Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control.


:Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-liver glycogen over the diurnal cycle was characterized using size exclusion chromatography and transmission electron microscopy. Glycogen was found to be formed as smaller β particles, and then only assembled into large α particles, with a broad size distribution, significantly after the time when glycogen content had reached a maximum. This pathway, missing in diabetic animals, is likely to give optimal blood-glucose control during the daily feeding cycle. Lack of this control may contribute to, or result from, diabetes. This discovery suggests novel approaches to diabetes management.






Sullivan MA,Aroney ST,Li S,Warren FJ,Joo JS,Mak KS,Stapleton DI,Bell-Anderson KS,Gilbert RG




Has Abstract


2014-02-10 00:00:00












  • Combined effects of Ag nanoparticles and oxygen plasma treatment on PLGA morphological, chemical, and antibacterial properties.

    abstract::The purpose of this study is to investigate the combined effects of oxygen plasma treatments and silver nanoparticles (Ag) on PLGA in order to modulate the surface antimicrobial properties through tunable bacteria adhesion mechanisms. PLGA nanocomposite films, produced by solvent casting with 1 wt % and 7 wt % of Ag n...


    pub_type: 杂志文章


    authors: Fortunati E,Mattioli S,Visai L,Imbriani M,Fierro JL,Kenny JM,Armentano I

    更新日期:2013-03-11 00:00:00

  • DNA is wrapped by the nuclear aggregates of polyamines: the imaging evidence.

    abstract::In the cell nucleus, putrescine, spermidine, and spermine self-assemble with phosphate ions to generate three forms of compounds, named nuclear aggregates of polyamines (NAPs), which may interact with DNA. In an in vitro setting mimicking the cell nucleus milieu, this molecular aggregation occurs within well-defined r...


    pub_type: 杂志文章


    authors: Iacomino G,Picariello G,Sbrana F,Di Luccia A,Raiteri R,D'Agostino L

    更新日期:2011-04-11 00:00:00

  • Thermodynamic Analysis of the Interaction of Heparin with Lysozyme.

    abstract::Glycosaminoglycan (GAG)-protein binding governs critically important signaling events in living matter. Aiming at a quantitative analysis of the involved processes, we herein present a thermodynamic study of the interaction of the model GAG heparin and lysozyme in aqueous solution. Heparin is a highly charged linear p...


    pub_type: 杂志文章


    authors: Walkowiak JJ,Ballauff M,Zimmermann R,Freudenberg U,Werner C

    更新日期:2020-11-09 00:00:00

  • Disulfide-Based Diblock Copolymer Worm Gels: A Wholly-Synthetic Thermoreversible 3D Matrix for Sheet-Based Cultures.

    abstract::It is well-known that 3D in vitro cell cultures provide a much better model than 2D cell cultures for understanding the in vivo microenvironment of cells. However, significant technical challenges in handling and analyzing 3D cell cultures remain, which currently limits their widespread application. Herein, we demonst...


    pub_type: 杂志文章


    authors: Simon KA,Warren NJ,Mosadegh B,Mohammady MR,Whitesides GM,Armes SP

    更新日期:2015-12-14 00:00:00

  • Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity.

    abstract::Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular ...


    pub_type: 杂志文章


    authors: Maciel D,Figueira P,Xiao S,Hu D,Shi X,Rodrigues J,Tomás H,Li Y

    更新日期:2013-09-09 00:00:00

  • Low-fouling, biospecific films prepared by the continuous assembly of polymers.

    abstract::We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a facile and versatile technology to prepare engineered nanocoatings for various biomedical applications. Low-fouling coatings on particles were obtained by the formation of multicomposition...


    pub_type: 杂志文章


    authors: Guntari SN,Wong EH,Goh TK,Chandrawati R,Blencowe A,Caruso F,Qiao GG

    更新日期:2013-08-12 00:00:00

  • Diffusion of 1-ethyl-3-methyl-imidazolium acetate in glucose, cellobiose, and cellulose solutions.

