On-off switching of gene expression regulated with carbohydrate-lectin interaction.

abstract：:A layer-by-layer film composed of DNA and inorganic zirconium ion (Zr(4+)) was fabricated on the surface of gold thin film, and an electric field triggered disintegration of the multilayer film was studied by using electrochemical surface plasmon resonance (EC-SPR). EC-SPR results demonstrated that the film was disass...

journal_title：Biomacromolecules

authors： Wang F,Li D,Li G,Liu X,Dong S

更新日期：2008-10-01 00:00:00

abstract：:Electrospun poly(glycolide-co-lactide) (PLA10GA90, LA/GA ratio 10/90) biodegradable nanofiber membranes possessed very high surface area to volume ratios and were completely noncrystalline with a relatively lowered glass transition temperature. These characteristics led to very different structure, morphology, and pro...

journal_title：Biomacromolecules

authors： Zong X,Ran S,Kim KS,Fang D,Hsiao BS,Chu B

更新日期：2003-03-01 00:00:00

abstract：:To provide for prolonged, site-specific delivery of basic fibroblast growth factor (bFGF) to the grafted skin in a convenient manner, biodegradable chitosan-gelatin microspheres containing bFGF were fabricated and incorporated into a porous chitosan-gelatin scaffold in this study. The microspheres are an integral part...

journal_title：Biomacromolecules

authors： Liu H,Fan H,Cui Y,Chen Y,Yao K,Goh JC

更新日期：2007-05-01 00:00:00

abstract：:In biomedicine, PEGylation is one of the most successful strategies to modify the physicochemical and biological properties of peptides, proteins, and other biomacromolecules. Because of the polydisperse nature of regular PEGs and limited PEGylation strategies, it is challenging to quantitatively fine-tune and accurat...

journal_title：Biomacromolecules

authors： Wang X,Li Y,Wu T,Yang Z,Zheng X,Chen S,Zhou X,Jiang ZX

更新日期：2020-02-10 00:00:00

abstract：:Electrospun natural polymer membranes were fabricated from collagen or gelatin coated with a bioactive recombinant fragment of perlecan, a natural heparan sulfate proteoglycan. The electrospinning process allowed the facile processing of a three-dimensional, porous fibril (2-6 microm in diameter) matrix suitable for t...

journal_title：Biomacromolecules

authors： Casper CL,Yang W,Farach-Carson MC,Rabolt JF

更新日期：2007-04-01 00:00:00

abstract：:Shear flow is indirectly implicated in amyloid formation in vitro. Despite the association between amyloid fibrils and disease, and the prevalence of flow in physiological systems, the effect of this parameter is uncharacterized. We designed a novel Couette cell to quantitatively investigate shear exposure during fibr...

journal_title：Biomacromolecules

authors： Hill EK,Krebs B,Goodall DG,Howlett GJ,Dunstan DE

更新日期：2006-01-01 00:00:00

abstract：:Developing new protein-based materials with a programmable assembly is of great scientific interest and technological importance. Inspired by nature's use of post-translational modifications (PTMs) to control the function and location of proteins, we have leveraged lipidation-the PTM of proteins with lipids-to synthes...

journal_title：Biomacromolecules

authors： Hossain MS,Liu X,Maynard TI,Mozhdehi D

更新日期：2020-02-10 00:00:00

abstract：:Dextrin, a glucose polymer with low molecular weight, was used to develop a fully resorbable hydrogel, without using chemical initiators. Dextrin was first oxidized (oDex) with sodium periodate and then cross-linked with adipic acid dihidrazide, a nontoxic cross-linking molecule. Furthermore, a new bidimensional compo...

journal_title：Biomacromolecules

authors： Molinos M,Carvalho V,Silva DM,Gama FM

更新日期：2012-02-13 00:00:00

abstract：:A porous scaffold as a cell-compatible material was designed and prepared using a phospholipid copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate, and enantiomeric macromonomers, the poly(L-lactic acid) (PLLA) macromonomer, and poly(D-lactic acid) (PDLA) macromonomer. On the bas...

journal_title：Biomacromolecules

authors： Watanabe J,Eriguchi T,Ishihara K

更新日期：2002-09-01 00:00:00

abstract：:A new series of cationic, thermo-sensitive, and biodegradable poly(L-lactide)-poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PLLA-PEOz-PLLA) triblock copolymers were synthesized by ring-opening polymerization. With increasing molecular weight and crystallinity of hydrophobic PLLA blocks, the critical micellization concent...

