Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues.

abstract：:The ability of microbally produced poly(gamma,d-glutamic acid) to form stable polyelectrolyte-opposite charged surfactant complexes was investigated. A sonicated sample of polyacid with a molecular weight about 10(5) Da and a content of d enantiomer higher than 90% was used in this study. Nearly stoichiometric complex...

journal_title：Biomacromolecules

authors： Pérez-Camero G,García-Alvarez M,Martínez De Ilarduya A,Fernández C,Campos L,Muñoz-Guerra S

更新日期：2004-01-01 00:00:00

abstract：:The manufacture of biodegradable materials from agricultural sources is a real challenge, because of environmental concerns and the need to make full use of resources. Cottonseed is an important protein source that could be used in nonfood applications, as a substitute for synthetic polymers. For the first time, the v...

journal_title：Biomacromolecules

authors： Grevellec J,Marquié C,Ferry L,Crespy A,Vialettes V

更新日期：2001-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) has attracted widespread attention in recent years as a noninvasive and highly selective approach for cancer treatment. We have previously reported a significant increase in the 90-day complete response rate when tumor-bearing mice are treated with the epidermal growth factor receptor (EGFR)...

journal_title：Biomacromolecules

authors： Yan L,Miller J,Yuan M,Liu JF,Busch TM,Tsourkas A,Cheng Z

更新日期：2017-06-12 00:00:00

abstract：:The formation of a suitable extracellular matrix (ECM) that promotes cell adhesion, organization, and proliferation is essential within biomaterial scaffolds for tissue engineering applications. In this work, short elastin mimetic peptide sequences, EM-19 and EM-23, were engineered to mimic the active motifs of human ...

journal_title：Biomacromolecules

authors： Patel D,Menon R,Taite LJ

更新日期：2011-02-14 00:00:00

abstract：:The new combinations of monomers presented in this work were evaluated in order to create an elastic material for potential application in soft tissue engineering. Thermoplastic elastomers (TPE) of trimethylene carbonate (TMC) with L-lactide (LLA) and 1,5-dioxepan-2-one (DXO) have been synthesized using a cyclic five-...

journal_title：Biomacromolecules

authors： Andronova N,Albertsson AC

更新日期：2006-05-01 00:00:00

abstract：:Gene therapy is rapidly regaining traction in terms of research activity and investment across the globe, with clear potential to revolutionize medicine and tissue regeneration. Viral vectors remain the most commonly utilized gene delivery vehicles, due to their high efficiency, however, they are acknowledged to have ...

journal_title：Biomacromolecules

authors： Wong LY,Xia B,Wolvetang E,Cooper-White J

更新日期：2018-02-12 00:00:00

abstract：:Ternary compatible blends of chitosan, poly(vinyl alcohol), and poly(lactic acid) were prepared by an oil-in-water (O/W) emulsion process. Solutions of chitosan in aqueous acetic acid, poly(vinyl alcohol) (PVA) in water, and poly(lactic acid) (PLA) in chloroform were blended with a high-shear mixer. PVA was used as an...

journal_title：Biomacromolecules

authors： Grande R,Carvalho AJ

更新日期：2011-04-11 00:00:00

abstract：:The controlled delivery of growth factors is a very challenging task because many different issues have to be addressed to develop the best suited system. A wide range of approaches have been employed for the controlled delivery of growth factors by hydrogels. Direct loading, electrostatic interaction, covalent bindin...

journal_title：Biomacromolecules

authors： Silva AK,Richard C,Bessodes M,Scherman D,Merten OW

更新日期：2009-01-12 00:00:00

abstract：:Twenty-five kDa polyethylenimine (PEI) is one of the most efficient nonviral gene transfer agents currently applied as a golden standard for in vitro transfection. In this study, novel 25 kDa PEI derivatives with reductively cleavable cystamine periphery (PEI-Cys) were designed to reduce carrier-associated cytotoxicit...

journal_title：Biomacromolecules

authors： Wang Y,Zheng M,Meng F,Zhang J,Peng R,Zhong Z

更新日期：2011-04-11 00:00:00

abstract：:Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures toward diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biom...

journal_title：Biomacromolecules

authors： Ko JW,Choi WS,Kim J,Kuk SK,Lee SH,Park CB

更新日期：2017-11-13 00:00:00

abstract：:Biobased poly(γ-butyrolactone) (PγBL) as a fully biodegradable and bioabsorbable biomaterial has shown superior properties compared to those of other aliphatic polyesters. It is of great importance to prepare amphiphilic block copolymer containing PγBL block to make ordered nano-objects for biomedical applications suc...

