Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe.

abstract：:Vitamin E is an important nutrient with antioxidant and non-antioxidant functions, and certain evidence suggests that it has a cardiovascular protective role. It is therefore important to maintain an optimal vitamin E status. In the present paper, a number of MS applications to monitor vitamin E status and its interac...

journal_title：Biochemical Society transactions

authors： Lodge JK

更新日期：2008-10-01 00:00:00

abstract：:Exosomes are small extracellular vesicles which stem from endosomes fusing with the plasma membrane; they contain lipids, proteins and RNAs that are able to modify receiving cells. Functioning of the brain relies on synapses, and certain patterns of synaptic activity can change the strength of responses at sparse grou...

journal_title：Biochemical Society transactions

authors： Chivet M,Javalet C,Hemming F,Pernet-Gallay K,Laulagnier K,Fraboulet S,Sadoul R

更新日期：2013-02-01 00:00:00

abstract：:Genomic DNA is constantly under threat from intracellular and environmental factors that damage its chemical structure. Uncorrected DNA damage may impede cellular propagation or even result in cell death, making it critical to restore genomic integrity. Decades of research have revealed a wide range of mechanisms thro...

journal_title：Biochemical Society transactions

authors： Ghodke H,Ho H,van Oijen AM

更新日期：2018-02-19 00:00:00

abstract：:Despite decades of research, many aspects of the biology of Mycobacterium tuberculosis remain unclear, and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem. Important discoveries linking the metabolism of M. tube...

journal_title：Biochemical Society transactions

authors： Beste DJ,McFadden J

更新日期：2010-10-01 00:00:00

abstract：:The 26S proteasome is a non-lysosomal protease in the cytosol and nucleus of eukaryotic cells. Its main function is to mediate ubiquitin-dependent proteolysis. The 26S proteasome is a multimeric complex composed by the 20S proteasome CP (core particle) and the 19S RPs (regulatory particles). Although the atomic struct...

journal_title：Biochemical Society transactions

authors： Matias AC,Ramos PC,Dohmen RJ

更新日期：2010-02-01 00:00:00

abstract：:Rapid interphase chromosome territory repositioning appears to function through the action of nuclear myosin and actin, in a nuclear motor complex. We have found that chromosome repositioning when cells leave the cell cycle is not apparent in cells that have mutant lamin A or that are lacking emerin. We discuss the po...

journal_title：Biochemical Society transactions

authors： Mehta IS,Elcock LS,Amira M,Kill IR,Bridger JM

更新日期：2008-12-01 00:00:00

abstract：:The analysis of deep sequencing data allows for a genome-wide overview of all the small RNA molecules (the 'sRNome') that are present in a single organism. In the present paper, we review the processing of CRISPR (clustered regularly interspaced short palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and t...

journal_title：Biochemical Society transactions

authors： Richter H,Mohr S,Randau L

更新日期：2013-02-01 00:00:00

abstract：:Approximately 30-50% of individuals who are allergic to natural rubber latex (NRL) show an associated hypersensitivity to some plant-derived foods, especially freshly consumed fruits. This association of latex allergy and allergy to plant-derived foods is called latex-fruit syndrome. An increasing number of plant sour...

journal_title：Biochemical Society transactions

authors： Wagner S,Breiteneder H

更新日期：2002-11-01 00:00:00

abstract：:Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis...

journal_title：Biochemical Society transactions

authors： De Coppi P

更新日期：2014-06-01 00:00:00

abstract：:A combination of EXAFS, transmission electron microscopy and energy-dispersive X-ray was used to conduct a molecular and atomic analysis of the uranium complexes formed by Acidithiobacillus ferrooxidans. The results demonstrate that this bacterium accumulates uranium as phosphate compounds. We suggest that at toxic le...

journal_title：Biochemical Society transactions

authors： Merroun M,Hennig C,Rossberg A,Geipel G,Reich T,Selenska-Pobell S

更新日期：2002-08-01 00:00:00

abstract：:The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the 'hallmarks o...

