Thermoreversible poly(ethylene glycol)-g-chitosan hydrogel as a therapeutic T lymphocyte depot for localized glioblastoma immunotherapy.

abstract：:The effect of increasing water composition on the rheological and microstructural behavior of a ternary cellulose acetate (CA)/N,N-dimethylacetamide (DMA)/water system is examined. Addition of water to the CA/DMA system results in enhanced steady shear viscosity and dynamic viscoelastic properties and ultimately to ph...

journal_title：Biomacromolecules

authors： Appaw C,Gilbert RD,Khan SA,Kadla JF

更新日期：2007-05-01 00:00:00

abstract：:Poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) are biopolyesters reported to provide favorable microenvironments for cell culture and possess potential for tissue engineering applications. Both biopolymers have been investigated for applications in a variety of medical scenarios,...

journal_title：Biomacromolecules

authors： Ahmed T,Marçal H,Lawless M,Wanandy NS,Chiu A,Foster LJ

更新日期：2010-10-11 00:00:00

abstract：:Copolymers of (R)-3-hydroxybutyric acid (HB) and epsilon-caprolactone (CL) with a composition ranging from 28 to 81 mol % of HB were synthesized by transesterification of the corresponding homopolymers in solution in the presence of 4-toluenesulfonic acid. The copolyesters were characterized with regard to their molec...

journal_title：Biomacromolecules

authors： Impallomeni G,Giuffrida M,Barbuzzi T,Musumarra G,Ballistreri A

更新日期：2002-07-01 00:00:00

abstract：:Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, p...

journal_title：Biomacromolecules

authors： Zaquen N,Lu H,Chang T,Mamdooh R,Lutsen L,Vanderzande D,Stenzel M,Junkers T

更新日期：2016-12-12 00:00:00

abstract：:The main objective of the present work was the development of new nanoparticulate carrier systems for the delivery of plasmid DNA. These new carriers consist of a blend matrix formed by a poly(lactic-co-glycolic acid) (PLGA) copolymer and polyoxyethylene derivatives. More specifically, we have prepared nanostructures ...

journal_title：Biomacromolecules

authors： Csaba N,Caamaño P,Sánchez A,Domínguez F,Alonso MJ

更新日期：2005-01-01 00:00:00

abstract：:Dextran surface grafting density was systematically varied via a two-step process involving SiO(2) amination by aminopropyltriethoxy silane (APTES) followed by oxidized dextran (M(w) = 110 kDa) chemisorption. Dextran oxidation kinetics with sodium metaperiodate (NaIO(4)) were quantified by (1)H NMR and pH measurements...

journal_title：Biomacromolecules

authors： Miksa D,Irish ER,Chen D,Composto RJ,Eckmann DM

更新日期：2006-02-01 00:00:00

abstract：:Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential to offer cures for previously untreatable diseases. However, they present an enormous delivery challenge due to poor absorption and rapid me...

journal_title：Biomacromolecules

authors： Iqbal S,Blenner M,Alexander-Bryant A,Larsen J

更新日期：2020-04-13 00:00:00

abstract：:There is a distinct need for antimicrobial compounds that can act at surfaces without leaching into the environment. Such materials should be easy to synthesize, be easy to apply to surfaces, and display reasonable levels of antimicrobial and antifungal activity. Here we describe such a surface-active compound and dem...

journal_title：Biomacromolecules

authors： Ravikumar T,Murata H,Koepsel RR,Russell AJ

更新日期：2006-10-01 00:00:00

abstract：:In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...

journal_title：Biomacromolecules

authors： Peng Y,Wu P,Siesler HW

更新日期：2003-07-01 00:00:00

abstract：:The competitive absorption of blood plasma components including fibrinogen (FG), bovine serum albumin (BSA), and platelet-rich plasma (PRP) on l-valine-based poly(ester urea) (PEU) surfaces were investigated. Using four different PEU polymers, possessing compositionally dependent trends in thermal, mechanical, and cri...

journal_title：Biomacromolecules

authors： Childers EP,Peterson GI,Ellenberger AB,Domino K,Seifert GV,Becker ML

更新日期：2016-10-10 00:00:00

abstract：:A novel pH-sensitive amphiphilic copolymer brush poly(methyl methacrylate-co-methacrylic acid)-b-poly(poly(ethylene glycol) methyl ether monomethacrylate) [P(MMA-co-MAA)-b-PPEGMA] was defined and synthesized by atom transfer radical polymerization (ATRP) technique. The molecular structures and characteristics of this ...

