Abstract：
:Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-liver glycogen over the diurnal cycle was characterized using size exclusion chromatography and transmission electron microscopy. Glycogen was found to be formed as smaller β particles, and then only assembled into large α particles, with a broad size distribution, significantly after the time when glycogen content had reached a maximum. This pathway, missing in diabetic animals, is likely to give optimal blood-glucose control during the daily feeding cycle. Lack of this control may contribute to, or result from, diabetes. This discovery suggests novel approaches to diabetes management.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Sullivan MA,Aroney ST,Li S,Warren FJ,Joo JS,Mak KS,Stapleton DI,Bell-Anderson KS,Gilbert RGdoi
10.1021/bm401714vsubject
Has Abstractpub_date
2014-02-10 00:00:00pages
660-5issue
2eissn
1525-7797issn
1526-4602journal_volume
15pub_type
杂志文章abstract：:Oligopeptide hydrogels are emerging as useful matrices for cell culture with commercial products on the market, but L-oligopeptides are labile to proteases. An obvious solution is to create D-oligopeptide hydrogels, which lack enzymatic recognition. However, D-oligopeptide matrices do not support cell growth as well a...
journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2011-07-11 00:00:00
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journal_title：Biomacromolecules
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更新日期：2014-08-11 00:00:00
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
pub_type： 杂志文章,评审
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更新日期：2009-01-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2014-03-10 00:00:00
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journal_title：Biomacromolecules
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doi：10.1021/bm7005938
更新日期：2007-12-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01072
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm900474k
更新日期：2009-10-12 00:00:00
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journal_title：Biomacromolecules
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更新日期：2005-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060693x
更新日期：2006-11-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm1014365
更新日期：2011-04-11 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060133y
更新日期：2006-11-01 00:00:00
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journal_title：Biomacromolecules
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更新日期：2012-06-11 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2013-11-11 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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更新日期：2014-03-10 00:00:00
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journal_title：Biomacromolecules
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更新日期：2015-07-13 00:00:00
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更新日期：2009-08-10 00:00:00
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journal_title：Biomacromolecules
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更新日期：2016-06-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2016-11-14 00:00:00
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