Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control.

Abstract:

:Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-liver glycogen over the diurnal cycle was characterized using size exclusion chromatography and transmission electron microscopy. Glycogen was found to be formed as smaller β particles, and then only assembled into large α particles, with a broad size distribution, significantly after the time when glycogen content had reached a maximum. This pathway, missing in diabetic animals, is likely to give optimal blood-glucose control during the daily feeding cycle. Lack of this control may contribute to, or result from, diabetes. This discovery suggests novel approaches to diabetes management.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Sullivan MA,Aroney ST,Li S,Warren FJ,Joo JS,Mak KS,Stapleton DI,Bell-Anderson KS,Gilbert RG

doi

10.1021/bm401714v

subject

Has Abstract

pub_date

2014-02-10 00:00:00

pages

660-5

issue

2

eissn

1525-7797

issn

1526-4602

journal_volume

15

pub_type

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