Gout and Osteoarthritis: Associations, Pathophysiology, and Therapeutic Implications.

Abstract:

:Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of proinflammatory monosodium urate crystals in joints. Clinicians have long noted a predilection for both diseases to occur in the same joints. In this review, we provide an overview into research elucidating possible biochemical, mechanical, and immunological relationships between gout and OA. We additionally consider the potential implications of these relationships for OA treatment.

journal_name

Curr Rheumatol Rep

authors

Yokose C,Chen M,Berhanu A,Pillinger MH,Krasnokutsky S

doi

10.1007/s11926-016-0613-9

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

65

issue

10

eissn

1523-3774

issn

1534-6307

pii

10.1007/s11926-016-0613-9

journal_volume

18

pub_type

杂志文章,评审
  • Takayasu Arteritis: Recent Developments.

    abstract:PURPOSE OF REVIEW:Takayasu arteritis (TA) is a granulomatous inflammatory disorder that affects large vessels, especially aorta and its proximal branches. Its diagnosis can be extremely challenging due to the non-specificity of the systemic inflammatory manifestations during the early phase of the disease and usually f...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-019-0848-3

    authors: Zaldivar Villon MLF,de la Rocha JAL,Espinoza LR

    更新日期:2019-07-18 00:00:00

  • Regulatory T Cells in SLE: Biology and Use in Treatment.

    abstract::T regulatory cells (Tregs) represent a phenotypically and functionally heterogeneous group of lymphocytes that exert immunosuppressive activities on effector immune responses. Tregs play a key role in maintaining immune tolerance and homeostasis through diverse mechanisms which involve interactions with components of ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-016-0616-6

    authors: Giang S,La Cava A

    更新日期:2016-11-01 00:00:00

  • Acupuncture in the treatment of rheumatic diseases.

    abstract::Acupuncture has been used for millennia in traditional Chinese medicine as a technique believed to restore the balance of energy in the body caused by disease through the use of needles inserted into specific points or energy channels. This energy is called the de qi. The use of acupuncture for the treatment of pain i...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-012-0295-x

    authors: Amezaga Urruela M,Suarez-Almazor ME

    更新日期:2012-12-01 00:00:00

  • Cutaneous vasculitis.

    abstract::Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-005-0037-4

    authors: Hayat S,Berney SM

    更新日期:2005-08-01 00:00:00

  • Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis.

    abstract::Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a multisystem disease, the pathogenesis of which remains undetermined. Following two microarray studies, we reported the differential expression of 88 human genes in patients with CFS; 85 of these genes were upregulated and 3 were downregulated. The top fu...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章

    doi:10.1007/s11926-008-0079-5

    authors: Kerr JR

    更新日期:2008-12-01 00:00:00

  • Anxiety and Mood Disorders in Systemic Lupus Erythematosus: Current Insights and Future Directions.

    abstract:PURPOSE OF REVIEW:Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically synthesize recent literature on these conditions in adults with SLE...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-018-0797-2

    authors: Tisseverasinghe A,Peschken C,Hitchon C

    更新日期:2018-11-12 00:00:00

  • Economic Theory and Self-Reported Measures of Presenteeism in Musculoskeletal Disease.

    abstract::This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-016-0600-1

    authors: Jones C,Payne K,Gannon B,Verstappen S

    更新日期:2016-08-01 00:00:00

  • Idiopathic Pericarditis-an Autoinflammatory Disease?

    abstract:PURPOSE OF THE REVIEW:Idiopathic acute and recurrent pericarditis are rare diseases of unknown origin. Here, we review trigger factors, pathomechanism, and treatment options for acute and recurrent pericarditis. RECENT FINDINGS:Acute pericarditis can be triggered by viral infections, myocardial ischemia, heart cathete...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-019-0820-2

    authors: Blank N,Lorenz HM

    更新日期:2019-03-09 00:00:00

  • The Paradox of Bone Formation and Bone Loss in Ankylosing Spondylitis: Evolving New Concepts of Bone Formation and Future Trends in Management.

    abstract:PURPOSE OF REVIEW:The purpose of the study is to briefly review the molecular mechanisms that leads to structural damage in ankylosing spondylitis (AS), defined as new bone formation resulting in complete or incomplete ankylosis of the spine, and the impact of treatment with biologics to retard this process. RECENT FI...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-017-0644-x

    authors: Magrey MN,Khan MA

    更新日期:2017-04-01 00:00:00

  • Genetics of hyperuricemia and gout: implications for the present and future.

    abstract::Gout is the most common inflammatory arthropathy and occurs in the setting of elevated serum urate levels. Gout is also known to be associated with multiple comorbidities including cardiovascular disease and the metabolic syndrome. Recent advances in research have increased our understanding and improved our knowledge...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-012-0309-8

    authors: George RL,Keenan RT

    更新日期:2013-02-01 00:00:00

  • Bone loss in rheumatoid arthritis: systemic, periarticular, and focal.

