Abstract:
:The copper(II) complex formation equilibria of N-(2-carboxyethyl)chitosans with three different degrees of substitution (DS = 0.42, 0.92, and 1.61) were studied in aqueous solution by pH-potentiometric and UV-spectrophotometric techniques. It was demonstrated that the complexation model of CE-chitosans depends on DS: the [Cu(Glc-NR(2))(2)] complexes are predominant for two lower substituted samples ("bridge model", log beta(12) = 10.06 and 11.6, respectively), whereas the increase of DS leads to formation mainly of the [Cu(Glc-NR(2))] complexes ("pendant model", log beta(11) = 6.41). As a model for copper complexation with a disubstituted residue of CE-chitosan, the complex of N-methyliminodipropionate [CuMidp(H(2)O)].(H(2)O) was synthesized and structurally characterized by XRD. The unit cell consists of two crystallographically nonequivalent Cu atoms having slightly distorted square pyramidal coordination; Midp constitutes the basal plane of the pyramid and acts as a tetradentate NO(3) chelate-bridging ligand by the formation of two six-membered chelate rings (average Cu-O 1.99 A, Cu-N 2.04 A) and a bridge via carbonyl O atom (average Cu-O 1.99 A), an apical position is occupied by a water molecule (average Cu-Ow 2.30 A).
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Skorik YA,Gomes CA,Podberezskaya NV,Romanenko GV,Pinto LF,Yatluk YGdoi
10.1021/bm049597rkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
189-95issue
1eissn
1525-7797issn
1526-4602journal_volume
6pub_type
杂志文章abstract::Dual-cross-linked network (DCN) hydrogels with multiresponsive and self-healing properties are attracting intensive interests due to their enhanced mechanical strength for a wide range of applications. Herein, we developed a DCN hydrogel that combines a dynamic imine and a benzoxaboronic ester with a neutral pKa value...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01548
更新日期:2020-12-15 00:00:00
abstract::Inorganic polyphosphates, linear polymers of orthophosphate, occur naturally throughout biology and have many industrial applications. Their biodegradable nature makes them attractive for a multitude of uses, and it would be important to understand how polyphosphates are turned over enzymatically. Studies of inorganic...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500872g
更新日期:2014-08-11 00:00:00
abstract::We report the facile preparation of gels from the hydrothermal treatment of suspensions of cellulose nanocrystals (CNCs). The properties of the hydrogels have been investigated by rheology, electron microscopy, and spectroscopy with respect to variation in the temperature, time, and CNC concentration used in preparati...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b00906
更新日期:2016-08-08 00:00:00
abstract::In this paper we report on protein refolding by means of a liquid-liquid transfer technique using a calixarene. We have found that a calix[6]areneacetic acid derivative forms a supramolecular complex with urea-denatured cytochrome c at the oil-water interface, which enables quantitative transfer of the protein from an...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070418q
更新日期:2007-10-01 00:00:00
abstract::Mechanically fibrillated cellulose nanofibrils (CNFs) have attracted special attention as building blocks for the development of advanced materials and composites. A correlation exists between CNF morphology and the properties of the materials they form. However, this correlation is often evaluated indirectly by proce...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00432
更新日期:2019-07-08 00:00:00
abstract::Poly(L-lactide) (PLLA) with various alkyl ester chain end groups were synthesized by ring-opening polymerization of L-lactide in the presence of zinc alkoxide as a catalyst. The structural effect of chain end groups on the rate of enzymatic and nonenzymatic degradations for amorphous films of PLLA were investigated at...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701259r
更新日期:2008-03-01 00:00:00
abstract::The maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matrix communications si...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm401926k
更新日期:2014-03-10 00:00:00
abstract::The determination of the collagen and glycosaminoglycan (GAG) contents of native and particularly bioengineered tissues is of considerable interest because the collagen-to-GAG ratio determines the water content of the tissue, which is crucial regarding its mechanical properties. (1)H NMR spectroscopy subsequent to the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300485j
更新日期:2012-07-09 00:00:00
abstract::A novel poly(epsilon-caprolactone)-organosiloxane hybrid material containing calcium salt (Si-O-PCL) was prepared and evaluated as a bioactive and degradable bone substitute material. The Si-O-PCL hybrid was synthesized by the end-capping of 3-isocyanatopropyl triethoxysilane with alpha,omega-hydroxyl PCL following so...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049885n
更新日期:2004-07-01 00:00:00
abstract::Coiled coils are a common structural motif in many natural proteins that can also be utilized in the design and preparation of drug delivery systems for the noncovalent connection of two macromolecules. In this work, two different pairs of peptides forming coiled coil hetero-oligomers were designed, synthesized, and c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500436p
更新日期:2014-07-14 00:00:00
abstract::Amphiphilic glycopolymers, polylactide-grafted dextran copolymers (Dex-g-PLA), were synthesized with a well-controlled architecture obtained through a three-step procedure: partial silylation of the dextran hydroxyl groups, ring-opening polymerization of D,L-lactide initiated from remaining hydroxyl groups, silylether...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701101n
更新日期:2008-03-01 00:00:00
abstract::Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG and hyaluronan, is co...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300671s
更新日期:2012-08-13 00:00:00
abstract::Bone fractures constitute a major cause of morbidity and mortality especially in the elderly. Complications associated with osteoporosis drugs and the age of the patient slow bone turnover and render such fractures difficult to heal. Increasing the speed of fracture repair by administration of a fracture-targeted bone...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00777
更新日期:2015-10-12 00:00:00