journal_title：Biomacromolecules

authors： Yang YQ,Zheng LS,Guo XD,Qian Y,Zhang LJ

更新日期：2011-01-10 00:00:00

abstract：:We demonstrate the fabrication of protein·gold nanoparticle (AuNP) nanocomposites in situ, leading to distinct assemblies dependent upon protein secondary structure. In the presence of pentameric coiled-coil proteins C and Q, which contain histidine tags and have helicities of 54 and 65%, respectively, templation of A...

journal_title：Biomacromolecules

authors： Hume J,Chen R,Jacquet R,Yang M,Montclare JK

更新日期：2015-06-08 00:00:00

abstract：:Natural silk spinning offers several advantages over the synthetic fiber spinning, although the underlying mechanisms of this process are yet to be fully elucidated. Silkworm silks, specifically B. mori, comprise two main proteins: fibroin, which forms the fiber, and sericin, a coextruded coating that acts as a matrix...

journal_title：Biomacromolecules

authors： Kwak HW,Ju JE,Shin M,Holland C,Lee KH

更新日期：2017-08-14 00:00:00

abstract：:This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to ...

journal_title：Biomacromolecules

authors： Moura MJ,Figueiredo MM,Gil MH

更新日期：2007-12-01 00:00:00

abstract：:Following the work carried out on guar gum in our first paper of a series, the "pressure cell" solubilization method was applied to two other less highly substituted galactomannans: locust bean gum (LBG) and tara gum. True molecular solution of the polymers was achieved using appropriate temperature, time, and pressur...

journal_title：Biomacromolecules

authors： Picout DR,Ross-Murphy SB,Jumel K,Harding SE

更新日期：2002-07-01 00:00:00

abstract：:Inorganic polyphosphates, linear polymers of orthophosphate, occur naturally throughout biology and have many industrial applications. Their biodegradable nature makes them attractive for a multitude of uses, and it would be important to understand how polyphosphates are turned over enzymatically. Studies of inorganic...

journal_title：Biomacromolecules

authors： Hebbard CF,Wang Y,Baker CJ,Morrissey JH

更新日期：2014-08-11 00:00:00

abstract：:A library-orientated approach is used to gain understanding of the interactions of well-defined nanoparticles with primary human endothelial cells, which are a key component of the vasculature. Fifteen sequentially modified gold nanoparticles (AuNPs) based on three different core sizes (18, 35, 65 nm) and five polymer...

journal_title：Biomacromolecules

authors： Freese C,Gibson MI,Klok HA,Unger RE,Kirkpatrick CJ

更新日期：2012-05-14 00:00:00

abstract：:A major challenge in drug delivery is the internalization through the apical plasma membrane of the polarized epithelial cells lining organs facing the external environment, e.g., lungs and the gastrointestinal tract. The reduced permeation of drugs entering through this pathway is in part due to the mucosal barrier a...

journal_title：Biomacromolecules

authors： Harush-Frenkel O,Rozentur E,Benita S,Altschuler Y

更新日期：2008-02-01 00:00:00

abstract：:Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations...

journal_title：Biomacromolecules

authors： Ramachandran S,Taraban MB,Trewhella J,Gryczynski I,Gryczynski Z,Yu YB

更新日期：2010-06-14 00:00:00

abstract：:Polymer conjugation increases an enzyme's circulation time and stability for use as a therapeutic agent, but this attachment indubitably affects its properties. Covalent attachment of multiple polyethylene glycol chains with sizes of either 2, 5, 10, or 20 kDa increases the molecular weight and hydrodynamic radius of ...

journal_title：Biomacromolecules

authors： Chiu K,Agoubi LL,Lee I,Limpar MT,Lowe JW Jr,Goh SL

更新日期：2010-12-13 00:00:00

abstract：:The drying dynamics of protein coatings is of importance for many applications. The main focus of research so far was to investigate macroscopic properties of protein coatings, leaving drying dynamics virtually unexplored. A unique combination of techniques is used to monitor drying of a coating containing the protein...

journal_title：Biomacromolecules

authors： Bouman J,de Vries R,Venema P,Belton P,Baukh V,Huinink HP,van der Linden E

