Adhesion of Blood Plasma Proteins and Platelet-rich Plasma on l-Valine-Based Poly(ester urea).

Abstract:

:The competitive absorption of blood plasma components including fibrinogen (FG), bovine serum albumin (BSA), and platelet-rich plasma (PRP) on l-valine-based poly(ester urea) (PEU) surfaces were investigated. Using four different PEU polymers, possessing compositionally dependent trends in thermal, mechanical, and critical surface tension measurements, water uptake studies were carried out to determine in vitro behavior of the materials. Quartz crystal microbalance (QCM) measurements were used to quantify the adsorption characteristics of PRP onto PEU thin films by coating the surfaces initially with FG or BSA. Pretreatment of the PEU surfaces with FG inhibited the adsorption of PRP and BSA decreased the absorption 4-fold. In vitro studies demonstrated that cells cultured on l-valine-based PEU thin films allowed attachment and spreading of rat aortic cells. These measurements will be critical toward efforts to use this new class of materials in blood-contacting biomaterials applications.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Childers EP,Peterson GI,Ellenberger AB,Domino K,Seifert GV,Becker ML

doi

10.1021/acs.biomac.6b01195

subject

Has Abstract

pub_date

2016-10-10 00:00:00

pages

3396-3403

issue

10

eissn

1525-7797

issn

1526-4602

journal_volume

17

pub_type

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