Injectable and Self-Healing Dynamic Hydrogels Based on Metal(I)-Thiolate/Disulfide Exchange as Biomaterials with Tunable Mechanical Properties.

abstract：:The thermally induced aggregation of bovine β-lactoglobulin in the glass state was studied both as the pure protein and in trehalose mixtures. Calorimetric measurements and size exclusion chromatography were used to characterize the glass state and aggregation, respectively. The initial aggregation rate was characteri...

journal_title：Biomacromolecules

authors： Pérez-Moral N,Adnet C,Noel TR,Parker R

更新日期：2010-11-08 00:00:00

abstract：:We have developed herein an engineered polymer-based nanoplatform showing the convergence of two-photon fluorescence imaging and bimodal phototherapeutic activity in a single nanostructure. It was achieved through the appropriate choice of three different components: a β-cyclodextrin-based polymer acting as a suitable...

journal_title：Biomacromolecules

authors： Kandoth N,Kirejev V,Monti S,Gref R,Ericson MB,Sortino S

更新日期：2014-05-12 00:00:00

abstract：:Adhesive hydrogels were prepared by copolymerizing dopamine methacrylamide with either acrylic acid (AAc) or N-(3-aminopropyl)methacrylamide hydrochloride (APMH). The effect of incorporating the anionic and cationic side chains on the oxidation state of catechol was characterized using the FOX assay to track the produ...

journal_title：Biomacromolecules

authors： Narkar AR,Kelley JD,Pinnaratip R,Lee BP

更新日期：2018-05-14 00:00:00

abstract：:Under the right conditions, some biological systems can maintain high viability after being frozen and thawed, but many others (e.g., organs and many mammalian cells) cannot. To increase the rates of post-thaw viability and widen the library of living cells and tissues that can be stored frozen, an improved understand...

journal_title：Biomacromolecules

authors： Burkey AA,Hillsley A,Harris DT,Baltzegar JR,Zhang DY,Sprague WW,Rosales AM,Lynd NA

更新日期：2020-08-10 00:00:00

abstract：:We present a synthetic approach toward soft, glycooligomer-functionalized microgel particles mimicking carbohydrate presenting cell surfaces and analyze their specific binding to a model lectin (Concanavalin A, ConA). Focusing on multivalent presentation, a series of sequence-controlled glycooligomers with varying spa...

journal_title：Biomacromolecules

authors： Jacobi F,Camaleño de la Calle A,Boden S,Grafmüller A,Hartmann L,Schmidt S

更新日期：2018-08-13 00:00:00

abstract：:Polymers are appealing as pH-responsive elements of multicomponent systems designed to promote cytosolic delivery of macromolecular drugs (including proteins and genes), but so far the delivery efficiency achieved has been relatively modest. Therefore, the aim of this study was to apply several physicochemical techniq...

journal_title：Biomacromolecules

authors： Griffiths PC,Khayat Z,Tse S,Heenan RK,King SM,Duncan R

更新日期：2007-03-01 00:00:00

abstract：:We report a simple and novel top-down method based on a drop-casting process for the controlled synthesis of all-bone-minerals biomimetic multicomponent bionanocomposites. Integration of micro- and nanoscale binary features into nanofibrous biocompatible polymer scaffold structures is successfully demonstrated. Compos...

journal_title：Biomacromolecules

authors： Biswas A,Bayer IS,Zhao H,Wang T,Watanabe F,Biris AS

更新日期：2010-10-11 00:00:00

abstract：:Electrospinning for the formation of nanoscale diameter fibers has been explored for high-performance filters and biomaterial scaffolds for vascular grafts or wound dressings. Fibers with nanoscale diameters provide benefits due to high surface area. In the present study we explore electrospinning for protein-based bi...

journal_title：Biomacromolecules

authors： Jin HJ,Fridrikh SV,Rutledge GC,Kaplan DL

更新日期：2002-11-01 00:00:00

abstract：:Biofilm formation, in which bacteria are embedded within an extracellular matrix, is the default form of microbial life in most natural and engineered habitats. In this work, atomistic molecular dynamics simulations were employed to examine the self-assembly of the polysaccharide Granulan to provide insight into the m...

journal_title：Biomacromolecules

authors： Seviour T,Malde AK,Kjelleberg S,Yuan Z,Mark AE

更新日期：2012-06-11 00:00:00

abstract：:First generation, photocrosslinkable dendrimers consisting of natural metabolites (i.e., succinic acid, glycerol, and beta-alanine) and nonimmunogenic poly(ethylene glycol) (PEG) were synthesized divergently in high yields using ester and carbamate forming reactions. Aqueous solutions of these dendrimers were photocro...

