CXCR4-Targeted and Redox Responsive Dextrin Nanogel for Metastatic Breast Cancer Therapy.

abstract：:Polystyrene-polyisocyanopeptide (PS-PIAT) polymersomes containing CALB in two different locations, one in the aqueous inner compartment and one in the bilayer, were investigated for enzymatic ring-opening polymerization of lactones in water. It is shown that the monomers 8-octanolactone and dodecalactone yield oligome...

journal_title：Biomacromolecules

authors： Nallani M,de Hoog HP,Cornelissen JJ,Palmans AR,van Hest JC,Nolte RJ

更新日期：2007-12-01 00:00:00

abstract：:Safe delivery systems that can not only encapsulate hydrophobic drug molecules, but also release them in response to specific triggers are important in several therapeutic and biomedical applications. In this paper, we have designed a nanogel based on molecules that are generally recognized as safe (GRAS). We have sho...

journal_title：Biomacromolecules

authors： Prasad P,Molla MR,Cui W,Canakci M,Osborne B,Mager J,Thayumanavan S

更新日期：2015-11-09 00:00:00

abstract：:Injectable hydrogels based on extracellular matrix-derived polymers show much promise in the field of tissue engineering and regenerative medicine. However, the hydrogels reported to date have at least one characteristic that limits their potential for clinical use, such as excessive swelling, complicated and potentia...

journal_title：Biomacromolecules

authors： Pupkaite J,Rosenquist J,Hilborn J,Samanta A

更新日期：2019-09-09 00:00:00

abstract：:Poly(L-lactide)-based microspheres having cationic or anionic surfaces were prepared using polydepsipeptide-block-poly(L-lactide)s as surfactants. Polydepsipeptide-block-poly(L-lactide)s having amino or carboxylic acid groups on their side chains were synthesized through anionic ring-opening polymerizations of L-lacti...

journal_title：Biomacromolecules

authors： Ouchi T,Toyohara M,Arimura H,Ohya Y

更新日期：2002-09-01 00:00:00

abstract：:We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assemble...

journal_title：Biomacromolecules

authors： Hosta-Rigau L,Chandrawati R,Saveriades E,Odermatt PD,Postma A,Ercole F,Breheney K,Wark KL,Städler B,Caruso F

更新日期：2010-12-13 00:00:00

abstract：:Solid-state NMR is especially useful when the structures of peptides and proteins should be analyzed by taking into account the structural distribution, that is, the distribution of the torsion angle of the individual residue. In this study, two-dimensional spin-diffusion solid-state NMR spectra of 13C-double-labeled ...

journal_title：Biomacromolecules

authors： Ohgo K,Kawase T,Ashida J,Asakura T

更新日期：2006-04-01 00:00:00

abstract：:Silk fibroin hydrogels with tunable properties could be obtained from aqueous fibroin solutions (4.2 w/v %) in a short period of time. This was achieved by the addition of ethylene glycol diglycidyl ether (EGDE) into the reaction solution. Introduction of EGDE cross-links between the fibroin molecules decreases the mo...

journal_title：Biomacromolecules

authors： Karakutuk I,Ak F,Okay O

更新日期：2012-04-09 00:00:00

abstract：:Effects of poly(ethylene glycol) (PEG) conjugation on peptide interactions with lipid membranes and lipopolysaccharide (LPS) were investigated for KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYTLR), an antimicrobial and anti-inflammatory peptide derived from human heparin cofactor II. In particular, effects of PEG length and locali...

journal_title：Biomacromolecules

authors： Singh S,Papareddy P,Mörgelin M,Schmidtchen A,Malmsten M

更新日期：2014-04-14 00:00:00

abstract：:Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized usi...

journal_title：Biomacromolecules

authors： O'Toole MG,Henderson RM,Soucy PA,Fasciotto BH,Hoblitzell PJ,Keynton RS,Ehringer WD,Gobin AS

更新日期：2012-08-13 00:00:00

abstract：:There has been little study on the effect of composition or molecular weight on the biodegradation rate of photo-cross-linked biodegradable aliphatic polyesters though such information is important for tissue engineering scaffolds. We have synthesized a new series of photopolymerizable linear poly(epsilon-caprolactone...

journal_title：Biomacromolecules

authors： Shen JY,Pan XY,Lim CH,Chan-Park MB,Zhu X,Beuerman RW

更新日期：2007-02-01 00:00:00

abstract：:The resistance developed by life-threatening bacteria toward conventional antibiotics has become a major concern in public health. To combat antibiotic resistance, there has been a significant interest in the development of antimicrobial cationic polymers due to the ease of synthesis and low manufacturing cost compare...

