containing either peptide or vinyl-derived backbones, was tested for ice recrystallization inhibition activity, which is commonly associated with antifreeze (glyco)proteins. It was revealed that only polymers bearing hydroxyl groups in the side chain could inhibit ice growth. Furthermore, well-defined glycopolymers were shown to have a small but significant recrystallization inhibition effect, showing that it may be possible to design antifreeze glycoprotein mimics based upon polymers derived from vinyl monomers.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Gibson MI,Barker CA,Spain SG,Albertin L,Cameron NR

doi

10.1021/bm801069x

subject

Has Abstract

pub_date

2009-02-09 00:00:00

pages

328-33

issue

2

eissn

1525-7797

issn

1526-4602

pii

10.1021/bm801069x

journal_volume

10

pub_type

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