Controlled release and entrapment of enantiomers in self-assembling scaffolds composed of beta-sheet peptides.

abstract：:Effects of poly(ethylene glycol) (PEG) conjugation on peptide interactions with lipid membranes and lipopolysaccharide (LPS) were investigated for KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYTLR), an antimicrobial and anti-inflammatory peptide derived from human heparin cofactor II. In particular, effects of PEG length and locali...

journal_title：Biomacromolecules

authors： Singh S,Papareddy P,Mörgelin M,Schmidtchen A,Malmsten M

更新日期：2014-04-14 00:00:00

abstract：:Despite the good clinical efficacy of interferon-alpha (IFNα) to treat some types of cancer and viral infections, this biological drug is underused given its severe adverse effects and high dosing parenteral regimens. Aiming to achieve a breakthrough in therapy with IFNα, this work reports for the first time on the de...

journal_title：Biomacromolecules

authors： Cánepa C,Imperiale JC,Berini CA,Lewicki M,Sosnik A,Biglione MM

更新日期：2017-10-09 00:00:00

abstract：:Magnetosomes are natural magnetic nanoparticles with exceptional properties that are synthesized in magnetotactic bacteria by a highly regulated biomineralization process. Their usability in many applications could be further improved by encapsulation in biocompatible polymers. In this study, we explored the productio...

journal_title：Biomacromolecules

authors： Mickoleit F,Borkner CB,Toro-Nahuelpan M,Herold HM,Maier DS,Plitzko JM,Scheibel T,Schüler D

更新日期：2018-03-12 00:00:00

abstract：:Poly((N-vinylpyrrolidone)-block-poly(vinyl acetate)) (PVP-b-PVAc) block copolymers of varying molecular weight and hydrophobic block lengths were synthesized via controlled radical polymerization and investigated as carriers for the solubilization of highly hydrophobic riminophenazine compounds. These compounds have r...

journal_title：Biomacromolecules

authors： Bailly N,Thomas M,Klumperman B

更新日期：2012-12-10 00:00:00

abstract：:A recombinant silk-elastin-like protein copolymer SELP-47K containing tandemly repeated amino acid sequence blocks from silk, GAGAGS, and elastin, GVGVP, was fabricated into microdiameter fibers using a wet-spinning technique. Raman spectral analysis revealed the formation of antiparallel beta-sheet crystals of the si...

journal_title：Biomacromolecules

authors： Qiu W,Teng W,Cappello J,Wu X

更新日期：2009-03-09 00:00:00

abstract：:The formation of amylose-polystyrene inclusion complexes via a novel two-step approach is described. In the first-step, styrene was inserted inside the amylose helical cavity, followed by free radical polymerization in the second step. The inclusion complexes were characterized by attenuated total reflection fourier t...

journal_title：Biomacromolecules

authors： Kumar K,Woortman AJ,Loos K

更新日期：2013-06-10 00:00:00

abstract：:This paper presents the formation of a novel biomimetic interface consisting of an electrolessly deposited gold film overlaid with a tethered bilayer lipid membrane (tBLM). Self-assembly of colloidal gold particles was used to create an electrolessly deposited gold film on a glass slide. The properties of the film wer...

journal_title：Biomacromolecules

authors： Kohli N,Hassler BL,Parthasarathy L,Richardson RJ,Ofoli RY,Worden RM,Lee I

更新日期：2006-12-01 00:00:00

abstract：:A new 320-member polymer library of end-modified poly(β-amino ester)s was synthesized. This library was chosen such that small differences to the structures of component backbone, side-chain, and end-group monomers could be systematically and simultaneously evaluated. The in vitro transfection efficacy and cytotoxicit...

journal_title：Biomacromolecules

authors： Sunshine JC,Akanda MI,Li D,Kozielski KL,Green JJ

更新日期：2011-10-10 00:00:00

abstract：:This paper shows a simple and effective way to avoid the dissociation of multimeric enzymes by coating their surface with a large cationic polymer (e.g., polyethylenimine (PEI)) by ionic exchange. As model enzymes, glutamate dehydrogenase (GDH) from Thermus thermophilus and formate dehydrogenase (FDH) from Pseudomonas...

journal_title：Biomacromolecules

authors： Bolivar JM,Rocha-Martin J,Mateo C,Cava F,Berenguer J,Fernandez-Lafuente R,Guisan JM

更新日期：2009-04-13 00:00:00

abstract：:Chimeric DNA containing parallel (ps) and antiparallel (aps) duplex elements as well as poly-dC tracts were designed and synthesized. Oligonucleotide duplexes with ps chain orientation containing reverse Watson-Crick dA-dT base pairs and short d(C)2 tails are stabilized under slightly acidic conditions by hemiprotonat...

