Abstract：
:Stereocomplexation of poly(L-lactide) (PLLA) with star shaped D-lactic acid (D-LA) oligomers with different architectures and end-groups clearly altered the degradation rate and affected the degradation product patterns. Altogether, nine materials were studied: standard PLLA and eight blends of PLLA with either 30 or 50 wt % of four different D-LA oligomers. The influence of several factors, including temperature, degradation time, and amount and type of D-LA oligomer, on the hydrolytic degradation process was investigated using a fractional factorial experimental design. Stereocomplexes containing star shaped D-LA oligomers with four alcoholic end-groups underwent a rather slow hydrolytic degradation with low release of degradation products. Materials with linear D-LA oligomers exhibited similar mass loss but released higher concentrations of shorter acidic degradation products. Increasing the fraction of D-LA oligomers with a linear structure or with four alcoholic end-groups resulted in slower mass loss due to higher degree of stereocomplexation. The opposite results were obtained after addition of D-LA oligomers with carboxylic chain-ends. These materials demonstrated lower degree of stereocomplexation and larger mass and molar mass loss, and also the release of degradation products increased. Increasing the number of alcoholic chain-ends from four to six decreased the degree of stereocomplexation, leading to faster mass loss. The degree of stereocomplexation and degradation rate were customized by changing the architecture and end-groups of the D-LA oligomers.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Andersson SR,Hakkarainen M,Inkinen S,Södergård A,Albertsson ACdoi
10.1021/bm300196hsubject
Has Abstractpub_date
2012-04-09 00:00:00pages
1212-22issue
4eissn
1525-7797issn
1526-4602journal_volume
13pub_type
杂志文章abstract：:Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clin...
journal_title：Biomacromolecules
pub_type： 杂志文章,评审
doi：10.1021/acs.biomac.9b00043
更新日期：2019-04-08 00:00:00
abstract：:Six methyl celluloses (MCs), one with a degree of substitution (DS) of 1.32 and five with DS between 1.83 and 1.88, were thoroughly investigated. Monomer composition and methyl distribution in the polymer chain were analyzed after total or partial random hydrolysis and appropriate derivatization with gas chromatograph...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm050941+
更新日期：2006-05-01 00:00:00
abstract：:The thermally induced aggregation of bovine β-lactoglobulin in the glass state was studied both as the pure protein and in trehalose mixtures. Calorimetric measurements and size exclusion chromatography were used to characterize the glass state and aggregation, respectively. The initial aggregation rate was characteri...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm100785d
更新日期：2010-11-08 00:00:00
abstract：:Neutral cellulose nanocrystals dispersed in water were shown in a previous work to stabilize oil/water interfaces and produce Pickering emulsions with outstanding stability, whereas sulfated nanocrystals obtained from cotton did not show interfacial properties. To develop a better understanding of the stabilization me...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm201599j
更新日期：2012-01-09 00:00:00
abstract：:Aggregation phenomena in aqueous solutions of purified human tracheobronchial mucin have been studied by rheological methods, steady-state fluorescence, quasielastic light scattering, and spin probe techniques. At temperatures below 30 degrees C and concentrations above 15 mg/mL and in the absence of chaotropic agents...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm005532m
更新日期：2000-10-01 00:00:00
abstract：:High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytot...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm8007988
更新日期：2008-11-01 00:00:00
abstract：:Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential to offer cures for previously untreatable diseases. However, they present an enormous delivery challenge due to poor absorption and rapid me...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01754
更新日期：2020-04-13 00:00:00
abstract：:On-line size-exclusion chromatography monitoring of potato phosphorylase catalyzed amylose synthesis--starting from alpha-D-glucose-1-P and maltohexaose--revealed rather monodisperse amylose populations. In the presence of lipids, amylose-lipid complexes spontaneously formed and precipitated. They were recovered by ce...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0502011
更新日期：2005-09-01 00:00:00
abstract：:A unified kinetic pathway for the enzyme-catalyzed polymerization and degradation of poly(ε-caprolactone) was developed. This model tracks the complete distribution of individual chain lengths, both enzyme-bound and in solution, and successfully predicts monomer conversion and the molecular mass distribution as a func...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm2009312
更新日期：2011-09-12 00:00:00
abstract：:PLGA nanoparticles are among the most studied polymer nanoformulations for several drugs against different kinds of malignant diseases, thanks to their in vivo stability and tumor localization exploiting the well-documented "enhanced permeation and retention" (EPR) effect. In this paper, we have developed uniform curc...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm3017324
更新日期：2013-03-11 00:00:00
abstract：:The extracellular matrix is an environment rich with structural, mechanical, and molecular signals that can impact cell biology. Traditional approaches in hydrogel biomaterial design often rely on modifying the concentration of cross-linking groups to adjust mechanical properties. However, this strategy provides limit...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b00118
更新日期：2017-04-10 00:00:00
abstract：:Highly fluorescent N-substituted 1-cyanobenz[f]isoindole chitosans (CBI-CSs) with various degrees of N-substitution (DS) were synthesized by reacting chitosan (CS) with naphthalene-2,3-dicarboxaldehyde (NDA) in the presence of cyanide under mild acidic conditions. Introduction of 1-cyanobenz[f]isoindole moieties into ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm5004459
更新日期：2014-08-11 00:00:00
abstract：:The adsorption of human immunoglobulin G (hIgG) and bovine serum albumin (BSA) on cellulose supports were investigated. The dynamics and extent of related adsorption processes were monitored by surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D). Amine groups were instal...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm201236a