    abstract::Solutions of glucose, cellobiose and microcrystalline cellulose in the ionic liquid 1-ethyl-3-methyl-imidazolium ([C2mim][OAc]) have been examined using pulsed-field gradient (1)H NMR. Diffusion coefficients of the cation and anion across the temperature range 20-70 °C have been determined for a range of concentration...


    pub_type: 杂志文章


    authors: Ries ME,Radhi A,Keating AS,Parker O,Budtova T

    更新日期:2014-02-10 00:00:00

  • Biogenic synthesis and photocatalysis of Pd-PdO nanoclusters reinforced hierarchical TiO2 films with interwoven and tubular conformations.

    abstract::Hierarchical nanocomposite films with Pd-PdO nanoparticles anchored uniformly on the inner surface of TiO2 nanotubes were achieved through a stepwise bioredox/artificial oxygenation approach by using the natural eggshell membrane (ESM) as a template. The Pd content ratio of Pd-PdO loading could be arbitrarily varied f...


    pub_type: 杂志文章


    authors: Su H,Dong Q,Han J,Zhang D,Guo Q

    更新日期:2008-02-01 00:00:00

  • Molecular Orientation Enhancement of Silk by the Hot-Stretching-Induced Transition from α-Helix-HFIP Complex to β-Sheet.

    abstract::Enhancing the molecular orientation of the regenerated silk fibroin (RF) up to a level comparable to the native silk is highly challenging. Our novel and promising strategy for the poststretching process is (1) creating at first an α-helix-HFIP complex with a hexagonal packing as an intermediate state and then (2) str...


    pub_type: 杂志文章


    authors: Yoshioka T,Tashiro K,Ohta N

    更新日期:2016-04-11 00:00:00

  • Selective localization of multiwalled carbon nanotubes in poly(epsilon-caprolactone)/polylactide blend.

    abstract::Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work,...


    pub_type: 杂志文章


    authors: Wu D,Zhang Y,Zhang M,Yu W

    更新日期:2009-02-09 00:00:00

  • Mineralization, biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone regeneration.

    abstract::Gelatin microspheres are well-known for their capacity to release growth factors in a controlled manner, but gelatin microspheres do not calcify in the absence of so-called bioactive substances that induce deposition of calcium phosphate (CaP) bone mineral. This study has investigated if CaP nanocrystals can be incorp...


    pub_type: 杂志文章


    authors: Leeuwenburgh SC,Jo J,Wang H,Yamamoto M,Jansen JA,Tabata Y

    更新日期:2010-10-11 00:00:00

  • Hydrogels for Therapeutic Delivery: Current Developments and Future Directions.

    abstract::Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydro...


    pub_type: 杂志文章


    authors: Buwalda SJ,Vermonden T,Hennink WE

    更新日期:2017-02-13 00:00:00

  • Molecular dynamics study of complexes of poly(glutamate) and dodecyltrimethylammonium.

    abstract::The supramolecular organization of self-assembled stoichiometric complexes formed by dodecyltrimethylammonium cations and ionized poly(gamma-glutamic) acid has been investigated in chloroform solution. Atomistic molecular dynamics simulations have been performed considering three different starting conformations for t...


    pub_type: 杂志文章


    authors: Zanuy D,Alemán C

    更新日期:2007-02-01 00:00:00

  • Polymer micelle with pH-triggered hydrophobic-hydrophilic transition and de-cross-linking process in the core and its application for targeted anticancer drug delivery.

    abstract::In this study, an novel amphiphilic block copolymer P[PEGMA-b-(DEMA-co-APMA)]-FA and its cross-linker uracil-(CH2)6-uracil (U-(CH2)6-U) were synthesized and used as the targeted and pH-responsive nanocarriers for anticancer drug delivery. The hydrophobic block of the copolymer contains adenine (A) and tertiary amine m...


    pub_type: 杂志文章


    authors: Fan J,Zeng F,Wu S,Wang X

    更新日期:2012-12-10 00:00:00

  • Design of an injectable in situ gelation biomaterials for vitreous substitute.

    abstract::To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its im...


    pub_type: 杂志文章


    authors: Annaka M,Mortensen K,Vigild ME,Matsuura T,Tsuji S,Ueda T,Tsujinaka H

    更新日期:2011-11-14 00:00:00

  • Emulsifying properties of biodegradable polylactide-grafted dextran copolymers.

