In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-Based Hydrogel.

abstract：:Covalently modified albumin (BSA) microparticles were developed for potential use as an adjuvant in mucosal vaccines against hepatitis B. To synthesize consistent protein particles, a covalent approach was proposed to modify BSA. Our strategy was to bond maleic anhydride (MA) molecules to BSA structure by nucleophilic...

journal_title：Biomacromolecules

authors： Sitta DL,Guilherme MR,Garcia FP,Cellet TS,Nakamura CV,Muniz EC,Rubira AF

更新日期：2013-09-09 00:00:00

abstract：:To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its im...

journal_title：Biomacromolecules

authors： Annaka M,Mortensen K,Vigild ME,Matsuura T,Tsuji S,Ueda T,Tsujinaka H

更新日期：2011-11-14 00:00:00

abstract：:Peak force infrared (PFIR) microscopy is a recently developed approach to acquire multiple chemical and physical material properties simultaneously and with nanometer resolution: topographical features, infrared (IR)-sensitive maps, adhesion, stiffness, and locally resolved IR spectra. This multifunctional mapping is ...

journal_title：Biomacromolecules

authors： Gusenbauer C,Jakob DS,Xu XG,Vezenov DV,Cabane É,Konnerth J

更新日期：2020-10-12 00:00:00

abstract：:Greener alternatives to synthetic polymers are constantly being investigated and sought after. Chitin is a natural polysaccharide that gives structural support to crustacean shells, insect exoskeletons, and fungal cell walls. Like cellulose, chitin resides in nanosized structural elements that can be isolated as nanof...

journal_title：Biomacromolecules

authors： Nawawi WMFBW,Jones M,Murphy RJ,Lee KY,Kontturi E,Bismarck A

更新日期：2020-01-13 00:00:00

abstract：:A layer-by-layer film composed of DNA and inorganic zirconium ion (Zr(4+)) was fabricated on the surface of gold thin film, and an electric field triggered disintegration of the multilayer film was studied by using electrochemical surface plasmon resonance (EC-SPR). EC-SPR results demonstrated that the film was disass...

journal_title：Biomacromolecules

authors： Wang F,Li D,Li G,Liu X,Dong S

更新日期：2008-10-01 00:00:00

abstract：:Amino groups were covalently introduced onto a polycaprolactone (PCL) surface by the reaction between 1,6-hexanediamine and the ester groups of PCL. The occurrence of the aminolysis and the introduction of free NH(2) groups were verified qualitatively by fluorescence spectroscopy, where rhodamine B isothiocyanate was ...

journal_title：Biomacromolecules

authors： Zhu Y,Gao C,Liu X,Shen J

更新日期：2002-11-01 00:00:00

abstract：:Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these...

journal_title：Biomacromolecules

authors： Le TMD,Duong HTT,Thambi T,Giang Phan VH,Jeong JH,Lee DS

更新日期：2018-08-13 00:00:00

abstract：:Multiblock copolymers (MBCs) are fascinating in the field of biology-polymer chemistry interfaces. Synthesizing libraries of MBCs with tailor-made functionality is challenging as it involves multiple steps. Herein, a simple synthesis, analogous to polyurethane/Michael addition reactions, has been introduced to obtain ...

journal_title：Biomacromolecules

authors： Nutan B,Kumar A,Jewrajka SK

更新日期：2020-12-14 00:00:00

abstract：:The Bacillus subtilis protease Proleather FG-F catalyzed the transesterification of inulin with vinyl acrylate (VA) in dimethylformamide (DMF). The reaction conversion for different VA concentrations was greater than 57% after 96 h at 50 degrees C. The degree of substitution (DS, defined as the amount of acrylate grou...

journal_title：Biomacromolecules

authors： Ferreira L,Carvalho R,Gil MH,Dordick JS

更新日期：2002-03-01 00:00:00

abstract：:Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) hyaluronic acid (HA) hydrogels offers a potential therapeutic biomaterial for nucleus pulposus (NP...

journal_title：Biomacromolecules

authors： Isa IL,Srivastava A,Tiernan D,Owens P,Rooney P,Dockery P,Pandit A

更新日期：2015-06-08 00:00:00

abstract：:Our previous studies have demonstrated the efficacy of generation 5 poly(amidoamine) dendrimers (G5-PAMAM) as a platform for the targeted delivery of chemotherapeutics. However, anticancer therapy can be subverted by anti-apoptotic changes in cancer cells. Bcl-2 and several of its peptides are commonly overexpressed i...

