Synthesis of various glycopolymer architectures via RAFT polymerization: from block copolymers to stars.

abstract：:Synthetic spider silk holds great potential for use in various applications spanning medical uses to ultra lightweight armor; however, producing synthetic fibers with mechanical properties comparable to natural spider silk has eluded the scientific community. Natural dragline spider silks are commonly made from protei...

journal_title：Biomacromolecules

authors： Jenkins JE,Creager MS,Lewis RV,Holland GP,Yarger JL

更新日期：2010-01-11 00:00:00

abstract：:A challenge in the development of multifunctional drug delivery systems is to establish a reasonable and effective synthetic route for multifunctional polymer preparation. Herein, we propose a unique protocol to prepare multifunctional micelles by a cross-assembly process using three different functional polyurethanes...

journal_title：Biomacromolecules

authors： Pan Z,Ren Y,Song N,Song Y,Li J,He X,Luo F,Tan H,Fu Q

更新日期：2016-06-13 00:00:00

abstract：:Human serum albumin (HSA) is known to exist as N (pH approximately 7), B (pH approximately 9), and F (pH approximately 3.5) isomeric forms and an equilibrium intermediate state (I) accumulate in the urea induced unfolding pathway of HSA around 4.8-5.2 M urea concentrations. These states displayed characteristic struct...

journal_title：Biomacromolecules

authors： Ahmad B,Parveen S,Khan RH

更新日期：2006-04-01 00:00:00

abstract：:A library-orientated approach is used to gain understanding of the interactions of well-defined nanoparticles with primary human endothelial cells, which are a key component of the vasculature. Fifteen sequentially modified gold nanoparticles (AuNPs) based on three different core sizes (18, 35, 65 nm) and five polymer...

journal_title：Biomacromolecules

authors： Freese C,Gibson MI,Klok HA,Unger RE,Kirkpatrick CJ

更新日期：2012-05-14 00:00:00

abstract：:Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these...

journal_title：Biomacromolecules

authors： Le TMD,Duong HTT,Thambi T,Giang Phan VH,Jeong JH,Lee DS

更新日期：2018-08-13 00:00:00

abstract：:Elastin-like peptides (ELPs) have been used widely to confer thermoresponsive characteristics onto various materials, but to this point mostly linear ELPs have been studied. A class of linear and dendritic (branched) ELPs based on the GLPGL pentamer repeat unit was synthesized using an on-resin divergent strategy. The...

journal_title：Biomacromolecules

authors： Navon Y,Zhou M,Matson JB,Bitton R

更新日期：2016-01-11 00:00:00

abstract：:The polarity of polymer-actin complexes obtained by mixing F-actin with synthetic polymers carrying positive charges such as poly(L-lysine), x,y-ionene bromide polymers, and poly(N-[3-(dimethylamino)propyl]acrylamide) (PDMAPAA-Q) have been investigated. Actin complexes formed with poly(L-lysine) and PDMAPAA-Q, which c...

journal_title：Biomacromolecules

authors： Kakugo A,Shikinaka K,Takekawa N,Sugimoto S,Osada Y,Gong JP

更新日期：2005-03-01 00:00:00

abstract：:Reductively degradable biopolymers have emerged as a unique class of smart biomedical materials. Here, a functional coupling agent, cystamine diisocyanate (CDI), was designed to offer a facile access to reductively degradable biopolymers via polycondensation with various diols. CDI was readily obtained with a decent y...

journal_title：Biomacromolecules

authors： Wang X,Zhang J,Cheng R,Meng F,Deng C,Zhong Z

更新日期：2016-03-14 00:00:00

abstract：:The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials. In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow eva...

journal_title：Biomacromolecules

authors： Walters CM,Boott CE,Nguyen TD,Hamad WY,MacLachlan MJ

更新日期：2020-03-09 00:00:00

abstract：:Bone fractures constitute a major cause of morbidity and mortality especially in the elderly. Complications associated with osteoporosis drugs and the age of the patient slow bone turnover and render such fractures difficult to heal. Increasing the speed of fracture repair by administration of a fracture-targeted bone...

journal_title：Biomacromolecules

authors： Low SA,Galliford CV,Yang J,Low PS,Kopeček J

更新日期：2015-10-12 00:00:00

abstract：:Twenty-five kDa polyethylenimine (PEI) is one of the most efficient nonviral gene transfer agents currently applied as a golden standard for in vitro transfection. In this study, novel 25 kDa PEI derivatives with reductively cleavable cystamine periphery (PEI-Cys) were designed to reduce carrier-associated cytotoxicit...

