Resilin-PEG Hybrid Hydrogels Yield Degradable Elastomeric Scaffolds with Heterogeneous Microstructure.

abstract：:Silk fibroin (SF) protein, produced by silkworm Bombyx mori, is a promising biomaterial, while sophorolipid (SL) is an amphiphilic functional biosurfactant synthesized by nonpathogenic yeast Candida bombicola. SL is a mixture of two forms, acidic (ASL) and lactonic (LSL), which when added to SF results in accelerated ...

journal_title：Biomacromolecules

authors： Dubey P,Kumar S,Aswal VK,Ravindranathan S,Rajamohanan PR,Prabhune A,Nisal A

更新日期：2016-10-10 00:00:00

abstract：:Cocontinuous phase structures of immiscible polymers can be developed under appropriate melt-blending conditions. Because of the presence of interfacial tension, such cocontinuous structures start to coarsen when heated to a temperature higher than the melting/softening temperature of both phases. In this study, a met...

journal_title：Biomacromolecules

authors： Yao D,Zhang W,Zhou JG

更新日期：2009-05-11 00:00:00

abstract：:The main objective of the present work was the development of new nanoparticulate carrier systems for the delivery of plasmid DNA. These new carriers consist of a blend matrix formed by a poly(lactic-co-glycolic acid) (PLGA) copolymer and polyoxyethylene derivatives. More specifically, we have prepared nanostructures ...

journal_title：Biomacromolecules

authors： Csaba N,Caamaño P,Sánchez A,Domínguez F,Alonso MJ

更新日期：2005-01-01 00:00:00

abstract：:Synthetic and natural mucoadhesive biomaterials in optimized galenical formulations are potentially useful for the transmucosal delivery of active ingredients to improve their localized and prolonged effects. Chitosans (CS) have potent mucoadhesive characteristics, but the exact mechanisms underpinning such interactio...

journal_title：Biomacromolecules

authors： Menchicchi B,Fuenzalida JP,Bobbili KB,Hensel A,Swamy MJ,Goycoolea FM

更新日期：2014-10-13 00:00:00

abstract：:Polyrotaxanes, a family of rod-shaped nanomaterials comprised of noncovalent polymer/macrocycle assemblies, are being used in a growing number of materials and biomedical applications. Their physiochemical properties can vary widely as a function of composition, potentially leading to different in vivo performance out...

journal_title：Biomacromolecules

authors： Collins CJ,Mondjinou Y,Loren B,Torregrosa-Allen S,Simmons CJ,Elzey BD,Ayat N,Lu ZR,Thompson D

更新日期：2016-09-12 00:00:00

abstract：:Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and investiga...

journal_title：Biomacromolecules

authors： Hintze V,Samsonov SA,Anselmi M,Moeller S,Becher J,Schnabelrauch M,Scharnweber D,Pisabarro MT

更新日期：2014-08-11 00:00:00

abstract：:The pressure and temperature dependence of the cloud point transition of an aqueous solution of an elastin-like polypeptide (MGLDGSMG(VPGIG)40VPLE), prepared by bacterial expression of the corresponding artificial gene, was measured. A temperature-pressure diagram was constructed over a wide range of conditions. The (...

journal_title：Biomacromolecules

authors： Tamura T,Yamaoka T,Kunugi S,Panitch A,Tirrell DA

更新日期：2000-01-01 00:00:00

abstract：:The mucilaginous viscin tissue within mistletoe berries possesses an extraordinary ability to be rapidly processed under ambient conditions into stiff cellulosic fibers (>14 GPa) through simple mechanical drawing. This rapid and extreme transformation process is hydration-dependent and involves an astonishing >200-fol...

journal_title：Biomacromolecules

authors： Horbelt N,Eder M,Bertinetti L,Fratzl P,Harrington MJ

更新日期：2019-08-12 00:00:00

abstract：:A heterofunctional support for enzyme immobilization may be defined as that which possesses several distinct functionalities on its surface able to interact with a protein. We will focus on those supports in which a final covalent attachment between the enzyme and the support is achieved. Heterofunctionality sometimes...

journal_title：Biomacromolecules

authors： Barbosa O,Torres R,Ortiz C,Berenguer-Murcia A,Rodrigues RC,Fernandez-Lafuente R

更新日期：2013-08-12 00:00:00

abstract：:Hydrogels have been widely explored for biomedical applications, with injectable hydrogels being of particular interest for their ability to precisely deliver drugs and cells to targets. Although these hydrogels have demonstrated satisfactory properties in many cases, challenges still remain for commercialization. In ...