journal_title：Biomacromolecules

authors： Myc A,Patri AK,Baker JR Jr

更新日期：2007-10-01 00:00:00

abstract：:Cardiovascular diseases plague human health because of the lack of transplantable small-diameter blood vessel (SDBV) grafts. Although expanded polytetrafluoroethylene (ePTFE) has the potential to be used as a biocompatible material for SDBV grafts, long-term patency is still the biggest challenge. As discussed in this...

journal_title：Biomacromolecules

authors： Wang D,Xu Y,Lin YJ,Yilmaz G,Zhang J,Schmidt G,Li Q,Thomson JA,Turng LS

更新日期：2020-09-14 00:00:00

abstract：:Reduction-sensitive shell-sheddable glyco-nanoparticles were designed and developed based on poly(ε-caprolactone)-graft-SS-lactobionic acid (PCL-g-SS-LBA) copolymer for efficient hepatoma-targeting delivery of doxorubicin (DOX). PCL-g-SS-LBA was prepared by ring-opening copolymerization of ε-caprolactone and pyridyl d...

journal_title：Biomacromolecules

authors： Chen W,Zou Y,Meng F,Cheng R,Deng C,Feijen J,Zhong Z

更新日期：2014-03-10 00:00:00

abstract：:Many polymers, including polyethylene, feature a relatively low melting point and hence must be cross-linked to make them viable for applications that demand a high stiffness and creep resistance at elevated temperatures. The resulting thermoset plastics cannot be recycled, and therefore alternative materials with a r...

journal_title：Biomacromolecules

authors： Peterson A,Östergren I,Lotsari A,Venkatesh A,Thunberg J,Ström A,Rojas R,Andersson M,Berglund LA,Boldizar A,Müller C

更新日期：2019-10-14 00:00:00

abstract：:An appropriate modification technique for silk materials is needed to effectively improve their physical properties for specific applications. A telechelic-type polyalanine (T-polyA) was synthesized by papain-catalyzed polymerization as a novel reinforcing agent for silk materials. A silk fibroin obtained from Bombyx ...

journal_title：Biomacromolecules

authors： Tsuchiya K,Masunaga H,Numata K

更新日期：2017-03-13 00:00:00

abstract：:Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA). First, alginate macroinitiator was prepared by partial depolymerization of native alginate, solubility modificati...

journal_title：Biomacromolecules

authors： Kapishon V,Whitney RA,Champagne P,Cunningham MF,Neufeld RJ

更新日期：2015-07-13 00:00:00

abstract：:Chitosan is a well sought-after polysaccharide in biomedical applications and has been blended with various macromolecules to mitigate undesirable properties. However, the effects of blending on the unique antibacterial activity of chitosan as well as changes in fatigue and degradation properties are not well understo...

journal_title：Biomacromolecules

authors： Sarasam AR,Krishnaswamy RK,Madihally SV

更新日期：2006-04-01 00:00:00

abstract：:Vaginal films featuring the pH-dependent release of tenofovir (TFV) were developed for the prevention of sexual transmission of human immunodeficiency syndrome (HIV). Films based on hydroxypropyl methylcellulose and zein were prepared incorporating different plasticizers [oleic acid, lactic acid, glycerol, and polyeth...

journal_title：Biomacromolecules

authors： Notario-Pérez F,Cazorla-Luna R,Martín-Illana A,Galante J,Ruiz-Caro R,Sarmento B,das Neves J,Veiga MD

更新日期：2021-01-06 00:00:00

abstract：:Cationic kraft lignin (CKL) macromolecules were produced via polymerizing kraft lignin (KL) with [2-(acryloyloxy)ethyl]trimethylammonium chloride (ATAC) or [2-(methacryloyloxy)ethyl]trimethylammonium methyl sulfate (METAM). Despite slightly different charge densities (2.3-2.5 mmol/g) of CKL, lignin-METAM (KL-METAM) ha...

journal_title：Biomacromolecules

authors： Sabaghi S,Fatehi P

更新日期：2019-10-14 00:00:00

abstract：:Periodic patterns resembling spirals were observed to form spontaneously upon unassisted cooling of d-glucaric acid- and d-galactaric acid-based polyamide solutions in N-methyl-N-morpholine oxide (NMMO) monohydrate. Similar observations were made in d-galactaric acid-based polyamide/ionic liquid (IL) solutions. The mo...

journal_title：Biomacromolecules

authors： Rosu C,Russo PS,Daly WH,Cueto R,Pople JA,Laine RA,Negulescu II

更新日期：2015-09-14 00:00:00

abstract：:A wool fiber sample was submitted to chemical-free steam explosion in view of potential exploitation of keratin-based industrial and farm wastes. Fiber keratin was converted into a dark-yellow sludge that was submitted to phase separation by filtration, centrifugation, and precipitation of the soluble materials from t...