journal_title：Biomacromolecules

authors： Wang Y,Zheng M,Meng F,Zhang J,Peng R,Zhong Z

更新日期：2011-04-11 00:00:00

abstract：:Stereocomplexation of poly(L-lactide) (PLLA) with star shaped D-lactic acid (D-LA) oligomers with different architectures and end-groups clearly altered the degradation rate and affected the degradation product patterns. Altogether, nine materials were studied: standard PLLA and eight blends of PLLA with either 30 or ...

journal_title：Biomacromolecules

authors： Andersson SR,Hakkarainen M,Inkinen S,Södergård A,Albertsson AC

更新日期：2012-04-09 00:00:00

abstract：:Receptor-mediated, cell-specific delivery of siRNA enables silencing of target genes in specific tissues, opening the door to powerful therapeutic options for a multitude of diseases. However, the development of delivery systems capable of targeted and effective siRNA delivery typically requires multiple steps and the...

journal_title：Biomacromolecules

authors： Benoit DS,Srinivasan S,Shubin AD,Stayton PS

更新日期：2011-07-11 00:00:00

abstract：:Agmatine-containing bioreducible polymer, poly(cystaminebis(acrylamide)-agmatine) (poly(CBA-AG)) was synthesized for gene delivery systems. It could form 200-300 nm sized and positively charged polyplexes with pDNA, which could release pDNA in reducing the environment due to the internal disulfide bonds cleavage. Poly...

journal_title：Biomacromolecules

authors： Choi JY,Ryu K,Lee GJ,Kim K,Kim TI

更新日期：2015-09-14 00:00:00

abstract：:Recently, we have developed a photopolymerizable poly(L-lysine) (PLL) that can be covalently incorporated into poly(ethylene glycol) diacrylate (PEGDA) hydrogels to improve their bioactivity by providing positive charges. To explore the potential of these PLL-grafted PEGDA hydrogels as a cell delivery vehicle and lumi...

journal_title：Biomacromolecules

authors： Cai L,Lu J,Sheen V,Wang S

更新日期：2012-05-14 00:00:00

abstract：:The effect of moisture content and temperature on water diffusion into a modified high amylose (< or = 90%) maize thermoplastic starch blend was investigated. Gravimetric and magnetic resonance imaging (MRI) studies were conducted to elucidate the diffusion mechanism and diffusion coefficients for this system. The dif...

journal_title：Biomacromolecules

authors： Russo MA,Strounina E,Waret M,Nicholson T,Truss R,Halley PJ

更新日期：2007-01-01 00:00:00

abstract：:Stability of four dissimilar basic proteins (chymotrypsinogen A, ribonuclease A, cytochrome c, lysozyme) in the complex with four polyanions (heparin, poly(vinylsulfate), poly(4-styrene-sulfonate), Nafion) has been studied by differential scanning calorimetry. The polyanions were chosen because of their different char...

journal_title：Biomacromolecules

authors： Sedlák E,Fedunová D,Veselá V,Sedláková D,Antalík M

更新日期：2009-09-14 00:00:00

abstract：:Positive strand RNA viruses replicate in specialized niches called membranous web within the cytoplasm of host cells. These virus replication organelles sequester viral proteins, RNA, and a variety of host factors within a fluid, amorphous matrix of clusters of endoplasmic reticulum (ER) derived vesicles. They are tho...

journal_title：Biomacromolecules

authors： Ho JCS,Steininger C,Hiew SH,Kim MC,Reimhult E,Miserez A,Cho N,Parikh AN,Liedberg B

更新日期：2019-04-08 00:00:00

abstract：:Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These...

journal_title：Biomacromolecules

authors： Hsiao HC,Santos A,Howell DW,Patterson JL,Fuchs-Young RS,Bondos SE

更新日期：2016-11-14 00:00:00

abstract：:The synthesis and polymerization of six AB(3) tapered self-assembling methacrylate monomers (5a, 5b, 5c,5d, 17a, and 17b) based on first generation alkyl substituted benzyl ether monodendrons (i.e., minidendrons) containing oligooxyethylene units at their focal point and the polymerizable group on their periphery are ...

journal_title：Biomacromolecules

authors： Percec V,Bera TK

更新日期：2002-01-01 00:00:00

abstract：:Glycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, and migration and tissue homeostasis. Here, we demonstrate supramolecular GAG-like glycopeptide nanofibers mimicking bioactive functions of natural hyaluronic acid molecules. Sel...

journal_title：Biomacromolecules

authors： Ustun Yaylaci S,Sardan Ekiz M,Arslan E,Can N,Kilic E,Ozkan H,Orujalipoor I,Ide S,Tekinay AB,Guler MO

