Surface modification of polycaprolactone membrane via aminolysis and biomacromolecule immobilization for promoting cytocompatibility of human endothelial cells.

abstract：:The islet amyloid polypeptide (IAPP) is a regulatory peptide that can aggregate into fibrillar structures associated with type 2 diabetes. In this study, the IAPP21-27 segment was modified with a biotin linker at the N-terminus (Btn-GNNFGAIL) to immobilize peptide fibrils on streptavidin-coated surfaces. Key residues ...

journal_title：Biomacromolecules

authors： John T,Bandak J,Sarveson N,Hackl C,Risselada HJ,Prager A,Elsner C,Abel B

更新日期：2020-02-10 00:00:00

abstract：:The growing importance of biodegradable conducting polymers (CPs) have fueled the rapid development of this unique class of polymeric materials in recent years. Possessing both the electrical conductivity approaching those of metallic conductors and the biodegradability of biocompatible polymers, biodegradable CPs are...

journal_title：Biomacromolecules

authors： Kenry,Liu B

更新日期：2018-06-11 00:00:00

abstract：:Enzymatic hydrolysis of selected copolymers of cellulose diacetate-graft-poly(L-lactide)s (CDA-g-PLLAs) were conducted with proteinase K for film specimens, which were solely quenched from the molten state or, further, annealed at temperatures below or above their glass transition temperatures. The hydrolysis rates de...

journal_title：Biomacromolecules

authors： Teramoto Y,Nishio Y

更新日期：2004-03-01 00:00:00

abstract：:We created the dual-responsive nanovehicle that can effectively combine and abundantly utilize magnetic and glutathione (GSH)-reductive triggers to control the drug delivery and achieve more intelligent and powerful targeting. In the nanovehicles, paramagnetic fullerene (C60@CTAF) was prepared via one-step modificatio...

journal_title：Biomacromolecules

authors： Wang L,Wang Y,Hao J,Dong S

更新日期：2017-03-13 00:00:00

abstract：:A new PPF-BCN/hyPCL32-N3 injectable system that can be cross-linked by catalyst-free, strain promoted alkyne-azide cycloaddition (SPAAC) click chemistry was developed for tissue engineering applications. The system consisted of two components: PPF-BCN, poly(propylene fumarate) (PPF) functionalized with (1R,8S,9s)-bicy...

journal_title：Biomacromolecules

authors： Liu X,Miller AL 2nd,Xu H,Waletzki BE,Lu L

更新日期：2019-09-09 00:00:00

abstract：:Images of high methoxyl orange pectin deposited from solution and high methoxyl sugar acid gels (HMSAG) were obtained by atomic force microscopy (AFM) in the tapping mode. For the first time, images of pectin deposited from water revealed that the transition from pectin networks to individual molecules or aggregates t...

journal_title：Biomacromolecules

authors： Fishman ML,Cooke PH,Chau HK,Coffin DR,Hotchkiss AT Jr

更新日期：2007-02-01 00:00:00

abstract：:Ionic liquids (ILs) are composed only of ions. Of special interest to this review are those where at least one ion (the cation) is organic and whose melting points are below or not far above room temperature. ILs are designated as "green" solvents because they have extremely low vapor pressure, are non-inflammable, an...

journal_title：Biomacromolecules

authors： El Seoud OA,Koschella A,Fidale LC,Dorn S,Heinze T

更新日期：2007-09-01 00:00:00

abstract：:The interaction of polysaccharides with water has a critical impact on their biological function as well as their technological applications. We performed ellipsometry experiments at different relative humidities (RH) to measure the equilibrium swelling of ultrathin films of different polysaccharides: native and modif...

journal_title：Biomacromolecules

authors： Grossutti M,Dutcher JR

更新日期：2020-12-14 00:00:00

abstract：:The purpose of this study was to gain mechanistic insights into the effect of different formulation parameters on the degradation and release behavior of protein-loaded nanoparticulate carrier systems based on an aliphatic polyester with pendant hydroxyl groups, poly(lactic-co-glycolic-hydroxymethyl glycolic acid) (pL...

journal_title：Biomacromolecules

authors： Samadi N,van Nostrum CF,Vermonden T,Amidi M,Hennink WE

更新日期：2013-04-08 00:00:00

abstract：:On-line size-exclusion chromatography monitoring of potato phosphorylase catalyzed amylose synthesis--starting from alpha-D-glucose-1-P and maltohexaose--revealed rather monodisperse amylose populations. In the presence of lipids, amylose-lipid complexes spontaneously formed and precipitated. They were recovered by ce...