更新日期：2011-12-12 00:00:00
abstract：:Vascular grafts that can support total replacement and maintenance by the body of the injured vessel would improve outcomes of major surgical reconstructions. Building scaffolds using components of the native vessel can encourage biological recognition by native cells as well as mimic mechanical characteristics of the...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b01165
更新日期：2017-11-13 00:00:00
abstract：:Noncontact mode atomic force microscopy was used to investigate native silk proteins prepared in different ways. Low protein concentrations revealed that single protein molecules exhibit a simple, round shape with apparent diameters of 20-25 nm. Shearing the native protein solutions after extraction from the gland and...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm201509b
更新日期：2012-03-12 00:00:00
abstract：:A major challenge in drug delivery is the internalization through the apical plasma membrane of the polarized epithelial cells lining organs facing the external environment, e.g., lungs and the gastrointestinal tract. The reduced permeation of drugs entering through this pathway is in part due to the mucosal barrier a...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm700535p
更新日期：2008-02-01 00:00:00
abstract：:Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm100138m
更新日期：2010-06-14 00:00:00
abstract：:Bovine hemoglobin (Hb) was encapsulated inside polymer vesicles (polymersomes) to form polymersome encapsulated Hb (PEH) dispersions. PEH particles are 100% surface PEGylated with longer PEG chains and possess thicker hydrophobic membranes as compared to conventional liposomes. Polymersomes were self-assembled from po...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0501454
更新日期：2005-07-01 00:00:00
abstract：:Electrospinning of cellulose nanocrystals (CNC)/poly(lactic acid) (PLA) emulsions has been demonstrated to be an effective dispersion and alignment method to control assembly of CNC into continuous composite ultrafine fibers. CNC-PLA nanocomposite random-fiber mats and aligned-fiber yarns were prepared by emulsion ele...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm400540v
更新日期：2013-11-11 00:00:00
abstract：:Materials with fungi-bioinspired surface have been designed to host ergosterol-binding polyene antibiotics and to release them via a competitive mechanism only when fungi are present in the medium. Silicone rubber (SR) surfaces were endowed with selective loading and fungi-triggered release of polyene antifungal agent...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm500257s
更新日期：2014-05-12 00:00:00
abstract：:Biopolymers bearing hydrophobic side-chains, such as hydrophobically modified chitosan (hmC), can connect liposomes into a gel network via hydrophobic interactions. In this paper, we show that such liposome gels possess an attractive combination of properties for certain drug delivery applications. Their shear-thinnin...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm301143d
更新日期：2012-10-08 00:00:00
abstract：:Antifreeze glycoproteins (AFGPs) are a subclass of biological antifreezes found in deep sea Teleost fish. These compounds have the ability to depress the freezing point of the organism such that it can survive the subzero temperatures encountered in its environment. This physical property is very attractive for the cr...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm061044o
更新日期：2007-05-01 00:00:00
abstract：:Generation of bioenergy, new functional polymers, or chemicals and biomaterials from hemicelluloses are important uses for biomass. In this paper, a novel functional biopolymer with carbon-carbon double bond and carboxyl groups was prepared by a homogeneous esterification of xylan-rich hemicelluloses (XH) with maleic ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm1010118
更新日期：2010-12-13 00:00:00
abstract：:Glycerol derivatives of cutin and suberin monomers were synthesized by acid catalysis. Their dispersion in an aqueous solution was examined by phase contrast microscopy, neutron scattering, and solid state NMR. It is shown that the phase behavior strongly depends on the nature of the derivatives forming either lumps o...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049325o
更新日期：2005-01-01 00:00:00
abstract：:A combination of chemo-photodynamic therapy has been manifested as a promising strategy for efficient cancer treatment due to the enhanced therapeutic efficacy. Here, we designed doxorubicin (DOX)-loaded photoresponsive micelles (DPRMs) based on a combination of chlorin e6 (Ce6) and lipoic acid (LA) conjugated methoxy...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b00607
更新日期：2018-08-13 00:00:00
abstract：:Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths near 1 MPa. An increase ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm501456g
更新日期：2015-01-12 00:00:00
abstract：:Biomimetic nanoengineering built through integrating the specific cell membrane with artificially synthetic nanomedicines represents one of the most promising directions for the actualization of personalized therapy. For addressing the technical hurdle against the development of this biomimetic technology, the present...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b00242
更新日期：2018-06-11 00:00:00
abstract：:There has been little study on the effect of composition or molecular weight on the biodegradation rate of photo-cross-linked biodegradable aliphatic polyesters though such information is important for tissue engineering scaffolds. We have synthesized a new series of photopolymerizable linear poly(epsilon-caprolactone...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060766c
更新日期：2007-02-01 00:00:00
abstract：:Biobased poly(γ-butyrolactone) (PγBL) as a fully biodegradable and bioabsorbable biomaterial has shown superior properties compared to those of other aliphatic polyesters. It is of great importance to prepare amphiphilic block copolymer containing PγBL block to make ordered nano-objects for biomedical applications suc...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b01239
更新日期：2019-01-14 00:00:00
abstract：:Electrospun natural polymer membranes were fabricated from collagen or gelatin coated with a bioactive recombinant fragment of perlecan, a natural heparan sulfate proteoglycan. The electrospinning process allowed the facile processing of a three-dimensional, porous fibril (2-6 microm in diameter) matrix suitable for t...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm061003s
更新日期：2007-04-01 00:00:00
