Effective detection and separation method for G-quadruplex DNA based on its specific precipitation with Mg(2+).

abstract：:The time-dependent diffusion and mechanical properties of gelatin in solution, in the gel state, and during the sol/gel transition were determined using fluorescence recovery after photobleaching (FRAP) and rheology. The parameters in the experimental design were 2% w/w and 5% w/w gelatin concentration; 15, 20, and 25...

journal_title：Biomacromolecules

authors： Hagman J,Lorén N,Hermansson AM

更新日期：2010-12-13 00:00:00

abstract：:Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...

journal_title：Biomacromolecules

authors： Söntjens SH,Nettles DL,Carnahan MA,Setton LA,Grinstaff MW

更新日期：2006-01-01 00:00:00

abstract：:Multicomponent poly(ethylene glycol) (PEG) brushes (i.e., ≥ 2 adjacent PEG brushes) can be used to engineer culture substrates with microscale, nonfouling regions decorated with covalently immobilized ligands that mediate biospecific interactions. However, synthesizing such brushes with orthogonal immobilization chemi...

journal_title：Biomacromolecules

authors： Sha J,Lippmann ES,McNulty J,Ma Y,Ashton RS

更新日期：2013-09-09 00:00:00

abstract：:To develop a safe, effective, and biocompatible gene delivery vector, a series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization of AGC polymers was performed by NMR and elemental analysis. AGC polymers demonstrated excel...

journal_title：Biomacromolecules

authors： Layek B,Singh J

更新日期：2013-02-11 00:00:00

abstract：:The interaction of polysaccharides with water has a critical impact on their biological function as well as their technological applications. We performed ellipsometry experiments at different relative humidities (RH) to measure the equilibrium swelling of ultrathin films of different polysaccharides: native and modif...

journal_title：Biomacromolecules

authors： Grossutti M,Dutcher JR

更新日期：2020-12-14 00:00:00

abstract：:Glycogen is mainly found as the principal storage form of glucose in cells. Many bacteria are able to synthesize large amounts of glycogen under unfavorable life conditions. By combining infrared spectroscopy, single molecule force spectroscopy (SMFS) and immuno-staining technique, we evidenced that planktonic P. flu...

journal_title：Biomacromolecules

authors： Quilès F,Polyakov P,Humbert F,Francius G

更新日期：2012-07-09 00:00:00

abstract：:Bacterial cellulose (BC) is a polysaccharide known as a suitable matrix for proper wound healing. To improve this ability, BC was functionalized with silk sericin (SS) that has cytoprotective and mitogenic effects. The composites obtained by solution impregnation were stabilized by hydrogen bonds, and SS could be rele...

journal_title：Biomacromolecules

authors： Lamboni L,Li Y,Liu J,Yang G

更新日期：2016-09-12 00:00:00

abstract：:Cartilage tissue engineering highly relies on the ability to store and transport chondrocytes in order to be clinically successful. Cryopreservation is a most reliable technology for chondrocyte storage, but it suffers from the intrinsic toxicity of current state-of-the-art cryoprotectant, dimethyl sulfoxide (DMSO). I...

journal_title：Biomacromolecules

authors： Liu M,Zhang X,Guo H,Zhu Y,Wen C,Sui X,Yang J,Zhang L

更新日期：2019-10-14 00:00:00

abstract：:Native cellulose consists of a set of parallel chains composed of glucose. Most of the time, these chains are highly ordered and form a structure that is known as a microfibril. On the other hand, highly crystalline forms of cellulose are more difficult to process and often are unpredictable in their behavior. If an o...

journal_title：Biomacromolecules

authors： Kondo T,Togawa E,Brown RM Jr

更新日期：2001-01-01 00:00:00

abstract：:The design of functional systems with sizes in the nanometer range is a key challenge in fields such as biomedicine, nanotechnology, and engineering. Some of the most promising materials nowadays consist of self-assembling peptides or peptide-polymer hybrid materials because of their versatility and the resulting prop...

journal_title：Biomacromolecules

authors： Mikhalevich V,Craciun I,Kyropoulou M,Palivan CG,Meier W

更新日期：2017-11-13 00:00:00

abstract：:Polymer therapeutics, including polymeric drugs and polymer-protein conjugates, are clinically established as first-generation nanomedicines. Knowing that the coiled-coil peptide motif is fundamentally important in the regulation of many cellular and pathological processes, the aim of these studies was to examine the ...

journal_title：Biomacromolecules

authors： Deacon SP,Apostolovic B,Carbajo RJ,Schott AK,Beck K,Vicent MJ,Pineda-Lucena A,Klok HA,Duncan R

