Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues.

abstract：:Positive strand RNA viruses replicate in specialized niches called membranous web within the cytoplasm of host cells. These virus replication organelles sequester viral proteins, RNA, and a variety of host factors within a fluid, amorphous matrix of clusters of endoplasmic reticulum (ER) derived vesicles. They are tho...

journal_title：Biomacromolecules

authors： Ho JCS,Steininger C,Hiew SH,Kim MC,Reimhult E,Miserez A,Cho N,Parikh AN,Liedberg B

更新日期：2019-04-08 00:00:00

abstract：:Hybrid dendritic-linear block copolymers based on a 4-arm poly(ethylene glycol) (PEG) core were synthesized using an accelerated AB2/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an e...

journal_title：Biomacromolecules

authors： Albertazzi L,Mickler FM,Pavan GM,Salomone F,Bardi G,Panniello M,Amir E,Kang T,Killops KL,Bräuchle C,Amir RJ,Hawker CJ

更新日期：2012-12-10 00:00:00

abstract：:Biomimetic nanoengineering built through integrating the specific cell membrane with artificially synthetic nanomedicines represents one of the most promising directions for the actualization of personalized therapy. For addressing the technical hurdle against the development of this biomimetic technology, the present...

journal_title：Biomacromolecules

authors： Zhu J,Zhang M,Zheng D,Hong S,Feng J,Zhang XZ

更新日期：2018-06-11 00:00:00

abstract：:Protein transduction domains (PTDs) that readily transverse cellular membranes are of great interest and are attractive tools for the intracellular delivery of bioactive molecules. Learning to program synthetic polymers and oligomers with the appropriate chemical information to capture adequately the biological activi...

journal_title：Biomacromolecules

authors： Tezgel AÖ,Telfer JC,Tew GN

更新日期：2011-08-08 00:00:00

abstract：:Self-assembled hydrogen-bonded networks of the polysaccharide pectin, a mechanically functional component of plant cell walls, have been of recent interest as biomimetic exemplars of physical gels, and the microrheological and strain-stiffening behaviors have been previously investigated. Despite this detailed rheolog...

journal_title：Biomacromolecules

authors： Mansel BW,Chu CY,Leis A,Hemar Y,Chen HL,Lundin L,Williams MA

更新日期：2015-10-12 00:00:00

abstract：:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains...

journal_title：Biomacromolecules

authors： Fu X,Ma Y,Shen Y,Fu W,Li Z

更新日期：2014-03-10 00:00:00

abstract：:Materials with fungi-bioinspired surface have been designed to host ergosterol-binding polyene antibiotics and to release them via a competitive mechanism only when fungi are present in the medium. Silicone rubber (SR) surfaces were endowed with selective loading and fungi-triggered release of polyene antifungal agent...

journal_title：Biomacromolecules

authors： Segura T,Puga AM,Burillo G,Llovo J,Brackman G,Coenye T,Concheiro A,Alvarez-Lorenzo C

更新日期：2014-05-12 00:00:00

abstract：:This work demonstrates that hydrogen peroxide (H2O2) is generated in weak polyacrylamide hydrogels due to mechanochemical reactions to osmotic swelling. Hydrogels are important tools and materials for many biomedical applications, particularly for growth of stem cells. However, swollen gels are under constant tension,...

journal_title：Biomacromolecules

authors： Parameswar AV,Fitch KR,Bull DS,Duke VR,Goodwin AP

更新日期：2018-08-13 00:00:00

abstract：:Glycerol derivatives of cutin and suberin monomers were synthesized by acid catalysis. Their dispersion in an aqueous solution was examined by phase contrast microscopy, neutron scattering, and solid state NMR. It is shown that the phase behavior strongly depends on the nature of the derivatives forming either lumps o...

journal_title：Biomacromolecules

authors： Douliez JP,Barrault J,Jerome F,Heredia A,Navailles L,Nallet F

更新日期：2005-01-01 00:00:00

abstract：:Self-cross-linking polyelectrolytes are used to strengthen the surface of calcium alginate beads for cell encapsulation. Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride), containing 30 mol % 2-aminoethyl methacrylate, and poly(sodium methacrylate), containing 30 mol % 2-(methacryloyloxy)ethyl acetoacetate, w...

journal_title：Biomacromolecules

authors： Mazumder MA,Shen F,Burke NA,Potter MA,Stöver HD

更新日期：2008-09-01 00:00:00

abstract：:The single-coat protein (CP) of bacteriophage Qβ self-assembles into T = 3 icosahedral virus-like particles (VLPs), of interest for a wide range of applications. These VLPs are very stable, but identification of the specific molecular determinants of this stability is lacking. To investigate these determinants along w...

