Biopolymer-connected liposome networks as injectable biomaterials capable of sustained local drug delivery.

abstract：:The photoluminescence features of Eu(3+)-, Tb(3+)-, Tb(3+)/Eu(3+)-alginate aerogel (hydrogel and alcogel) and Eu(3+)-alginate xerogel hybrids were investigated. The Eu(3+)-alginate aerogel and alcogel exhibit the highest (5)D0 quantum efficiencies (9.9 and 8.2%, respectively), while the hydrogel and xerogel have lower...

journal_title：Biomacromolecules

authors： Liu F,Carlos LD,Ferreira RA,Rocha J,Gaudino MC,Robitzer M,Quignard F

更新日期：2008-07-01 00:00:00

abstract：:Hydrogels with pH-sensitive poly(acrylic acid) (PAAc) chains and biodegradable acryloyl-poly(-caprolactone)-2-hydroxylethyl methacrylate (AC-PCL-HEMA) chains were designed and synthesized. The morphology of hydrogel was observed by scanning electron microscopy. The degradation of the hydrogel in the presence of Pseudo...

journal_title：Biomacromolecules

authors： Wu DQ,Sun YX,Xu XD,Cheng SX,Zhang XZ,Zhuo RX

更新日期：2008-04-01 00:00:00

abstract：:Despite recent advances in tumor treatment through cancer immunotherapy, the efficacy of this approach remains to be improved. Looking forward to high rates of objective clinical response, cancer immunotherapy combined with chemotherapy has gained increasing attention recently. Here, we constructed liposomes with matr...

journal_title：Biomacromolecules

authors： Liu Y,Chen XG,Yang PP,Qiao ZY,Wang H

更新日期：2019-02-11 00:00:00

abstract：:Hydrogels derived from resilin-like polypeptides (RLPs) have shown outstanding mechanical resilience and cytocompatibility; expanding the versatility of RLP-based materials via conjugation with other polypeptides and polymers would offer great promise in the design of a range of materials. Here, we present an investig...

journal_title：Biomacromolecules

authors： McGann CL,Akins RE,Kiick KL

更新日期：2016-01-11 00:00:00

abstract：:Heparin, a sulfated polysaccharide derived from animal sources, is the most commonly used parenteral anticoagulant drug, but it suffers from significant safety and supply issues. Herein, we describe the preparation of heparin mimetic homo- and copolymers via the reversible addition-fragmentation chain transfer (RAFT) ...

journal_title：Biomacromolecules

authors： Nahain AA,Ignjatovic V,Monagle P,Tsanaktsidis J,Vamvounis G,Ferro V

更新日期：2020-02-10 00:00:00

abstract：:Anionic copolymer systems containing sulfated monomers have great potential for delivery of cationic therapeutics, but N-isopropylacrylamide (NIPAm) 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) copolymer nanoparticles have seen limited characterization to date with regard to physical properties relevant to load...

journal_title：Biomacromolecules

authors： Bartlett RL 2nd,Medow MR,Panitch A,Seal B

更新日期：2012-04-09 00:00:00

abstract：:Hemicellulose-based hydrogels were prepared by radical polymerization of 2-hydroxyethyl methacrylate or poly(ethylene glycol) dimethacrylate with oligomeric hydrosoluble hemicellulose modified with well-defined amounts of methacrylic functions. The polymerization reaction was carried out in water at 40 degrees C using...

journal_title：Biomacromolecules

authors： Söderqvist Lindblad M,Albertsson AC,Ranucci E,Laus M,Giani E

更新日期：2005-03-01 00:00:00

abstract：:Water-soluble conjugated polymers (WCPs) composed of a hydrophobic polythiophene main chain with hydrophilic tertiary amine side-chains can directly self-assemble into sphere-like nano-objects in an aqueous solution due to phase separation between the hydrophilic and hydrophobic segments of the polymeric structure. Du...

journal_title：Biomacromolecules

authors： Cheng CC,Lai YC,Shieh YT,Chang YH,Lee AW,Chen JK,Lee DJ,Lai JY

更新日期：2020-12-14 00:00:00

abstract：:The interaction of polysaccharides with water has a critical impact on their biological function as well as their technological applications. We performed ellipsometry experiments at different relative humidities (RH) to measure the equilibrium swelling of ultrathin films of different polysaccharides: native and modif...

journal_title：Biomacromolecules

authors： Grossutti M,Dutcher JR

更新日期：2020-12-14 00:00:00

abstract：:Water soluble polymer anticancer conjugates can improve the pharmacokinetics of covalently bound drugs by limiting cellular uptake to the endocytic route, thus prolonging plasma circulation time and consequently facilitating tumor targeting by the enhanced permeability and retention (EPR) effect. Many of the first gen...

