Abstract:
:The controlled delivery of growth factors is a very challenging task because many different issues have to be addressed to develop the best suited system. A wide range of approaches have been employed for the controlled delivery of growth factors by hydrogels. Direct loading, electrostatic interaction, covalent binding, and the use of carriers are the main strategies presented in the literature. They are all detailed in the first part of this review. Recent work emphasizing biologically inspired strategies is also included. Also, both natural and synthetic materials are discussed. The second part comprises the methods to evaluate such delivery approaches. Both in vivo and in vitro techniques are presented. Improvements based on the discussed approaches may illustrate future paths toward the development of an ideal growth factor delivery system.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Silva AK,Richard C,Bessodes M,Scherman D,Merten OWdoi
10.1021/bm801103csubject
Has Abstractpub_date
2009-01-12 00:00:00pages
9-18issue
1eissn
1525-7797issn
1526-4602pii
10.1021/bm801103cjournal_volume
10pub_type
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