Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control.

abstract：:Tannic acid (TA) can form stable complexes with proteins, attracting significant attention as protein delivery systems. However, its systemic application has been limited due to nonspecific interaction. Here, we report a simple technique to prepare systemically applicable protein delivery systems using sequential self...

journal_title：Biomacromolecules

authors： Honda Y,Nomoto T,Matsui M,Takemoto H,Kaihara Y,Miura Y,Nishiyama N

更新日期：2020-09-14 00:00:00

abstract：:Reduction-sensitive shell-sheddable glyco-nanoparticles were designed and developed based on poly(ε-caprolactone)-graft-SS-lactobionic acid (PCL-g-SS-LBA) copolymer for efficient hepatoma-targeting delivery of doxorubicin (DOX). PCL-g-SS-LBA was prepared by ring-opening copolymerization of ε-caprolactone and pyridyl d...

journal_title：Biomacromolecules

authors： Chen W,Zou Y,Meng F,Cheng R,Deng C,Feijen J,Zhong Z

更新日期：2014-03-10 00:00:00

abstract：:Combining molecular weight distribution (MWD) data for linear chains of debranched starch from capillary electrophoresis and from size exclusion chromatography (SEC) with detection by differential refractive index and by multi-angle laser light scattering has enabled Mark-Houwink parameters to be determined for linear...

journal_title：Biomacromolecules

authors： Castro JV,Ward RM,Gilbert RG,Fitzgerald MA

更新日期：2005-07-01 00:00:00

abstract：:Cellular uptake and intracellular targeting to specific organelles are key events in the cellular processing of nanomaterials. Herein, we perform a detailed structure-property relationship study on carboxylic acid-side-chain-bearing polyacrylates to provide design criteria for the manipulation of their cellular intera...

journal_title：Biomacromolecules

authors： Mahmoud AM,Morrow JP,Pizzi D,Azizah AM,Davis TP,Tabor RF,Kempe K

更新日期：2020-08-10 00:00:00

abstract：:We examine the protein distribution within an electrospun polymer nanofiber using polyvinyl alcohol and bovine serum albumin as a model system. We hypothesize that the location of the protein within the nanofiber can be controlled by carefully selecting the pH and the applied polarity of the electric field as the pH a...

journal_title：Biomacromolecules

authors： Tang C,Ozcam AE,Stout B,Khan SA

更新日期：2012-05-14 00:00:00

abstract：:A subtle but highly pertinent factor in the self-assembly of hierarchical nanostructures is the kinetic landscape. Self-assembly of a hierarchical multicomponent system requires the intricate balance of noncovalent interactions on a similar energy scale that can result in several self-assembly processes occurring at d...

journal_title：Biomacromolecules

authors： Ang J,Jung BT,Dong H,Xu T

更新日期：2017-03-13 00:00:00

abstract：:Collagen is a versatile structural molecule in nature and is used as a building block in many highly organized tissues, such as bone, skin, and cornea. The functionality and performance of these tissues are controlled by their hierarchical organization ranging from the molecular up to macroscopic length scales. In the...

journal_title：Biomacromolecules

authors： Masic A,Bertinetti L,Schuetz R,Galvis L,Timofeeva N,Dunlop JW,Seto J,Hartmann MA,Fratzl P

更新日期：2011-11-14 00:00:00

abstract：:We have investigated the self-assembly of fluorenylmethoxycarbonyl-conjugated dialanine (Fmoc-AA) molecules using combined computational and experimental approaches. Fmoc-AA gels were characterized using transmission electron microscopy (TEM), circular dichroism (CD), Fourier transform infrared (FTIR), and wide-angle ...

journal_title：Biomacromolecules

authors： Mu X,Eckes KM,Nguyen MM,Suggs LJ,Ren P

更新日期：2012-11-12 00:00:00

abstract：:Biobased poly(γ-butyrolactone) (PγBL) as a fully biodegradable and bioabsorbable biomaterial has shown superior properties compared to those of other aliphatic polyesters. It is of great importance to prepare amphiphilic block copolymer containing PγBL block to make ordered nano-objects for biomedical applications suc...

journal_title：Biomacromolecules

authors： Shen Y,Zhang J,Zhao Z,Zhao N,Liu F,Li Z

更新日期：2019-01-14 00:00:00

abstract：:In this work, cell-responsive polysaccharide hydrogels were prepared by a simple procedure based on the sequential bioconjugation and cross-linking of the polysaccharide backbone with bioactive peptides and poly(ethylene glycol)-bis(thiol) (PEG-(SH)2), respectively. Using thiol-ene reactions, we successfully functiona...

