Abstract：
:The growing importance of biodegradable conducting polymers (CPs) have fueled the rapid development of this unique class of polymeric materials in recent years. Possessing both the electrical conductivity approaching those of metallic conductors and the biodegradability of biocompatible polymers, biodegradable CPs are highly sought after. In fact, they have emerged as the ideal biomaterials, having immense potential for augmenting a wide range of practical biomedical applications. Herein, we provide a broad overview of recent advances in the development of biodegradable CPs and their biomedical applications. We first introduce the fundamentals of conducting and biodegradable polymers, followed by discussions on the major strategies currently used to fabricate biodegradable CPs. We then highlight the potential biomedical applications of biodegradable CPs (specifically those for tissue engineering, regenerative medicine, and biomedical imaging as well as biomedical implants, bioelectronics devices, and consumer electronics). We conclude this review by offering our perspectives on the current challenges and future opportunities facing the development and practical applications of biodegradable CPs.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Kenry,Liu Bdoi
10.1021/acs.biomac.8b00275subject
Has Abstractpub_date
2018-06-11 00:00:00pages
1783-1803issue
6eissn
1525-7797issn
1526-4602journal_volume
19pub_type
杂志文章,评审abstract：:We investigate the effects of mixing a colloidal suspension of tunicate-derived cellulose nanocrystals (t-CNCs) with aqueous colloidal suspensions of two protein diblock copolymers, EC and CE, which bear two different self-assembling domains (SADs) derived from elastin (E) and the coiled-coil region of cartilage oligo...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm401304w
更新日期：2013-12-09 00:00:00
abstract：:Cocontinuous phase structures of immiscible polymers can be developed under appropriate melt-blending conditions. Because of the presence of interfacial tension, such cocontinuous structures start to coarsen when heated to a temperature higher than the melting/softening temperature of both phases. In this study, a met...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm900008d
更新日期：2009-05-11 00:00:00
abstract：:Inulin, the polydisperse reserve polysaccharide from chicory, has been modified by carbamoylation in organic solvents. The reaction of inulin with a range of alkyl isocyanates resulted, after crystalization, in a variety of carbamoylated inulins from which the interfacial properties were determined. The medium and lon...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm015570l
更新日期：2001-01-01 00:00:00
abstract：:This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm700762w
更新日期：2007-12-01 00:00:00
abstract：:Oligonucleotide-spider silk conjugates can be placed on silicon wafers by complementary DNA strands, which are coupled chemically to the surface. Such specific immobilization of spider silk proteins allows the nucleation and guided growth of β-sheet-rich nanofibrils in the presence of phosphate ions on the surface. Ad...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b01333
更新日期：2019-01-14 00:00:00
abstract：:The maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matrix communications si...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm401926k
更新日期：2014-03-10 00:00:00
abstract：:The development of improved cryopreservative materials is necessary to enable complete recovery of living cells and tissue after frozen storage. Remarkably, poly(vinyl alcohol) (PVA) displays some of the same cryoprotective properties as many antifreeze proteins found in cold tolerant organisms. In particular, PVA is ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b01502
更新日期：2018-01-08 00:00:00
abstract：:In this work, cell-responsive polysaccharide hydrogels were prepared by a simple procedure based on the sequential bioconjugation and cross-linking of the polysaccharide backbone with bioactive peptides and poly(ethylene glycol)-bis(thiol) (PEG-(SH)2), respectively. Using thiol-ene reactions, we successfully functiona...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm501613u
更新日期：2015-03-09 00:00:00
abstract：:Greener alternatives to synthetic polymers are constantly being investigated and sought after. Chitin is a natural polysaccharide that gives structural support to crustacean shells, insect exoskeletons, and fungal cell walls. Like cellulose, chitin resides in nanosized structural elements that can be isolated as nanof...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01141
更新日期：2020-01-13 00:00:00
abstract：:Amphiphilic glycopolymers, polylactide-grafted dextran copolymers (Dex-g-PLA), were synthesized with a well-controlled architecture obtained through a three-step procedure: partial silylation of the dextran hydroxyl groups, ring-opening polymerization of D,L-lactide initiated from remaining hydroxyl groups, silylether...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm701101n
更新日期：2008-03-01 00:00:00
abstract：:Nanoparticles (NPs) composed of chitosan (CS) and poly(gamma-glutamic acid) (gamma-PGA) were prepared by a simple ionic-gelation method for oral insulin delivery. Fourier transform infrared (FT-IR) spectra indicated that CS and gamma-PGA were ionized at pH 2.5-6.6, while X-ray diffractograms demonstrated that the crys...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0607776
更新日期：2007-01-01 00:00:00
abstract：:Silkworm silk has excellent mechanical properties, biocompatibility, and promising applications in the biomedical sector. Silkworms spin silk at the beginning and end of each of their five instar stages, as well as spinning mature silk after the fifth instar. We evaluated the mechanical properties and structure of 10 ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b01576
更新日期：2019-03-11 00:00:00
