Effects of PEGylation on membrane and lipopolysaccharide interactions of host defense peptides.

abstract：:Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these...

journal_title：Biomacromolecules

authors： Le TMD,Duong HTT,Thambi T,Giang Phan VH,Jeong JH,Lee DS

更新日期：2018-08-13 00:00:00

abstract：:This investigation describes the formulation and characterization of rheologically structured vehicles (RSVs) designed for improved drug delivery to the vagina. Interactive, multicomponent, polymeric platforms were manufactured containing hydroxyethylcellulose (HEC, 5% w/w) polyvinylpyrrolidone (PVP, 4% w/w), Pluronic...

journal_title：Biomacromolecules

authors： Andrews GP,Donnelly L,Jones DS,Curran RM,Morrow RJ,Woolfson AD,Malcolm RK

更新日期：2009-09-14 00:00:00

abstract：:Macromolecular dynamics in biological systems, which play a crucial role for biomolecular function and activity at ambient temperature, depend strongly on moisture content. Yet, a generally accepted quantitative model of hydration-dependent phenomena based on local relaxation and diffusive dynamics of both polymer and...

journal_title：Biomacromolecules

authors： Chen P,Terenzi C,Furó I,Berglund LA,Wohlert J

更新日期：2018-07-09 00:00:00

abstract：:Nanoconfined self-assemblies within aerosol nanoparticles and control of the secondary structures are shown here upon ionically complexing poly(L-lysine) (PLL) with dodecylbenzenesulfonic acid (DBSA) surfactant and using solvents chloroform, 1-propanol, or dimethylformamide. Different solvent volatilities and drying t...

journal_title：Biomacromolecules

authors： Rahikkala A,Junnila S,Vartiainen V,Ruokolainen J,Ikkala O,Kauppinen E,Raula J

更新日期：2014-07-14 00:00:00

abstract：:This paper reports the synthesis of hyaluronan (HA) and its derivatives via the hyaluronidase-catalyzed polymerization of 2-substituted oxazoline derivative monomers designed as "transition-state analogue substrates". Polymerization of 2-methyl oxazoline monomer from N-acetylhyalobiuronate (GlcAbeta(1-->3)GlcNAc) effe...

journal_title：Biomacromolecules

authors： Ochiai H,Ohmae M,Mori T,Kobayashi S

更新日期：2005-03-01 00:00:00

abstract：:A shortage of available organ donors has created a need for engineered tissues. In this context, polymer-based hydrogels that break down inside the body are often used as constructs for growth factors and cells. Herein, we report imine cross-linked gels where degradation is controllable by the introduction of mixed im...

journal_title：Biomacromolecules

authors： Boehnke N,Cam C,Bat E,Segura T,Maynard HD

更新日期：2015-07-13 00:00:00

abstract：:Protein-based polymers are increasingly being used in biomaterial applications because of their ease of customization and potential monodispersity. These advantages make protein polymers excellent candidates for bioanalytical applications. Here we describe improved methods for producing drag-tags for free-solution con...

journal_title：Biomacromolecules

authors： Lin JS,Albrecht JC,Meagher RJ,Wang X,Barron AE

更新日期：2011-06-13 00:00:00

abstract：:Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-li...

journal_title：Biomacromolecules

authors： Sullivan MA,Aroney ST,Li S,Warren FJ,Joo JS,Mak KS,Stapleton DI,Bell-Anderson KS,Gilbert RG

更新日期：2014-02-10 00:00:00

abstract：:Despite the good clinical efficacy of interferon-alpha (IFNα) to treat some types of cancer and viral infections, this biological drug is underused given its severe adverse effects and high dosing parenteral regimens. Aiming to achieve a breakthrough in therapy with IFNα, this work reports for the first time on the de...

journal_title：Biomacromolecules

authors： Cánepa C,Imperiale JC,Berini CA,Lewicki M,Sosnik A,Biglione MM

更新日期：2017-10-09 00:00:00

abstract：:To evaluate the antidiarrheal effect of ginseng, the active principals of ginseng were studied in vitro model of rotavirus infection, the leading cause of severe diarrhea. Two pectic polysaccharides, named as GP50-dHR (56.0 kDa) and GP50-eHR (77.0 kDa), were purified from hot water extract of ginseng by bioassay-linke...