journal_title：Biomacromolecules

authors： Gelders GG,Goesaert H,Delcour JA

更新日期：2005-09-01 00:00:00

abstract：:Celluloses from different origins were dissolved stepwise in N,N-dimethylacetamide/lithium chloride (9% v/w; DMAc/LiCl) with the aim to study the time course of the dissolution process, completeness of dissolution in the dissolved fractions, possible discrimination effects, and differences between the celluloses. Cell...

journal_title：Biomacromolecules

authors： Henniges U,Kostic M,Borgards A,Rosenau T,Potthast A

更新日期：2011-04-11 00:00:00

abstract：:Nanocoating of individual mammalian cells with polymer layers has been of increasing interest in biotechnology and biomedical engineering applications. Electrostatic layer-by-layer (LbL) deposition of polyelectrolytes on negatively charged cell surfaces has been utilized for cell nanocoatings using synthetic or natura...

journal_title：Biomacromolecules

authors： Hasturk O,Sahoo JK,Kaplan DL

更新日期：2020-07-13 00:00:00

abstract：:A shortage of available organ donors has created a need for engineered tissues. In this context, polymer-based hydrogels that break down inside the body are often used as constructs for growth factors and cells. Herein, we report imine cross-linked gels where degradation is controllable by the introduction of mixed im...

journal_title：Biomacromolecules

authors： Boehnke N,Cam C,Bat E,Segura T,Maynard HD

更新日期：2015-07-13 00:00:00

abstract：:We investigate the effects of mixing a colloidal suspension of tunicate-derived cellulose nanocrystals (t-CNCs) with aqueous colloidal suspensions of two protein diblock copolymers, EC and CE, which bear two different self-assembling domains (SADs) derived from elastin (E) and the coiled-coil region of cartilage oligo...

journal_title：Biomacromolecules

authors： Haghpanah JS,Tu R,Da Silva S,Yan D,Mueller S,Weder C,Foster EJ,Sacui I,Gilman JW,Montclare JK

更新日期：2013-12-09 00:00:00

abstract：:In the present study we describe the synthesis, wet spinning, mechanical testing, and degradation of poly(urethane urea)s (PUURs) intended for clinical use in anterior cruciate ligament (ACL) reconstruction. The effects of soft segment chemical composition and molar mass and the kind of diamine chain extender on the m...

journal_title：Biomacromolecules

authors： Gisselfält K,Edberg B,Flodin P

更新日期：2002-09-01 00:00:00

abstract：:Spider dragline silk exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity. In this paper, we recombinantly produced an unusual but naturally occurring short major ampullate spidroin (MaSp1s) as a...

journal_title：Biomacromolecules

authors： Thamm C,Scheibel T

更新日期：2017-04-10 00:00:00

abstract：:Enhancing the molecular orientation of the regenerated silk fibroin (RF) up to a level comparable to the native silk is highly challenging. Our novel and promising strategy for the poststretching process is (1) creating at first an α-helix-HFIP complex with a hexagonal packing as an intermediate state and then (2) str...

journal_title：Biomacromolecules

authors： Yoshioka T,Tashiro K,Ohta N

更新日期：2016-04-11 00:00:00

abstract：:Oriented immobilization of proteins is an important step in creating protein-based functional materials. In this study, a method was developed to orient proteins on hydroxyapatite (HA) surfaces, a widely used bone implant material, to improve protein bioactivity by employing enhanced green fluorescent protein (EGFP) a...

journal_title：Biomacromolecules

authors： Yewle JN,Wei Y,Puleo DA,Daunert S,Bachas LG

更新日期：2012-06-11 00:00:00

abstract：:The gold standard for implant metals is titanium, and coatings such as collagen-I, RGD-peptide, chondroitin sulfate, and calcium phosphate have been used to modify its biocompatibility. We investigated how titanium coated with pectins, adaptable bioactive plant polysaccharides with anti-inflammatory effects, supports ...

journal_title：Biomacromolecules

authors： Kokkonen H,Cassinelli C,Verhoef R,Morra M,Schols HA,Tuukkanen J

更新日期：2008-09-01 00:00:00

abstract：:Degradation of fibrillar collagen is critical for tissue maintenance. Yet, understanding collagen catabolism has been challenging partly due to a lack of atomistic picture for its load-dependent conformational dynamics, as both mechanical load and local unfolding of collagen affect its cleavage by matrix metalloprotei...

