Abstract:
:The design of functional systems with sizes in the nanometer range is a key challenge in fields such as biomedicine, nanotechnology, and engineering. Some of the most promising materials nowadays consist of self-assembling peptides or peptide-polymer hybrid materials because of their versatility and the resulting properties that can be achieved with these structures. Self-assembly of pure amphiphilic peptides or in combination with block copolymers results in a large variety of nanostructures (micelles, nanoparticles (NPs), compartments, planar membranes) each with different characteristics and tunable properties. Here, we describe such novel peptide- or peptide-polymer-based supramolecular nanostructures and emphasize their functionality and various promising applications.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Mikhalevich V,Craciun I,Kyropoulou M,Palivan CG,Meier Wdoi
10.1021/acs.biomac.7b00764subject
Has Abstractpub_date
2017-11-13 00:00:00pages
3471-3480issue
11eissn
1525-7797issn
1526-4602journal_volume
18pub_type
杂志文章,评审abstract::A novel aptamer modified thermosensitive liposome was designed as an efficient magnetic resonance imaging probe. In this paper, Gd-DTPA was encapsulated into an optimized thermosensitive liposome (TSL) formulation, followed by conjugation with AS1411 for specific targeting against tumor cells that overexpress nucleoli...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00250
更新日期:2015-09-14 00:00:00
abstract::Controlling self-assembly is critical to the advancement of nanotechnology. A rugged or crenated assembly energy surface can redirect assembly off path. By using a defined starting point and an energy surface made rough by a strong association energy, we can impose entirely new assembly paths and products. Normally, t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901160b
更新日期:2010-02-08 00:00:00
abstract::Water soluble polymer anticancer conjugates can improve the pharmacokinetics of covalently bound drugs by limiting cellular uptake to the endocytic route, thus prolonging plasma circulation time and consequently facilitating tumor targeting by the enhanced permeability and retention (EPR) effect. Many of the first gen...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049381p
更新日期:2005-03-01 00:00:00
abstract::Degradation of fibrillar collagen is critical for tissue maintenance. Yet, understanding collagen catabolism has been challenging partly due to a lack of atomistic picture for its load-dependent conformational dynamics, as both mechanical load and local unfolding of collagen affect its cleavage by matrix metalloprotei...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500641f
更新日期:2014-08-11 00:00:00
abstract::Recent developments in ionic liquid electrolytes for cellulose or biomass dissolution has also allowed for high-resolution 1H and 13C NMR on very high molecular weight cellulose. This permits the development of advanced liquid-state quantitative NMR methods for characterization of unsubstituted and low degree of subst...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b00295
更新日期:2018-07-09 00:00:00
abstract::Many biological processes are regulated by reversible binding events, with these interactions between macromolecules representing the core of dynamic chemistry. As such, any attempt to gain a better understanding of such interactions, which would pave the way to the extrapolation of natural designs to create new advan...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b01103
更新日期:2015-10-12 00:00:00
abstract::Here we present time-resolved in situ transmission electron microscopy (TEM) observations and real-time manipulation of nematic ordered cellulose and ultradrawn polyethylene films. Drawn films of these two polymers exhibited a unique response to the low-dose electron beam. Electron beam damage was minimal based on ret...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060546z
更新日期:2007-01-01 00:00:00
abstract::In this paper we extend our previous experimental work on interaction between polyelectrolytes and liposomes. First, the adsorption of chitosan and alkylated chitosan (cationic polyelectrolytes) with different alkyl chain lengths on lipid membranes of liposomes is examined. The amount of both chitosans adsorbed remain...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800400y
更新日期:2008-08-01 00:00:00
abstract::A series of copolymers of trimethylene carbonate (TMC) and L-lactide (LLA) were synthesized and evaluated as scaffolds for the production of artificial blood vessels. The polymers were end-functionalized with acrylate, cast into films, and cross-linked using UV light. The mechanical, degradation, and biocompatibility ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201291e
更新日期:2011-11-14 00:00:00
abstract::We report here the first evidence for the interaction of poly(ethylene glycol) (PEG) with hyaluronan (HA) in aqueous solutions. PEG-HA complexes (Kapp = 45,000 ± 8000 M-1) contained about 3.3 ± 0.1 of ethylene glycol units per disaccharide of HA. The carboxyl of the D-glucuronic acid and the amide of the N-acetyl-D-gl...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01504
更新日期:2020-12-16 00:00:00
abstract::Oral delivery remains a challenge for poorly permeable hydrophilic macromolecules. Poly(amido amine) (PAMAM) dendrimers have shown potential for their possible oral delivery. Transepithelial transport of carboxyl-terminated G3.5 and amine-terminated G4 PAMAM dendrimers was assessed using isolated rat jejunal mucosae m...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm5004465
更新日期:2014-08-11 00:00:00
abstract::Softwood and hardwood celluloses were oxidized by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation. The TEMPO-oxidized cellulose fibers were converted to transparent dispersions in water, which consisted of individual nanofibers 3-4 nm in width. Films were then prepared from the TEMPO-oxidized c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801065u
更新日期:2009-01-12 00:00:00
abstract::The extracellular matrix is an environment rich with structural, mechanical, and molecular signals that can impact cell biology. Traditional approaches in hydrogel biomaterial design often rely on modifying the concentration of cross-linking groups to adjust mechanical properties. However, this strategy provides limit...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b00118
更新日期:2017-04-10 00:00:00