journal_title：Biomacromolecules

authors： Baek SH,Lee JG,Park SY,Bae ON,Kim DH,Park JH

更新日期：2010-08-09 00:00:00

abstract：:Biomimetic mineralization of collagen is an advantageous method to obtain resorbable collagen/hydroxy-apatite composites for application in bone regeneration. In this report, established procedures for mineralization of bovine collagen were adapted to a new promising source of collagen from salmon skin challenged by t...

journal_title：Biomacromolecules

authors： Hoyer B,Bernhardt A,Heinemann S,Stachel I,Meyer M,Gelinsky M

更新日期：2012-04-09 00:00:00

abstract：:In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA; hydrophobic) units were synthesized by RAFT polymerization...

journal_title：Biomacromolecules

authors： Kelsch A,Tomcin S,Rausch K,Barz M,Mailänder V,Schmidt M,Landfester K,Zentel R

更新日期：2012-12-10 00:00:00

abstract：:Biopolymers bearing hydrophobic side-chains, such as hydrophobically modified chitosan (hmC), can connect liposomes into a gel network via hydrophobic interactions. In this paper, we show that such liposome gels possess an attractive combination of properties for certain drug delivery applications. Their shear-thinnin...

journal_title：Biomacromolecules

authors： Lee JH,Oh H,Baxa U,Raghavan SR,Blumenthal R

更新日期：2012-10-08 00:00:00

abstract：:In tissue engineering, incorporation of bone morphogenetic protein-2 (BMP-2) into biomaterial scaffolds is an attractive strategy to stimulate bone repair. However, suboptimal release of BMP-2 remains a great concern, which may cause unfavorable bone formation as well as severe inflammation. In this study, genipin-cro...

journal_title：Biomacromolecules

authors： Zhang Q,Tan K,Zhang Y,Ye Z,Tan WS,Lang M

更新日期：2014-01-13 00:00:00

abstract：:A strategy to manipulate the disulfide bond breaking triggered unfolding, and subsequently assembly of human serum albumin (HSA) in a lipophilic drug-dependent manner is present. In this study, the hydrophobic region, a molecular switch of the HSA, was regulated to form HSA-paclitaxel (HSA-PTX) nanoparticles by a faci...

journal_title：Biomacromolecules

authors： Gong G,Xu Y,Zhou Y,Meng Z,Ren G,Zhao Y,Zhang X,Wu J,Hu Y

更新日期：2012-01-09 00:00:00

abstract：:Hydrogels with pH-sensitive poly(acrylic acid) (PAAc) chains and biodegradable acryloyl-poly(-caprolactone)-2-hydroxylethyl methacrylate (AC-PCL-HEMA) chains were designed and synthesized. The morphology of hydrogel was observed by scanning electron microscopy. The degradation of the hydrogel in the presence of Pseudo...

journal_title：Biomacromolecules

authors： Wu DQ,Sun YX,Xu XD,Cheng SX,Zhang XZ,Zhuo RX

更新日期：2008-04-01 00:00:00

abstract：:Inulin, the polydisperse polyfructose, extracted from chicory, has been modified via transesterification, using fatty acid methyl esters (FAME). The grafting of an alkyl chain onto the inulin backbone under different conditions for the development of potential tensio-active derivatives is described. The modification o...

journal_title：Biomacromolecules

authors： Rogge TM,Stevens CV

更新日期：2004-09-01 00:00:00

abstract：:Polystyrene-polyisocyanopeptide (PS-PIAT) polymersomes containing CALB in two different locations, one in the aqueous inner compartment and one in the bilayer, were investigated for enzymatic ring-opening polymerization of lactones in water. It is shown that the monomers 8-octanolactone and dodecalactone yield oligome...

journal_title：Biomacromolecules

authors： Nallani M,de Hoog HP,Cornelissen JJ,Palmans AR,van Hest JC,Nolte RJ

更新日期：2007-12-01 00:00:00

abstract：:Glycosaminoglycan (GAG)-protein binding governs critically important signaling events in living matter. Aiming at a quantitative analysis of the involved processes, we herein present a thermodynamic study of the interaction of the model GAG heparin and lysozyme in aqueous solution. Heparin is a highly charged linear p...

journal_title：Biomacromolecules

authors： Walkowiak JJ,Ballauff M,Zimmermann R,Freudenberg U,Werner C

更新日期：2020-11-09 00:00:00

abstract：:Poly((N-vinylpyrrolidone)-block-poly(vinyl acetate)) (PVP-b-PVAc) block copolymers of varying molecular weight and hydrophobic block lengths were synthesized via controlled radical polymerization and investigated as carriers for the solubilization of highly hydrophobic riminophenazine compounds. These compounds have r...