journal_title：Biomacromolecules

authors： Mei H,Budow S,Seela F

更新日期：2012-12-10 00:00:00

abstract：:The Bacillus subtilis protease Proleather FG-F catalyzed the transesterification of inulin with vinyl acrylate (VA) in dimethylformamide (DMF). The reaction conversion for different VA concentrations was greater than 57% after 96 h at 50 degrees C. The degree of substitution (DS, defined as the amount of acrylate grou...

journal_title：Biomacromolecules

authors： Ferreira L,Carvalho R,Gil MH,Dordick JS

更新日期：2002-03-01 00:00:00

abstract：:Recent research indicates that the progression of Parkinson's disease can start from neurons of the enteric nervous system, which are in close contact with the gastrointestinal epithelium: α-synuclein molecules can be transferred from these epithelial cells in a prion-like fashion to enteric neurons. Thin mucus layers...

journal_title：Biomacromolecules

authors： Marczynski M,Rickert CA,Semerdzhiev SA,van Dijk WR,Segers-Nolten IMJ,Claessens MMAE,Lieleg O

更新日期：2019-12-09 00:00:00

abstract：:Binding interactions between low molecular weight heparin (LMWH) and heparin-binding peptides (HBP) have been applied as a strategy for the assembly of hydrogels that are capable of sequestering growth factors and delivering them in a controlled manner. In this work, the assembly of four-arm star poly(ethylene glycol)...

journal_title：Biomacromolecules

authors： Yamaguchi N,Chae BS,Zhang L,Kiick KL,Furst EM

更新日期：2005-07-01 00:00:00

abstract：:We report structural and dynamical aspects of DNAs from various sources including synthetic oligonucleotides in bulk buffer and as a complex with histone1 (H1). High-resolution transmission electron microscopic (HRTEM) studies reveal the structural change of the DNAs upon complexation with H1 leading to formation of c...

journal_title：Biomacromolecules

authors： Sarkar R,Pal SK

更新日期：2007-11-01 00:00:00

abstract：:We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a facile and versatile technology to prepare engineered nanocoatings for various biomedical applications. Low-fouling coatings on particles were obtained by the formation of multicomposition...

journal_title：Biomacromolecules

authors： Guntari SN,Wong EH,Goh TK,Chandrawati R,Blencowe A,Caruso F,Qiao GG

更新日期：2013-08-12 00:00:00

abstract：:A modular approach to engineering cross-linked elastic biomaterials is presented for fine-tuning of material mechanical and biological properties. The three components, soluble elastin, hyaluronic acid, and silk fibroin, contribute with different features to the overall properties of the final material system. The ela...

journal_title：Biomacromolecules

authors： Serban MA,Kluge JA,Laha MM,Kaplan DL

更新日期：2010-09-13 00:00:00

abstract：:Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine. Current treatments are suboptimal, and thus the development of an enzyme replacement therapy based on PEGylated human truncated CBS (PEG-CBS) has been initiated. Attenuation of potency was obs...

journal_title：Biomacromolecules

authors： Majtan T,Park I,Carrillo RS,Bublil EM,Kraus JP

更新日期：2017-06-12 00:00:00

abstract：:Bioresponsive poly(amidoamine)s (PAA)s are currently under development as endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first time, small-angle neutron scattering (SANS) is used to systematically investigate the pH-dependent conformational change of an endosomolytic polymer, the...

journal_title：Biomacromolecules

authors： Griffiths PC,Paul A,Khayat Z,Wan KW,King SM,Grillo I,Schweins R,Ferruti P,Franchini J,Duncan R

更新日期：2004-07-01 00:00:00

abstract：:On-line size-exclusion chromatography monitoring of potato phosphorylase catalyzed amylose synthesis--starting from alpha-D-glucose-1-P and maltohexaose--revealed rather monodisperse amylose populations. In the presence of lipids, amylose-lipid complexes spontaneously formed and precipitated. They were recovered by ce...

journal_title：Biomacromolecules

authors： Gelders GG,Goesaert H,Delcour JA

更新日期：2005-09-01 00:00:00

abstract：:The thermal conductive properties, including the thermal diffusivity and resultant thermal conductivity, of nonwoven nanocellulose sheets were investigated by separately measuring the thermal diffusivity of the sheets in the in-plane and thickness directions with a periodic heating method. The cross-sectional area (or...