journal_title：Biomacromolecules

authors： Wang CH,Hsiue GH

更新日期：2003-11-01 00:00:00

abstract：:Heparin, a sulfated polysaccharide derived from animal sources, is the most commonly used parenteral anticoagulant drug, but it suffers from significant safety and supply issues. Herein, we describe the preparation of heparin mimetic homo- and copolymers via the reversible addition-fragmentation chain transfer (RAFT) ...

journal_title：Biomacromolecules

authors： Nahain AA,Ignjatovic V,Monagle P,Tsanaktsidis J,Vamvounis G,Ferro V

更新日期：2020-02-10 00:00:00

abstract：:Elastin-like peptides (ELPs) have been used widely to confer thermoresponsive characteristics onto various materials, but to this point mostly linear ELPs have been studied. A class of linear and dendritic (branched) ELPs based on the GLPGL pentamer repeat unit was synthesized using an on-resin divergent strategy. The...

journal_title：Biomacromolecules

authors： Navon Y,Zhou M,Matson JB,Bitton R

更新日期：2016-01-11 00:00:00

abstract：:We have constructed a tandem gene expression cassette containing three Ralstonia eutropha poly[(R)-3-hydroxybutyrate] (PHB) synthesis genes under the control of the Pichia pastoris glyceraldehyde-3-phosphate promoter and the green fluorescent protein (Gfp) under the control of the P. pastoris alcohol oxidase promoter....

journal_title：Biomacromolecules

authors： Vijayasankaran N,Carlson R,Srienc F

更新日期：2005-03-01 00:00:00

abstract：:This Article describes the synthesis and characterization of renewable self-adhesive coatings with tunable viscoelastic properties and equipped with well-defined amounts of carboxylic acid "sticker" groups with adhesion promoting characteristics. Hydroxyl-ended polyesters with various architectures (linear, branched) ...

journal_title：Biomacromolecules

authors： Vendamme R,Olaerts K,Gomes M,Degens M,Shigematsu T,Eevers W

更新日期：2012-06-11 00:00:00

abstract：:We investigate lysozyme-lysozyme and lysozyme-salt interactions in electrolyte solutions using a molecular-thermodynamic model. An equation of state based on the statistical mechanical perturbation theory is applied to describe the interactions. The perturbation term includes a new square-well potential of mean force,...

journal_title：Biomacromolecules

authors： Chang BH,Bae YC

更新日期：2003-11-01 00:00:00

abstract：:An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during the remodeling of tissue microenvironments following injury and during disease processes such as cancer. We hypothesized that multimodality HA-based probes selectively target and detectably accumulate at sites of high HA metabolism...

journal_title：Biomacromolecules

authors： Veiseh M,Breadner D,Ma J,Akentieva N,Savani RC,Harrison R,Mikilus D,Collis L,Gustafson S,Lee TY,Koropatnick J,Luyt LG,Bissell MJ,Turley EA

更新日期：2012-01-09 00:00:00

abstract：:Developing green and nontoxic biomaterials, derived from renewable sources and processable through 3D bioprinting technologies, is an emerging challenge of sustainable tissue engineering. Here, pectin from citrus peels was cross-linked for the first time with (3-glycidyloxypropyl)trimethoxysilane (GPTMS) through a one...

journal_title：Biomacromolecules

authors： Lapomarda A,De Acutis A,Chiesa I,Fortunato GM,Montemurro F,De Maria C,Mattioli Belmonte M,Gottardi R,Vozzi G

更新日期：2020-02-10 00:00:00

abstract：:Benefiting from their inherent localized and controlled release properties, hydrogels are ideal delivery systems for therapeutic drugs or nanoparticles. In particular, applications of hydrogels for the delivery and release of photoresponsive drugs or nanoparticles are receiving increasing attention. However, the effec...

journal_title：Biomacromolecules

authors： Xia LY,Zhang X,Cao M,Chen Z,Wu FG

更新日期：2017-10-09 00:00:00

abstract：:Saccharide-functionalized shell cross-linked (SCK) polymer micelles designed as polyvalent nanoscaffolds for selective interactions with receptors on Gram negative bacteria were constructed from mixed micelles composed of poly(acrylic acid-b-methyl acrylate) and mannosylated poly(acrylic acid-b-methyl acrylate). The m...

journal_title：Biomacromolecules

authors： Joralemon MJ,Murthy KS,Remsen EE,Becker ML,Wooley KL

更新日期：2004-05-01 00:00:00

abstract：:Cancer cells have a large amount of ROS (reactive oxygen species) because of disturbed ROS homeostasis. Cancer cells therefore undertake redox adaptation to drive proliferation in tumor environments and even survive during anticancer treatment by upregulating endogenous antioxidants. As one of antioxidant defense syst...