journal_title：Biomacromolecules

authors： Degoricija L,Bansal PN,Söntjens SH,Joshi NS,Takahashi M,Snyder B,Grinstaff MW

更新日期：2008-10-01 00:00:00

abstract：:The objective of this study is to investigate the influence of point mutations on the structural stability of coiled coil fragments of the human hair intermediate filament by molecular dynamics simulations and free energy calculations. Mutations in the helix termination motif of human hair keratin gene hHb6 seem to be...

journal_title：Biomacromolecules

authors： Danciulescu C,Nick B,Wortmann FJ

更新日期：2004-11-01 00:00:00

abstract：:On-line size-exclusion chromatography monitoring of potato phosphorylase catalyzed amylose synthesis--starting from alpha-D-glucose-1-P and maltohexaose--revealed rather monodisperse amylose populations. In the presence of lipids, amylose-lipid complexes spontaneously formed and precipitated. They were recovered by ce...

journal_title：Biomacromolecules

authors： Gelders GG,Goesaert H,Delcour JA

更新日期：2005-09-01 00:00:00

abstract：:Textile chitosan fiber scaffolds were developed and tested in terms of biocompatibility for human bone marrow stromal cells (hBMSCs). A part of the scaffolds was further modified by coating with fibrillar collagen type I in order to biologize the surface. hBMSCs of two donors were used for cell culture experiments in ...

journal_title：Biomacromolecules

authors： Heinemann C,Heinemann S,Lode A,Bernhardt A,Worch H,Hanke T

更新日期：2009-05-11 00:00:00

abstract：:Greener alternatives to synthetic polymers are constantly being investigated and sought after. Chitin is a natural polysaccharide that gives structural support to crustacean shells, insect exoskeletons, and fungal cell walls. Like cellulose, chitin resides in nanosized structural elements that can be isolated as nanof...

journal_title：Biomacromolecules

authors： Nawawi WMFBW,Jones M,Murphy RJ,Lee KY,Kontturi E,Bismarck A

更新日期：2020-01-13 00:00:00

abstract：:Injectable gels that support load are desirable for restoring the mechanical properties of degenerated load-bearing tissue. As these gels become increasingly sophisticated, the need to remotely image them and monitor their swelling increases. However, imaging such gels and monitoring their swelling using noninvasive m...

journal_title：Biomacromolecules

authors： Shanks HR,Milani AH,Lu D,Saunders BR,Carney L,Adlam DJ,Hoyland JA,Blount C,Dickinson M

更新日期：2019-07-08 00:00:00

abstract：:Poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) are biopolyesters reported to provide favorable microenvironments for cell culture and possess potential for tissue engineering applications. Both biopolymers have been investigated for applications in a variety of medical scenarios,...

journal_title：Biomacromolecules

authors： Ahmed T,Marçal H,Lawless M,Wanandy NS,Chiu A,Foster LJ

更新日期：2010-10-11 00:00:00

abstract：:Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These...

journal_title：Biomacromolecules

authors： Hsiao HC,Santos A,Howell DW,Patterson JL,Fuchs-Young RS,Bondos SE

更新日期：2016-11-14 00:00:00

abstract：:Enzymatic adsorption and degradation of three types of aliphatic polyester films and two types of polyolefin films by the extracellular PHB depolymerase from Alcaligenes faecalis T1 have been studied by using a quartz crystal microbalance (QCM) technique. Hydrolysis of poly[(R)-3-hydroxybutyrate] was quantitatively fo...

journal_title：Biomacromolecules

authors： Yamashita K,Aoyagi Y,Abe H,Doi Y

更新日期：2001-04-01 00:00:00

abstract：:Acrylic acid (AAc) has been utilized to introduce reactive carboxyl groups to a temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). However, AAc introduction shifts the copolymer phase transition temperatures higher and dampens the steep homopolymer phase transition with increasing AAc content. We pr...

journal_title：Biomacromolecules

authors： Ebara M,Yamato M,Hirose M,Aoyagi T,Kikuchi A,Sakai K,Okano T

更新日期：2003-03-01 00:00:00

abstract：:The effect of solution pH during layer-by-layer assembly of polyelectrolyte multilayer (PEM) coatings on properties relevant to orthopedic implant success was investigated. Bone morphogenetic protein 2 (BMP-2), a potent osteoconductive growth factor, was adsorbed onto the surface of anodized titanium, and PEM coatings...