journal_title：Biomacromolecules

authors： Shen Y,Zhang J,Zhao Z,Zhao N,Liu F,Li Z

更新日期：2019-01-14 00:00:00

abstract：:The self-assembly properties of fibrous proteins such as collagen are frequently used to form three-dimensional scaffolds. In this study we investigated the effect of nonuniform alternating and static electric-fields on the self-assembly properties of a dilute solution of vimentin. In the presence of both types of fie...

journal_title：Biomacromolecules

authors： Colbourne TR,Hill IG,Kreplak L

更新日期：2009-07-13 00:00:00

abstract：:Synthetic lethality is a molecular-targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between superoxide dismutase 1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with a customized lung cancer screen-1-loaded ...

journal_title：Biomacromolecules

authors： Gupta A,Ahmad A,Singh H,Kaur S,K M N,Ansari MM,Jayamurugan G,Khan R

更新日期：2018-03-12 00:00:00

abstract：:Oxidative coupling of phenol-containing precursor poly(amino acid)s, poly(alpha-glutamine), poly(alpha/beta-asparagine), and poly(gamma-glutamine) derivatives, has been examined to produce a new class of soluble poly(amino acid)s. Under appropriate reaction conditions, the Fe-salen and HRP catalysts efficiently induce...

journal_title：Biomacromolecules

authors： Fukuoka T,Uyama H,Kobayashi S

更新日期：2004-05-01 00:00:00

abstract：:Electrically conducting polymeric membranes were prepared by incorporating multiwalled carbon nanotubes (MWCNTs) into bacterial cellulose pellicles produced by Gluconacetobacter xylinum. The MWCNTs were dispersed in a surfactant (cationic cetyl trimethylammonium bromide) solution, and cellulose pellicles were dipped i...

journal_title：Biomacromolecules

authors： Yoon SH,Jin HJ,Kook MC,Pyun YR

更新日期：2006-04-01 00:00:00

abstract：:A variety of natural polymers and proteins are considered to be 3D cell culture structures able to mimic the extracellular matrix (ECM) to promote bone tissue regeneration. Pectin, a natural polysaccharide extracted from the plant cell walls and having a chemical structure similar to alginate, provides interesting pro...

journal_title：Biomacromolecules

authors： Munarin F,Guerreiro SG,Grellier MA,Tanzi MC,Barbosa MA,Petrini P,Granja PL

更新日期：2011-03-14 00:00:00

abstract：:A heterofunctional support for enzyme immobilization may be defined as that which possesses several distinct functionalities on its surface able to interact with a protein. We will focus on those supports in which a final covalent attachment between the enzyme and the support is achieved. Heterofunctionality sometimes...

journal_title：Biomacromolecules

authors： Barbosa O,Torres R,Ortiz C,Berenguer-Murcia A,Rodrigues RC,Fernandez-Lafuente R

更新日期：2013-08-12 00:00:00

abstract：:New aspects concerning the mechanism of formation of chitosan physical hydrogels without any cross-linking agent were studied. The gelation took place during the evaporation of a hydroalcoholic solution of chitosan. We first demonstrated that it was possible to form a physical hydrogel from a hydrochloride form of chi...

journal_title：Biomacromolecules

authors： Boucard N,Viton C,Domard A

更新日期：2005-11-01 00:00:00

abstract：:The maintenance of hepatocyte phenotype and functions remains as a great challenge in the generation of functional liver tissue and in vitro model for drug metabolism studies. The use of hepatocyte coculture systems plays essential roles in the establishment of cell-cell and cell-extracellular matrix communications si...

journal_title：Biomacromolecules

authors： Liu Y,Li H,Yan S,Wei J,Li X

更新日期：2014-03-10 00:00:00

abstract：:We utilize an aqueous extract of fish proteins (FPs) as a coating for minimizing the adsorption of fibrinogen (Fg) and human serum albumin (HSA). The surfaces include stainless steel (SS), gold (Au), silicon dioxide (SiO(2)), and poly(styrene) (PS). The adsorption processes (kinetics and adsorbed mass) are followed by...

journal_title：Biomacromolecules

authors： Pillai S,Arpanaei A,Meyer RL,Birkedal V,Gram L,Besenbacher F,Kingshott P

更新日期：2009-10-12 00:00:00

abstract：:To develop a safe, effective, and biocompatible gene delivery vector, a series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization of AGC polymers was performed by NMR and elemental analysis. AGC polymers demonstrated excel...

