Abstract:
:Benefiting from their inherent localized and controlled release properties, hydrogels are ideal delivery systems for therapeutic drugs or nanoparticles. In particular, applications of hydrogels for the delivery and release of photoresponsive drugs or nanoparticles are receiving increasing attention. However, the effect of the hydrogel matrix on the fluorescence emission and singlet oxygen generation efficiency of the embedded photosensitizers (PSs) has not been clarified. Herein, meso-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP) as a water-soluble PS was encapsulated into an injectable hydrogel formed by glycol chitosan and dibenzaldehyde-terminated telechelic poly(ethylene glycol). Compared to free TMPyP solution, the TMPyP encapsulated in the hydrogel exhibits three distinct advantages: (1) more singlet oxygen was generated under the same laser irradiation condition; (2) much longer tumor retention was observed due to the low fluidity of the hydrogel; and (3) the fluorescence intensity of TMPyP was significantly enhanced in the hydrogel due to its decreased self-quenching effect. These excellent characteristics lead to remarkable anticancer efficacy and superior fluorescence emission property of the TMPyP-hydrogel system, promoting the development of imaging-guided photodynamic therapy.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Xia LY,Zhang X,Cao M,Chen Z,Wu FGdoi
10.1021/acs.biomac.7b00725subject
Has Abstractpub_date
2017-10-09 00:00:00pages
3073-3081issue
10eissn
1525-7797issn
1526-4602journal_volume
18pub_type
杂志文章abstract::Anionic copolymer systems containing sulfated monomers have great potential for delivery of cationic therapeutics, but N-isopropylacrylamide (NIPAm) 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) copolymer nanoparticles have seen limited characterization to date with regard to physical properties relevant to load...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300173x
更新日期:2012-04-09 00:00:00
abstract::In this work, biodegradable branched polycationic polymers were synthesized by Michael addition polymerization from different amine monomers and the triacrylate monomer trimethylolpropane triacrylate. The polymers varied in the number of amines that dissociate in different pH ranges, which are considered to be benefic...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901147k
更新日期:2010-03-08 00:00:00
abstract::Oriented immobilization of proteins is an important step in creating protein-based functional materials. In this study, a method was developed to orient proteins on hydroxyapatite (HA) surfaces, a widely used bone implant material, to improve protein bioactivity by employing enhanced green fluorescent protein (EGFP) a...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201865r
更新日期:2012-06-11 00:00:00
abstract::We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assemble...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm101020e
更新日期:2010-12-13 00:00:00
abstract::Solid-state NMR is especially useful when the structures of peptides and proteins should be analyzed by taking into account the structural distribution, that is, the distribution of the torsion angle of the individual residue. In this study, two-dimensional spin-diffusion solid-state NMR spectra of 13C-double-labeled ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0600522
更新日期:2006-04-01 00:00:00
abstract::Herein we present an innovative approach to produce biocompatible, degradable, and stealth polymeric nanoparticles based on poly(lipoic acid), stabilized by a PEG-ended surfactant. Taking advantage of the well-known thiol-induced polymerization of lipoic acid, a universal and nontoxic nanovector consisted of a solid c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01321
更新日期:2020-12-21 00:00:00
abstract::Decomposable hollow capsules based on deoxyribonucleic acid (DNA) and a low molecular weight organic molecule, a naturally occurring polyamine, spermidine (SP), were formed by applying the layer-by-layer adsorption strategy to colloid particles, viz., assembling DNA/SP multilayers on colloids and subsequently removing...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm010052w
更新日期:2001-10-01 00:00:00
abstract::Sjögren's syndrome (SS) is an autoimmune disease associated with severe exocrinopathy, which is characterized by profound lymphocytic infiltration (dacryoadenitis) and loss of function of the tear-producing lacrimal glands (LGs). Systemic administration of Rapamycin (Rapa) significantly reduces LG inflammation in the ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01468
更新日期:2020-12-27 00:00:00
abstract::Plastics ending up in soil or landfill environment will eventually be degraded. At the same time a slow migration of additives from the plastics will occur. The additives and the degradation products of these and the polymer are potential compounds for bioconversion. To predict the rate of the migration of antioxidant...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0000283
更新日期:2000-10-01 00:00:00
abstract::The effect of moisture content and temperature on water diffusion into a modified high amylose (< or = 90%) maize thermoplastic starch blend was investigated. Gravimetric and magnetic resonance imaging (MRI) studies were conducted to elucidate the diffusion mechanism and diffusion coefficients for this system. The dif...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060791i
更新日期:2007-01-01 00:00:00
abstract::The synthesis of poly(methyl methacrylate-co-methacryloxysuccinimide-graft-poly(ethylene glycol)) (PMMA-co-PMASI-g-PEG) via living free radical polymerization provides a convenient route to well-defined amphiphilic graft copolymers having a controllable number of reactive functional groups, variable length PEG grafts,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700541e
更新日期:2007-10-01 00:00:00
abstract::Cancer cells have a large amount of ROS (reactive oxygen species) because of disturbed ROS homeostasis. Cancer cells therefore undertake redox adaptation to drive proliferation in tumor environments and even survive during anticancer treatment by upregulating endogenous antioxidants. As one of antioxidant defense syst...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b01802
更新日期:2019-02-11 00:00:00
abstract::Highly cross-linked networks formed by the photoinitiated polymerization of multifunctional monomers are finding application in the field of biomaterials because of their chemical versatility, reaction control, and ability to polymerize under physiological conditions. Typically, degradation is introduced into these ne...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025677o
更新日期:2003-01-01 00:00:00
