Abstract:
:The resistance developed by life-threatening bacteria toward conventional antibiotics has become a major concern in public health. To combat antibiotic resistance, there has been a significant interest in the development of antimicrobial cationic polymers due to the ease of synthesis and low manufacturing cost compared to host-defense peptides (HDPs). Herein, we report the design and synthesis of amphiphilic polycarbonates containing primary amino groups. These polymers exhibit potent antimicrobial activity and excellent selectivity to Gram-positive bacteria, including multidrug resistant pathogens. Fluorescence and TEM studies suggest that these polymers are likely to kill bacteria by disrupting bacterial membranes. These polymers also show low tendency to elicit resistance in bacteria. Their further development may lead to new antimicrobial agents combating drug-resistance.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Nimmagadda A,Liu X,Teng P,Su M,Li Y,Qiao Q,Khadka NK,Sun X,Pan J,Xu H,Li Q,Cai Jdoi
10.1021/acs.biomac.6b01385subject
Has Abstractpub_date
2017-01-09 00:00:00pages
87-95issue
1eissn
1525-7797issn
1526-4602journal_volume
18pub_type
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