abstract::Single-molecule measurements of the interaction of leukocyte function-associated antigen-1 (LFA-1), expressed on Jurkat T cells, with intercellular adhesion molecules-1 and -2 (ICAM-1 and ICAM-2) were conducted using atomic force microscopy (AFM). The force spectra (i.e., unbinding force versus loading rate) of both t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060559c
更新日期:2006-11-01 00:00:00
abstract::A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0507094
更新日期:2006-03-01 00:00:00
abstract::We synthesized positively charged biodegradable hydrogels by cross-linking of agmatine-modified poly(ethylene glycol)-tethered fumarate (Agm-PEGF) and poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) to investigate the effect of the guanidino groups of the agmatine on hydrogel swelling behavior and smooth mus...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0200433
更新日期:2002-09-01 00:00:00
abstract::Sjögren's syndrome (SS) is an autoimmune disease associated with severe exocrinopathy, which is characterized by profound lymphocytic infiltration (dacryoadenitis) and loss of function of the tear-producing lacrimal glands (LGs). Systemic administration of Rapamycin (Rapa) significantly reduces LG inflammation in the ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01468
更新日期:2020-12-27 00:00:00
abstract::A new, convenient pathway is developed to synthesize highly hydrolytically labile poly(ortho ester amide) (POEA) copolymers that overcomes some of the major weaknesses of the traditional methods of synthesizing poly(ortho esters) and their derivatives. A diamine monomer containing a built-in, stabilized ortho ester gr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9000475
更新日期:2009-04-13 00:00:00
abstract::This paper describes the synthesis and cytotoxicity of poly(anhydride esters) that are composed of several salicylate derivatives, including halogenated salicylates, aminosalicylates, salicylsalicylic acid, and thiolsalicylic acid. The incorporation of these nonsteroidal antiinflammatory drugs (NSAIDs) into a biodegra...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049544+
更新日期:2005-01-01 00:00:00
abstract::Stability of four dissimilar basic proteins (chymotrypsinogen A, ribonuclease A, cytochrome c, lysozyme) in the complex with four polyanions (heparin, poly(vinylsulfate), poly(4-styrene-sulfonate), Nafion) has been studied by differential scanning calorimetry. The polyanions were chosen because of their different char...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900480t
更新日期:2009-09-14 00:00:00
abstract::Degradation of fibrillar collagen is critical for tissue maintenance. Yet, understanding collagen catabolism has been challenging partly due to a lack of atomistic picture for its load-dependent conformational dynamics, as both mechanical load and local unfolding of collagen affect its cleavage by matrix metalloprotei...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500641f
更新日期:2014-08-11 00:00:00
abstract::Hemicellulose-based hydrogels were prepared by radical polymerization of 2-hydroxyethyl methacrylate or poly(ethylene glycol) dimethacrylate with oligomeric hydrosoluble hemicellulose modified with well-defined amounts of methacrylic functions. The polymerization reaction was carried out in water at 40 degrees C using...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049515z
更新日期:2005-03-01 00:00:00
abstract::Properties of Aloe vera galacturonate hydrogels formed via Ca(2+) crosslinking have been studied in regard to key parameters influencing gel formation including molecular weight, ionic strength, and molar ratio of Ca(2+) to COO(-) functionality. Dynamic oscillatory rheology and pulsed field gradient NMR (PFG-NMR) stud...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8008457
更新日期:2008-11-01 00:00:00
abstract::Peptide RATEA16 spontaneously self-assembled into higher-order nanofiber hydrogels with extremely high water content (>99.5% (wt/vol)) under physiological condition. The hydrogels could undergo pH-reversible transitions from viscous solution to elastic hydrogel and to precipitate. The supramolecular self-assembly and ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701143g
更新日期:2008-06-01 00:00:00
abstract::Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025724c
更新日期:2003-05-01 00:00:00
abstract::The thermal conductive properties, including the thermal diffusivity and resultant thermal conductivity, of nonwoven nanocellulose sheets were investigated by separately measuring the thermal diffusivity of the sheets in the in-plane and thickness directions with a periodic heating method. The cross-sectional area (or...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00617
更新日期:2015-07-13 00:00:00
abstract::Recently, some attempts have been made to enhance the gas barrier properties of semicrystalline polymers by precisely controlling the arrangement of their impermeable crystalline lamellae. However, it is still a great challenge to achieve regular arrangement of the lamellae along the direction perpendicular to the gas...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500167u
更新日期:2014-04-14 00:00:00
abstract::Collagen is a versatile structural molecule in nature and is used as a building block in many highly organized tissues, such as bone, skin, and cornea. The functionality and performance of these tissues are controlled by their hierarchical organization ranging from the molecular up to macroscopic length scales. In the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201008b
更新日期:2011-11-14 00:00:00
abstract::A scanning laser system has been used to generate three-dimensional trimethylolpropane trimethacrylate (TRIM) cross-linked poly(2-hydroxylethyl methacrylate) polymer microstructures through azo-bis(isobutyro)nitrile (AIBN) photopolymerization using a 20 x 0.5 NA microscope objective and 365 nm laser excitation. Macrop...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0506952
更新日期:2006-03-01 00:00:00
abstract::A dual-targeted siRNA nanocarrier has been synthesized and validated that is selectively activated in environments where there is colocalization of two breast cancer hallmarks, elevated matrix metalloproteinase (MMP) activity and folate receptor overexpression. This siRNA nanocarrier is self-assembled from two polymer...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm501394m
更新日期:2015-01-12 00:00:00