Abstract：
:We investigated the rheological properties and the penetration of differently sized carboxylated nanoparticles in pig pulmonary mucus, on different distance and time scales. Nanoparticles were either mechanically mixed into the mucus samples or deposited as an aerosol, the latter resembling a more physiologically relevant delivery scenario. After mechanical dispersion, 500 nm particles were locally trapped; a fraction of carboxylated tracer particles of 100 or 200 nm in diameter could however freely diffuse in these networks over distances of approximately 20 μm. In contrast, after aerosol deposition on top of the mucus layer only particles with a size of 100 nm were able to penetrate into mucus, suggesting the presence of smaller pores at the air-mucus interface compared to within mucus. These findings are relevant to an understanding of the fate of potentially harmful aerosol particles, such as pathogens, pollutants, and other nanomaterials after incidental inhalation, as well as for the design of pulmonary drug delivery systems.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Murgia X,Pawelzyk P,Schaefer UF,Wagner C,Willenbacher N,Lehr CMdoi
10.1021/acs.biomac.6b00164subject
Has Abstractpub_date
2016-04-11 00:00:00pages
1536-42issue
4eissn
1525-7797issn
1526-4602journal_volume
17pub_type
杂志文章abstract：:Many polymers, including polyethylene, feature a relatively low melting point and hence must be cross-linked to make them viable for applications that demand a high stiffness and creep resistance at elevated temperatures. The resulting thermoset plastics cannot be recycled, and therefore alternative materials with a r...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b00993
更新日期：2019-10-14 00:00:00
abstract：:Surface modification is often needed in tissue engineering to enhance the interaction between cells and synthetic materials and improve the cytocompatibility and cellular functions. In this study, block copolymers of poly(L-lactic acid) and poly(ethyl ethylene phosphate) (PLLA-b-PEEP) were synthesized and used to modi...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm900390k
更新日期：2009-08-10 00:00:00
abstract：:A simple, sequential approach for creation of hydrolytically degradable poly(ethylene glycol) (PEG) hydrogels has been developed and characterized. The chemistry involves an initial step growth polymerization reaction between PEG-diacrylate and dithiothreitol (DTT) to form acrylate-terminated (-PEG-DTT-)n PEG chains, ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm701179s
更新日期：2008-03-01 00:00:00
abstract：:It is well-known that 3D in vitro cell cultures provide a much better model than 2D cell cultures for understanding the in vivo microenvironment of cells. However, significant technical challenges in handling and analyzing 3D cell cultures remain, which currently limits their widespread application. Herein, we demonst...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b01266
更新日期：2015-12-14 00:00:00
abstract：:Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm025724c
更新日期：2003-05-01 00:00:00
abstract：:Hydrogel scaffolds are used in biomedicine to study cell differentiation and tissue evolution, where it is critical to control the delivery of chemical cues both spatially and temporally. While large molecules can be physically entrapped in a hydrogel, moderate molecular weight therapeutics must be tethered to the hyd...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm400169d
更新日期：2013-04-08 00:00:00
abstract：:The detection of phase separation and identification of miscibility in biopolymer blends is an important aspect for the improvement of their physical properties. In this article, the phase separation in blends of poly(3-hydroxybutyrate) (PHB) with poly(L-lactic acid) (PLA) and poly(epsilon-caprolactone) (PCL), respect...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm701035p
更新日期：2008-02-01 00:00:00
abstract：:Polymers are appealing as pH-responsive elements of multicomponent systems designed to promote cytosolic delivery of macromolecular drugs (including proteins and genes), but so far the delivery efficiency achieved has been relatively modest. Therefore, the aim of this study was to apply several physicochemical techniq...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060930w
更新日期：2007-03-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b01465
更新日期：2019-04-08 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm1009359
更新日期：2010-10-11 00:00:00
abstract：:Here we present time-resolved in situ transmission electron microscopy (TEM) observations and real-time manipulation of nematic ordered cellulose and ultradrawn polyethylene films. Drawn films of these two polymers exhibited a unique response to the low-dose electron beam. Electron beam damage was minimal based on ret...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060546z
更新日期：2007-01-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm070418q
更新日期：2007-10-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm2009312
更新日期：2011-09-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm301125g
更新日期：2012-11-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049793y
更新日期：2004-09-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0155120
更新日期：2001-07-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm050777q
更新日期：2006-03-01 00:00:00
abstract：:New aspects concerning the mechanism of formation of chitosan physical hydrogels without any cross-linking agent were studied. The gelation took place during the evaporation of a hydroalcoholic solution of chitosan. We first demonstrated that it was possible to form a physical hydrogel from a hydrochloride form of chi...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm050653d
更新日期：2005-11-01 00:00:00
abstract：:Encapsulation of hydrophilic cancer drugs in polymeric nanocapsules was achieved in a one-pot process via the inverse miniemulsion periphery RAFT polymerization (IMEPP) approach. The chosen guest molecule was gemcitabine hydrochloride, which is used as the first-line treatment of pancreatic cancer. The resulting nanoc...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b00545
更新日期：2015-07-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm701380a
更新日期：2008-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm3002683
更新日期：2012-05-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm050521k
更新日期：2005-11-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060559c
更新日期：2006-11-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01425
更新日期：2020-02-10 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm050960j
更新日期：2006-06-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049885n
更新日期：2004-07-01 00:00:00
abstract：:Silk-elastin-like proteins (SELPs) have enormous potential for use as customizable biomaterials in numerous biomedical and materials applications, yet success in harnessing this potential has been limited by the lack of a commercially viable industrially relevant production process. We have developed a scalable fed-ba...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm5005564
更新日期：2014-07-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm200358r
更新日期：2011-06-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm058014q
更新日期：2005-11-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm800287z
更新日期：2008-07-01 00:00:00