journal_title：Biomacromolecules

authors： Jing J,Fournier A,Szarpak-Jankowska A,Block MR,Auzély-Velty R

更新日期：2015-03-09 00:00:00

abstract：:Hydrogel fibers that possessed a cell-adhesive surface and were degradable via enzymatic reactions were developed for fabricating tubular constructs with smooth muscle cell (SMC) and endothelial cell (EC) layers, similar to native blood vessels, in collagen gels. The fibers were prepared by soaking hydrogel fibers pre...

journal_title：Biomacromolecules

authors： Sakai S,Yamaguchi S,Takei T,Kawakami K

更新日期：2008-07-01 00:00:00

abstract：:A surface force balance was used to measure the normal and shear forces between two mica surfaces each bearing an adsorbed layer of porcine gastric mucin ("Orthana" mucin), genetically similar to human MUC6. This mucin is a highly purified, 546 kDa, weakly negative, polyampholytic molecule with a "dumbbell" structure....

journal_title：Biomacromolecules

authors： Harvey NM,Yakubov GE,Stokes JR,Klein J

更新日期：2011-04-11 00:00:00

abstract：:Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection ...

journal_title：Biomacromolecules

authors： Gong Y,Soleymani Abyaneh H,Drossis N,Niederquell A,Kuentz M,Leroux JC,de Haan HW,Gauthier MA

更新日期：2019-09-09 00:00:00

abstract：:Electrospinning of cellulose nanocrystals (CNC)/poly(lactic acid) (PLA) emulsions has been demonstrated to be an effective dispersion and alignment method to control assembly of CNC into continuous composite ultrafine fibers. CNC-PLA nanocomposite random-fiber mats and aligned-fiber yarns were prepared by emulsion ele...

journal_title：Biomacromolecules

authors： Li Y,Ko FK,Hamad WY

更新日期：2013-11-11 00:00:00

abstract：:As with many other biosourced colloids, chitin nanocrystals (ChNCs) can form liquid crystalline phases with chiral nematic ordering. In this work, we demonstrate that it is possible to finely tune the liquid crystalline behavior of aqueous ChNC suspensions finely. Such control was made possible by carefully studying h...

journal_title：Biomacromolecules

authors： Narkevicius A,Steiner LM,Parker RM,Ogawa Y,Frka-Petesic B,Vignolini S

更新日期：2019-07-08 00:00:00

abstract：:A one-step synthesis of a curcumin-derived hydrogel (curcumin content of 25-75 mol %) is reported. Curcumin is incorporated into the hydrogel backbone and cross-linked through biodegradable carbonate linkages. Curcumin as a part of the polymer backbone is protected from oxidation and degradation, while hydrogel hydrol...

journal_title：Biomacromolecules

authors： Shpaisman N,Sheihet L,Bushman J,Winters J,Kohn J

更新日期：2012-08-13 00:00:00

abstract：:We study the fibrillation pathway of ovalbumin protein and report the simultaneous formation of several types of fibrils, with clear structural and physical differences. We compare the fibrillation mechanisms at low pH with and without salt, and follow the kinetics of fibrils growth by atomic force microscopy (AFM), s...

journal_title：Biomacromolecules

authors： Lara C,Gourdin-Bertin S,Adamcik J,Bolisetty S,Mezzenga R

更新日期：2012-12-10 00:00:00

abstract：:Over the past 10 years, polyglycerols and their structurally related analogs have received considerable attention in the biomedical field. Poly(glycidyl methacrylate) (PGMA) is a versatile polymer because its pendant epoxide groups can be opened with different functional groups to generate poly(glycerol methacrylate)s...

journal_title：Biomacromolecules

authors： Gao H,Elsabahy M,Giger EV,Li D,Prud'homme RE,Leroux JC

更新日期：2010-04-12 00:00:00

abstract：:We report a biodegradable fluorescent theranostic nanoprobe design strategy for simultaneous visualization and quantitative determination of antibacterial activity for the treatment of bacterial infections. Cationic-charged polycaprolactone (PCL) was tailor-made through ring-opening polymerization methodology, and it ...

journal_title：Biomacromolecules

authors： Ghosh R,Malhotra M,Madhuri Sathe RR,Jayakannan M

更新日期：2020-07-13 00:00:00

abstract：:The mechanical rigidity and degradation rate of hydrogels utilized as cell transplantation vehicles have been regarded as critical factors in new tissue formation. However, conventional approaches to accelerate the degradation rate of gels deteriorate their function as a mechanical support in parallel. We hypothesized...

journal_title：Biomacromolecules

authors： Kong HJ,Kaigler D,Kim K,Mooney DJ

更新日期：2004-09-01 00:00:00

abstract：:Multiblock copolymers (MBCs) are fascinating in the field of biology-polymer chemistry interfaces. Synthesizing libraries of MBCs with tailor-made functionality is challenging as it involves multiple steps. Herein, a simple synthesis, analogous to polyurethane/Michael addition reactions, has been introduced to obtain ...