abstract::An artificial spinning system using regenerated silk fibroin solutions is adopted to produce high-performance silk fibers. In previous studies, alcohol-based agents, such as methanol or ethanol, were used to coagulate silk dope solutions, producing silk fiber with poor mechanical properties compared with those of nati...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b00232
更新日期:2018-06-11 00:00:00
abstract::Regulating cell migration dynamics is of significance in tissue engineering and regenerative medicine. A 3D scaffold was created to provide various topographies based on a poly(ε-caprolactone) (PCL) self-induced nanohybrid shish-kebab structure, which consisted of aligned PCL nanofibers and spaced PCL crystal lamellae...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01638
更新日期:2020-03-09 00:00:00
abstract::We report a facile method of generating ultradense poly(l-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) surface by using high temperature alone, which in turn provides dramatic improvement in resisting nonspecific bioadsorption. X-ray photoelectron spectroscopy (XPS) revealed that the surface graft density increased...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301125g
更新日期:2012-11-12 00:00:00
abstract::The synthesis of core-shell star copolymers via living free radical polymerization provides a convenient route to three-dimensional nanostructures having a poly(ethylene glycol) outer shell, a hydrophilic inner shell bearing reactive functional groups, and a central hydrophobic core. By starting with well-defined line...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm7014152
更新日期:2008-04-01 00:00:00
abstract::The intermolecular distributions of amide groups within two commercial LMA pectins was studied after removal of the methyl esters followed by fractionation of the different populations by anion exchange chromatography. The populations obtained had almost equal degrees of amidation while the values of the degree of blo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050960j
更新日期:2006-06-01 00:00:00
abstract::Cellulose nanofibers were prepared by TEMPO-mediated oxidation of wood pulp and tunicate cellulose. The cellulose nanofiber suspension in water was spun into an acetone coagulation bath. The spinning rate was varied from 0.1 to 100 m/min to align the nanofibers to the spun fibers. The fibers spun from the wood nanofib...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm101510r
更新日期:2011-03-14 00:00:00
abstract::A novel linear multifunctional polyethylene glycol (PEG)-dexamethasone (Dex) conjugate (click PEG-Dex) was synthesized using facile Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (a click reaction). Dex was conjugated to the click PEG via an acid-labile hydrazone bond to allow the drug release in a pathophysiologic...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100578c
更新日期:2010-10-11 00:00:00
abstract::Vascular grafts that can support total replacement and maintenance by the body of the injured vessel would improve outcomes of major surgical reconstructions. Building scaffolds using components of the native vessel can encourage biological recognition by native cells as well as mimic mechanical characteristics of the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b01165
更新日期:2017-11-13 00:00:00
abstract::Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of maleimide-coated silv...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00101
更新日期:2015-04-13 00:00:00
abstract::A novel, two-layer hierarchical architecture based on surface-initiated atom transfer radical polymerization was investigated. It combines a thin and highly dense first layer, for nonfouling properties, with a loose second layer for high immobilization levels of active biomolecules. Sodium azide treatment, to reduce t...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301335r
更新日期:2012-12-10 00:00:00
abstract::A polyethylene glycol (PEG) retinylamine (Ret-NH2) conjugate PEG-GFL-NH-Ret with a glycine-phenylalanine-leucine (GFL) spacer was synthesized for controlled oral delivery of Ret-NH2 to treat retinal degenerative diseases, including Stargardt disease (STGD) and age-related macular degeneration (AMD). The peptide spacer...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm501352s
更新日期:2014-12-08 00:00:00
abstract::l-Proline is the only, out of 20 essential, amino acid that contains a cyclized substituted α-amino group (is formally an imino acid), which restricts its conformational shape. The synthesis of well-defined homo- and copolymers of l-proline has been plagued either by the low purity of the monomer or the inability of m...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200495n
更新日期:2011-06-13 00:00:00
abstract::Protein-based polymers are increasingly being used in biomaterial applications because of their ease of customization and potential monodispersity. These advantages make protein polymers excellent candidates for bioanalytical applications. Here we describe improved methods for producing drag-tags for free-solution con...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200358r
更新日期:2011-06-13 00:00:00
abstract::Two organosolv lignins from different origins, namely, almond shells and maritime pine, were modified by using a nanoclay and nanosilicate. Prior to modification, they were activated via glyoxalation to enhance the reactivity of the lignins and thus ease the introduction of the nanoparticles into their structure. The ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00799
更新日期:2019-09-09 00:00:00
abstract::Recently, we have developed a photopolymerizable poly(L-lysine) (PLL) that can be covalently incorporated into poly(ethylene glycol) diacrylate (PEGDA) hydrogels to improve their bioactivity by providing positive charges. To explore the potential of these PLL-grafted PEGDA hydrogels as a cell delivery vehicle and lumi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300381d
更新日期:2012-05-14 00:00:00
abstract::Hydrogels are promising materials for biomedical applications such as tissue engineering and controlled drug release. In the past two decades, the peptide hydrogel subclass has attracted an increasing level of interest from the scientific community because of its numerous advantages, such as biocompatibility, biodegra...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b01840
更新日期:2017-03-13 00:00:00
abstract::The blue mussel (Mytilus edulis) foot protein 5 (Mefp-5) is an adhesive protein that is mainly composed of glycine, l-lysine, and 3,4-dihydroxy-l-phenylalanine (DOPA). Thousands of adhesive pads have been analyzed in previous studies, whereby it has been found that adhesion is largely achieved by the redox-chemistry o...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm5009052
更新日期:2014-08-11 00:00:00