Wormlike Nanovector with Enhanced Drug Loading Using Blends of Biodegradable Block Copolymers.

abstract：:The maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matrix communications si...

journal_title：Biomacromolecules

authors： Liu Y,Li H,Yan S,Wei J,Li X

更新日期：2014-03-10 00:00:00

abstract：:A drying environment is always a proposition faced by dynamic living organisms using water, which are driven by biopolymer-based micro- and macrostructures. Here, we introduce a drying process for aqueous liquid crystalline (LC) solutions composed of biopolymer with extremely high molecular weight components such as p...

journal_title：Biomacromolecules

authors： Okeyoshi K,Okajima MK,Kaneko T

更新日期：2016-06-13 00:00:00

abstract：:The short average service life of traditional dental composite restorative materials and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting compositions. Novel monomers and their polymers, reinforcing fillers, and adhesive ...

journal_title：Biomacromolecules

authors： Gonzalez-Bonet A,Kaufman G,Yang Y,Wong C,Jackson A,Huyang G,Bowen R,Sun J

更新日期：2015-10-12 00:00:00

abstract：:Bovine serum albumin (BSA) and poly(diallyldimethylammonium chloride) (PDADMAC) spontaneously form, over a range of ionic strength I and pH, dense fluids rich in both macroions. To study their nanostructure, these coacervates were prepared at low I and high pH (strong interaction) or at high I and lower pH (weaker int...

journal_title：Biomacromolecules

authors： Bohidar H,Dubin PL,Majhi PR,Tribet C,Jaeger W

更新日期：2005-05-01 00:00:00

abstract：:This paper reports the synthesis of hyaluronan (HA) and its derivatives via the hyaluronidase-catalyzed polymerization of 2-substituted oxazoline derivative monomers designed as "transition-state analogue substrates". Polymerization of 2-methyl oxazoline monomer from N-acetylhyalobiuronate (GlcAbeta(1-->3)GlcNAc) effe...

journal_title：Biomacromolecules

authors： Ochiai H,Ohmae M,Mori T,Kobayashi S

更新日期：2005-03-01 00:00:00

abstract：:The conformation of a single elastin-like peptide GVG(VPGVG)3 in liquid water is studied by computer simulations in the temperature interval between 280 and 440 K. Two main conformational states of the peptide can be distinguished: a rigid conformational state, dominating at low temperatures, and a flexible conformati...

journal_title：Biomacromolecules

authors： Krukau A,Brovchenko I,Geiger A

更新日期：2007-07-01 00:00:00

abstract：:The development and use of synthetic, cross-linked, macromolecular substrates with tunable elasticity has been instrumental in revealing the mechanisms by which cells sense and respond to their mechanical microenvironment. We here describe a hydrogel based on radical-free, cross-linked poly(ethylene glycol) to study t...

journal_title：Biomacromolecules

authors： Missirlis D,Spatz JP

更新日期：2014-01-13 00:00:00

abstract：:Characterization of poly-3-hydroxybutyric acid (PHB) and poly-3-hydroxybutyric-co-valeric acid (PHBV, 13% valerate) in chloroform was performed using size exclusion chromatography coupled to a multi-angle light scattering detector (SEC-MALS). Absolute molar mass averages, molar mass distribution, and the radius of gyr...

journal_title：Biomacromolecules

authors： Zagar E,Krzan A

更新日期：2004-03-01 00:00:00

abstract：:The present study focuses on the formation of microcapsules containing catalytically active L-asparaginase (L-ASNase), a protein drug of high value in antileukemic therapy. We make use of the layer-by-layer (LbL) technique to coat protein-loaded calcium carbonate (CaCO3) particles with two or three poly dextran/poly-L...

journal_title：Biomacromolecules

authors： Karamitros CS,Yashchenok AM,Möhwald H,Skirtach AG,Konrad M

更新日期：2013-12-09 00:00:00

abstract：:It is demonstrated that the molecular solubility of softwood hemicelluloses is significantly influenced by pretreatment of the fibers, extraction, and downstream processing. To quantify these effects, four hemicellulose samples were extracted from different thermomechanical pulps of Norway spruce. The molecular solubi...

journal_title：Biomacromolecules

authors： Kishani S,Vilaplana F,Xu W,Xu C,Wågberg L

更新日期：2018-04-09 00:00:00

abstract：:Effects of molecular weight (Lc) and field strength (E) on conformation of polymer chains and their density are investigated at the surface and bulk of a driven chain system in three dimensions with a Monte Carlo simulation. As the polymer chains deposit on the surface, a linear density gradient develops in low field....