journal_title：Biomacromolecules

authors： Noh J,Jung E,Lee J,Hyun H,Hong S,Lee D

更新日期：2019-02-11 00:00:00

abstract：:Subunit vaccines can have excellent safety profiles, but their ability to give rise to robust immune responses is often compromised. For glycan-based vaccines, insufficient understanding of B and T cell epitope combinations that yield optimal immune activation hinders optimization. To determine which antigen features ...

journal_title：Biomacromolecules

authors： Bennett NR,Jarvis CM,Alam MM,Zwick DB,Olson JM,Nguyen HV,Johnson JA,Cook ME,Kiessling LL

更新日期：2019-12-09 00:00:00

abstract：:AQ-Pal14 is a 30-residue polypeptide that was designed to form an α-helical coiled coil that contains a metal-binding 4-pyridylalanine residue on its solvent-exposed surface. However, characterization of this peptide shows that it exists as a three-stranded coiled coil, not a two-stranded one as predicted from its des...

journal_title：Biomacromolecules

authors： Zaytsev DV,Xie F,Mukherjee M,Bludin A,Demeler B,Breece RM,Tierney DL,Ogawa MY

更新日期：2010-10-11 00:00:00

abstract：:Nanofibrous biocomposite scaffolds of type I collagen and nanohydroxyapatite (nanoHA) of varying compositions (wt %) were prepared by electrostatic cospinning. The scaffolds were characterized for structure and morphology by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), atomic fo...

journal_title：Biomacromolecules

authors： Thomas V,Dean DR,Jose MV,Mathew B,Chowdhury S,Vohra YK

更新日期：2007-02-01 00:00:00

abstract：:Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures toward diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biom...

journal_title：Biomacromolecules

authors： Ko JW,Choi WS,Kim J,Kuk SK,Lee SH,Park CB

更新日期：2017-11-13 00:00:00

abstract：:Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...

journal_title：Biomacromolecules

authors： Söntjens SH,Nettles DL,Carnahan MA,Setton LA,Grinstaff MW

更新日期：2006-01-01 00:00:00

abstract：:Immobilizing zwitterionic molecules on material surfaces has been a promising strategy for creating antifouling surfaces. Herein, we show the ability to surface derivatize an allyl-ether-functionalized thermoplastic polyurethane (TPU) with a zwitterionic thiol in a radically induced thiol-ene reaction. The thermoplast...

journal_title：Biomacromolecules

authors： Nikam SP,Chen P,Nettleton K,Hsu YH,Becker ML

更新日期：2020-07-13 00:00:00

abstract：:The pressure and temperature dependence of the cloud point transition of an aqueous solution of an elastin-like polypeptide (MGLDGSMG(VPGIG)40VPLE), prepared by bacterial expression of the corresponding artificial gene, was measured. A temperature-pressure diagram was constructed over a wide range of conditions. The (...

journal_title：Biomacromolecules

authors： Tamura T,Yamaoka T,Kunugi S,Panitch A,Tirrell DA

更新日期：2000-01-01 00:00:00

abstract：:We present a synthetic approach toward soft, glycooligomer-functionalized microgel particles mimicking carbohydrate presenting cell surfaces and analyze their specific binding to a model lectin (Concanavalin A, ConA). Focusing on multivalent presentation, a series of sequence-controlled glycooligomers with varying spa...

journal_title：Biomacromolecules

authors： Jacobi F,Camaleño de la Calle A,Boden S,Grafmüller A,Hartmann L,Schmidt S

更新日期：2018-08-13 00:00:00

abstract：:Understanding the self-assembly mechanism of caged proteins provides clues to develop their potential applications in nanotechnology, such as a nanoscale drug delivery system. The E2 protein from Bacillus stearothermophilus , with a virus-like caged structure, has drawn much attention for its potential application as...

journal_title：Biomacromolecules

authors： Peng T,Lee H,Lim S

更新日期：2012-03-12 00:00:00

abstract：:To devise a sensitive cellulase assay based on substrates having most of the physical characteristics of native cellulose, 5-(4,6-dichlorotriazinyl)aminofluorescein (DTAF) was used as a grafting agent to prepare suspensions of fluorescent microfibrils from bacterial cellulose. These suspensions were digested by a seri...

journal_title：Biomacromolecules

authors： Helbert W,Chanzy H,Husum TL,Schülein M,Ernst S

更新日期：2003-05-01 00:00:00