Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery.

abstract：:Type I collagen is explored heavily for use in biomaterials, but the role of other extracellular matrix components in regulating collagen organization is gaining attention. We show that as the ratio of type III to type I collagen increases, fibril diameter decreases. A mixture of the two collagen types results in a mo...

journal_title：Biomacromolecules

authors： Stuart K,Panitch A

更新日期：2009-01-12 00:00:00

abstract：:Nanoconfined self-assemblies within aerosol nanoparticles and control of the secondary structures are shown here upon ionically complexing poly(L-lysine) (PLL) with dodecylbenzenesulfonic acid (DBSA) surfactant and using solvents chloroform, 1-propanol, or dimethylformamide. Different solvent volatilities and drying t...

journal_title：Biomacromolecules

authors： Rahikkala A,Junnila S,Vartiainen V,Ruokolainen J,Ikkala O,Kauppinen E,Raula J

更新日期：2014-07-14 00:00:00

abstract：:The supramolecular organization of self-assembled stoichiometric complexes formed by dodecyltrimethylammonium cations and ionized poly(gamma-glutamic) acid has been investigated in chloroform solution. Atomistic molecular dynamics simulations have been performed considering three different starting conformations for t...

journal_title：Biomacromolecules

authors： Zanuy D,Alemán C

更新日期：2007-02-01 00:00:00

abstract：:Presently there is great interest in the construction of nanostructures from DNA fragments. Here we report the preparation of much larger helical textures with different shapes from pure DNA fragments. We have observed them while preparing crystals of the dodecamer d(AAAAAATTTTTT), which only contains adenine and thym...

journal_title：Biomacromolecules

authors： Subirana JA,Creixell M,Baldini R,Campos JL

更新日期：2008-01-01 00:00:00

abstract：:Generation of bioenergy, new functional polymers, or chemicals and biomaterials from hemicelluloses are important uses for biomass. In this paper, a novel functional biopolymer with carbon-carbon double bond and carboxyl groups was prepared by a homogeneous esterification of xylan-rich hemicelluloses (XH) with maleic ...

journal_title：Biomacromolecules

authors： Peng XW,Ren JL,Sun RC

更新日期：2010-12-13 00:00:00

abstract：:The mechanical rigidity and degradation rate of hydrogels utilized as cell transplantation vehicles have been regarded as critical factors in new tissue formation. However, conventional approaches to accelerate the degradation rate of gels deteriorate their function as a mechanical support in parallel. We hypothesized...

journal_title：Biomacromolecules

authors： Kong HJ,Kaigler D,Kim K,Mooney DJ

更新日期：2004-09-01 00:00:00

abstract：:We examined the antibacterial and hemolytic activities in a series of amphiphilic block and random copolymers of poly(vinyl ether) derivatives prepared by base-assisting living cationic polymerization. Block and random amphiphilic copolymers with similar monomer compositions showed the same level of activity against ...

journal_title：Biomacromolecules

authors： Oda Y,Kanaoka S,Sato T,Aoshima S,Kuroda K

更新日期：2011-10-10 00:00:00

abstract：:Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens. Here we report on a generic polymer-protein ligation strategy to formulate protein antigens into reversible polymeric conjugates for ...

journal_title：Biomacromolecules

authors： Lybaert L,Vanparijs N,Fierens K,Schuijs M,Nuhn L,Lambrecht BN,De Geest BG

更新日期：2016-03-14 00:00:00

abstract：:Protein transduction domains (PTDs) that readily transverse cellular membranes are of great interest and are attractive tools for the intracellular delivery of bioactive molecules. Learning to program synthetic polymers and oligomers with the appropriate chemical information to capture adequately the biological activi...

journal_title：Biomacromolecules

authors： Tezgel AÖ,Telfer JC,Tew GN

更新日期：2011-08-08 00:00:00

abstract：:This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...

journal_title：Biomacromolecules

authors： Dubruel P,Dekie L,Schacht E

更新日期：2003-09-01 00:00:00

abstract：:Silk fibroin hydrogels with tunable properties could be obtained from aqueous fibroin solutions (4.2 w/v %) in a short period of time. This was achieved by the addition of ethylene glycol diglycidyl ether (EGDE) into the reaction solution. Introduction of EGDE cross-links between the fibroin molecules decreases the mo...