journal_title：Biomacromolecules

authors： Foo GM,Pandey RB

更新日期：2000-10-01 00:00:00

abstract：:Amphiphilic polymer conetworks (APCNs) are materials with a very large interface between their hydrophilic and hydrophobic phases due to their nanophase-separated morphologies. Proteins were found to enrich in APCNs by up to 2 orders of magnitude when incubated in aqueous protein solutions, raising the question of the...

journal_title：Biomacromolecules

authors： Dech S,Cramer T,Ladisch R,Bruns N,Tiller JC

更新日期：2011-05-09 00:00:00

abstract：:This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...

journal_title：Biomacromolecules

authors： Dubruel P,Dekie L,Schacht E

更新日期：2003-09-01 00:00:00

abstract：:Coniferyl alcohol was polymerized in pectin solution in order to mimic the lignification that is the final step of biosynthesis of plant cell wall. Dehydrogenated polymers (DHP = coniferyl alcohol polymers = synthetic lignin) interact with pectin to form hydrophobic clusters as monitored by pyrene fluorescence spectro...

journal_title：Biomacromolecules

authors： Lairez D,Cathala B,Monties B,Bedos-Belval F,Duran H,Gorrichon L

更新日期：2005-03-01 00:00:00

abstract：:Bacterial biofilms tolerate extreme levels of antibiotics. Treatment of biofilm infections therefore requires the development of new or modified antimicrobials that can penetrate biofilms and are effective against dormant persistent cells. One such new approach uses the biodegradable biopolymer chitosan and its deriva...

journal_title：Biomacromolecules

authors： Sahariah P,Másson M,Meyer RL

更新日期：2018-09-10 00:00:00

abstract：:Dextran surface grafting density was systematically varied via a two-step process involving SiO(2) amination by aminopropyltriethoxy silane (APTES) followed by oxidized dextran (M(w) = 110 kDa) chemisorption. Dextran oxidation kinetics with sodium metaperiodate (NaIO(4)) were quantified by (1)H NMR and pH measurements...

journal_title：Biomacromolecules

authors： Miksa D,Irish ER,Chen D,Composto RJ,Eckmann DM

更新日期：2006-02-01 00:00:00

abstract：:The hierarchical self-assembly of cellulose nanocrystals (CNCs) is an important phenomenon occurring naturally in plant cell walls. Utilization of this assembly for advanced applications requires a fundamental theoretical understanding of interactions between the CNCs, which is still incomplete. Hence, in this work, w...

journal_title：Biomacromolecules

authors： Garg M,Linares M,Zozoulenko I

更新日期：2020-08-10 00:00:00

abstract：:This paper describes the synthesis and characterization of polymer-peptide conjugates to be used as infection-resistant coating for biomaterial implants and devices. Antiadhesive polymer brushes composed of block copolymer Pluronic F-127 (PF127) were functionalized with antimicrobial peptides (AMP), able to kill bacte...

journal_title：Biomacromolecules

authors： Muszanska AK,Rochford ET,Gruszka A,Bastian AA,Busscher HJ,Norde W,van der Mei HC,Herrmann A

更新日期：2014-06-09 00:00:00

abstract：:A porous scaffold as a cell-compatible material was designed and prepared using a phospholipid copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate, and enantiomeric macromonomers, the poly(L-lactic acid) (PLLA) macromonomer, and poly(D-lactic acid) (PDLA) macromonomer. On the bas...

journal_title：Biomacromolecules

authors： Watanabe J,Eriguchi T,Ishihara K

更新日期：2002-09-01 00:00:00

abstract：:Enzymatic glyco-modification of transparent cellulose films with lactose was achieved by nonaqueous biocatalysis, and rat hepatocyte attachment behavior to the lactose-modified cellulose films was investigated. Regenerated cellulose films were incubated with lactose using a surfactant-enveloped cellulase in lithium ch...

journal_title：Biomacromolecules

authors： Esaki K,Yokota S,Egusa S,Okutani Y,Ogawa Y,Kitaoka T,Goto M,Wariishi H

更新日期：2009-05-11 00:00:00

abstract：:Surface pressure isotherms and structural and surface dilatational properties of three hydroxypropylmethycelluloses (HPMCs, called E4M, E50LV, and F4M) adsorbed films at the air-water interface were determined. In this work we present evidence that HPMC molecules are able to diffuse and saturate the air-water interfac...

