Abstract:
:A novel approach for the preparation of nano- and microcapsules in aqueous solutions by using thermoresponsive polymer (TRP) templates (mesoglobules) is described. The method comprised three steps: formation of mesoglobules, coating the templates by seeded radical copolymerization, followed by core dissolution and core removal upon cooling. When mesoglobule entraps biomacromolecules during the process of their formation, it makes it possible to load a controlled amount of bioactive compounds without covalent attachment. Special attention is paid to the mesoglobule dissolution upon cooling, as well as their loading efficiency. Details on the outer shell formation and the possibilities for targeting ligands incorporation and control of the shell porosity are discussed. Finally, the seeded radical copolymerization was used for covering DNA complexes with cationic copolymers bearing TRP blocks. This Review is an attempt to convince researchers of the promising perspectives for using mesoglobules as potential reservoirs, carriers, and transferring agents for biologically active substances.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Haladjova E,Toncheva-Moncheva N,Apostolova MD,Trzebicka B,Dworak A,Petrov P,Dimitrov I,Rangelov S,Tsvetanov CBdoi
10.1021/bm501194gsubject
Has Abstractpub_date
2014-12-08 00:00:00pages
4377-95issue
12eissn
1525-7797issn
1526-4602journal_volume
15pub_type
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