journal_title：Biomacromolecules

authors： Andersson L,Davies J,Duncan R,Ferruti P,Ford J,Kneller S,Mendichi R,Pasut G,Schiavon O,Summerford C,Tirk A,Veronese FM,Vincenzi V,Wu G

更新日期：2005-03-01 00:00:00

abstract：:Nanoparticles (NPs) with high drug loading and pH-responsivity were prepared by nanoprecipitation of a hydrophobic polymer-drug conjugate (PDC). The PDC, polylactide-graft-doxorubicin (PLA-g-DOX), was synthesized by azide-alkyne click reaction to transform acetylene-functionalized PLA into PLA-graft-aldehyde (PLA-g-AL...

journal_title：Biomacromolecules

authors： Yu Y,Chen CK,Law WC,Weinheimer E,Sengupta S,Prasad PN,Cheng C

更新日期：2014-02-10 00:00:00

abstract：:Poly(3-(tert-butoxycarbonyl)-N-vinyl-2-pyrrolidone) has been synthesized and characterized by gel permeation chromatography, Fourier transform infrared spectroscopy, NMR spectroscopy, and thermal analysis. The polymer is a chemically amplified photoresist. Arrays of lines with 25 microm width and 25 microm spacing wer...

journal_title：Biomacromolecules

authors： He W,Gonsalves KE,Pickett JH,Halberstadt C

更新日期：2003-01-01 00:00:00

abstract：:This study is devoted to developing amphiphilic block polymers based on phenylborate ester, which can self-assemble to form nanoparticles, as a glucose-sensitive drug carrier. Poly(ethylene glycol)-block-poly[(2-phenylboronic esters-1,3-dioxane-5-ethyl) methylacrylate] (MPEG5000-block-PBDEMA) was fabricated with MPEG5...

journal_title：Biomacromolecules

authors： Yao Y,Zhao L,Yang J,Yang J

更新日期：2012-06-11 00:00:00

abstract：:G-quadruplex is a type of DNA secondary structure formed by specific guanine-rich sequences. Because of their enrichment in functional genomic regions and their biological significance, G-quadruplexes are recognized as significant drug targets for cancer and other diseases. Here, we tested the precipitation efficiency...

journal_title：Biomacromolecules

authors： Lin J,Yan YY,Ou TM,Tan JH,Huang SL,Li D,Huang ZS,Gu LQ

更新日期：2010-12-13 00:00:00

abstract：:Surface pressure isotherms and structural and surface dilatational properties of three hydroxypropylmethycelluloses (HPMCs, called E4M, E50LV, and F4M) adsorbed films at the air-water interface were determined. In this work we present evidence that HPMC molecules are able to diffuse and saturate the air-water interfac...

journal_title：Biomacromolecules

authors： Pérez OE,Sánchez CC,Rodríguez Patino JM,Pilosof AM

更新日期：2006-01-01 00:00:00

abstract：:Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...

journal_title：Biomacromolecules

authors： Manchineella S,Murugan NA,Govindaraju T

更新日期：2017-11-13 00:00:00

abstract：:A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...

journal_title：Biomacromolecules

authors： Charlot A,Heyraud A,Guenot P,Rinaudo M,Auzély-Velty R

更新日期：2006-03-01 00:00:00

abstract：:We report the synthesis of PEG-coated, core-cross-linked polymeric micelles (CCPMs) derived from an amine-terminated amphiphilic block copolymer, poly(PEG-methacrylate)-b-poly(triethoxysilyl propylmethacrylate). The block copolymer self-assembled to form micellar nanoparticles, and a Cy-7-like near-infrared fluorescen...

journal_title：Biomacromolecules

authors： Yang Z,Zheng S,Harrison WJ,Harder J,Wen X,Gelovani JG,Qiao A,Li C

更新日期：2007-11-01 00:00:00

abstract：:A stepwise anticancer drug delivery system based on an injectable supramolecular hydrogel was presented. In this system, poly(ethylene glycol)-b-poly(acrylic acid) (PEG-b-PAA) block copolymer nanoparticles containing cisplatin were released by erosion of the hydrogels and then the cisplatin was released from the nanop...

journal_title：Biomacromolecules

authors： Zhu W,Li Y,Liu L,Chen Y,Wang C,Xi F

更新日期：2010-11-08 00:00:00

abstract：:We study the self-assembly of genetically engineered protein-based triblock copolymers consisting of a central pH-responsive silk-like middle block (S(H)n, where S(H) is a silk-like octapeptide, (GA)3GH and n is the number of repeats) flanked by hydrophilic random coil outer blocks (C2). Our previous work has already ...