更新日期：2011-01-10 00:00:00

abstract：:We demonstrate the fabrication of protein·gold nanoparticle (AuNP) nanocomposites in situ, leading to distinct assemblies dependent upon protein secondary structure. In the presence of pentameric coiled-coil proteins C and Q, which contain histidine tags and have helicities of 54 and 65%, respectively, templation of A...

journal_title：Biomacromolecules

authors： Hume J,Chen R,Jacquet R,Yang M,Montclare JK

更新日期：2015-06-08 00:00:00

abstract：:Synthetic and natural mucoadhesive biomaterials in optimized galenical formulations are potentially useful for the transmucosal delivery of active ingredients to improve their localized and prolonged effects. Chitosans (CS) have potent mucoadhesive characteristics, but the exact mechanisms underpinning such interactio...

journal_title：Biomacromolecules

authors： Menchicchi B,Fuenzalida JP,Bobbili KB,Hensel A,Swamy MJ,Goycoolea FM

更新日期：2014-10-13 00:00:00

abstract：:Structures of three pectic arabinogalactans, one from Vernonia kotschyana (Vk2a) and two from Cochlospermum tinctorium (Ct50A1 and Ct50A2), and their complement fixation and induction of B cell proliferation in vitro were compared. The polysaccharide Vk2a expressed potent biological activity in both assays compared wi...

journal_title：Biomacromolecules

authors： Nergard CS,Kiyohara H,Reynolds JC,Thomas-Oates JE,Matsumoto T,Yamada H,Patel T,Petersen D,Michaelsen TE,Diallo D,Paulsen BS

更新日期：2006-01-01 00:00:00

abstract：:Injectable in situ crosslinkable biomaterials seeded with multipotent progenitor cells and coupled with minimally invasive arthroscopic techniques are an attractive alternative for treating irregularly shaped osteochondral defects. An in situ crosslinkable poly(lactide-co-ethylene oxide-co-fumarate) (PLEOF) macromer h...

journal_title：Biomacromolecules

authors： He X,Jabbari E

更新日期：2007-03-01 00:00:00

abstract：:A lamellar compound resulted from reaction of acrylic acid inside crystalline beta-chitin and the structure was investigated. Beta-chitin acts like a layered crystal, having stacked molecular sheets composed of parallel chains bound in one direction by intermolecular amide hydrogen bonding. Small guest molecules can b...

journal_title：Biomacromolecules

authors： Saito Y,Tomotake Y,Shida S

更新日期：2007-04-01 00:00:00

abstract：:Biodegradable multilayered capsules encapsulating basic fibroblast growth factor (bFGF) were developed as a cytokine release carrier for drug delivery systems. The multilayered hollow capsules were fabricated via the layer-by-layer (LbL) assembly of chitosan (CT) and dextran sulfate (Dex). The bFGF was encapsulated in...

journal_title：Biomacromolecules

authors： Itoh Y,Matsusaki M,Kida T,Akashi M

更新日期：2008-08-01 00:00:00

abstract：:The copper(II) complex formation equilibria of N-(2-carboxyethyl)chitosans with three different degrees of substitution (DS = 0.42, 0.92, and 1.61) were studied in aqueous solution by pH-potentiometric and UV-spectrophotometric techniques. It was demonstrated that the complexation model of CE-chitosans depends on DS: ...

journal_title：Biomacromolecules

authors： Skorik YA,Gomes CA,Podberezskaya NV,Romanenko GV,Pinto LF,Yatluk YG

更新日期：2005-01-01 00:00:00

abstract：:The synthesis, characterization, and degradation kinetics of three alpha-cyclodextrin (alpha-CD)-poly(ethylene glycol) (PEG) polyrotaxanes with endcaps that were installed using Cu(I)-catalyzed Huisgen cyclization is reported. PEG1500, azidated with azidoacetic acid, was threaded with alpha-CD to form a pseudopolyrota...

journal_title：Biomacromolecules

authors： Loethen S,Ooya T,Choi HS,Yui N,Thompson DH

更新日期：2006-09-01 00:00:00

abstract：:Experimental and theoretical investigations of the swelling and mechanical properties of hydrogels formed from chitosan, bovine serum albumin (BSA), and chitosan/BSA mixtures cross-linked with genipin were performed. The properties of cross-linked chitosan hydrogels were explained in terms of its polyelectrolyte behav...