journal_title：Biomacromolecules

authors： Teng X,Hwang W

更新日期：2014-08-11 00:00:00

abstract：:Peptide ligation is an indispensable step in the chemical synthesis of target peptides and proteins that are difficult to synthesize at once by a solid-phase synthesis. The ligation reaction is generally conducted with two peptide fragments at a high aqueous concentration to increase the reaction rate; however, this o...

journal_title：Biomacromolecules

authors： Hayashi G,Yanase M,Nakatsuka Y,Okamoto A

更新日期：2019-03-11 00:00:00

abstract：:Chemotherapy faces challenges, including poor aqueous solubility of the drugs, and cardiotoxicity. Micellar drug delivery systems (DDS) are used to encapsulate anticancer drugs for better therapeutic effects, however, with poor loading content. Herein, we synthesized a micellar DDS using γ-benzyloxy substituted poly(ε...

journal_title：Biomacromolecules

authors： Soltantabar P,Calubaquib EL,Mostafavi E,Biewer MC,Stefan MC

更新日期：2020-04-13 00:00:00

abstract：:The copolymer of methyl methacrylate (MMA) and 2-[2',3',5'-triiodobenzoyl]oxoethyl methacrylate (1), ratio 3:1 (mass:mass), was prepared via a free-radical polymerization in bulk. The copolymer (M(w) = 97.8 kD and M(n) = 41.5 kD) was dissolved in chloroform and subsequently transformed into beads with a diameter in th...

journal_title：Biomacromolecules

authors： Saralidze K,Aldenhoff YB,Knetsch ML,Koole LH

更新日期：2003-05-01 00:00:00

abstract：:Dextran surface grafting density was systematically varied via a two-step process involving SiO(2) amination by aminopropyltriethoxy silane (APTES) followed by oxidized dextran (M(w) = 110 kDa) chemisorption. Dextran oxidation kinetics with sodium metaperiodate (NaIO(4)) were quantified by (1)H NMR and pH measurements...

journal_title：Biomacromolecules

authors： Miksa D,Irish ER,Chen D,Composto RJ,Eckmann DM

更新日期：2006-02-01 00:00:00

abstract：:Spiders have evolved a complex system of silk producing glands. Each of the glands produces silk with strength and elasticity tailored to its biological purpose. Sequence analysis of the major ampullate silk reveals four highly conserved concatenated blocks of amino acids: (GA) n , A n , GPGXX, and GGX. While the GPGX...

journal_title：Biomacromolecules

authors： Brooks AE,Stricker SM,Joshi SB,Kamerzell TJ,Middaugh CR,Lewis RV

更新日期：2008-06-01 00:00:00

abstract：:The synthesis of quaternary ammonium (QA)-functionalized silica nanoparticles with and without nitric oxide (NO) release capabilities is described. Glycidyltrialkylammonium chlorides of varied alkyl chain lengths (i.e., methyl, butyl, octyl, and dodecyl) were tethered to the surface of amine-containing silica nanopart...

journal_title：Biomacromolecules

authors： Carpenter AW,Worley BV,Slomberg DL,Schoenfisch MH

更新日期：2012-10-08 00:00:00

abstract：:Nearly monodispersed silica nanoparticles having a controlled size from 5 to 450 nm were synthesized via a sol-gel process, and then the optimum conditions for the surface treatment of the synthesized silica nanoparticles with a silane coupling agent (i.e., 3-methacryloxypropyltrimethoxysilane (gamma-MPS)) were explor...

journal_title：Biomacromolecules

authors： Kim JW,Kim LU,Kim CK

更新日期：2007-01-01 00:00:00

abstract：:In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...

journal_title：Biomacromolecules

authors： Peng Y,Wu P,Siesler HW

更新日期：2003-07-01 00:00:00

abstract：:Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and investiga...

journal_title：Biomacromolecules

authors： Hintze V,Samsonov SA,Anselmi M,Moeller S,Becher J,Schnabelrauch M,Scharnweber D,Pisabarro MT

更新日期：2014-08-11 00:00:00

abstract：:Biodegradable aliphatic polyesters such as poly(lactide) and poly(ε-caprolactone), largely used in tissue engineering applications, lack suitable functional groups and biological cues to enable interactions with cells. Because of the ubiquity of thiol groups in the biological environment and the pliability of thiol ch...

journal_title：Biomacromolecules

authors： Fuoco T,Finne-Wistrand A,Pappalardo D

更新日期：2016-04-11 00:00:00