Abstract:
:The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Higgs R,Jefferies CAdoi
10.1042/BST0360453subject
Has Abstractpub_date
2008-06-01 00:00:00pages
453-8issue
Pt 3eissn
0300-5127issn
1470-8752pii
BST0360453journal_volume
36pub_type
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