Abstract：
:Amyloid-like fibrils are prepared from protein in the lab by controlled heat treatments, yet these must be further assembled to match the desirable mechanical and structural properties of biological fibers. Here, β-lactoglobulin fibrils were incorporated into poly(ethylene oxide) fibers of 40-180 nm diameter by electrospinning. Protein fibrils presented as short segments dispersed within electrospun fibers, with no change in fibril diameter after electrospinning. Imaging analysis revealed fibrils were aligned within 20° relative to the fiber long axis, and alignment was further confirmed by polarized FTIR and anisotropic SAXS/WAXS scattering patterns. The elastic modulus of fibers increased with protein fibril content from 0.8 to 2 GPa, which is superior to reported values of silk, collagen, and gelatin. The present setup allows for manufacture of large quantities of polymeric fibers containing protein fibrils with varied diameter and mechanical strength, endowing great potential for a variety of applications.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Chen D,Narayanan N,Federici E,Yang Z,Zuo X,Gao J,Fang F,Deng M,Campanella OH,Jones OGdoi
10.1021/acs.biomac.0c00500subject
Has Abstractpub_date
2020-07-13 00:00:00pages
2772-2785issue
7eissn
1525-7797issn
1526-4602journal_volume
21pub_type
杂志文章abstract：:The carboxyl-terminal domain (CTD, residues 146-231) of the HIV-1 capsid (CA) protein plays an important role in the CA-CA dimerization and viral assembly of the human immunodeficiency virus type 1. Disrupting the native conformation of the CA is essential for blocking viral capsid formation and viral replication. Thu...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm801151r
更新日期：2009-02-09 00:00:00
abstract：:The extracellular matrix is an environment rich with structural, mechanical, and molecular signals that can impact cell biology. Traditional approaches in hydrogel biomaterial design often rely on modifying the concentration of cross-linking groups to adjust mechanical properties. However, this strategy provides limit...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b00118
更新日期：2017-04-10 00:00:00
abstract：:An artificial spinning system using regenerated silk fibroin solutions is adopted to produce high-performance silk fibers. In previous studies, alcohol-based agents, such as methanol or ethanol, were used to coagulate silk dope solutions, producing silk fiber with poor mechanical properties compared with those of nati...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b00232
更新日期：2018-06-11 00:00:00
abstract：:Binding human serum albumin (HSA) of three polyoxometalates (POMs) with the Wells-Dawson structure, alpha(2)-[P2W17O61]10- (abbreviated as alpha(2)-P2W17) and two of its metal-substituted derivatives, alpha(2)-[NiP2W17O61]8- and alpha(2)-[CuP2W17O61]8- (alpha(2)-P2W17Ni and alpha(2)-P2W17Cu, respectively) was studied ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm701120j
更新日期：2008-03-01 00:00:00
abstract：:Protein-based polymers are increasingly being used in biomaterial applications because of their ease of customization and potential monodispersity. These advantages make protein polymers excellent candidates for bioanalytical applications. Here we describe improved methods for producing drag-tags for free-solution con...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm200358r
更新日期：2011-06-13 00:00:00
abstract：:Controlling self-assembly is critical to the advancement of nanotechnology. A rugged or crenated assembly energy surface can redirect assembly off path. By using a defined starting point and an energy surface made rough by a strong association energy, we can impose entirely new assembly paths and products. Normally, t...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm901160b
更新日期：2010-02-08 00:00:00
abstract：:Herein we present a unique method of using dynamic cross-links, which are dynamic covalent bonding and ionic interaction, for the construction of injectable double-network (DN) hydrogels, with the objective of cell delivery for cartilage repair. Glycol chitosan and dibenzaldhyde capped poly(ethylene oxide) formed the ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b00452
更新日期：2017-07-10 00:00:00
abstract：:Minimally invasive implants and/or scaffolds integrated with multiple functionalities are of interest in the clinical settings. In this paper, chitosan (CTS) functionalized poly(lactic-co-glycolic acid) (PLGA) microspheres containing a model payload, lysozyme (Lyz), were prepared by a water-in-oil-in-water emulsion me...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm4003464
更新日期：2013-06-10 00:00:00
abstract：:Disulfide bonds stabilize the tertiary- and quaternary structure of proteins. In addition, they can be used to engineer redox-sensitive (bio)materials and drug-delivery systems. Many of these applications require control of the stability of the disulfide bond. It has recently been shown that the charged microenvironme...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm400501c
更新日期：2013-07-08 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm401304w
更新日期：2013-12-09 00:00:00
abstract：:Neutron reflectometry was used to investigate the time-dependent beta-casein adsorption at the silica-aqueous solution interface. The transient and steady-state structural characteristics of the adsorbed layer were determined from reflectivity curves, fitted to three-layer and two-layer models. The results show that t...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0155221
更新日期：2001-10-01 00:00:00
abstract：:Marine mussels tether to seashore surfaces with byssal threads, proteinaceous fibers that effectively dissipate energy from crashing waves. Protein-metal coordination bonds have been proposed to contribute to the characteristic mechanical and self-healing properties of byssal threads; however, very little is understoo...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b00803
更新日期：2015-09-14 00:00:00