abstract：:We describe a facile method to amine functionalize and subsequently fluorescently label polymethacrylamides synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. RAFT-generated poly(N-(2-hydroxypropyl) methacrylamide-b-N-[3-(dimethylamino)propyl] methacrylamide) (poly(HPMA-b-DMAPMA)),...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm700514q
更新日期：2007-08-01 00:00:00
abstract：:The present study focuses on the formation of microcapsules containing catalytically active L-asparaginase (L-ASNase), a protein drug of high value in antileukemic therapy. We make use of the layer-by-layer (LbL) technique to coat protein-loaded calcium carbonate (CaCO3) particles with two or three poly dextran/poly-L...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm401341k
更新日期：2013-12-09 00:00:00
abstract：:Plastics ending up in soil or landfill environment will eventually be degraded. At the same time a slow migration of additives from the plastics will occur. The additives and the degradation products of these and the polymer are potential compounds for bioconversion. To predict the rate of the migration of antioxidant...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0000283
更新日期：2000-10-01 00:00:00
abstract：:The drying dynamics of protein coatings is of importance for many applications. The main focus of research so far was to investigate macroscopic properties of protein coatings, leaving drying dynamics virtually unexplored. A unique combination of techniques is used to monitor drying of a coating containing the protein...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm501549b
更新日期：2015-01-12 00:00:00
abstract：:A dual-targeted siRNA nanocarrier has been synthesized and validated that is selectively activated in environments where there is colocalization of two breast cancer hallmarks, elevated matrix metalloproteinase (MMP) activity and folate receptor overexpression. This siRNA nanocarrier is self-assembled from two polymer...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm501394m
更新日期：2015-01-12 00:00:00
abstract：:Spider silk has been extensively studied for its outstanding mechanical properties. Partial intermediate and C-terminal sequences of different spider silk proteins have been determined, and during the past decade also N-terminal domains have been characterized. However, only some of these N-terminal domains have been ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060693x
更新日期：2006-11-01 00:00:00
abstract：:A well-defined N-(2-hydroxypropyl)methacrylamide-s-N-(3-aminopropyl)methacrylamide (HPMA-s-APMA) copolymer, synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, was utilized for the rational design of multiconjugates containing both a gene therapeutic, small interfering RNA (siRNA), ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm901249n
更新日期：2010-02-08 00:00:00
abstract：:Six methyl celluloses (MCs), one with a degree of substitution (DS) of 1.32 and five with DS between 1.83 and 1.88, were thoroughly investigated. Monomer composition and methyl distribution in the polymer chain were analyzed after total or partial random hydrolysis and appropriate derivatization with gas chromatograph...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm050941+
更新日期：2006-05-01 00:00:00
abstract：:Self-assembling amphiphilic designer peptides have been successfully applied as nanomaterials in biomedical applications. Understanding molecular interactions at the peptide-membrane interface is crucial, since interactions at this site often determine (in)compatibility. The present study aims to elucidate how model m...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.6b01089
更新日期：2016-11-14 00:00:00
abstract：:In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased pathological changes in the pa...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm501390d
更新日期：2015-01-12 00:00:00
abstract：:This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm034014j
更新日期：2003-09-01 00:00:00
abstract：:Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work,...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm801183f
更新日期：2009-02-09 00:00:00
abstract：:Endo-beta-1,4-xylanases (EC 3.2.1.8) are the main enzymes involved in the hydrolysis of xylans, the most abundant hemicelluloses in plant biomass. However, the development of efficient endoxylanases for use in biorefinery processes is currently hampered by insufficient knowledge regarding the impact of the cell wall n...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm9004518
更新日期：2009-09-14 00:00:00
abstract：:An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol-ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed ex...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.0c00530
更新日期：2020-09-14 00:00:00
abstract：:Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm400768m
更新日期：2013-09-09 00:00:00
abstract：:The aggregation phenomena in aqueous solutions of hydrophobically modified (HM) chitosan, containing 4 mol % of n-dodecyl side chains, were studied by viscometry and fluorescence spectroscopy with pyrene as a probe. The results are compared with those for unmodified chitosan. Surprisingly, fluorescence data reveal the...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm005649a
更新日期：2001-07-01 00:00:00
abstract：:Here we present time-resolved in situ transmission electron microscopy (TEM) observations and real-time manipulation of nematic ordered cellulose and ultradrawn polyethylene films. Drawn films of these two polymers exhibited a unique response to the low-dose electron beam. Electron beam damage was minimal based on ret...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060546z
更新日期：2007-01-01 00:00:00
abstract：:N-Alkylated chitosan (NACS) may improve the blood clotting efficiency of chitosan (CS). To study its blood coagulation capability, a series of NACSs with various carbon chain lengths and degrees of substitution (DS) of alkyl groups were synthesized and characterized by FTIR, NMR, elemental analysis, and X-ray diffract...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.7b01492
更新日期：2018-03-12 00:00:00