journal_title：Biomacromolecules

authors： Fiedler JD,Higginson C,Hovlid ML,Kislukhin AA,Castillejos A,Manzenrieder F,Campbell MG,Voss NR,Potter CS,Carragher B,Finn MG

更新日期：2012-08-13 00:00:00

abstract：:Protein-based polymers are increasingly being used in biomaterial applications because of their ease of customization and potential monodispersity. These advantages make protein polymers excellent candidates for bioanalytical applications. Here we describe improved methods for producing drag-tags for free-solution con...

journal_title：Biomacromolecules

authors： Lin JS,Albrecht JC,Meagher RJ,Wang X,Barron AE

更新日期：2011-06-13 00:00:00

abstract：:This paper describes the synthesis and characterization of polymer-peptide conjugates to be used as infection-resistant coating for biomaterial implants and devices. Antiadhesive polymer brushes composed of block copolymer Pluronic F-127 (PF127) were functionalized with antimicrobial peptides (AMP), able to kill bacte...

journal_title：Biomacromolecules

authors： Muszanska AK,Rochford ET,Gruszka A,Bastian AA,Busscher HJ,Norde W,van der Mei HC,Herrmann A

更新日期：2014-06-09 00:00:00

abstract：:Cellulose is the most familiar and most abundant strong biopolymer, but the reasons for its outstanding mechanical performance are not well understood. Each glucose unit in a cellulose chain is joined to the next by a covalent C-O-C linkage flanked by two hydrogen bonds. This geometry suggests some form of cooperativi...

journal_title：Biomacromolecules

authors： Altaner CM,Thomas LH,Fernandes AN,Jarvis MC

更新日期：2014-03-10 00:00:00

abstract：:Biopolymers bearing hydrophobic side-chains, such as hydrophobically modified chitosan (hmC), can connect liposomes into a gel network via hydrophobic interactions. In this paper, we show that such liposome gels possess an attractive combination of properties for certain drug delivery applications. Their shear-thinnin...

journal_title：Biomacromolecules

authors： Lee JH,Oh H,Baxa U,Raghavan SR,Blumenthal R

更新日期：2012-10-08 00:00:00

abstract：:Owing to their diverse functions and tunable physicochemical properties, peptides are promising alternatives to the conventional gene delivery tools that are available for plant systems. However, peptide-mediated gene delivery is limited by low transfection efficiency in plants because of the insufficient cytosolic tr...

journal_title：Biomacromolecules

authors： Miyamoto T,Tsuchiya K,Numata K

更新日期：2020-07-13 00:00:00

abstract：:Electrospinning of cellulose nanocrystals (CNC)/poly(lactic acid) (PLA) emulsions has been demonstrated to be an effective dispersion and alignment method to control assembly of CNC into continuous composite ultrafine fibers. CNC-PLA nanocomposite random-fiber mats and aligned-fiber yarns were prepared by emulsion ele...

journal_title：Biomacromolecules

authors： Li Y,Ko FK,Hamad WY

更新日期：2013-11-11 00:00:00

abstract：:An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol-ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed ex...

journal_title：Biomacromolecules

authors： Han J,Chen Q,Shen Y,Liu Z,Hao X,Zhong M,Zhao Z,Bockstaller MR

更新日期：2020-09-14 00:00:00

abstract：:Neutron reflectometry was used to investigate effects of calcium ions on the interfacial behavior of beta-casein at the silicon oxide-aqueous solution interface. The structural characteristics of the adsorbed layer were determined from reflectivity curves fitted to three- and two-layer optical models. The results show...

journal_title：Biomacromolecules

authors： Follows D,Holt C,Nylander T,Thomas RK,Tiberg F

更新日期：2004-03-01 00:00:00

abstract：:New applications in regenerative biotechnology require the ability to understand and control protein-surface interactions on micrometer and submicrometer length scales. Evidence presented here shows that micropatterned amphiphilic comb polymer films exhibit a pretreatment-dependent behavior with respect to protein ads...

journal_title：Biomacromolecules

authors： Zhang Z,Ma H,Hausner DB,Chilkoti A,Beebe TP Jr

更新日期：2005-11-01 00:00:00

abstract：:Polymer therapeutics, including polymeric drugs and polymer-protein conjugates, are clinically established as first-generation nanomedicines. Knowing that the coiled-coil peptide motif is fundamentally important in the regulation of many cellular and pathological processes, the aim of these studies was to examine the ...