journal_title：Biomacromolecules

authors： Salvi C,Lyu X,Peterson AM

更新日期：2016-06-13 00:00:00

abstract：:Major ampullate silk, also known as dragline silk, is one of the strongest biomaterials known. This silk is composed of two proteins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2). Only partial cDNA sequences have been obtained for these proteins, and these sequences are toward the C-termin...

journal_title：Biomacromolecules

authors： Motriuk-Smith D,Smith A,Hayashi CY,Lewis RV

更新日期：2005-11-01 00:00:00

abstract：:Oriented immobilization of proteins is an important step in creating protein-based functional materials. In this study, a method was developed to orient proteins on hydroxyapatite (HA) surfaces, a widely used bone implant material, to improve protein bioactivity by employing enhanced green fluorescent protein (EGFP) a...

journal_title：Biomacromolecules

authors： Yewle JN,Wei Y,Puleo DA,Daunert S,Bachas LG

更新日期：2012-06-11 00:00:00

abstract：:Introducing exogenous genes into plant cells is essential for a wide range of applications in agriculture and plant biotechnology fields. Cationic peptide carriers with cell-penetrating and DNA-binding domains successfully deliver exogenous genes into plants. However, their cell-penetrating activity may be attenuated ...

journal_title：Biomacromolecules

authors： Miyamoto T,Tsuchiya K,Numata K

更新日期：2019-02-11 00:00:00

abstract：:The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the degradation characteristics of the microspheres. To this end, an in-vitro degradation study was conducted. PLLA-microspheres with and without Ho...

journal_title：Biomacromolecules

authors： Zielhuis SW,Nijsen JF,Krijger GC,van het Schip AD,Hennink WE

更新日期：2006-07-01 00:00:00

abstract：:The nature of the hydration of proteins and the subsequent implications for functionality is a matter of importance in both pharmaceutical and food applications. Most published studies rely on the use of one technique and attempt to characterize the system. Few studies have used combinations of techniques. In this pap...

journal_title：Biomacromolecules

authors： Almutawah A,Barker SA,Belton PS

更新日期：2007-05-01 00:00:00

abstract：:Micellar peroxidase-catalyzed synthesis of chiral polyaniline (PANI) in the presence of dodecylbenzenesulfonic acid (DBSA) was developed. The effect of DBSA concentration on the catalytic efficiency of horseradish and palm tree peroxidases was examined. Favorable conditions for the enzymatic synthesis of chiral PANI, ...

journal_title：Biomacromolecules

authors： Caramyshev AV,Lobachov VM,Selivanov DV,Sheval EV,Vorobiev AKh,Katasova ON,Polyakov VY,Makarov AA,Sakharov IY

更新日期：2007-08-01 00:00:00

abstract：:In this contribution, a hydrophobically modified polysaccharide derivative is synthesized in an eco-friendly solvent water by conjugation of benzylamine with the backbone of the biopolymer. Owing to the presence of aromatic moieties, the resulting water-soluble polysaccharide derivative self-assembles spontaneously an...

journal_title：Biomacromolecules

authors： Mohan T,Rathner R,Reishofer D,Koller M,Elschner T,Spirk S,Heinze T,Stana-Kleinschek K,Kargl R

更新日期：2015-08-10 00:00:00

abstract：:Biomimetic mineralization of collagen is an advantageous method to obtain resorbable collagen/hydroxy-apatite composites for application in bone regeneration. In this report, established procedures for mineralization of bovine collagen were adapted to a new promising source of collagen from salmon skin challenged by t...

journal_title：Biomacromolecules

authors： Hoyer B,Bernhardt A,Heinemann S,Stachel I,Meyer M,Gelinsky M

更新日期：2012-04-09 00:00:00

abstract：:Herein we present an innovative approach to produce biocompatible, degradable, and stealth polymeric nanoparticles based on poly(lipoic acid), stabilized by a PEG-ended surfactant. Taking advantage of the well-known thiol-induced polymerization of lipoic acid, a universal and nontoxic nanovector consisted of a solid c...

journal_title：Biomacromolecules

authors： Trzciński JW,Morillas-Becerril L,Scarpa S,Tannorella M,Muraca F,Rastrelli F,Castellani C,Fedrigo M,Angelini A,Tavano R,Papini E,Mancin F

更新日期：2020-12-21 00:00:00

abstract：:A new mathematical model is presented for the analysis of the substituent distribution in the polymer chain of polysaccharide derivatives. For the first time, the influence of substitution on the reactivity of neighbored monomer units is taken into account. The model was applied to various cellulose and amylose ethers...

journal_title：Biomacromolecules

authors： Mischnick P,Hennig C

更新日期：2001-04-01 00:00:00