    abstract::Amphiphilic glycopolymers, polylactide-grafted dextran copolymers (Dex-g-PLA), were synthesized with a well-controlled architecture obtained through a three-step procedure: partial silylation of the dextran hydroxyl groups, ring-opening polymerization of D,L-lactide initiated from remaining hydroxyl groups, silylether...


    pub_type: 杂志文章


    authors: Raynaud J,Choquenet B,Marie E,Dellacherie E,Nouvel C,Six JL,Durand A

    更新日期:2008-03-01 00:00:00

  • Self-Assembled Peptide-Carbon Nitride Hydrogel as a Light-Responsive Scaffold Material.

    abstract::Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures toward diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biom...


    pub_type: 杂志文章


    authors: Ko JW,Choi WS,Kim J,Kuk SK,Lee SH,Park CB

    更新日期:2017-11-13 00:00:00

  • Biodegradable and pH-sensitive hydrogels for cell encapsulation and controlled drug release.

    abstract::Hydrogels with pH-sensitive poly(acrylic acid) (PAAc) chains and biodegradable acryloyl-poly(-caprolactone)-2-hydroxylethyl methacrylate (AC-PCL-HEMA) chains were designed and synthesized. The morphology of hydrogel was observed by scanning electron microscopy. The degradation of the hydrogel in the presence of Pseudo...


    pub_type: 杂志文章


    authors: Wu DQ,Sun YX,Xu XD,Cheng SX,Zhang XZ,Zhuo RX

    更新日期:2008-04-01 00:00:00

  • Fully convergent solid phase synthesis of antifreeze glycoprotein analogues.

    abstract::The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the u...


    pub_type: 杂志文章


    authors: Eniade A,Ben RN

    更新日期:2001-07-01 00:00:00

  • Dual Thermosensitive Hydrogels Assembled from the Conserved C-Terminal Domain of Spider Dragline Silk.

    abstract::Stimuli-responsive hydrogels have great potentials in biomedical and biotechnological applications. Due to the advantages of precise control over molecular weight and being biodegradable, protein-based hydrogels and their applications have been extensively studied. However, protein hydrogels with dual thermosensitive ...


    pub_type: 杂志文章


    authors: Qian ZG,Zhou ML,Song WW,Xia XX

    更新日期:2015-11-09 00:00:00

  • Modification of Poly(ethylene 2,5-furandicarboxylate) with Biobased 1,5-Pentanediol: Significantly Toughened Copolyesters Retaining High Tensile Strength and O2 Barrier Property.

    abstract::Poly(ethylene 2,5-furandicarboxylate) (PEF) is a biobased polyester characterized by high gas barrier properties as well as high tensile modulus and strength, but poor toughness. Toughening PEF without sacrificing its modulus, strength and gas barrier performance is a great challenge for PEF modification. In this stud...


    pub_type: 杂志文章


    authors: Xie H,Wu L,Li BG,Dubois P

    更新日期:2019-01-14 00:00:00

  • Poly(ethylene glycol)-poly(ester-carbonate) block copolymers carrying PEG-peptidyl-doxorubicin pendant side chains: synthesis and evaluation as anticancer conjugates.

    abstract::Water soluble polymer anticancer conjugates can improve the pharmacokinetics of covalently bound drugs by limiting cellular uptake to the endocytic route, thus prolonging plasma circulation time and consequently facilitating tumor targeting by the enhanced permeability and retention (EPR) effect. Many of the first gen...


    pub_type: 杂志文章


    authors: Andersson L,Davies J,Duncan R,Ferruti P,Ford J,Kneller S,Mendichi R,Pasut G,Schiavon O,Summerford C,Tirk A,Veronese FM,Vincenzi V,Wu G

    更新日期:2005-03-01 00:00:00

  • Molecular switch for the assembly of lipophilic drug incorporated plasma protein nanoparticles and in vivo image.

    abstract::A strategy to manipulate the disulfide bond breaking triggered unfolding, and subsequently assembly of human serum albumin (HSA) in a lipophilic drug-dependent manner is present. In this study, the hydrophobic region, a molecular switch of the HSA, was regulated to form HSA-paclitaxel (HSA-PTX) nanoparticles by a faci...