journal_title：Biomacromolecules

authors： Deacon SP,Apostolovic B,Carbajo RJ,Schott AK,Beck K,Vicent MJ,Pineda-Lucena A,Klok HA,Duncan R

更新日期：2011-01-10 00:00:00

abstract：:The unsatisfied results of cancer therapy are caused by many issues and metastasis of cancer cells is one of the major challenge. It has been reported that inhibiting the SDF1/CXCR4 interaction can significantly reduce the metastasis of breast cancer cells to regional lymph nodes and lung. Herein, a nanogel system equ...

journal_title：Biomacromolecules

authors： Zhang F,Gong S,Wu J,Li H,Oupicky D,Sun M

更新日期：2017-06-12 00:00:00

abstract：:C13-dipeptides that did not gel on their own were found to form hydrogels when combined with mixtures (coassembly). At pH = 4.6, by mixing negatively charged C13-WD (C13-WD2- and/or C13-WD-) with C13-KW or C13-YK, where the side chain of K carried positive charge, two composite hydrogels with different mechanical prop...

journal_title：Biomacromolecules

authors： Hu T,Zhang Z,Euston SR,Geng M,Pan S

更新日期：2020-12-14 00:00:00

abstract：:A new, convenient pathway is developed to synthesize highly hydrolytically labile poly(ortho ester amide) (POEA) copolymers that overcomes some of the major weaknesses of the traditional methods of synthesizing poly(ortho esters) and their derivatives. A diamine monomer containing a built-in, stabilized ortho ester gr...

journal_title：Biomacromolecules

authors： Tang R,Palumbo RN,Ji W,Wang C

更新日期：2009-04-13 00:00:00

abstract：:Chitosan possesses many characteristics of an ideal gene delivery system. However, the transfection efficiency of conventional chitosans is generally found to be low. In this study, we investigated the self-branching of chitosans as a strategy to improve its gene transfer properties without compromising its safety pro...

journal_title：Biomacromolecules

authors： Malmo J,Vårum KM,Strand SP

更新日期：2011-03-14 00:00:00

abstract：:Poly(3-(tert-butoxycarbonyl)-N-vinyl-2-pyrrolidone) has been synthesized and characterized by gel permeation chromatography, Fourier transform infrared spectroscopy, NMR spectroscopy, and thermal analysis. The polymer is a chemically amplified photoresist. Arrays of lines with 25 microm width and 25 microm spacing wer...

journal_title：Biomacromolecules

authors： He W,Gonsalves KE,Pickett JH,Halberstadt C

更新日期：2003-01-01 00:00:00

abstract：:Bacterial biofilms tolerate extreme levels of antibiotics. Treatment of biofilm infections therefore requires the development of new or modified antimicrobials that can penetrate biofilms and are effective against dormant persistent cells. One such new approach uses the biodegradable biopolymer chitosan and its deriva...

journal_title：Biomacromolecules

authors： Sahariah P,Másson M,Meyer RL

更新日期：2018-09-10 00:00:00

abstract：:Coatings derived from surface active block copolymers (SABCs) having a combination of hydrophobic aliphatic (linear hydrocarbon or propylene oxide-derived groups) and hydrophilic poly(ethlyene glycol) (PEG) side chains have been developed. The coatings demonstrate superior performance against protein adsorption as wel...

journal_title：Biomacromolecules

authors： Cho Y,Sundaram HS,Finlay JA,Dimitriou MD,Callow ME,Callow JA,Kramer EJ,Ober CK

更新日期：2012-06-11 00:00:00

abstract：:Poor cell survival in vitro and in vivo is one of the key challenges in tissue engineering. Prosurvival therapeutic proteins, such as insulin-like growth factor-1 (IGF-1), can promote cell viability but require controlled delivery systems due to their short half-lives and rapid clearance. Biocompatible materials are c...

journal_title：Biomacromolecules

authors： Parker J,Mitrousis N,Shoichet MS

更新日期：2016-02-08 00:00:00

abstract：:Following the work carried out on guar gum in our first paper of a series, the "pressure cell" solubilization method was applied to two other less highly substituted galactomannans: locust bean gum (LBG) and tara gum. True molecular solution of the polymers was achieved using appropriate temperature, time, and pressur...

journal_title：Biomacromolecules

authors： Picout DR,Ross-Murphy SB,Jumel K,Harding SE

更新日期：2002-07-01 00:00:00