Abstract:
:Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These cell lines, originally derived from fibrocystic breast tissue, represent a continuum of tumorigenic behavior. Immortal but nontumorigenic MCF10A cells, as well as semitumorigenic MCF10AT cells, attached and spread on Ubx fibers. MCF10CA-1a cells, the most highly transformed line, secreted high concentrations of matrix metalloproteinases when cultured on Ubx materials, resulting in differences in cell attachment and cytoskeletal structure, and enabling invasive behavior. Because the mechanical and functional properties of Ubx fibers can be genetically manipulated, these materials provide a valuable tool for cancer research, allowing creation of diverse microenvironments that allow assessment of invasive, metastatic behavior.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Hsiao HC,Santos A,Howell DW,Patterson JL,Fuchs-Young RS,Bondos SEdoi
10.1021/acs.biomac.6b01311subject
Has Abstractpub_date
2016-11-14 00:00:00pages
3790-3799issue
11eissn
1525-7797issn
1526-4602journal_volume
17pub_type
杂志文章abstract::Amyloid-like fibrils are prepared from protein in the lab by controlled heat treatments, yet these must be further assembled to match the desirable mechanical and structural properties of biological fibers. Here, β-lactoglobulin fibrils were incorporated into poly(ethylene oxide) fibers of 40-180 nm diameter by electr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00500
更新日期:2020-07-13 00:00:00
abstract::Bone-marrow-derived mesenchymal stem cells (BMSCs) possess vast potential for tissue engineering and regenerative medicine. In this study, an injectable hydrogel comprising poly(l-glutamic acid)-graft-tyramine (PLG-g-TA) with tunable microenvironment was developed via enzyme-catalyzed cross-linking and used as an arti...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b00884
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049325o
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2019-02-11 00:00:00
abstract::We report structural and dynamical aspects of DNAs from various sources including synthetic oligonucleotides in bulk buffer and as a complex with histone1 (H1). High-resolution transmission electron microscopic (HRTEM) studies reveal the structural change of the DNAs upon complexation with H1 leading to formation of c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700690p
更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-09-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2019-04-08 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2014-06-09 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2016-10-10 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01072
更新日期:2019-11-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900958c
更新日期:2010-01-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b00154
更新日期:2017-06-12 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500754r
更新日期:2014-08-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00961
更新日期:2015-10-12 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm7009043
更新日期:2007-12-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00933
更新日期:2020-12-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2020-09-14 00:00:00
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更新日期:2003-09-01 00:00:00
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更新日期:2006-08-01 00:00:00
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