journal_title：Biomacromolecules

authors： Karakutuk I,Ak F,Okay O

更新日期：2012-04-09 00:00:00

abstract：:Images of high methoxyl orange pectin deposited from solution and high methoxyl sugar acid gels (HMSAG) were obtained by atomic force microscopy (AFM) in the tapping mode. For the first time, images of pectin deposited from water revealed that the transition from pectin networks to individual molecules or aggregates t...

journal_title：Biomacromolecules

authors： Fishman ML,Cooke PH,Chau HK,Coffin DR,Hotchkiss AT Jr

更新日期：2007-02-01 00:00:00

abstract：:We have investigated the thermodynamic and dynamic behavior of multistranded β-lactoglobulin protein fibrils in water, by combining static, dynamic, and depolarized dynamic light scattering (SLS, DLS, DDLS), small angle neutron scattering (SANS), rheology, and cryogenic transmission electron microscopy (cryo-TEM). We ...

journal_title：Biomacromolecules

authors： Bolisetty S,Harnau L,Jung JM,Mezzenga R

更新日期：2012-10-08 00:00:00

abstract：:Nanoparticles (NPs) with high drug loading and pH-responsivity were prepared by nanoprecipitation of a hydrophobic polymer-drug conjugate (PDC). The PDC, polylactide-graft-doxorubicin (PLA-g-DOX), was synthesized by azide-alkyne click reaction to transform acetylene-functionalized PLA into PLA-graft-aldehyde (PLA-g-AL...

journal_title：Biomacromolecules

authors： Yu Y,Chen CK,Law WC,Weinheimer E,Sengupta S,Prasad PN,Cheng C

更新日期：2014-02-10 00:00:00

abstract：:The synthesis of core-shell star copolymers via living free radical polymerization provides a convenient route to three-dimensional nanostructures having a poly(ethylene glycol) outer shell, a hydrophilic inner shell bearing reactive functional groups, and a central hydrophobic core. By starting with well-defined line...

journal_title：Biomacromolecules

authors： Fukukawa K,Rossin R,Hagooly A,Pressly ED,Hunt JN,Messmore BW,Wooley KL,Welch MJ,Hawker CJ

更新日期：2008-04-01 00:00:00

abstract：:In the present study we describe the synthesis, wet spinning, mechanical testing, and degradation of poly(urethane urea)s (PUURs) intended for clinical use in anterior cruciate ligament (ACL) reconstruction. The effects of soft segment chemical composition and molar mass and the kind of diamine chain extender on the m...

journal_title：Biomacromolecules

authors： Gisselfält K,Edberg B,Flodin P

更新日期：2002-09-01 00:00:00

abstract：:We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs). The obtained particles exhibit no toxicity while maintaining the capability to deliver a small interfering RNA sequence (siRNA) targeting the anti-apoptotic factor, survivin, in prostate c...

journal_title：Biomacromolecules

authors： Cavalieri F,Beretta GL,Cui J,Braunger JA,Yan Y,Richardson JJ,Tinelli S,Folini M,Zaffaroni N,Caruso F

更新日期：2015-07-13 00:00:00

abstract：:Major ampullate silk, also known as dragline silk, is one of the strongest biomaterials known. This silk is composed of two proteins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2). Only partial cDNA sequences have been obtained for these proteins, and these sequences are toward the C-termin...

journal_title：Biomacromolecules

authors： Motriuk-Smith D,Smith A,Hayashi CY,Lewis RV

更新日期：2005-11-01 00:00:00

abstract：:The extracellular matrix is an environment rich with structural, mechanical, and molecular signals that can impact cell biology. Traditional approaches in hydrogel biomaterial design often rely on modifying the concentration of cross-linking groups to adjust mechanical properties. However, this strategy provides limit...

journal_title：Biomacromolecules

authors： Pedron S,Pritchard AM,Vincil GA,Andrade B,Zimmerman SC,Harley BA

更新日期：2017-04-10 00:00:00

abstract：:The design of functional systems with sizes in the nanometer range is a key challenge in fields such as biomedicine, nanotechnology, and engineering. Some of the most promising materials nowadays consist of self-assembling peptides or peptide-polymer hybrid materials because of their versatility and the resulting prop...

journal_title：Biomacromolecules

authors： Mikhalevich V,Craciun I,Kyropoulou M,Palivan CG,Meier W

更新日期：2017-11-13 00:00:00

abstract：:The islet amyloid polypeptide (IAPP) is a regulatory peptide that can aggregate into fibrillar structures associated with type 2 diabetes. In this study, the IAPP21-27 segment was modified with a biotin linker at the N-terminus (Btn-GNNFGAIL) to immobilize peptide fibrils on streptavidin-coated surfaces. Key residues ...

