Abstract:
:A strategy to manipulate the disulfide bond breaking triggered unfolding, and subsequently assembly of human serum albumin (HSA) in a lipophilic drug-dependent manner is present. In this study, the hydrophobic region, a molecular switch of the HSA, was regulated to form HSA-paclitaxel (HSA-PTX) nanoparticles by a facile route. High-resolution transmission electron microscopy and fluorescence quenching indicate that HSA coassembled with PTX, which acts as a bridge to form core-shell nanoparticles about 50-240 nm in size, and that PTX might bind to the subdomain IIA sites of HSA. Change of ultraviolet absorption and circular dichroism spectra reveal the formation of HSA-PTX nanoparticles, which is a safety, injectable pharmaceutic nanocarrier system for tumor target. This method to prepare nanocarrier systems for hydrophobic guest molecules reveals a general principle of self-assembly for other plasma proteins and other pharmacologically active substances with poor water solubility. It also provides a basis for developing nanocarrier systems for a wide range of applications in nanomedicine, from drug delivery to bioimaging systems.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Gong G,Xu Y,Zhou Y,Meng Z,Ren G,Zhao Y,Zhang X,Wu J,Hu Ydoi
10.1021/bm201401ssubject
Has Abstractpub_date
2012-01-09 00:00:00pages
23-8issue
1eissn
1525-7797issn
1526-4602journal_volume
13pub_type
杂志文章abstract::Given the significance of hydrogels as cell-instructive materials, it is important to understand how differences in their chemical and physical properties are able to direct cell fate. For example, it remains unclear how different hydrogel cross-linking chemistries and gelation mechanisms influence cell behavior. Here...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b01740
更新日期:2017-03-13 00:00:00
abstract::Celluloses from different origins were dissolved stepwise in N,N-dimethylacetamide/lithium chloride (9% v/w; DMAc/LiCl) with the aim to study the time course of the dissolution process, completeness of dissolution in the dissolved fractions, possible discrimination effects, and differences between the celluloses. Cell...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm101555q
更新日期:2011-04-11 00:00:00
abstract::Hemicellulose-based hydrogels were prepared by radical polymerization of 2-hydroxyethyl methacrylate or poly(ethylene glycol) dimethacrylate with oligomeric hydrosoluble hemicellulose modified with well-defined amounts of methacrylic functions. The polymerization reaction was carried out in water at 40 degrees C using...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049515z
更新日期:2005-03-01 00:00:00
abstract::The thermal conductive properties, including the thermal diffusivity and resultant thermal conductivity, of nonwoven nanocellulose sheets were investigated by separately measuring the thermal diffusivity of the sheets in the in-plane and thickness directions with a periodic heating method. The cross-sectional area (or...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00617
更新日期:2015-07-13 00:00:00
abstract::Weissella confusa VTT E-90392 is an efficient producer of a dextran that is mainly composed of α-(1→6)-linked D-glucosyl units and very few α-(1→3) branch linkages. A mixture of the Chaetomium erraticum endodextranase and the Aspergillus niger α-glucosidase was used to hydrolyze W. confusa dextran to glucose and a set...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm1011536
更新日期:2011-02-14 00:00:00
abstract::Amphiphilic polymer conetworks (APCNs) are materials with a very large interface between their hydrophilic and hydrophobic phases due to their nanophase-separated morphologies. Proteins were found to enrich in APCNs by up to 2 orders of magnitude when incubated in aqueous protein solutions, raising the question of the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm1015877
更新日期:2011-05-09 00:00:00
abstract::Poly(L-lactide)-based microspheres having cationic or anionic surfaces were prepared using polydepsipeptide-block-poly(L-lactide)s as surfactants. Polydepsipeptide-block-poly(L-lactide)s having amino or carboxylic acid groups on their side chains were synthesized through anionic ring-opening polymerizations of L-lacti...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0200231
更新日期:2002-09-01 00:00:00
abstract::Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b00924
更新日期:2017-11-13 00:00:00
abstract::The aggregation phenomena in aqueous solutions of hydrophobically modified (HM) chitosan, containing 4 mol % of n-dodecyl side chains, were studied by viscometry and fluorescence spectroscopy with pyrene as a probe. The results are compared with those for unmodified chitosan. Surprisingly, fluorescence data reveal the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm005649a
更新日期:2001-07-01 00:00:00
abstract::New aspects concerning the mechanism of formation of chitosan physical hydrogels without any cross-linking agent were studied. The gelation took place during the evaporation of a hydroalcoholic solution of chitosan. We first demonstrated that it was possible to form a physical hydrogel from a hydrochloride form of chi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050653d
更新日期:2005-11-01 00:00:00
abstract::Exendin-4 (EX4), a glucagon-like peptide-1 receptor (GLP-1R) agonist that regulates blood glucose levels, has been used in the management of type-2 diabetes mellitus. EX4 can be PEGylated to improve its antidiabetic effects by enhancing its stability and extending the circulation half-life. Here, to determine whether ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b01756
更新日期:2016-03-14 00:00:00
abstract::In this paper we report on protein refolding by means of a liquid-liquid transfer technique using a calixarene. We have found that a calix[6]areneacetic acid derivative forms a supramolecular complex with urea-denatured cytochrome c at the oil-water interface, which enables quantitative transfer of the protein from an...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070418q
更新日期:2007-10-01 00:00:00
abstract::Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the polyol. The close and multivalent ar...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801253c
更新日期:2009-02-09 00:00:00
abstract::The extracellular matrix is an environment rich with structural, mechanical, and molecular signals that can impact cell biology. Traditional approaches in hydrogel biomaterial design often rely on modifying the concentration of cross-linking groups to adjust mechanical properties. However, this strategy provides limit...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b00118