journal_title：Biomacromolecules

authors： Zhang J,Muirhead B,Dodd M,Liu L,Xu F,Mangiacotte N,Hoare T,Sheardown H

更新日期：2016-11-14 00:00:00

abstract：:There is a lack of hydrogel materials whose properties can be tuned at the point of use. Biological hydrogels, such as collagen, gelate at physiological temperatures; however, they are not always ideal as scaffolds because of their low mechanical strength. Their mechanics can be improved through cross-linking and chem...

journal_title：Biomacromolecules

authors： Barnes AL,Genever PG,Rimmer S,Coles MC

更新日期：2016-03-14 00:00:00

abstract：:Minimization of drug side effects is a hallmark of advanced targeted therapy. Herein we describe the synthesis of polysaccharide-based nanocapsules prepared from furcellaran and chitosan via layer-by-layer deposition using electrostatic interaction. Using doxorubicin as a model drug, prepared nanocapsules showed excel...

journal_title：Biomacromolecules

authors： Milosavljevic V,Jamroz E,Gagic M,Haddad Y,Michalkova H,Balkova R,Tesarova B,Moulick A,Heger Z,Richtera L,Kopel P,Adam V

更新日期：2020-02-10 00:00:00

abstract：:Tiopronin (N-(2-mercaptopropionyl)glycine)-protected gold nanoparticles (TPAu) were cross-linked to collagen via EDC (1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide) coupling. On average, each TPAu forms eight amide bonds with collagen lysine moieties. The resulting gels were studied with environmental SEM, TEM, micr...

journal_title：Biomacromolecules

authors： Castaneda L,Valle J,Yang N,Pluskat S,Slowinska K

更新日期：2008-12-01 00:00:00

abstract：:Biopolymers bearing hydrophobic side-chains, such as hydrophobically modified chitosan (hmC), can connect liposomes into a gel network via hydrophobic interactions. In this paper, we show that such liposome gels possess an attractive combination of properties for certain drug delivery applications. Their shear-thinnin...

journal_title：Biomacromolecules

authors： Lee JH,Oh H,Baxa U,Raghavan SR,Blumenthal R

更新日期：2012-10-08 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease associated with severe exocrinopathy, which is characterized by profound lymphocytic infiltration (dacryoadenitis) and loss of function of the tear-producing lacrimal glands (LGs). Systemic administration of Rapamycin (Rapa) significantly reduces LG inflammation in the ...

journal_title：Biomacromolecules

authors： Ju Y,Edman MC,Guo H,Janga SR,Peddi S,Louie SG,Junge JA,MacKay JA,Hamm-Alvarez SF

更新日期：2020-12-27 00:00:00

abstract：:This study describes the first use of laccase-lipase enzymatic reaction for the synthesis of novel perfectly structured alternating copolymers. Initially, six types of complexing agents, linear(A)-linear(B), linear(A)-linear(B)-linear(A), linear-dendritic, dendritic-linear-dendritic, linear-hyperbranched, and hyperbra...

journal_title：Biomacromolecules

authors： Scheibel DM,Gitsov I

更新日期：2019-02-11 00:00:00

abstract：:This paper introduces a chitosan microneedle patch for efficient and sustained transdermal delivery of hydrophilic macromolecules. Chitosan microneedles have sufficient mechanical strength to be inserted in vitro into porcine skin at approximately 250 μm in depth and in vivo into rat skin at approximately 200 μm in de...

journal_title：Biomacromolecules

authors： Chen MC,Ling MH,Lai KY,Pramudityo E

更新日期：2012-12-10 00:00:00

abstract：:Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...

journal_title：Biomacromolecules

authors： Söntjens SH,Nettles DL,Carnahan MA,Setton LA,Grinstaff MW

更新日期：2006-01-01 00:00:00

abstract：:Tannic acid (TA) can form stable complexes with proteins, attracting significant attention as protein delivery systems. However, its systemic application has been limited due to nonspecific interaction. Here, we report a simple technique to prepare systemically applicable protein delivery systems using sequential self...

journal_title：Biomacromolecules

authors： Honda Y,Nomoto T,Matsui M,Takemoto H,Kaihara Y,Miura Y,Nishiyama N

更新日期：2020-09-14 00:00:00

abstract：:The synthesis of biocompatible, thermo-responsive ABA triblock copolymers in which the outer A blocks comprise poly(N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctional initiato...