journal_title：Biomacromolecules

authors： Beun LH,Storm IM,Werten MW,de Wolf FA,Cohen Stuart MA,de Vries R

更新日期：2014-09-08 00:00:00

abstract：:In the present work, a novel synthetic methodology for the preparation of scaffold of biopolymeric nature is described. In particular, a porous gelatin scaffold was prepared by foam templating. The gas phase, nitrogen, was generated by means of the reaction between sulfamic acid and sodium nitrite in situ a concentrat...

journal_title：Biomacromolecules

authors： Barbetta A,Gumiero A,Pecci R,Bedini R,Dentini M

更新日期：2009-12-14 00:00:00

abstract：:Coiled coils are a common structural motif in many natural proteins that can also be utilized in the design and preparation of drug delivery systems for the noncovalent connection of two macromolecules. In this work, two different pairs of peptides forming coiled coil hetero-oligomers were designed, synthesized, and c...

journal_title：Biomacromolecules

authors： Pechar M,Pola R,Laga R,Braunová A,Filippov SK,Bogomolova A,Bednárová L,Vaněk O,Ulbrich K

更新日期：2014-07-14 00:00:00

abstract：:Recently, some attempts have been made to enhance the gas barrier properties of semicrystalline polymers by precisely controlling the arrangement of their impermeable crystalline lamellae. However, it is still a great challenge to achieve regular arrangement of the lamellae along the direction perpendicular to the gas...

journal_title：Biomacromolecules

authors： Bai H,Huang C,Xiu H,Zhang Q,Deng H,Wang K,Chen F,Fu Q

更新日期：2014-04-14 00:00:00

abstract：:Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens. Here we report on a generic polymer-protein ligation strategy to formulate protein antigens into reversible polymeric conjugates for ...

journal_title：Biomacromolecules

authors： Lybaert L,Vanparijs N,Fierens K,Schuijs M,Nuhn L,Lambrecht BN,De Geest BG

更新日期：2016-03-14 00:00:00

abstract：:Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths near 1 MPa. An increase ...

journal_title：Biomacromolecules

authors： Zhou J,Defante AP,Lin F,Xu Y,Yu J,Gao Y,Childers E,Dhinojwala A,Becker ML

更新日期：2015-01-12 00:00:00

abstract：:Weissella confusa VTT E-90392 is an efficient producer of a dextran that is mainly composed of α-(1→6)-linked D-glucosyl units and very few α-(1→3) branch linkages. A mixture of the Chaetomium erraticum endodextranase and the Aspergillus niger α-glucosidase was used to hydrolyze W. confusa dextran to glucose and a set...

journal_title：Biomacromolecules

authors： Maina NH,Virkki L,Pynnönen H,Maaheimo H,Tenkanen M

更新日期：2011-02-14 00:00:00

abstract：:A successful strategy for the immobilization of rennet from Mucor miehei has been developed. The strategy is based on the immobilization of the enzyme, via their sugar chains at high ionic strength on aminated supports having primary amino groups with a very low pK value. The rennet was covalently immobilized via suga...

journal_title：Biomacromolecules

authors： Pessela BC,Torres R,Fuentes M,Mateo C,Fernandez-Lafuente R,Guisán JM

更新日期：2004-09-01 00:00:00

abstract：:A surface force balance was used to measure the normal and shear forces between two mica surfaces each bearing an adsorbed layer of porcine gastric mucin ("Orthana" mucin), genetically similar to human MUC6. This mucin is a highly purified, 546 kDa, weakly negative, polyampholytic molecule with a "dumbbell" structure....

journal_title：Biomacromolecules

authors： Harvey NM,Yakubov GE,Stokes JR,Klein J

更新日期：2011-04-11 00:00:00

abstract：:This paper describes the synthesis and characterization of polymer-peptide conjugates to be used as infection-resistant coating for biomaterial implants and devices. Antiadhesive polymer brushes composed of block copolymer Pluronic F-127 (PF127) were functionalized with antimicrobial peptides (AMP), able to kill bacte...

journal_title：Biomacromolecules

authors： Muszanska AK,Rochford ET,Gruszka A,Bastian AA,Busscher HJ,Norde W,van der Mei HC,Herrmann A

更新日期：2014-06-09 00:00:00

abstract：:In the fields of surgery and regenerative medicine, it is crucial to understand the interactions of proteins with the biomaterials used as implants. Protein adsorption directly influences cell-material interactions in vivo and, as a result, regulates, for example, cell adhesion on the surface of the implant. Therefore...

journal_title：Biomacromolecules

authors： Schönwälder SM,Bally F,Heinke L,Azucena C,Bulut ÖD,Heißler S,Kirschhöfer F,Gebauer TP,Neffe AT,Lendlein A,Brenner-Weiß G,Lahann J,Welle A,Overhage J,Wöll C

更新日期：2014-07-14 00:00:00