更新日期：2015-01-12 00:00:00

abstract：:Macromolecular dynamics in biological systems, which play a crucial role for biomolecular function and activity at ambient temperature, depend strongly on moisture content. Yet, a generally accepted quantitative model of hydration-dependent phenomena based on local relaxation and diffusive dynamics of both polymer and...

journal_title：Biomacromolecules

authors： Chen P,Terenzi C,Furó I,Berglund LA,Wohlert J

更新日期：2018-07-09 00:00:00

abstract：:Recombinant Escherichia coli strains harboring a plasmid containing a novel artificial polyhydroxyalkanoate (PHA) operon consisting of the Aeromonas PHA biosynthesis related genes and Ralstonia eutropha reductase gene were developed for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) [P(3HB-co-3HHx)] fro...

journal_title：Biomacromolecules

authors： Park SJ,Ahn WS,Green PR,Lee SY

更新日期：2001-04-01 00:00:00

abstract：:Bioprinting has become an important tool for fabricating regenerative implants and in vitro cell culture platforms. However, until today, extrusion-based bioprinting processes are limited to resolutions of hundreds of micrometers, which hamper the reproduction of intrinsic functions and morphologies of living tissues....

journal_title：Biomacromolecules

authors： Castilho M,Levato R,Bernal PN,de Ruijter M,Sheng CY,van Duijn J,Piluso S,Ito K,Malda J

更新日期：2021-01-07 00:00:00

abstract：:The proteinaceous material present in beta-lactoglobulin fibrils formed after heating (20 h at 85 degrees C) at pH 2 was identified during this study. Fibrils were separated from the nonaggregated material, and the fibrils were dissociated using 8 M guanidine chloride and 0.1 M 1,4-dithiothreitol (pH 8). Characterizat...

journal_title：Biomacromolecules

authors： Akkermans C,Venema P,van der Goot AJ,Gruppen H,Bakx EJ,Boom RM,van der Linden E

更新日期：2008-05-01 00:00:00

abstract：:Poly((N-vinylpyrrolidone)-block-poly(vinyl acetate)) (PVP-b-PVAc) block copolymers of varying molecular weight and hydrophobic block lengths were synthesized via controlled radical polymerization and investigated as carriers for the solubilization of highly hydrophobic riminophenazine compounds. These compounds have r...

journal_title：Biomacromolecules

authors： Bailly N,Thomas M,Klumperman B

更新日期：2012-12-10 00:00:00

abstract：:In this work, biodegradable branched polycationic polymers were synthesized by Michael addition polymerization from different amine monomers and the triacrylate monomer trimethylolpropane triacrylate. The polymers varied in the number of amines that dissociate in different pH ranges, which are considered to be benefic...

journal_title：Biomacromolecules

authors： Chew SA,Hacker MC,Saraf A,Raphael RM,Kasper FK,Mikos AG

更新日期：2010-03-08 00:00:00

abstract：:Enzymatic ring-opening copolymerization of 5-benzyloxy-trimethylene carbonate (BTMC) and 1,4-dioxan-2-one (DON) was investigated for the first time. Immobilized porcine pancreas lipase (IPPL) on silica particles was selected to perform the copolymerization. A series of novel biodegradable copolymers with different com...

journal_title：Biomacromolecules

authors： He F,Jia HL,Liu G,Wang YP,Feng J,Zhuo RX

更新日期：2006-08-01 00:00:00

abstract：:One of the major drawbacks found in most bone tissue engineering approaches developed so far consists in the lack of strategies to promote vascularisation. Some studies have addressed different issues that may enhance vascularisation in tissue engineered constructs, most of them involving the use of growth factors (GF...

journal_title：Biomacromolecules

authors： Santo VE,Frias AM,Carida M,Cancedda R,Gomes ME,Mano JF,Reis RL

更新日期：2009-06-08 00:00:00

abstract：:A wool fiber sample was submitted to chemical-free steam explosion in view of potential exploitation of keratin-based industrial and farm wastes. Fiber keratin was converted into a dark-yellow sludge that was submitted to phase separation by filtration, centrifugation, and precipitation of the soluble materials from t...

journal_title：Biomacromolecules

authors： Tonin C,Zoccola M,Aluigi A,Varesano A,Montarsolo A,Vineis C,Zimbardi F

更新日期：2006-12-01 00:00:00