journal_title：Biomacromolecules

authors： John T,Bandak J,Sarveson N,Hackl C,Risselada HJ,Prager A,Elsner C,Abel B

更新日期：2020-02-10 00:00:00

abstract：:We investigated the rheological properties and the penetration of differently sized carboxylated nanoparticles in pig pulmonary mucus, on different distance and time scales. Nanoparticles were either mechanically mixed into the mucus samples or deposited as an aerosol, the latter resembling a more physiologically rele...

journal_title：Biomacromolecules

authors： Murgia X,Pawelzyk P,Schaefer UF,Wagner C,Willenbacher N,Lehr CM

更新日期：2016-04-11 00:00:00

abstract：:The outcome for glioblastoma patients remains dismal for its invariably recrudesces within 2 cm of the resection cavity. Local immunotherapy has the potential to eradicate the residual infiltrative component of these tumors. Here, we report the development of a biodegradable hydrogel containing therapeutic T lymphocyt...

journal_title：Biomacromolecules

authors： Tsao CT,Kievit FM,Ravanpay A,Erickson AE,Jensen MC,Ellenbogen RG,Zhang M

更新日期：2014-07-14 00:00:00

abstract：:The determination of the collagen and glycosaminoglycan (GAG) contents of native and particularly bioengineered tissues is of considerable interest because the collagen-to-GAG ratio determines the water content of the tissue, which is crucial regarding its mechanical properties. (1)H NMR spectroscopy subsequent to the...

journal_title：Biomacromolecules

authors： Riemer T,Nimptsch A,Nimptsch K,Schiller J

更新日期：2012-07-09 00:00:00

abstract：:We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded ...

journal_title：Biomacromolecules

authors： Zhang H,Mardyani S,Chan WC,Kumacheva E

更新日期：2006-05-01 00:00:00

abstract：:First generation, photocrosslinkable dendrimers consisting of natural metabolites (i.e., succinic acid, glycerol, and beta-alanine) and nonimmunogenic poly(ethylene glycol) (PEG) were synthesized divergently in high yields using ester and carbamate forming reactions. Aqueous solutions of these dendrimers were photocro...

journal_title：Biomacromolecules

authors： Degoricija L,Bansal PN,Söntjens SH,Joshi NS,Takahashi M,Snyder B,Grinstaff MW

更新日期：2008-10-01 00:00:00

abstract：:These studies illustrate synthetic paths to covalently attach T1 and Φ11 bacteriophages (phages) to inert polymeric surfaces while maintaining the bacteriophage's biological activities capable of killing deadly human pathogens. The first step involved the formation of acid (COOH) groups on polyethylene (PE) and polyte...

journal_title：Biomacromolecules

authors： Pearson HA,Sahukhal GS,Elasri MO,Urban MW

更新日期：2013-05-13 00:00:00

abstract：:Partially benzylamidated, amphipathic poly(gamma-glutamic acid) (BzPGA) was synthesized from poly(gamma-glutamic acid) (PGA) and benzylamine by direct amidation in dimethyl sulfoxide (DMSO). Benzylamine and PGA were heated in DMSO for 1 to 26 h at temperatures between 110 and 130 degrees C, producing derivatives of va...

journal_title：Biomacromolecules

authors： Novak L,Banyai I,Fleischer-Radu JE,Borbély J

更新日期：2007-05-01 00:00:00

abstract：:The ability of small interfering RNA (siRNA) to efficiently silence the expression of specific genes provides the basis for exciting new therapies based on RNA interference (RNAi). The efficient intracellular delivery of siRNA from cell uptake through the endosomal trafficking pathways into the cytoplasm remains a sig...

journal_title：Biomacromolecules

authors： Convertine AJ,Diab C,Prieve M,Paschal A,Hoffman AS,Johnson PH,Stayton PS

更新日期：2010-11-08 00:00:00

abstract：:Silk fibroin (SF) protein, produced by silkworm Bombyx mori, is a promising biomaterial, while sophorolipid (SL) is an amphiphilic functional biosurfactant synthesized by nonpathogenic yeast Candida bombicola. SL is a mixture of two forms, acidic (ASL) and lactonic (LSL), which when added to SF results in accelerated ...

journal_title：Biomacromolecules

authors： Dubey P,Kumar S,Aswal VK,Ravindranathan S,Rajamohanan PR,Prabhune A,Nisal A

更新日期：2016-10-10 00:00:00