Abstract:
:Photodynamic therapy (PDT) has attracted widespread attention in recent years as a noninvasive and highly selective approach for cancer treatment. We have previously reported a significant increase in the 90-day complete response rate when tumor-bearing mice are treated with the epidermal growth factor receptor (EGFR) inhibitor erlotinib prior to PDT with the photosensitizer benzoporphyrin-derivative monoacid ring A (BPD-MA) compared to treatment with PDT alone. To further explore this strategy for anticancer therapy and clinical practice, we tested whether pretreatment with erlotinib also exhibited a synergistic therapeutic effect with a nanocarrier containing the clinically relevant photosensitizer protoporphyrin IX (PpIX). The PpIX was encapsulated within biodegradable polymeric micelles formed from the amphiphilic block copolymer poly(ethylene glycol)-polycaprolactone (PEG-PCL). The obtained micelles were characterized systematically in vitro. Further, an in vitro cytotoxicity study showed that PDT with PpIX loaded micelles did exhibit a synergistic effect when combined with erlotinib pretreatment. Considering the distinct advantages of polymeric nanocarriers in vivo, this study offers a promising new approach for the improved treatment of localized tumors. The strategy developed here has the potential to be extended to other photosensitizers currently used in the clinic for photodynamic therapy.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Yan L,Miller J,Yuan M,Liu JF,Busch TM,Tsourkas A,Cheng Zdoi
10.1021/acs.biomac.7b00274subject
Has Abstractpub_date
2017-06-12 00:00:00pages
1836-1844issue
6eissn
1525-7797issn
1526-4602journal_volume
18pub_type
杂志文章abstract::Starches from WT, lam, and r pea mutants differing in amylopectin/amylose contents (70, 90, and 28% amylopectin, respectively) were used in kinetic studies of pancreatic α-amylase action at 37 °C and for investigations of their supramolecular structure and physicochemical properties during heating. For WT and lam star...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm101070r
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060099n
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500754r
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301125g
更新日期:2012-11-12 00:00:00
abstract::An underwater bioadhesive generally comprises a multiprotein complex that provides a molecular basis for self-assembly. We report here a new class of self-assembling peptide inspired by a 20 kDa barnacle cement protein. Studies on the chemically synthesized 24-residue peptide have revealed that (1) it underwent irreve...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0612236
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300485j
更新日期:2012-07-09 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020100s
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abstract::A comprehensive understanding of the mechanism by which type I collagen (Col) interacts with hydroxyapatite nanoparticles (Hap NPs) in aqueous solutions is a pivotal step for guiding the design of biologically relevant nanocomposites with controlled hierarchical structure. In this paper we use a variety of Hap NPs dif...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01299
更新日期:2019-12-09 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800286v
更新日期:2008-07-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060144r
更新日期:2006-09-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm015525d
更新日期:2001-01-01 00:00:00
abstract::Nowadays, active targeting of nanotherapeutics is a challenging issue. Here, we propose a rational design of a ternary nanoassembly (SAP) composed of nonionic amphiphilic β-cyclodextrins (amphiphilic CD) incorporating pheophorbide (Pheo) as a phototherapeutic and an adamantanyl-folic acid conjugate (Ada-FA) to target ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00306
更新日期:2019-07-08 00:00:00
abstract::N-Alkylated chitosan (NACS) may improve the blood clotting efficiency of chitosan (CS). To study its blood coagulation capability, a series of NACSs with various carbon chain lengths and degrees of substitution (DS) of alkyl groups were synthesized and characterized by FTIR, NMR, elemental analysis, and X-ray diffract...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b01492
更新日期:2018-03-12 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01319
更新日期:2020-02-10 00:00:00
abstract::We present a new design of peptide-polymer conjugates where a polymer chain is covalently linked to the side chain of a helix bundle-forming peptide. The effect of conjugated polymer chains on the peptide structure was examined using a de novo designed three-helix bundle and a photoactive four-helix bundle. Upon attac...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800113g
更新日期:2008-08-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201401s
更新日期:2012-01-09 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901051c
更新日期:2009-12-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0300406
更新日期:2003-11-01 00:00:00
abstract::Poly(butylene adipate-co-terephthalate) (PBAT) was first chemically modified via free radical grafting with maleic anhydride (MA) and the MA-g-PBAT graft copolymer was then used as a matrix material to obtain cellulose nanocrystal (CNC)-reinforced MA-g-PBAT bionanocomposites via reactive extrusion process to accelerat...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b00578
更新日期:2017-07-10 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800557r
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050521k
更新日期:2005-11-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2011-04-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b00743
更新日期:2018-08-13 00:00:00
abstract::Numerous catechol-containing polymers, including biodegradable polymers, are currently heavily discussed for modern biomaterials. However, there is no report combining poly(phosphoester)s (PPEs) with catechols. Adhesive PPEs have been prepared via acyclic diene metathesis polymerization. A novel acetal-protected catec...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b01613
更新日期:2017-03-13 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.7b01313
更新日期:2017-12-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300959h
更新日期:2012-10-08 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049577p
更新日期:2005-01-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0344710
更新日期:2004-05-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm2017146
更新日期:2012-05-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b01567
更新日期:2019-02-11 00:00:00