journal_title：Biomacromolecules

authors： Uetani K,Okada T,Oyama HT

更新日期：2015-07-13 00:00:00

abstract：:Sequential copolymerizations of trimethylene carbonate (TMC) and l-lactide (LLA) were performed with 2,2-dibutyl-2-stanna-1,3-oxepane as a bifunctional cyclic initiator. The block lengths were varied via the monomer/initiator and via the TMC/l-lactide ratio. The cyclic triblock copolymers were transformed in situ into...

journal_title：Biomacromolecules

authors： Pospiech D,Komber H,Jehnichen D,Häussler L,Eckstein K,Scheibner H,Janke A,Kricheldorf HR,Petermann O

更新日期：2005-01-01 00:00:00

abstract：:Numerous catechol-containing polymers, including biodegradable polymers, are currently heavily discussed for modern biomaterials. However, there is no report combining poly(phosphoester)s (PPEs) with catechols. Adhesive PPEs have been prepared via acyclic diene metathesis polymerization. A novel acetal-protected catec...

journal_title：Biomacromolecules

authors： Becker G,Ackermann LM,Schechtel E,Klapper M,Tremel W,Wurm FR

更新日期：2017-03-13 00:00:00

abstract：:The synthesis of core-shell star copolymers via living free radical polymerization provides a convenient route to three-dimensional nanostructures having a poly(ethylene glycol) outer shell, a hydrophilic inner shell bearing reactive functional groups, and a central hydrophobic core. By starting with well-defined line...

journal_title：Biomacromolecules

authors： Fukukawa K,Rossin R,Hagooly A,Pressly ED,Hunt JN,Messmore BW,Wooley KL,Welch MJ,Hawker CJ

更新日期：2008-04-01 00:00:00

abstract：:A novel cellulose derivative, 6-O-dihydrophytylcellulose (DHPC), was first synthesized via a ring-opening polymerization and allowed to self-assemble onto an air-water interface. Langmuir-Blodgett (LB) films were characterized with atomic force microscope (AFM), UV-vis spectroscopy, and Fourier transform infrared spec...

journal_title：Biomacromolecules

authors： Sakakibara K,Ifuku S,Tsujii Y,Kamitakahara H,Takano T,Nakatsubo F

更新日期：2006-06-01 00:00:00

abstract：:Hollow poly(6-O-acryloyl-alpha-D-galactopyranose) (PAGP) nanospheres were prepared in a facile manner using the RAFT (reversible addition fragmentation chain transfer) process. Initially, an amphiphilic block copolymer, poly(lactide)-block-poly(6-O-acryloyl-alpha-D-galactopyranose) (PLA-b-PAGP), was synthesized using ...

journal_title：Biomacromolecules

authors： Ting SR,Gregory AM,Stenzel MH

更新日期：2009-02-09 00:00:00

abstract：:High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytot...

journal_title：Biomacromolecules

authors： Bat E,Plantinga JA,Harmsen MC,van Luyn MJ,Zhang Z,Grijpma DW,Feijen J

更新日期：2008-11-01 00:00:00

abstract：:Solid films of deoxyribonucleic acid (DNA) containing a hydrated ionic liquid, choline dihydrogen phosphate (CDP), were prepared by a solvent-casting method. Thermal properties, aggregation structure, thermal molecular motion, and tensile properties of CDP-containing DNA films were examined by thermogravimetry (TG), w...

journal_title：Biomacromolecules

authors： Morimitsu Y,Matsuno H,Ohta N,Sekiguchi H,Takahara A,Tanaka K

更新日期：2020-02-10 00:00:00

abstract：:Solid-state NMR is especially useful when the structures of peptides and proteins should be analyzed by taking into account the structural distribution, that is, the distribution of the torsion angle of the individual residue. In this study, two-dimensional spin-diffusion solid-state NMR spectra of 13C-double-labeled ...

journal_title：Biomacromolecules

authors： Ohgo K,Kawase T,Ashida J,Asakura T

更新日期：2006-04-01 00:00:00

abstract：:Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization o...

journal_title：Biomacromolecules

authors： Brandl F,Hammer N,Blunk T,Tessmar J,Goepferich A

更新日期：2010-02-08 00:00:00

abstract：:Nitrilotriacetic amine (NTA)-functionalized nanoparticles obtained by aqueous polymerization-induced self-assembly (PISA) are introduced as immobilization supports for polyhistidine-functionalized (His-tagged) enzymes. A novel initiator for nitroxide-mediated polymerization based on the nitroxide SG1 and carrying a pr...

journal_title：Biomacromolecules

authors： Keller D,Beloqui A,Martínez-Martínez M,Ferrer M,Delaittre G

更新日期：2017-09-11 00:00:00