journal_title：Biomacromolecules

authors： Nimmagadda A,Liu X,Teng P,Su M,Li Y,Qiao Q,Khadka NK,Sun X,Pan J,Xu H,Li Q,Cai J

更新日期：2017-01-09 00:00:00

abstract：:Tannic acid (TA) can form stable complexes with proteins, attracting significant attention as protein delivery systems. However, its systemic application has been limited due to nonspecific interaction. Here, we report a simple technique to prepare systemically applicable protein delivery systems using sequential self...

journal_title：Biomacromolecules

authors： Honda Y,Nomoto T,Matsui M,Takemoto H,Kaihara Y,Miura Y,Nishiyama N

更新日期：2020-09-14 00:00:00

abstract：:Aggregation phenomena in aqueous solutions of purified human tracheobronchial mucin have been studied by rheological methods, steady-state fluorescence, quasielastic light scattering, and spin probe techniques. At temperatures below 30 degrees C and concentrations above 15 mg/mL and in the absence of chaotropic agents...

journal_title：Biomacromolecules

authors： Bromberg LE,Barr DP

更新日期：2000-10-01 00:00:00

abstract：:Consensus motifs for sequences of both crystallizable and amorphous blocks in silks and natural structural analogues of silks vary widely. To design novel silklike polypeptides, an important question is therefore how the nature of either the crystallizable or the amorphous block affects the self-assembly and resulting...

journal_title：Biomacromolecules

authors： Willems L,van Westerveld L,Roberts S,Weitzhandler I,Calcines Cruz C,Hernandez-Garcia A,Chilkoti A,Mastrobattista E,van der Oost J,de Vries R

更新日期：2019-10-14 00:00:00

abstract：:Methylprednisolone steroid esters of hyaluronan differing in degree of functionalization and molecular weight were investigated in aqueous solution. Conformation and aggregation phenomena were elucidated by means of circular dichroism, viscometry, rheology, and nuclear magnetic resonance, mainly by (1)H pulsed field g...

journal_title：Biomacromolecules

authors： Taglienti A,Valentini M,Sequi P,Crescenzi V

更新日期：2005-05-01 00:00:00

abstract：:Silk-elastin-like proteins (SELPs) have enormous potential for use as customizable biomaterials in numerous biomedical and materials applications, yet success in harnessing this potential has been limited by the lack of a commercially viable industrially relevant production process. We have developed a scalable fed-ba...

journal_title：Biomacromolecules

authors： Collins T,Barroca M,Branca F,Padrão J,Machado R,Casal M

更新日期：2014-07-14 00:00:00

abstract：:A shortage of available organ donors has created a need for engineered tissues. In this context, polymer-based hydrogels that break down inside the body are often used as constructs for growth factors and cells. Herein, we report imine cross-linked gels where degradation is controllable by the introduction of mixed im...

journal_title：Biomacromolecules

authors： Boehnke N,Cam C,Bat E,Segura T,Maynard HD

更新日期：2015-07-13 00:00:00

abstract：:Medical glue represents a suitable tool to stop wound bleeding, seal wounds, bond tissues, or implant materials. However, the development of a medical glue for durable underwater bonding remains a challenge. Herein, we developed a hydrophobic hyperbranched polymer-based medical glue with water-resistant bonding abilit...

journal_title：Biomacromolecules

authors： Zhang Y,Li X,Zhu Q,Wei W,Liu X

更新日期：2020-12-14 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles are widely used as nanoprobes for magnetic resonance imaging (MRI). Water-soluble iron oxide nanoparticles were synthesized by coating iron oxide nanoparticles with a hydrophilic, biocompatible, biodegradable poly(amino acid) derivative, poly(2-hydroxyethyl aspartamide) graft...

journal_title：Biomacromolecules

authors： Yang HM,Park CW,Woo MA,Kim MI,Jo YM,Park HG,Kim JD

更新日期：2010-11-08 00:00:00

abstract：:The first step in the conventional approach to self-assembled biomaterials is to develop well-defined nanostructures in vitro, which is followed by disruption of the preformed nanostructures at the inside of the cell to achieve bioactivity. Here, we propose an inverse strategy to develop in-cell gain-of-function self-...