journal_title：Biomacromolecules

authors： Layek B,Singh J

更新日期：2013-02-11 00:00:00

abstract：:Biocompatible photoresponsive materials are of interest for targeted drug delivery, tissue engineering, 2D and 3D protein patterning, and other biomedical applications. We prepared light degradable hydrogels using a natural alginate polysaccharide cross-linked with iron(III) cations. The "hard" iron(III) cations used ...

journal_title：Biomacromolecules

authors： Narayanan RP,Melman G,Letourneau NJ,Mendelson NL,Melman A

更新日期：2012-08-13 00:00:00

abstract：:Natural selection has endorsed proteins with amazing structures and functionalities that cannot be matched by synthetic means, explaining the exponential interest in developing protein-based materials. Protein self-assembly allows fabricating complex supramolecular structures from relatively simple building blocks, a ...

journal_title：Biomacromolecules

authors： Wang W,Azizyan RA,Garro A,Kajava AV,Ventura S

更新日期：2020-10-12 00:00:00

abstract：:The objective of these investigations was to test the hypothesis that a rapid cytoplasmic release profile from nanoparticles would potentiate the anticancer activity of cisplatin. Cisplatin-loaded nanoparticles with pH-responsive poly[2-(N,N-diethylamino)ethyl methacrylate] (PDEA) cores were synthesized from PDEA-bloc...

journal_title：Biomacromolecules

authors： Xu P,Van Kirk EA,Murdoch WJ,Zhan Y,Isaak DD,Radosz M,Shen Y

更新日期：2006-03-01 00:00:00

abstract：:A series of Vitamin E (vitE)-labeled PEIs (PEI-vitEn) were synthesized and showed excellent complexation ability with plasmid DNA (pDNA). The cellular uptake of PEI-vitEn/pDNA complexes was greatly enhanced with the increase of vitE labeling, which is much better than that of control PEI25 in three different cell line...

journal_title：Biomacromolecules

authors： Liu J,Feng M,Liang D,Yang J,Tang X

更新日期：2016-10-10 00:00:00

abstract：:Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) was applied to investigate the interaction of bovine serum albumin (BSA) and fibrinogen with a biomedical-grade 316LVM stainless steel surface, in terms of the adsorption thermodynamics and adsorption-induced secondary structure changes of ...

journal_title：Biomacromolecules

authors： Desroches MJ,Chaudhary N,Omanovic S

更新日期：2007-09-01 00:00:00

abstract：:Repifermin, a truncated form of fibroblast growth factor-10 (FGF-10) also known as keratinocyte growth factor-2 (KGF-2), is a heparin-binding protein with potent regenerative properties. The protein unfolds and aggregates at relatively low temperature (~37 °C). Electrostatic interactions between polyanions and several...

journal_title：Biomacromolecules

authors： Khondee S,Olsen CM,Zeng Y,Middaugh CR,Berkland C

更新日期：2011-11-14 00:00:00

abstract：:The mycobacterial cell wall is extraordinarily thick and tight consisting mainly of (1). long chain fatty acids, the mycolic acids, and (2). a unique polysaccharide, arabinogalactan (AG). These two chemical constituents are covalently linked through ester bonds. Minnikin (The Biology of the Mycobacteria; Academic: Lon...

journal_title：Biomacromolecules

authors： Hong X,Hopfinger AJ

更新日期：2004-05-01 00:00:00

abstract：:A poly[(R)-3-hydroxybutyrate] (P(3HB))-degrading marine bacterium (strain NK-1, JCM10458) was isolated from the Pacific Ocean deep-sea floor (1165 m in depth) in Japan. The organism was a motile and Gram negative, aerobic, and rod-shaped bacterium, and its DNA had a guanine-plus-cytosine content of 57.7 mol%. On the b...

journal_title：Biomacromolecules

authors： Kasuya K,Mitomo H,Nakahara M,Akiba A,Kudo T,Doi Y

更新日期：2000-07-01 00:00:00

abstract：:The massive use of antibiotics in healthcare and agriculture has led to their artificial accumulation in natural habitats, which risks the structure and function of the microbial communities in ecosystems, threatens food and water security, and accelerates the development of resistome. Ideally, antibiotics should rema...

journal_title：Biomacromolecules

authors： Zheng W,Anzaldua M,Arora A,Jiang Y,McIntyre K,Doerfert M,Winter T,Mishra A,Ma H,Liang H

更新日期：2020-06-08 00:00:00