Abstract：
:Computationally designed peptides form desired antiparallel, tetrameric coiled-coil bundles that hierarchically assemble into a variety of well-controlled nanostructures depending on aqueous solution conditions. The bundles selectively self-assemble into different structures: nanotubes, platelets, or needle-like structures at solution pH values of 4.5, 7, and 10, respectively. The self-assembly produces hollow tubes or elongated needle-like structures at pH conditions associated with charged bundles (pH 4.5 or 10); at neutral pH, near the pI of the bundle, a plate-like self-assembled structure forms. Transmission electron microscopy and small-angle X-ray scattering show the nanotubes to be uniform with a tube diameter of ∼13 nm and lengths of up to several μm, yielding aspect ratios >1000. Combining the measured nanostructure geometry with the apparent charged states of the constituent amino acids, a tilted-bundle packing model is proposed for the formation of the homogeneous nanotubes. This work demonstrates the successful use of assembly pathway control for the construction of nanostructures with diverse, well-structured morphologies associated with the folding and self-association of a single type of molecule.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Tian Y,Polzer FB,Zhang HV,Kiick KL,Saven JG,Pochan DJdoi
10.1021/acs.biomac.8b01163subject
Has Abstractpub_date
2018-11-12 00:00:00pages
4286-4298issue
11eissn
1525-7797issn
1526-4602journal_volume
19pub_type
杂志文章abstract：:The polarity of polymer-actin complexes obtained by mixing F-actin with synthetic polymers carrying positive charges such as poly(L-lysine), x,y-ionene bromide polymers, and poly(N-[3-(dimethylamino)propyl]acrylamide) (PDMAPAA-Q) have been investigated. Actin complexes formed with poly(L-lysine) and PDMAPAA-Q, which c...
journal_title：Biomacromolecules
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journal_title：Biomacromolecules
pub_type： 杂志文章
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journal_title：Biomacromolecules
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pub_type： 杂志文章
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更新日期：2015-11-09 00:00:00
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更新日期：2002-09-01 00:00:00
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更新日期：2005-05-01 00:00:00
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更新日期：2009-12-14 00:00:00
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更新日期：2010-05-10 00:00:00
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更新日期：2013-09-09 00:00:00
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pub_type： 杂志文章
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更新日期：2010-09-13 00:00:00
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