journal_title：Biomacromolecules

authors： Nutan B,Kumar A,Jewrajka SK

更新日期：2020-12-14 00:00:00

abstract：:Thymic epithelial cells (TECs) are the main regulators of T lymphocyte development and selection, requiring a three-dimensional (3D) environment to properly perform these biological functions. The aim of this work was to develop a 3D culture substrate that allows the survival and proliferation of TECs. Thus, electrosp...

journal_title：Biomacromolecules

authors： Silva CS,Pinto RD,Amorim S,Pires RA,Correia-Neves M,Reis RL,Alves NL,Martins A,Neves NM

更新日期：2020-12-14 00:00:00

abstract：:Poly( n-butyl methacrylate) (PBMA) or poly( n-butyl acrylate) (PBA)-grafted brush coatings attached to glass were successfully prepared using atom-transfer radical polymerization "from the surface". The thicknesses and composition of the PBMA and PBA coatings were examined using ellipsometry and time-of-flight seconda...

journal_title：Biomacromolecules

authors： Awsiuk K,Stetsyshyn Y,Raczkowska J,Lishchynskyi O,Dąbczyński P,Kostruba A,Ohar H,Shymborska Y,Nastyshyn S,Budkowski A

更新日期：2019-06-10 00:00:00

abstract：:Wheat arabinoxylan was treated with two α-arabinofuranosidases exhibiting different mode of action to create three different polymeric substrates. These three substrate preparations were characterized by xylopyranose backbone sugars that are (1) singly substituted by arabinose at C2 or C3, (2) doubly substituted by ar...

journal_title：Biomacromolecules

authors： Littunen K,Mai-Gisondi G,Seppälä J,Master ER

更新日期：2017-05-08 00:00:00

abstract：:Reductively degradable biopolymers have emerged as a unique class of smart biomedical materials. Here, a functional coupling agent, cystamine diisocyanate (CDI), was designed to offer a facile access to reductively degradable biopolymers via polycondensation with various diols. CDI was readily obtained with a decent y...

journal_title：Biomacromolecules

authors： Wang X,Zhang J,Cheng R,Meng F,Deng C,Zhong Z

更新日期：2016-03-14 00:00:00

abstract：:We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin ...

journal_title：Biomacromolecules

authors： Yuk SH,Oh KS,Cho SH,Lee BS,Kim SY,Kwak BK,Kim K,Kwon IC

更新日期：2011-06-13 00:00:00

abstract：:The objective of these investigations was to test the hypothesis that a rapid cytoplasmic release profile from nanoparticles would potentiate the anticancer activity of cisplatin. Cisplatin-loaded nanoparticles with pH-responsive poly[2-(N,N-diethylamino)ethyl methacrylate] (PDEA) cores were synthesized from PDEA-bloc...

journal_title：Biomacromolecules

authors： Xu P,Van Kirk EA,Murdoch WJ,Zhan Y,Isaak DD,Radosz M,Shen Y

更新日期：2006-03-01 00:00:00

abstract：:The synthesis of poly(methyl methacrylate-co-methacryloxysuccinimide-graft-poly(ethylene glycol)) (PMMA-co-PMASI-g-PEG) via living free radical polymerization provides a convenient route to well-defined amphiphilic graft copolymers having a controllable number of reactive functional groups, variable length PEG grafts,...

journal_title：Biomacromolecules

authors： Pressly ED,Rossin R,Hagooly A,Fukukawa K,Messmore BW,Welch MJ,Wooley KL,Lamm MS,Hule RA,Pochan DJ,Hawker CJ

更新日期：2007-10-01 00:00:00

abstract：:A drying environment is always a proposition faced by dynamic living organisms using water, which are driven by biopolymer-based micro- and macrostructures. Here, we introduce a drying process for aqueous liquid crystalline (LC) solutions composed of biopolymer with extremely high molecular weight components such as p...

journal_title：Biomacromolecules

authors： Okeyoshi K,Okajima MK,Kaneko T

更新日期：2016-06-13 00:00:00

abstract：:This article reports on the successful preparation and characterization of cellulose nanocrystals (CNCs) surface-modified with polylactide (PLA) and poly(butylene succinate) (PBS) binary mixed homopolymer brushes. Their synthesis was designed as a three-step procedure combining polyester synthesis and surface-modifica...

journal_title：Biomacromolecules

authors： Mincheva R,Jasmani L,Josse T,Paint Y,Raquez JM,Gerbaux P,Eyley S,Thielemans W,Dubois P

更新日期：2016-09-12 00:00:00