journal_title：Biochemical Society transactions

authors： Lochhead PA,Gilley R,Cook SJ

更新日期：2012-02-01 00:00:00

abstract：:There is clear evidence implicating oxidative stress in the pathology of many different neurodegenerative diseases. ROS (reactive oxygen species) are the primary mediators of oxidative stress and many of the aggregating proteins and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a k...

journal_title：Biochemical Society transactions

authors： Tabner BJ,El-Agnaf OM,German MJ,Fullwood NJ,Allsop D

更新日期：2005-11-01 00:00:00

abstract：:Structure-based design has gained credibility as a valuable component of the modern drug discovery process. The technique of SSNMR (solid-state NMR) promises to be a useful counterpart to the conventional experimental techniques of X-ray crystallography and solution-state NMR for providing structural features of drug ...

journal_title：Biochemical Society transactions

authors： Middleton DA

更新日期：2007-11-01 00:00:00

abstract：:The revolution of genomics and growth of systems biology urged the creation of synthetic biology, an engineering discipline aiming at recreating and reprogramming cellular functions for industrial needs. There has been a huge effort in synthetic biology to develop versatile and programmable genetic regulators that wou...

journal_title：Biochemical Society transactions

authors： Apura P,Domingues S,Viegas SC,Arraiano CM

更新日期：2019-10-31 00:00:00

abstract：:TRP (transient receptor potential) channels comprise a superfamily of non-selective cation channels with at least seven subfamilies. The variety of subfamilies corresponds to the differences in the activation mechanisms and functions. TRPM3 (TRP melastatin 3) and TRPV4 (TRP vanilloid 3) have been characterized as cati...

journal_title：Biochemical Society transactions

authors： Harteneck C,Reiter B

更新日期：2007-02-01 00:00:00

abstract：:The cell-cycle-co-ordinated initiation of chromosomal replication is highly regulated. The ordered assembly and conformational change of specific proteins at the replication origin are crucial to the process of replication initiation. In Escherichia coli, ATP-DnaA molecules form multimeric complexes with the chromosom...

journal_title：Biochemical Society transactions

authors： Katayama T

更新日期：2008-02-01 00:00:00

abstract：:SOEs (sulfite-oxidizing enzymes) are physiologically vital and occur in all forms of life. During the catalytic cycle, the five-co-ordinate square pyramidal oxo-molybdenum active site passes through the Mo(V) state, and intimate details of the structure can be obtained from variable frequency pulsed EPR spectroscopy t...

journal_title：Biochemical Society transactions

authors： Enemark JH,Astashkin AV,Raitsimring AM

更新日期：2008-12-01 00:00:00

abstract：:In this study the network of ATP-consuming and -producing reactions, interacting via the cytosolic ATP/ADP+P(i) system, was studied for the first time in an intact organ, the isolated perfused rat liver, using top-down metabolic-control analysis. Flux control in the metabolically resting state (only oxidative phosphor...

journal_title：Biochemical Society transactions

authors： Soboll S,Brown GC

更新日期：2000-02-01 00:00:00

abstract：:The statins are inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (HMG-CoAR), and are utilized to decrease levels of atherogenic lipoproteins in patients with, or who are at high risk of, cardiovascular disease. This study describes the inhibition of a recombinant, catalytic fragment of human HMG-CoAR b...

journal_title：Biochemical Society transactions

authors： Holdgate GA,Ward WH,McTaggart F

更新日期：2003-06-01 00:00:00

abstract：:Microscopes are used to characterize small objects with the help of probes that interact with the specimen, such as photons and electrons in optical and electron microscopies, respectively. In atomic force microscopy (AFM), the probe is a nanometric tip located at the end of a microcantilever which palpates the specim...

journal_title：Biochemical Society transactions

authors： Moreno-Madrid F,Martín-González N,Llauró A,Ortega-Esteban A,Hernando-Pérez M,Douglas T,Schaap IA,de Pablo PJ