abstract：:Utilization of reversible interactions as sacrificial bonds in biopolymers is critical for the integral synthesis of mechanically superior biological materials. In this work, cellulose nanofibrils (CNFs) reinforced covalent polyacrylamide (PAAm) composite hydrogels are immersed into multivalent cation (Ca2+, Zn2+, Al3...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.6b01915
更新日期：2017-03-13 00:00:00
abstract：:We have studied the degradation of well-characterized soluble heteropolymeric chitosans by a novel family 46 chitosanase, ScCsn46A from Streptomyces coelicolor A3(2), to obtain insight into the enzyme's mode of action and to determine its potential for production of different chitooligosaccharides. The degradation of ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm1006745
更新日期：2010-09-13 00:00:00
abstract：:Highly cross-linked networks formed by the photoinitiated polymerization of multifunctional monomers are finding application in the field of biomaterials because of their chemical versatility, reaction control, and ability to polymerize under physiological conditions. Typically, degradation is introduced into these ne...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm025677o
更新日期：2003-01-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm400846h
更新日期：2013-10-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm000105u
更新日期：2001-04-01 00:00:00
abstract：:The complement system plays an important role in innate and adaptive immunity, which suggests that complement activation could be exploited as a potential strategy for vaccine adjuvants. Here we explored the potential of chitosan-based microparticles (CS-NH2 MPs) as a vaccine adjuvant with an active surface for comple...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm400930k
更新日期：2013-09-09 00:00:00
abstract：:Poly(butylene adipate-co-terephthalate) (PBAT) was first chemically modified via free radical grafting with maleic anhydride (MA) and the MA-g-PBAT graft copolymer was then used as a matrix material to obtain cellulose nanocrystal (CNC)-reinforced MA-g-PBAT bionanocomposites via reactive extrusion process to accelerat...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b00578
更新日期：2017-07-10 00:00:00
abstract：:We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm200413a
更新日期：2011-06-13 00:00:00
abstract：:Thin films of a biocompatible and nonbiofouling poly(oligo(ethylene glycol) methacrylate) ( pOEGMA) with various thicknesses were formed on gold and Si/SiO 2 substrates by a combination of the formation of self-assembled monolayers (SAMs) terminating in bromoester-an initiator of atom transfer radical polymerization (...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm7009043
更新日期：2007-12-01 00:00:00
abstract：:PolyHIPEs show great promise as tissue engineering scaffolds due to the tremendous control of pore size and interconnectivity afforded by this technique. Highly porous, fully biodegradable scaffolds were prepared by polymerization of the continuous phase of high internal phase emulsions (HIPEs) containing the macromer...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm7007235
更新日期：2007-12-01 00:00:00
abstract：:Bovine serum albumin (BSA) and poly(diallyldimethylammonium chloride) (PDADMAC) spontaneously form, over a range of ionic strength I and pH, dense fluids rich in both macroions. To study their nanostructure, these coacervates were prepared at low I and high pH (strong interaction) or at high I and lower pH (weaker int...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049174p
更新日期：2005-05-01 00:00:00
abstract：:A library-orientated approach is used to gain understanding of the interactions of well-defined nanoparticles with primary human endothelial cells, which are a key component of the vasculature. Fifteen sequentially modified gold nanoparticles (AuNPs) based on three different core sizes (18, 35, 65 nm) and five polymer...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm300248u
更新日期：2012-05-14 00:00:00
abstract：:The aggregation phenomena in aqueous solutions of hydrophobically modified (HM) chitosan, containing 4 mol % of n-dodecyl side chains, were studied by viscometry and fluorescence spectroscopy with pyrene as a probe. The results are compared with those for unmodified chitosan. Surprisingly, fluorescence data reveal the...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm005649a
更新日期：2001-07-01 00:00:00
abstract：:We present a new design of peptide-polymer conjugates where a polymer chain is covalently linked to the side chain of a helix bundle-forming peptide. The effect of conjugated polymer chains on the peptide structure was examined using a de novo designed three-helix bundle and a photoactive four-helix bundle. Upon attac...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm800113g
更新日期：2008-08-01 00:00:00
abstract：:The positive interaction of materials with tissues is an important step in regenerative medicine strategies. Hydrogels that are obtained from polysaccharides and proteins are expected to mimic the natural cartilage environment and thus provide an optimum milleu for tissue growth and regeneration. In this work, novel h...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm800874q
更新日期：2008-10-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b01313
更新日期：2017-12-11 00:00:00
abstract：:Computationally designed peptides form desired antiparallel, tetrameric coiled-coil bundles that hierarchically assemble into a variety of well-controlled nanostructures depending on aqueous solution conditions. The bundles selectively self-assemble into different structures: nanotubes, platelets, or needle-like struc...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b01163
更新日期：2018-11-12 00:00:00
abstract：:Poly(lactic acid) (PLA) copolymers having a significantly higher glass transition temperature (T(g)) than that of high molar mass PLA homopolymers (typically 60 +/- 5 degrees C) were prepared. Lactic acid was copolymerized with 1,4:3,6-dianhydro-D-glucitol (isosorbide, ISB) and succinic acid (SA-2), 1,2,3,4-butanetetr...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm901338n
更新日期：2010-05-10 00:00:00