journal_title：Biomacromolecules

authors： Bailly N,Thomas M,Klumperman B

更新日期：2012-12-10 00:00:00

abstract：:A strategy to light-trigger ionic cross-linking of alginates by incorporating a photosensitive Ca2+ cage (nitr-T) is presented. Upon irradiation, free Ca2+ was released, and this caused gelation of the alginate solution. Addition of Ca2+ "on-demand" allowed us to obtain homogeneous alginate (ALG) gels using concentrat...

journal_title：Biomacromolecules

authors： Cui J,Wang M,Zheng Y,Rodríguez Muñiz GM,del Campo A

更新日期：2013-05-13 00:00:00

abstract：:An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol-ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed ex...

journal_title：Biomacromolecules

authors： Han J,Chen Q,Shen Y,Liu Z,Hao X,Zhong M,Zhao Z,Bockstaller MR

更新日期：2020-09-14 00:00:00

abstract：:To continue expanding the use of Single Electron Transfer-Living Radical Polymerization (SET-LRP) in applications at the interface between macromolecular science, biomacromolecules, biology and medicine, it is essential to develop novel initiators that do not compromise the structural stability of synthesized polymers...

journal_title：Biomacromolecules

authors： Lligadas G,Enayati M,Grama S,Smail R,Sherman SE,Percec V

更新日期：2017-08-14 00:00:00

abstract：:Glycopolymer-polypeptide triblock copolymers of the structure, poly(l-alanine)-b-poly(2-acryloyloxyethyl-lactoside)-b-poly(l-alanine) (AGA), have been synthesized by sequential atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP). Controlled free radical polymerization of 2-O-acryloyl-oxye...

journal_title：Biomacromolecules

authors： Dong CM,Sun XL,Faucher KM,Apkarian RP,Chaikof EL

更新日期：2004-01-01 00:00:00

abstract：:We have constructed a tandem gene expression cassette containing three Ralstonia eutropha poly[(R)-3-hydroxybutyrate] (PHB) synthesis genes under the control of the Pichia pastoris glyceraldehyde-3-phosphate promoter and the green fluorescent protein (Gfp) under the control of the P. pastoris alcohol oxidase promoter....

journal_title：Biomacromolecules

authors： Vijayasankaran N,Carlson R,Srienc F

更新日期：2005-03-01 00:00:00

abstract：:The resistance developed by life-threatening bacteria toward conventional antibiotics has become a major concern in public health. To combat antibiotic resistance, there has been a significant interest in the development of antimicrobial cationic polymers due to the ease of synthesis and low manufacturing cost compare...

journal_title：Biomacromolecules

authors： Nimmagadda A,Liu X,Teng P,Su M,Li Y,Qiao Q,Khadka NK,Sun X,Pan J,Xu H,Li Q,Cai J

更新日期：2017-01-09 00:00:00

abstract：:We report the facile preparation of gels from the hydrothermal treatment of suspensions of cellulose nanocrystals (CNCs). The properties of the hydrogels have been investigated by rheology, electron microscopy, and spectroscopy with respect to variation in the temperature, time, and CNC concentration used in preparati...

journal_title：Biomacromolecules

authors： Lewis L,Derakhshandeh M,Hatzikiriakos SG,Hamad WY,MacLachlan MJ

更新日期：2016-08-08 00:00:00

abstract：:The unsatisfied results of cancer therapy are caused by many issues and metastasis of cancer cells is one of the major challenge. It has been reported that inhibiting the SDF1/CXCR4 interaction can significantly reduce the metastasis of breast cancer cells to regional lymph nodes and lung. Herein, a nanogel system equ...

journal_title：Biomacromolecules

authors： Zhang F,Gong S,Wu J,Li H,Oupicky D,Sun M

更新日期：2017-06-12 00:00:00

abstract：:We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin ...

journal_title：Biomacromolecules

authors： Yuk SH,Oh KS,Cho SH,Lee BS,Kim SY,Kwak BK,Kim K,Kwon IC

更新日期：2011-06-13 00:00:00

abstract：:We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a facile and versatile technology to prepare engineered nanocoatings for various biomedical applications. Low-fouling coatings on particles were obtained by the formation of multicomposition...

journal_title：Biomacromolecules

authors： Guntari SN,Wong EH,Goh TK,Chandrawati R,Blencowe A,Caruso F,Qiao GG

更新日期：2013-08-12 00:00:00