更新日期：2017-04-15 00:00:00

abstract：:PTB (polypyrimidine tract-binding protein) is a repressive regulator of alternative splicing. We have investigated the role of PTB in three model alternative splicing systems. In the alpha-actinin gene, PTB represses the SM (smooth muscle) exon by binding to key sites in the polypyrimidine tract. Repressive binding to...

journal_title：Biochemical Society transactions

authors： Spellman R,Rideau A,Matlin A,Gooding C,Robinson F,McGlincy N,Grellscheid SN,Southby J,Wollerton M,Smith CW

更新日期：2005-06-01 00:00:00

abstract：:Nitric oxide is an intermediate of denitrification, and is one of the radical species deployed by macrophages against invading pathogens, therefore bacterial responses to NO are of considerable importance. The Escherichia coli flavorubredoxin and its associated oxidoreductase reduce NO to nitrous oxide under anaerobic...

journal_title：Biochemical Society transactions

authors： Tucker N,D'autréaux B,Spiro S,Dixon R

更新日期：2005-02-01 00:00:00

abstract：:Ribonucleic acids are driving a multitude of biological processes where they act alone or in complex with proteins (ribonucleoproteins, RNP). To understand these processes both structural and mechanistic information about RNA is necessary. Due to their conformational plasticity RNA pose a challenge for mainstream stru...

journal_title：Biochemical Society transactions

authors： Sreemantula AK,Marchanka A

更新日期：2020-06-30 00:00:00

abstract：:Molecular bioenergetics deals with the construction, function and regulation of the powerhouses of life. The present overview sketches scenes and actors, farsighted goals and daring hypotheses, meticulous tool-making, painstaking benchwork, lucky discovery, serious scepticism, emphatic believing and strong characters ...

journal_title：Biochemical Society transactions

authors： Junge W

更新日期：2013-10-01 00:00:00

abstract：:Brain development is a tightly controlled process that depends upon differentiation and function of neurons to allow for the formation of functional neural networks. Mutation of genes encoding structural proteins is well recognized as causal for neurodevelopmental disorders (NDDs). Recent studies have shown that aberr...

journal_title：Biochemical Society transactions

authors： Sartor F,Anderson J,McCaig C,Miedzybrodzka Z,Müller B

更新日期：2015-12-01 00:00:00

abstract：:Native disulphide bonds are essential for the structure and function of many membrane and secretory proteins. Disulphide bonds are formed, reduced and isomerized in the endoplasmic reticulum of mammalian cells by a family of oxidoreductases, which includes protein disulphide isomerase (PDI), ERp57, ERp72, P5 and PDIR....

journal_title：Biochemical Society transactions

authors： Jessop CE,Chakravarthi S,Watkins RH,Bulleid NJ

更新日期：2004-11-01 00:00:00

abstract：:The transcript is populated with numerous overlapping codes that regulate all steps of gene expression. Deciphering these codes is very challenging due to the large number of variables involved, the non-modular nature of the codes, biases and limitations in current experimental approaches, our limited knowledge in gen...

journal_title：Biochemical Society transactions

authors： Bahiri-Elitzur S,Tuller T

更新日期：2020-08-28 00:00:00

abstract：:Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton pyrophosphatase (V-H(+)-PPase or VP1), the vacuolar proton ATPase (V-H(+)-ATPase) or both, maintain their acidity. A vacuolar transporter ch...

journal_title：Biochemical Society transactions

authors： Lander N,Cordeiro C,Huang G,Docampo R

更新日期：2016-02-01 00:00:00

abstract：:Genes encoding an alpha-oxygenase, in Nicotiana tabacum and Arabidopsis thaliana, have been recently isolated. However, the reaction mechanism of the enzyme has not so far been elucidated. In this study, a cDNA encoding the fatty acid alpha-oxygenase gene in rice plants was isolated. The deduced amino acid sequence sh...

journal_title：Biochemical Society transactions

authors： Koeduka T,Matsui K,Akakabe Y,Kajiwara T

更新日期：2000-12-01 00:00:00

abstract：:Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to av...

journal_title：Biochemical Society transactions

authors： Smith LM,May RC

更新日期：2013-04-01 00:00:00