    pub_type: 杂志文章


    authors: Gong G,Xu Y,Zhou Y,Meng Z,Ren G,Zhao Y,Zhang X,Wu J,Hu Y

    更新日期:2012-01-09 00:00:00

  • Solubility of Softwood Hemicelluloses.

    abstract::It is demonstrated that the molecular solubility of softwood hemicelluloses is significantly influenced by pretreatment of the fibers, extraction, and downstream processing. To quantify these effects, four hemicellulose samples were extracted from different thermomechanical pulps of Norway spruce. The molecular solubi...


    pub_type: 杂志文章


    authors: Kishani S,Vilaplana F,Xu W,Xu C,Wågberg L

    更新日期:2018-04-09 00:00:00

  • In situ cross-linkable novel alginate-dextran methacrylate IPN hydrogels for biomedical applications: mechanical characterization and drug delivery properties.

    abstract::In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharm...


    pub_type: 杂志文章


    authors: Matricardi P,Pontoriero M,Coviello T,Casadei MA,Alhaique F

    更新日期:2008-07-01 00:00:00

  • Understanding Poly(vinyl alcohol)-Mediated Ice Recrystallization Inhibition through Ice Adsorption Measurement and pH Effects.

    abstract::The development of improved cryopreservative materials is necessary to enable complete recovery of living cells and tissue after frozen storage. Remarkably, poly(vinyl alcohol) (PVA) displays some of the same cryoprotective properties as many antifreeze proteins found in cold tolerant organisms. In particular, PVA is ...


    pub_type: 杂志文章


    authors: Burkey AA,Riley CL,Wang LK,Hatridge TA,Lynd NA

    更新日期:2018-01-08 00:00:00

  • Lysozyme-lysozyme and lysozyme-salt interactions in the aqueous saline solution: a new square-well potential.

    abstract::We investigate lysozyme-lysozyme and lysozyme-salt interactions in electrolyte solutions using a molecular-thermodynamic model. An equation of state based on the statistical mechanical perturbation theory is applied to describe the interactions. The perturbation term includes a new square-well potential of mean force,...


    pub_type: 杂志文章


    authors: Chang BH,Bae YC

    更新日期:2003-11-01 00:00:00

  • Biodegradable nanoparticles meet the bronchial airway barrier: how surface properties affect their interaction with mucus and epithelial cells.

    abstract::Despite the wide interest raised by lung administration of nanoparticles (NPs) for the treatment of various diseases, little information is available on their effect toward the airway epithelial barrier function. In this study, the potential damage of the pulmonary epithelium upon exposure to poly(lactide-co-glycolide...


    pub_type: 杂志文章


    authors: Mura S,Hillaireau H,Nicolas J,Kerdine-Römer S,Le Droumaguet B,Deloménie C,Nicolas V,Pallardy M,Tsapis N,Fattal E

    更新日期:2011-11-14 00:00:00

  • Effects of the controlled-released basic fibroblast growth factor from chitosan-gelatin microspheres on human fibroblasts cultured on a chitosan-gelatin scaffold.

    abstract::To provide for prolonged, site-specific delivery of basic fibroblast growth factor (bFGF) to the grafted skin in a convenient manner, biodegradable chitosan-gelatin microspheres containing bFGF were fabricated and incorporated into a porous chitosan-gelatin scaffold in this study. The microspheres are an integral part...


    pub_type: 杂志文章


    authors: Liu H,Fan H,Cui Y,Chen Y,Yao K,Goh JC

    更新日期:2007-05-01 00:00:00

  • Aliphatic polyesters: great degradable polymers that cannot do everything.

    abstract::Nowadays the open and the patent literatures propose a large number of polymers whose main chains can be degraded usefully. Among these degradable polymers, aliphatic polyester-based polymeric structures are receiving special attention because they are all more or less sensitive to hydrolytic degradation, a feature of...


    pub_type: 杂志文章,评审


    authors: Vert M

    更新日期:2005-03-01 00:00:00