journal_title：Biomacromolecules

authors： Waqas M,Jeong WJ,Lee YJ,Kim DH,Ryou C,Lim YB

更新日期：2017-03-13 00:00:00

abstract：:Imbalanced homeostasis and oligomerization of the amyloid-β (Aβ) peptide in the brain are hallmarks of Alzheimer's disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing Aβ from the brain or inducing inflammation. Recent evidence suggests that clearance of Aβ by microglia...

journal_title：Biomacromolecules

authors： Richman M,Perelman A,Gertler A,Rahimipour S

更新日期：2013-01-14 00:00:00

abstract：:The adhesion of wet regenerated cellulose to colloidal complexes formed between carboxymethyl cellulose (CMC) and polyvinylamine (PVAm) was evaluated by measuring the force to delaminate pairs of regenerated cellulose membranes bound together with polyelectrolyte complex. The most important parameter was the surface c...

journal_title：Biomacromolecules

authors： Feng X,Pouw K,Leung V,Pelton R

更新日期：2007-07-01 00:00:00

abstract：:Chimeric DNA containing parallel (ps) and antiparallel (aps) duplex elements as well as poly-dC tracts were designed and synthesized. Oligonucleotide duplexes with ps chain orientation containing reverse Watson-Crick dA-dT base pairs and short d(C)2 tails are stabilized under slightly acidic conditions by hemiprotonat...

journal_title：Biomacromolecules

authors： Mei H,Budow S,Seela F

更新日期：2012-12-10 00:00:00

abstract：:Repifermin, a truncated form of fibroblast growth factor-10 (FGF-10) also known as keratinocyte growth factor-2 (KGF-2), is a heparin-binding protein with potent regenerative properties. The protein unfolds and aggregates at relatively low temperature (~37 °C). Electrostatic interactions between polyanions and several...

journal_title：Biomacromolecules

authors： Khondee S,Olsen CM,Zeng Y,Middaugh CR,Berkland C

更新日期：2011-11-14 00:00:00

abstract：:Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization o...

journal_title：Biomacromolecules

authors： Brandl F,Hammer N,Blunk T,Tessmar J,Goepferich A

更新日期：2010-02-08 00:00:00

abstract：:Relative to normal cells, tumor cells lack adequate capability of reactive oxygen scavenging. Thus, tumor cells can be selectively killed by increasing the concentration of reactive oxygen species in tumor tissue. In this report, we construct an integrated multifunctional polymeric nanoparticle which can selectively i...

journal_title：Biomacromolecules

authors： Wang Y,Yin W,Ke W,Chen W,He C,Ge Z

更新日期：2018-06-11 00:00:00

abstract：:We demonstrate the fabrication of protein·gold nanoparticle (AuNP) nanocomposites in situ, leading to distinct assemblies dependent upon protein secondary structure. In the presence of pentameric coiled-coil proteins C and Q, which contain histidine tags and have helicities of 54 and 65%, respectively, templation of A...

journal_title：Biomacromolecules

authors： Hume J,Chen R,Jacquet R,Yang M,Montclare JK

更新日期：2015-06-08 00:00:00

abstract：:Properties of Aloe vera galacturonate hydrogels formed via Ca(2+) crosslinking have been studied in regard to key parameters influencing gel formation including molecular weight, ionic strength, and molar ratio of Ca(2+) to COO(-) functionality. Dynamic oscillatory rheology and pulsed field gradient NMR (PFG-NMR) stud...

journal_title：Biomacromolecules

authors： McConaughy SD,Kirkland SE,Treat NJ,Stroud PA,McCormick CL

更新日期：2008-11-01 00:00:00

abstract：:The purpose of this study was to gain mechanistic insights into the effect of different formulation parameters on the degradation and release behavior of protein-loaded nanoparticulate carrier systems based on an aliphatic polyester with pendant hydroxyl groups, poly(lactic-co-glycolic-hydroxymethyl glycolic acid) (pL...

journal_title：Biomacromolecules

authors： Samadi N,van Nostrum CF,Vermonden T,Amidi M,Hennink WE

更新日期：2013-04-08 00:00:00

abstract：:Images of high methoxyl orange pectin deposited from solution and high methoxyl sugar acid gels (HMSAG) were obtained by atomic force microscopy (AFM) in the tapping mode. For the first time, images of pectin deposited from water revealed that the transition from pectin networks to individual molecules or aggregates t...

journal_title：Biomacromolecules

authors： Fishman ML,Cooke PH,Chau HK,Coffin DR,Hotchkiss AT Jr

更新日期：2007-02-01 00:00:00