Abstract:
:Polymerized high internal phase emulsions (polyHIPEs) have been utilized in the creation of injectable scaffolds that cure in situ to fill irregular bone defects and potentially improve tissue healing. Previously, thermally initiated scaffolds required hours to cure, which diminished the potential for clinical translation. Here, a double-barrel syringe system for fabricating redox-initiated polyHIPEs with dramatically shortened cure times upon injection was demonstrated with three methacrylated macromers. The polyHIPE cure time, compressive properties, and pore architecture were investigated with respect to redox initiator chemistry and concentration. Increased concentrations of redox initiators reduced cure times from hours to minutes and increased the compressive modulus and strength without compromising the pore architecture. Additionally, storage of the uncured emulsion at reduced temperatures for 6 months was shown to have minimal effects on the resulting graft properties. These studies indicate that the uncured emulsions can be stored in the clinic until they are needed and then rapidly cured after injection to rigid, high-porosity scaffolds. In summary, we have improved upon current methods of generating injectable polyHIPE grafts to meet translational design goals of long storage times and rapid curing (<15 min) without sacrificing porosity or mechanical properties.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Moglia RS,Whitely M,Dhavalikar P,Robinson J,Pearce H,Brooks M,Stuebben M,Cordner N,Cosgriff-Hernandez Edoi
10.1021/bm500754rsubject
Has Abstractpub_date
2014-08-11 00:00:00pages
2870-8issue
8eissn
1525-7797issn
1526-4602journal_volume
15pub_type
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