Abstract：
:The synthesis and polymerization of six AB(3) tapered self-assembling methacrylate monomers (5a, 5b, 5c,5d, 17a, and 17b) based on first generation alkyl substituted benzyl ether monodendrons (i.e., minidendrons) containing oligooxyethylene units at their focal point and the polymerizable group on their periphery are described. The corresponding polymers (6a, 6b, 6c, 6d, 18a, and 18b) self-assemble and subsequently self-organize in supramolecular networks that form a 2-D hexagonal lattice. This network consists of a continuous phase based on a paraffin barrier material perforated in a hexagonal array by ion-active channels constructed from the oligooxyethylenic units protected by the aromatic groups of the taper. Complexation of the oligooxyethylene channels of 6a-d with LiCF(3)SO(3) salt enhances the thermal stability of their hexagonal columnar (phi(h)) liquid crystalline phase. The enhancement of the thermal stability of the phi(h) phase of both monomers and polymers up to 86 degrees C is also achieved by shifting the placement of the polymerizable group from the 3 position to the 4 position of the 3,4,5-trisubstituted AB(3) benzoate monodendrons. The design of these macromolecules was inspired by the bilayer fluid mosaic structure of the cell membrane. The lipid bilayer of the cell membrane that acts in its ordered state as a barrier to the passage of polar molecules was replaced with the paraffinic barrier, while the protein-based ionic channels were replaced with oligooxyethylenic-based channels. The resulted supramolecular material has the mechanical integrity required for the design of ion-active nanostructured supramolecular systems.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Percec V,Bera TKdoi
10.1021/bm010138pkeywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
167-81issue
1eissn
1525-7797issn
1526-4602pii
bm010138pjournal_volume
3pub_type
杂志文章abstract：:The thermally induced aggregation of bovine β-lactoglobulin in the glass state was studied both as the pure protein and in trehalose mixtures. Calorimetric measurements and size exclusion chromatography were used to characterize the glass state and aggregation, respectively. The initial aggregation rate was characteri...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm100785d
更新日期：2010-11-08 00:00:00
abstract：:In situ cross-linkable hybrid hydrogels composed of gelatin and 4-arm-polypropylene oxide-polyethylene oxide (Tetronic) was developed as an injectable scaffold for tissue regeneration. The gelatin was modified by hydroxyphenyl propionic acid (HPA) and the Tetronic was conjugated with tyramines (Tet-TA). The hydrogels ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm201712z
更新日期：2012-03-12 00:00:00
abstract：:Forisomes are protein polymers found in leguminous plants that have the remarkable ability to undergo reversible "muscle-like" contractions in the presence of divalent cations and in extreme pH environments. To gain insight into the molecular basis of forisome structure and assembly, we used confocal laser scanning mi...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm3008499
更新日期：2012-10-08 00:00:00
abstract：:The carboxyl-terminal domain (CTD, residues 146-231) of the HIV-1 capsid (CA) protein plays an important role in the CA-CA dimerization and viral assembly of the human immunodeficiency virus type 1. Disrupting the native conformation of the CA is essential for blocking viral capsid formation and viral replication. Thu...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm801151r
更新日期：2009-02-09 00:00:00
abstract：:The interaction between positively charged poly(amido amine) (PAMAM) dendrimers of generation 4 and DNA has been investigated for two DNA lengths; 2000 basepairs (bp; L = 680 nm) and 4331 bp (L = 1472.5 nm) using a theoretical model by Schiessel for a semiflexible polyelectrolyte and hard spheres. The model was modifi...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm9000662
更新日期：2009-07-13 00:00:00
abstract：:Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and investiga...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm5006855
更新日期：2014-08-11 00:00:00
abstract：:A successful strategy for the immobilization of rennet from Mucor miehei has been developed. The strategy is based on the immobilization of the enzyme, via their sugar chains at high ionic strength on aminated supports having primary amino groups with a very low pK value. The rennet was covalently immobilized via suga...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049735c
更新日期：2004-09-01 00:00:00
abstract：:External magnetic field is a powerful approach to induce orientational order in originally disordered suspensions of magneto-responsive anisotropic particles. By small angle neutron scattering and optical birefringence measurement technology, we investigated the effect of magnetic field on the spatial ordering of hybr...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.6b00539
更新日期：2016-08-08 00:00:00
abstract：:Chitosan is a linear cationic biopolymer composed of glucosamine and N-acetyl-glucosamine that is only soluble in acidic aqueous solutions and precipitates when neutralized. However, it was recently discovered that chitosan dissolved in solutions containing glycerol phosphate was soluble at near neutral pH and produce...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm700520m
更新日期：2007-10-01 00:00:00
abstract：:Following the work carried out on guar gum in our first paper of a series, the "pressure cell" solubilization method was applied to two other less highly substituted galactomannans: locust bean gum (LBG) and tara gum. True molecular solution of the polymers was achieved using appropriate temperature, time, and pressur...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm025517c
更新日期：2002-07-01 00:00:00
abstract：:Enzymatic adsorption and degradation of three types of aliphatic polyester films and two types of polyolefin films by the extracellular PHB depolymerase from Alcaligenes faecalis T1 have been studied by using a quartz crystal microbalance (QCM) technique. Hydrolysis of poly[(R)-3-hydroxybutyrate] was quantitatively fo...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0000844
更新日期：2001-04-01 00:00:00
abstract：:Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths near 1 MPa. An increase ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm501456g
更新日期：2015-01-12 00:00:00