journal_title：Biomacromolecules

authors： Tonin C,Zoccola M,Aluigi A,Varesano A,Montarsolo A,Vineis C,Zimbardi F

更新日期：2006-12-01 00:00:00

abstract：:New therapeutic strategies for the treatment of neoplastic pathologies and, in particular, metastasis processes are based on the inhibitory effect of angiogenic processes. The present article deals with the design, preparation, and application of new "polymer drugs" with a clear inhibitory effect of the activation of ...

journal_title：Biomacromolecules

authors： García-Fernández L,Aguilar MR,Fernández MM,Lozano RM,Giménez G,Valverde S,San Román J

更新日期：2010-07-12 00:00:00

abstract：:Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of maleimide-coated silv...

journal_title：Biomacromolecules

authors： García-Astrain C,Chen C,Burón M,Palomares T,Eceiza A,Fruk L,Corcuera MÁ,Gabilondo N

更新日期：2015-04-13 00:00:00

abstract：:Double-network (DN) hydrogels are fabricated from poly(2-ethyl-2-oxazoline) (PEOXA)-peptide conjugates, which can be enzymatically crosslinked in the presence of Sortase A (SA), and physical networks of alginate (Alg), yielding matrices with improved mechanical properties with respect to the corresponding PEOXA and Al...

journal_title：Biomacromolecules

authors： Trachsel L,Johnbosco C,Lang T,Benetti EM,Zenobi-Wong M

更新日期：2019-12-09 00:00:00

abstract：:The coefficient of thermal expansion (CTE) of cellulose nanocrystal (CNC) films was characterized using novel experimental techniques complemented by molecular simulations. The characteristic birefringence exhibited by CNC films was utilized to calculate the in-plane CTE of self-organized and shear-oriented self-stand...

journal_title：Biomacromolecules

authors： Diaz JA,Wu X,Martini A,Youngblood JP,Moon RJ

更新日期：2013-08-12 00:00:00

abstract：:Nucleic acids have been engineered to participate in a wide variety of tasks. Among them, the enzyme-free amplification modes, enzyme-free DNA circuits (EFDCs), and hybridization chain reactions (HCRs) have been widely applied in a series of studies of bioanalysis. We demonstrated here an ultrasensitive hairpin probe-...

journal_title：Biomacromolecules

authors： Liao Y,Fu Y,Wu Y,Huang R,Zhou X,Xing D

更新日期：2015-11-09 00:00:00

abstract：:The blue mussel (Mytilus edulis) foot protein 5 (Mefp-5) is an adhesive protein that is mainly composed of glycine, l-lysine, and 3,4-dihydroxy-l-phenylalanine (DOPA). Thousands of adhesive pads have been analyzed in previous studies, whereby it has been found that adhesion is largely achieved by the redox-chemistry o...

journal_title：Biomacromolecules

authors： Numata K,Baker PJ

更新日期：2014-08-11 00:00:00

abstract：:A successful strategy for the immobilization of rennet from Mucor miehei has been developed. The strategy is based on the immobilization of the enzyme, via their sugar chains at high ionic strength on aminated supports having primary amino groups with a very low pK value. The rennet was covalently immobilized via suga...

journal_title：Biomacromolecules

authors： Pessela BC,Torres R,Fuentes M,Mateo C,Fernandez-Lafuente R,Guisán JM

更新日期：2004-09-01 00:00:00

abstract：:A dual-sensitive polymeric drug conjugate (HA-SS-MP) was synthesized by conjugating hydrophobic 6-mercaptopurine (MP) to thiolated hyaluronic acid (HA) as the carrier and ligand to deliver doxorubicin (Dox) to parental colon cancer and colon cancer stem cells. Because of the amphiphilic nature of HA-SS-MP, it was self...

journal_title：Biomacromolecules

authors： Debele TA,Yu LY,Yang CS,Shen YA,Lo CL

更新日期：2018-09-10 00:00:00

abstract：:Despite recent advances in tumor treatment through cancer immunotherapy, the efficacy of this approach remains to be improved. Looking forward to high rates of objective clinical response, cancer immunotherapy combined with chemotherapy has gained increasing attention recently. Here, we constructed liposomes with matr...

journal_title：Biomacromolecules

authors： Liu Y,Chen XG,Yang PP,Qiao ZY,Wang H

更新日期：2019-02-11 00:00:00