Abstract:
:There is increasing appreciation among researchers and clinicians of the value of investigating biology and pathobiology at the level of cellular kinase (kinome) activity. Kinome analysis provides valuable opportunity to gain insights into complex biology (including disease pathology), identify biomarkers of critical phenotypes (including disease prognosis and evaluation of therapeutic efficacy), and identify targets for therapeutic intervention through kinase inhibitors. The growing interest in kinome analysis has fueled efforts to develop and optimize technologies that enable characterization of phosphorylation-mediated signaling events in a cost-effective, high-throughput manner. In this review, we highlight recent advances to the central technologies currently available for kinome profiling and offer our perspectives on the key challenges remaining to be addressed.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Baharani A,Trost B,Kusalik A,Napper Sdoi
10.1042/BST20160163subject
Has Abstractpub_date
2017-02-08 00:00:00pages
65-77issue
1eissn
0300-5127issn
1470-8752pii
BST20160163journal_volume
45pub_type
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