abstract::The unsatisfied results of cancer therapy are caused by many issues and metastasis of cancer cells is one of the major challenge. It has been reported that inhibiting the SDF1/CXCR4 interaction can significantly reduce the metastasis of breast cancer cells to regional lymph nodes and lung. Herein, a nanogel system equ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b00208
更新日期:2017-06-12 00:00:00
abstract::A comprehensive knowledge of the in vivo fate of polymers is essential for their potential application in humans. In this study, the body distribution, accumulation, and elimination processes of intraperitoneally (ip) administered poly(vinyl alcohol) (PVA) in mice were investigated in detail. Two derivatives of PVA (1...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200899h
更新日期:2011-10-10 00:00:00
abstract::The adhesion of wet regenerated cellulose to colloidal complexes formed between carboxymethyl cellulose (CMC) and polyvinylamine (PVAm) was evaluated by measuring the force to delaminate pairs of regenerated cellulose membranes bound together with polyelectrolyte complex. The most important parameter was the surface c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm070307r
更新日期:2007-07-01 00:00:00
abstract::The effect of guluronate oligomers on the barrier properties of mucous matrices was investigated in terms of the mobility of nanoparticles in mucous matrices by fluorescence recovery after photobleaching (FRAP), cellular uptake of nanoparticles in mucus secreting cells (HT29-MTX), and mucin matrix architecture by scan...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500464b
更新日期:2014-06-09 00:00:00
abstract::Receptor-mediated, cell-specific delivery of siRNA enables silencing of target genes in specific tissues, opening the door to powerful therapeutic options for a multitude of diseases. However, the development of delivery systems capable of targeted and effective siRNA delivery typically requires multiple steps and the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200485b
更新日期:2011-07-11 00:00:00
abstract::Amphiphilic glycopolymers, polylactide-grafted dextran copolymers (Dex-g-PLA), were synthesized with a well-controlled architecture obtained through a three-step procedure: partial silylation of the dextran hydroxyl groups, ring-opening polymerization of D,L-lactide initiated from remaining hydroxyl groups, silylether...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701101n
更新日期:2008-03-01 00:00:00
abstract::A systematic study is carried out to understand how physical and covalent crosslinks affect the mechanical properties of an eight-arm poly(ethyleneglycol)-based hydrogel. Heparin and heparin-binding peptide are used as a physical crosslinker, and an enzymatically cleavable peptide with a cysteine on each end serves as...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801270k
更新日期:2009-05-11 00:00:00
abstract::The structure of three types of liposomes (egg yolk phosphatidylcholine (EPC) without modification and EPC vesicles containing cross-linked N-isopropylacrylamide (NIPAM) networks of low and a high concentration inside the vesicles) were analyzed by static and dynamic light scattering. Upon polymerization the network w...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0200074
更新日期:2002-05-01 00:00:00
abstract::The ability of microbally produced poly(gamma,d-glutamic acid) to form stable polyelectrolyte-opposite charged surfactant complexes was investigated. A sonicated sample of polyacid with a molecular weight about 10(5) Da and a content of d enantiomer higher than 90% was used in this study. Nearly stoichiometric complex...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034267c
更新日期:2004-01-01 00:00:00
abstract::The present study focuses on the formation of microcapsules containing catalytically active L-asparaginase (L-ASNase), a protein drug of high value in antileukemic therapy. We make use of the layer-by-layer (LbL) technique to coat protein-loaded calcium carbonate (CaCO3) particles with two or three poly dextran/poly-L...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm401341k
更新日期:2013-12-09 00:00:00
abstract::Tissue engineering approaches need biomaterials with suitable properties to provide an appropriate environment for cell attachment and growth. The performance of these biomaterials can be greatly enhanced through the incorporation of bioactive agents. For this reason, we developed chitosan films with cell-attachment a...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701049g
更新日期:2008-02-01 00:00:00
abstract::Electrochemically controlled, reversible assembly of biopolymers into hydrogel structures is a promising technique for on-demand cell or drug encapsulation and release systems. An electrochemically sol-gel transition has been demonstrated in regenerated Bombyx mori silk fibroin, offering a controllable way to generate...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm4004892
更新日期:2013-08-12 00:00:00
abstract::The objective of this study was to explore the use of reverse thermo-responsive (RTG) polymers for generating implants at their site of performance, following minimally invasive surgical procedures. Aiming at combining syringability and enhanced mechanical properties, a new family of injectable RTG-displaying polymers...
journal_title:Biomacromolecules
pub_type:
doi:10.1021/bm0495250
更新日期:2005-05-01 00:00:00
abstract::Ocular applications of polymeric materials have been widely investigated for medical diagnostics, treatment, and vision improvement. The human eye is a vital organ that connects us to the outside world so when the eye is injured, infected, or impaired, it needs immediate medical treatment to maintain clear vision and ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01525
更新日期:2021-01-06 00:00:00
abstract::Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) hyaluronic acid (HA) hydrogels offers a potential therapeutic biomaterial for nucleus pulposus (NP...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00168
更新日期:2015-06-08 00:00:00
abstract::Recombinant Escherichia coli strains harboring a plasmid containing a novel artificial polyhydroxyalkanoate (PHA) operon consisting of the Aeromonas PHA biosynthesis related genes and Ralstonia eutropha reductase gene were developed for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) [P(3HB-co-3HHx)] fro...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm000105u
更新日期:2001-04-01 00:00:00
abstract::The aim of this paper is to define optimal conditions for the extraction of chitin from shrimp shells. The kinetics of both demineralization and deproteinization with, in the latter case, the role of temperature are studied. The characterization of the residual calcium and protein contents, the molecular weights, and ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025602k
更新日期:2003-01-01 00:00:00