abstract：:Cartilage tissue engineering highly relies on the ability to store and transport chondrocytes in order to be clinically successful. Cryopreservation is a most reliable technology for chondrocyte storage, but it suffers from the intrinsic toxicity of current state-of-the-art cryoprotectant, dimethyl sulfoxide (DMSO). I...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01024
更新日期：2019-10-14 00:00:00
abstract：:Electrically conducting polymeric membranes were prepared by incorporating multiwalled carbon nanotubes (MWCNTs) into bacterial cellulose pellicles produced by Gluconacetobacter xylinum. The MWCNTs were dispersed in a surfactant (cationic cetyl trimethylammonium bromide) solution, and cellulose pellicles were dipped i...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm050597g
更新日期：2006-04-01 00:00:00
abstract：:Silicatein α exists within the protein filament of silica spicules of the marine sponge Tethya aurantium in a predominantly β-sheet structure. However, it is produced in a soluble form with mixed α-helix/β-sheet structure akin to its cathepsin L homologue. To understand this conformational transition in the context of...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm100932e
更新日期：2010-11-08 00:00:00
abstract：:There is a distinct need for antimicrobial compounds that can act at surfaces without leaching into the environment. Such materials should be easy to synthesize, be easy to apply to surfaces, and display reasonable levels of antimicrobial and antifungal activity. Here we describe such a surface-active compound and dem...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060476w
更新日期：2006-10-01 00:00:00
abstract：:The influence of 2,2,6,6-tetrametylpiperidine-1-oxyl (TEMPO)-mediated oxidation of wood cellulose and the mechanical disintegration of oxidized cellulose in water on degree of polymerization determined by viscosity measurement (DP(v)) and the apparent length of the TEMPO-oxidized cellulose nanofibrils (TOCNs) was inve...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm2017542
更新日期：2012-03-12 00:00:00
abstract：:Glycopolymer-polypeptide triblock copolymers of the structure, poly(l-alanine)-b-poly(2-acryloyloxyethyl-lactoside)-b-poly(l-alanine) (AGA), have been synthesized by sequential atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP). Controlled free radical polymerization of 2-O-acryloyl-oxye...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0343500
更新日期：2004-01-01 00:00:00
abstract：:In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0340624
更新日期：2003-07-01 00:00:00
abstract：:Amphiphilic polymer conetworks (APCNs) are materials with a very large interface between their hydrophilic and hydrophobic phases due to their nanophase-separated morphologies. Proteins were found to enrich in APCNs by up to 2 orders of magnitude when incubated in aqueous protein solutions, raising the question of the...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm1015877
更新日期：2011-05-09 00:00:00
abstract：:Hollow poly(6-O-acryloyl-alpha-D-galactopyranose) (PAGP) nanospheres were prepared in a facile manner using the RAFT (reversible addition fragmentation chain transfer) process. Initially, an amphiphilic block copolymer, poly(lactide)-block-poly(6-O-acryloyl-alpha-D-galactopyranose) (PLA-b-PAGP), was synthesized using ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm801123b
更新日期：2009-02-09 00:00:00
abstract：:Protein-based polymers are increasingly being used in biomaterial applications because of their ease of customization and potential monodispersity. These advantages make protein polymers excellent candidates for bioanalytical applications. Here we describe improved methods for producing drag-tags for free-solution con...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm200358r
更新日期：2011-06-13 00:00:00
abstract：:3-Helix micelles have demonstrated excellent in vitro and in vivo stability. Previous studies showed that the unique design of the peptide-polymer conjugate based on protein tertiary structure as the headgroup is the main design factor to achieve high kinetic stability. In this contribution, using amphiphiles with dif...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm5005788
更新日期：2014-08-11 00:00:00
abstract：:Amphiphilic random, gradient, and block copolymers of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and n-butyl methacrylate (BMA) were synthesized by atom transfer radical polymerization (ATRP) in water/2-propanol mixtures using a methoxy-poly(ethylene glycol) (MPEG) (M(n) = 2000) macroinitiator. Kinetic studies indic...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm034126a
更新日期：2003-09-01 00:00:00
abstract：:Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm400768m
更新日期：2013-09-09 00:00:00
abstract：:Bacterial biofilms tolerate extreme levels of antibiotics. Treatment of biofilm infections therefore requires the development of new or modified antimicrobials that can penetrate biofilms and are effective against dormant persistent cells. One such new approach uses the biodegradable biopolymer chitosan and its deriva...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b00718
更新日期：2018-09-10 00:00:00
abstract：:The production of large quantities of artificial spider silk fibers that match the mechanical properties of the native material has turned out to be challenging. Recent advancements in the field make biomimetic spinning approaches an attractive way forward since they allow the spider silk proteins to assemble into the...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.0c00100
更新日期：2020-06-08 00:00:00
abstract：:Degradation of fibrillar collagen is critical for tissue maintenance. Yet, understanding collagen catabolism has been challenging partly due to a lack of atomistic picture for its load-dependent conformational dynamics, as both mechanical load and local unfolding of collagen affect its cleavage by matrix metalloprotei...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm500641f
更新日期：2014-08-11 00:00:00
abstract：:Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01072
更新日期：2019-11-11 00:00:00
abstract：:Macromolecular dynamics in biological systems, which play a crucial role for biomolecular function and activity at ambient temperature, depend strongly on moisture content. Yet, a generally accepted quantitative model of hydration-dependent phenomena based on local relaxation and diffusive dynamics of both polymer and...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b00191
更新日期：2018-07-09 00:00:00