journal_title：Biomacromolecules

authors： Pérez OE,Sánchez CC,Rodríguez Patino JM,Pilosof AM

更新日期：2006-01-01 00:00:00

abstract：:We study the self-assembly of genetically engineered protein-based triblock copolymers consisting of a central pH-responsive silk-like middle block (S(H)n, where S(H) is a silk-like octapeptide, (GA)3GH and n is the number of repeats) flanked by hydrophilic random coil outer blocks (C2). Our previous work has already ...

journal_title：Biomacromolecules

authors： Beun LH,Storm IM,Werten MW,de Wolf FA,Cohen Stuart MA,de Vries R

更新日期：2014-09-08 00:00:00

abstract：:Core-shell structured nanoparticles (NPs) render the simultaneous coloading capacity of both hydrophobic and hydrophilic drugs and may eventually enhance therapeutic efficacy. In this study, we employed a facile squalenoylation technology to synthesize a new amphiphilic starch derivative from partially oxidized starch...

journal_title：Biomacromolecules

authors： Phan VHG,Trang Duong HT,Tran PT,Thambi T,Ho DK,Murgia X

更新日期：2020-12-21 00:00:00

abstract：:Photoexcited TiO2 degrades biomolecules such as nucleic acids, cell membrane proteins, and enzymes. Stabilization of enzyme activity against the deactivation caused by the combination of TiO2-UV is essential if we are to develop novel hybrid materials exhibiting photocatalytic and biocatalytic activities useful for de...

journal_title：Biomacromolecules

authors： Lele BS,Russell AJ

更新日期：2004-09-01 00:00:00

abstract：:Electrically conducting polymeric membranes were prepared by incorporating multiwalled carbon nanotubes (MWCNTs) into bacterial cellulose pellicles produced by Gluconacetobacter xylinum. The MWCNTs were dispersed in a surfactant (cationic cetyl trimethylammonium bromide) solution, and cellulose pellicles were dipped i...

journal_title：Biomacromolecules

authors： Yoon SH,Jin HJ,Kook MC,Pyun YR

更新日期：2006-04-01 00:00:00

abstract：:A polyethylene glycol (PEG) retinylamine (Ret-NH2) conjugate PEG-GFL-NH-Ret with a glycine-phenylalanine-leucine (GFL) spacer was synthesized for controlled oral delivery of Ret-NH2 to treat retinal degenerative diseases, including Stargardt disease (STGD) and age-related macular degeneration (AMD). The peptide spacer...

journal_title：Biomacromolecules

authors： Yu G,Wu X,Ayat N,Maeda A,Gao SQ,Golczak M,Palczewski K,Lu ZR

更新日期：2014-12-08 00:00:00

abstract：:To continue expanding the use of Single Electron Transfer-Living Radical Polymerization (SET-LRP) in applications at the interface between macromolecular science, biomacromolecules, biology and medicine, it is essential to develop novel initiators that do not compromise the structural stability of synthesized polymers...

journal_title：Biomacromolecules

authors： Lligadas G,Enayati M,Grama S,Smail R,Sherman SE,Percec V

更新日期：2017-08-14 00:00:00

abstract：:Hydrophobic methacrylic monomers were polymerized in aqueous media using methylated (1.8)-beta-cyclodextrin (MeCD) additives. Hydrophobic monomers tert-butyl methacrylate (tBuMA), cyclohexyl methacrylate (CMA), and 2-ethylhexyl methacrylate (2EHMA) were each dissolved in chloroform with MeCD. Chloroform was then evapo...

journal_title：Biomacromolecules

authors： Madison PH,Long TE

更新日期：2000-01-01 00:00:00

abstract：:The photoluminescence features of Eu(3+)-, Tb(3+)-, Tb(3+)/Eu(3+)-alginate aerogel (hydrogel and alcogel) and Eu(3+)-alginate xerogel hybrids were investigated. The Eu(3+)-alginate aerogel and alcogel exhibit the highest (5)D0 quantum efficiencies (9.9 and 8.2%, respectively), while the hydrogel and xerogel have lower...

journal_title：Biomacromolecules

authors： Liu F,Carlos LD,Ferreira RA,Rocha J,Gaudino MC,Robitzer M,Quignard F

更新日期：2008-07-01 00:00:00

abstract：:Surface modification of biodegradable vascular grafts is an important strategy to improve the in situ endothelialization of tissue engineered vascular grafts (TEVGs) and prevent major complications associated with current synthetic grafts. Important strategies for improving endothelialization include increasing endoth...

journal_title：Biomacromolecules

authors： Melchiorri AJ,Hibino N,Yi T,Lee YU,Sugiura T,Tara S,Shinoka T,Breuer C,Fisher JP

更新日期：2015-02-09 00:00:00