journal_title：Biomacromolecules

authors： Butler MF,Clark AH,Adams S

更新日期：2006-11-01 00:00:00

abstract：:Surface modification is often needed in tissue engineering to enhance the interaction between cells and synthetic materials and improve the cytocompatibility and cellular functions. In this study, block copolymers of poly(L-lactic acid) and poly(ethyl ethylene phosphate) (PLLA-b-PEEP) were synthesized and used to modi...

journal_title：Biomacromolecules

authors： Yang XZ,Sun TM,Dou S,Wu J,Wang YC,Wang J

更新日期：2009-08-10 00:00:00

abstract：:We have investigated the self-assembly of fluorenylmethoxycarbonyl-conjugated dialanine (Fmoc-AA) molecules using combined computational and experimental approaches. Fmoc-AA gels were characterized using transmission electron microscopy (TEM), circular dichroism (CD), Fourier transform infrared (FTIR), and wide-angle ...

journal_title：Biomacromolecules

authors： Mu X,Eckes KM,Nguyen MM,Suggs LJ,Ren P

更新日期：2012-11-12 00:00:00

abstract：:Twenty-five kDa polyethylenimine (PEI) is one of the most efficient nonviral gene transfer agents currently applied as a golden standard for in vitro transfection. In this study, novel 25 kDa PEI derivatives with reductively cleavable cystamine periphery (PEI-Cys) were designed to reduce carrier-associated cytotoxicit...

journal_title：Biomacromolecules

authors： Wang Y,Zheng M,Meng F,Zhang J,Peng R,Zhong Z

更新日期：2011-04-11 00:00:00

abstract：:Recombinant Escherichia coli strains harboring a plasmid containing a novel artificial polyhydroxyalkanoate (PHA) operon consisting of the Aeromonas PHA biosynthesis related genes and Ralstonia eutropha reductase gene were developed for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) [P(3HB-co-3HHx)] fro...

journal_title：Biomacromolecules

authors： Park SJ,Ahn WS,Green PR,Lee SY

更新日期：2001-04-01 00:00:00

abstract：:Nanoparticles with high aspect ratios have favorable attributes for drug delivery and bioimaging applications based on their enhanced tissue penetration and tumor homing properties. Here, we investigated a novel filamentous viral nanoparticle (VNP) based on the Pepino mosaic virus (PepMV), a relative of the establishe...

journal_title：Biomacromolecules

authors： Le DHT,Méndez-López E,Wang C,Commandeur U,Aranda MA,Steinmetz NF

更新日期：2019-01-14 00:00:00

abstract：:This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...

journal_title：Biomacromolecules

authors： Dubruel P,Dekie L,Schacht E

更新日期：2003-09-01 00:00:00

abstract：:Highly fluorescent N-substituted 1-cyanobenz[f]isoindole chitosans (CBI-CSs) with various degrees of N-substitution (DS) were synthesized by reacting chitosan (CS) with naphthalene-2,3-dicarboxaldehyde (NDA) in the presence of cyanide under mild acidic conditions. Introduction of 1-cyanobenz[f]isoindole moieties into ...

journal_title：Biomacromolecules

authors： Gonil P,Sajomsang W,Ruktanonchai UR,Na Ubol P,Treetong A,Opanasopit P,Puttipipatkhachorn S

更新日期：2014-08-11 00:00:00

abstract：:Sulfate cellulose nanocrystal (CNC) dispersions always present specific self-assembled cholesteric mesophases which is easily affected by the inherent properties of particle size, surface charge, and repulsion or affinity interaction, and external field force generated from ionic potential of added electrolytes, magne...

journal_title：Biomacromolecules

authors： Song W,Liu D,Prempeh N,Song R

更新日期：2017-10-09 00:00:00

abstract：:In this paper we propose a detailed analysis of structural and morphological properties of two poly-L-lysine (PLL)-based transfection formulations, PLL/DNA and pegylated PLL (PLL-g-PEG)/DNA, by means of atomic force microscopy (AFM) and transmission electron microscopy (TEM). Comparing PLL-g-PEG/DNA with PLL/DNA polyp...

journal_title：Biomacromolecules

authors： Stanić V,Arntz Y,Richard D,Affolter C,Nguyen I,Crucifix C,Schultz P,Baehr C,Frisch B,Ogier J

更新日期：2008-07-01 00:00:00

abstract：:Self-assembling amphiphilic designer peptides have been successfully applied as nanomaterials in biomedical applications. Understanding molecular interactions at the peptide-membrane interface is crucial, since interactions at this site often determine (in)compatibility. The present study aims to elucidate how model m...

journal_title：Biomacromolecules

authors： Kornmueller K,Lehofer B,Meindl C,Fröhlich E,Leitinger G,Amenitsch H,Prassl R

更新日期：2016-11-14 00:00:00