更新日期：2016-02-08 00:00:00

abstract：:Biocompatible photoresponsive materials are of interest for targeted drug delivery, tissue engineering, 2D and 3D protein patterning, and other biomedical applications. We prepared light degradable hydrogels using a natural alginate polysaccharide cross-linked with iron(III) cations. The "hard" iron(III) cations used ...

journal_title：Biomacromolecules

authors： Narayanan RP,Melman G,Letourneau NJ,Mendelson NL,Melman A

更新日期：2012-08-13 00:00:00

abstract：:In tissue engineering, incorporation of bone morphogenetic protein-2 (BMP-2) into biomaterial scaffolds is an attractive strategy to stimulate bone repair. However, suboptimal release of BMP-2 remains a great concern, which may cause unfavorable bone formation as well as severe inflammation. In this study, genipin-cro...

journal_title：Biomacromolecules

authors： Zhang Q,Tan K,Zhang Y,Ye Z,Tan WS,Lang M

更新日期：2014-01-13 00:00:00

abstract：:Cardiovascular diseases plague human health because of the lack of transplantable small-diameter blood vessel (SDBV) grafts. Although expanded polytetrafluoroethylene (ePTFE) has the potential to be used as a biocompatible material for SDBV grafts, long-term patency is still the biggest challenge. As discussed in this...

journal_title：Biomacromolecules

authors： Wang D,Xu Y,Lin YJ,Yilmaz G,Zhang J,Schmidt G,Li Q,Thomson JA,Turng LS

更新日期：2020-09-14 00:00:00

abstract：:Placing a physical barrier between the injured site and the adjacent tissues is a very common and highly effective approach to prevent abdominal adhesions in these days. A biodegradable trilayered barrier was fabricated to prevent formation of abdominal adhesions, in which a poly(lactide-co-glycolide)/poly(lactide)-b-...

journal_title：Biomacromolecules

authors： Xia Q,Liu Z,Wang C,Zhang Z,Xu S,Han CC

更新日期：2015-09-14 00:00:00

abstract：:Enzymatic ring-opening copolymerization of 5-benzyloxy-trimethylene carbonate (BTMC) and 1,4-dioxan-2-one (DON) was investigated for the first time. Immobilized porcine pancreas lipase (IPPL) on silica particles was selected to perform the copolymerization. A series of novel biodegradable copolymers with different com...

journal_title：Biomacromolecules

authors： He F,Jia HL,Liu G,Wang YP,Feng J,Zhuo RX

更新日期：2006-08-01 00:00:00

abstract：:The rational design of a polyplex gene carrier aims to balance maximal effectiveness of nucleic acid transfection into cells with minimal adverse effects. Depsipeptide blocks with an Mn ∼ 5 kDa exhibiting strong physical interactions were conjugated with PEI moieties (2.5 or 10 kDa) to di- and triblock copolymers. Upo...

journal_title：Biomacromolecules

authors： Wang W,Naolou T,Ma N,Deng Z,Xu X,Mansfeld U,Wischke C,Gossen M,Neffe AT,Lendlein A

更新日期：2017-11-13 00:00:00

abstract：:As a first step toward utilizing self-assembling peptide scaffolds to create tunable matrices for drug delivery, peptide RADAFI and RADAFII, containing the same amino acid composition but different positions of one phenylalanine residue, scaffolds were prepared for controlled release of chiral enantiomers. The release...

journal_title：Biomacromolecules

authors： Zhao Y,Tanaka M,Kinoshita T,Higuchi M,Tan T

更新日期：2009-12-14 00:00:00

abstract：:Assembly of (bio)polymers into long-range anisotropic nanostructured gels and aerogels is of great interest in advanced material engineering since it enables directional tuning of properties, such as diffusivity, light, heat, and sound propagation, cell proliferation, and mechanical properties. Here we present an appr...

journal_title：Biomacromolecules

authors： Plappert SF,Nedelec JM,Rennhofer H,Lichtenegger HC,Bernstorff S,Liebner FW

更新日期：2018-11-12 00:00:00

abstract：:Thanks to chemical stabilization, aldehyde-assisted fractionation (AAF) of lignocellulosic biomass has recently emerged as a powerful tool for the production of largely uncondensed lignin. Depolymerization of AAF lignin via ether cleavage provides aromatic monomers at near theoretical yields based on ether cleavage an...

journal_title：Biomacromolecules

authors： Vendamme R,Behaghel de Bueren J,Gracia-Vitoria J,Isnard F,Mulunda MM,Ortiz P,Wadekar M,Vanbroekhoven K,Wegmann C,Buser R,Héroguel F,Luterbacher JS,Eevers W

更新日期：2020-10-12 00:00:00