journal_title：Biomacromolecules

authors： Li C,Tang Y,Armes SP,Morris CJ,Rose SF,Lloyd AW,Lewis AL

更新日期：2005-03-01 00:00:00

abstract：:Poly( n-butyl methacrylate) (PBMA) or poly( n-butyl acrylate) (PBA)-grafted brush coatings attached to glass were successfully prepared using atom-transfer radical polymerization "from the surface". The thicknesses and composition of the PBMA and PBA coatings were examined using ellipsometry and time-of-flight seconda...

journal_title：Biomacromolecules

authors： Awsiuk K,Stetsyshyn Y,Raczkowska J,Lishchynskyi O,Dąbczyński P,Kostruba A,Ohar H,Shymborska Y,Nastyshyn S,Budkowski A

更新日期：2019-06-10 00:00:00

abstract：:The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials. In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow eva...

journal_title：Biomacromolecules

authors： Walters CM,Boott CE,Nguyen TD,Hamad WY,MacLachlan MJ

更新日期：2020-03-09 00:00:00

abstract：:Anionic copolymer systems containing sulfated monomers have great potential for delivery of cationic therapeutics, but N-isopropylacrylamide (NIPAm) 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) copolymer nanoparticles have seen limited characterization to date with regard to physical properties relevant to load...

journal_title：Biomacromolecules

authors： Bartlett RL 2nd,Medow MR,Panitch A,Seal B

更新日期：2012-04-09 00:00:00

abstract：:Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...

journal_title：Biomacromolecules

authors： Schatz C,Viton C,Delair T,Pichot C,Domard A

更新日期：2003-05-01 00:00:00

abstract：:Benefiting from their inherent localized and controlled release properties, hydrogels are ideal delivery systems for therapeutic drugs or nanoparticles. In particular, applications of hydrogels for the delivery and release of photoresponsive drugs or nanoparticles are receiving increasing attention. However, the effec...

journal_title：Biomacromolecules

authors： Xia LY,Zhang X,Cao M,Chen Z,Wu FG

更新日期：2017-10-09 00:00:00

abstract：:Gelatin microspheres are well-known for their capacity to release growth factors in a controlled manner, but gelatin microspheres do not calcify in the absence of so-called bioactive substances that induce deposition of calcium phosphate (CaP) bone mineral. This study has investigated if CaP nanocrystals can be incorp...

journal_title：Biomacromolecules

authors： Leeuwenburgh SC,Jo J,Wang H,Yamamoto M,Jansen JA,Tabata Y

更新日期：2010-10-11 00:00:00

abstract：:Spider dragline silk with its superlative tensile properties provides an ideal system to study the relationship between morphology and mechanical properties of a structural protein. Accordingly, we synthesized two hybrid multiblock copolymers by condensing poly(alanine) [(Ala)(5)] blocks of the structural proteins (sp...

journal_title：Biomacromolecules

authors： Zhou C,Leng B,Yao J,Qian J,Chen X,Zhou P,Knight DP,Shao Z

更新日期：2006-08-01 00:00:00

abstract：:Hemicellulose-based hydrogels were prepared by radical polymerization of 2-hydroxyethyl methacrylate or poly(ethylene glycol) dimethacrylate with oligomeric hydrosoluble hemicellulose modified with well-defined amounts of methacrylic functions. The polymerization reaction was carried out in water at 40 degrees C using...

journal_title：Biomacromolecules

authors： Söderqvist Lindblad M,Albertsson AC,Ranucci E,Laus M,Giani E

更新日期：2005-03-01 00:00:00

abstract：:The need for thermosets from renewable resources is continuously increasing to find eco-friendly alternatives to petroleum-derived materials. Products obtained from biomass have shown to play an important role in this challenge. Here, we present the structural characterization of new biobased thermosets made of humins...

journal_title：Biomacromolecules

authors： Cantarutti C,Dinu R,Mija A

更新日期：2020-02-10 00:00:00

abstract：:A temperature-responsive hydrogel composed of aqueous methylcellulose (MC) blended with distinct concentrations of PBS was prepared and characterized. The developed MC hydrogel underwent a sol-gel reversible transition upon heating or cooling at approximately 32 degrees C. This temperature-responsive hydrogel was empl...

journal_title：Biomacromolecules

authors： Yang MJ,Chen CH,Lin PJ,Huang CH,Chen W,Sung HW

更新日期：2007-09-01 00:00:00