更新日期:2017-04-10 00:00:00
abstract::A novel strategy for artificial regulation system of gene expression applying the specific molecular recognition between carbohydrate and lectin is proposed. Plasmid-lactose conjugates (pActin-lactose and pGFP-lactose) prepared via diazocoupling maintained the transcription activity with T7 RNA polymerase. Gel-shift a...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050255a
更新日期:2005-09-01 00:00:00
abstract::The mycobacterial cell wall is extraordinarily thick and tight consisting mainly of (1). long chain fatty acids, the mycolic acids, and (2). a unique polysaccharide, arabinogalactan (AG). These two chemical constituents are covalently linked through ester bonds. Minnikin (The Biology of the Mycobacteria; Academic: Lon...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034514c
更新日期:2004-05-01 00:00:00
abstract::Novel biodegradable poly(carbonate ester)s with photolabile protecting groups were synthesized by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one (MNC) with diethyl zinc (Et2Zn) as catalyst. The poly(L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700906k
更新日期:2008-01-01 00:00:00
abstract::We synthesized positively charged biodegradable hydrogels by cross-linking of agmatine-modified poly(ethylene glycol)-tethered fumarate (Agm-PEGF) and poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) to investigate the effect of the guanidino groups of the agmatine on hydrogel swelling behavior and smooth mus...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0200433
更新日期:2002-09-01 00:00:00
abstract::Fluorescence and circular dichroism spectroscopy were used to monitor the conformational transition of regenerated Bombyx mori silk fibroin (RSF) in aqueous solutions under different conditions. According to the analysis of fluorescence spectra using anilinonaphthalene-8-sulfonic acid magnesium salt (ANS) as an extern...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0343848
更新日期:2004-05-01 00:00:00
abstract::Eosinophil cationic protein (ECP) is an antimicrobial protein belonging to the superfamily of RNase A. ECP exhibits a broad spectrum of action against bacteria and, at higher concentrations, displays cytotoxic activity to eukaryotic cells. Recently, a powerful aggregation activity for lipid vesicles and for the gram-n...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100334u
更新日期:2010-08-09 00:00:00
abstract::Consensus motifs for sequences of both crystallizable and amorphous blocks in silks and natural structural analogues of silks vary widely. To design novel silklike polypeptides, an important question is therefore how the nature of either the crystallizable or the amorphous block affects the self-assembly and resulting...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00512
更新日期:2019-10-14 00:00:00
abstract::Introducing exogenous genes into plant cells is essential for a wide range of applications in agriculture and plant biotechnology fields. Cationic peptide carriers with cell-penetrating and DNA-binding domains successfully deliver exogenous genes into plants. However, their cell-penetrating activity may be attenuated ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b01304
更新日期:2019-02-11 00:00:00
abstract::The development of polymers that are both bactericidal and biocompatible would have many applications and are currently of research interest. Following the development of strongly bactericidal copolymers of 4-vinylpyridine and poly(ethylene glycol) methyl ether methacrylate, biocompatibility assays have been completed...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm1000839
更新日期:2010-05-10 00:00:00
abstract::In this work, we have applied an electrospinning method to control wettability and further hydrophobic modification of a hydrophobic polymer mat of poly(vinylidene fluoride-co-hexafluoropropylene). A correlation between the processing parameters, rheological properties of polymer solutions, and electrospinning ability...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400938n
更新日期:2013-11-11 00:00:00
abstract::A series of chitosan/chitin samples with DA's varying between 5.2 and 89% was prepared from the reacetylation under soft conditions of a unique chitosan sample allowing the preservation of the chain distribution. The study of the variation of pH for the same concentration of amine groups, at different ionic strengths,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015531+
更新日期:2001-10-01 00:00:00
abstract::To evaluate the antidiarrheal effect of ginseng, the active principals of ginseng were studied in vitro model of rotavirus infection, the leading cause of severe diarrhea. Two pectic polysaccharides, named as GP50-dHR (56.0 kDa) and GP50-eHR (77.0 kDa), were purified from hot water extract of ginseng by bioassay-linke...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100397p
更新日期:2010-08-09 00:00:00
abstract::A revised crystal structure for mercerized cellulose based on high-resolution synchrotron X-ray data collected from ramie fibers is reported (space group P2(1), a = 8.10(3) A, b = 9.03(3) A, c = 10.31(5) A, gamma = 117.10(5) degrees; 751 reflections in 304 composite spots; theta < 21.11 degrees; lambda = 0.7208 A; LAL...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm005612q
更新日期:2001-07-01 00:00:00
abstract::The adsorption of human immunoglobulin G (hIgG) and bovine serum albumin (BSA) on cellulose supports were investigated. The dynamics and extent of related adsorption processes were monitored by surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D). Amine groups were instal...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201236a
更新日期:2011-12-12 00:00:00
abstract::Softwood and hardwood celluloses were oxidized by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation. The TEMPO-oxidized cellulose fibers were converted to transparent dispersions in water, which consisted of individual nanofibers 3-4 nm in width. Films were then prepared from the TEMPO-oxidized c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801065u
更新日期:2009-01-12 00:00:00
abstract::In the present work, a novel synthetic methodology for the preparation of scaffold of biopolymeric nature is described. In particular, a porous gelatin scaffold was prepared by foam templating. The gas phase, nitrogen, was generated by means of the reaction between sulfamic acid and sodium nitrite in situ a concentrat...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901051c
更新日期:2009-12-14 00:00:00