    abstract::Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of th...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-012-0253-7

    authors: Deal C

    更新日期:2012-06-01 00:00:00

  • The clinical laboratory evaluation of the patient with noninflammatory myopathy.

    abstract::The investigations used to diagnose an inflammatory muscle disease include history and physical examination, evaluation of serum levels of enzymes derived from skeletal muscle, electromyography, magnetic resonance imaging, and muscle histology. The evaluation of patients who may have noninflammatory myopathy includes,...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-001-0035-0

    authors: Wortmann RL,Vladutiu GD

    更新日期:2001-08-01 00:00:00

  • Pain syndromes in children.

    abstract::The pediatric rheumatologist cares for children who may have a wide variety of causes of musculoskeletal pain. These include such diverse conditions as arthritis, low-back pain, hypermobility, metabolic bone pain, and amplified pain syndromes such as complex regional pain syndrome and fibromyalgia. This review examine...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-000-0072-0

    authors: Sherry DD

    更新日期:2000-08-01 00:00:00

  • Spondyloarthritis and the microbiome: new insights from an ancient hypothesis.

    abstract::The human microbiome, which represents the total collection of microorganisms (and their genes) inhabiting the human body, has increasingly been recognized as a potential key factor in the development of autoimmune disease. Multiple studies suggest that the microbiome has significant influence on immune homeostasis, w...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-014-0487-7

    authors: Manasson J,Scher JU

    更新日期:2015-02-01 00:00:00

  • The scleroderma kidney: progress in risk factors, therapy, and prevention.

    abstract::Scleroderma renal crisis (SRC) is characterized by malignant hypertension, oliguric/anuric acute renal failure, and important mortality, with a 5-year survival rate of 65%. SRC occurs in 2% to 5% of patients with systemic sclerosis (SSc), particularly those with diffuse cutaneous SSc in the first years of disease evol...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-010-0145-7

    authors: Bussone G,Bérezné A,Pestre V,Guillevin L,Mouthon L

    更新日期:2011-02-01 00:00:00

  • New insights into the biology and pathobiology of beta2-glycoprotein I.

    abstract::β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms b...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-010-0151-9

    authors: Giannakopoulos B,Mirarabshahi P,Krilis SA

    更新日期:2011-02-01 00:00:00

  • Exercise for patients with fibromyalgia: risks versus benefits.

    abstract::Although exercise in the form of stretching, strength maintenance, and aerobic conditioning is generally considered beneficial to patients with fibromyalgia (FM), there is no reliable evidence to explain why exercise should help alleviate the primary symptom of FM, namely pain. Study results are varied and do not prov...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-001-0009-2

    authors: Clark SR,Jones KD,Burckhardt CS,Bennett R

    更新日期:2001-04-01 00:00:00

  • Neurologic manifestations of the antiphospholipid syndrome.

    abstract::Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role ...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-007-0004-3

    authors: Roldan JF,Brey RL

    更新日期:2007-05-01 00:00:00

  • Innate Immune Responses and Osteoarthritis.

    abstract:PURPOSE OF THE REVIEW:Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory respo...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-017-0672-6

    authors: Kalaitzoglou E,Griffin TM,Humphrey MB

    更新日期:2017-08-01 00:00:00

  • Cell death in osteoarthritis.

    abstract::To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apop...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-008-0007-8

    authors: Del Carlo M Jr,Loeser RF

    更新日期:2008-01-01 00:00:00

  • Gene therapies for osteoarthritis.

    abstract::Osteoarthritis (OA) is a major health problem in urgent need of better treatment. Gene therapy offers to meet this need. Of the different strategies for using gene therapy in OA, local gene transfer to synovium is in the most advanced stage of development. Local gene transfer brings several advantages, including a foc...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-004-0081-5

    authors: Evans CH

    更新日期:2004-02-01 00:00:00

  • Epidemiology of spondyloarthritis: a review.

    abstract::The classification of Spondyloarthritis (SpA) has been revised with the introduction of the ASAS classification criteria. Although this has best been described in ankylosing spondylitis and psoriatic arthritis, there are population studies evaluating the epidemiology of the different subgroups of SpA. In this paper, w...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-013-0351-1

    authors: Bakland G,Nossent HC

    更新日期:2013-09-01 00:00:00

  • Imaging in Spondyloarthritis: Controversies in Recognition of Early Disease.

    abstract::Advanced imaging has become essential for recognition of clinically suspected early spondyloarthritis. This report summarizes recent progress towards a data-driven comprehensive definition of a positive sacroiliac joint MRI in axial spondyloarthritis, which incorporates contextual information provided by structural le...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-016-0607-7

    authors: Weber U,Jurik AG,Lambert RG,Maksymowych WP

    更新日期:2016-09-01 00:00:00

  • Bone health and systemic lupus erythematosus.

    abstract::Osteoporosis is a potentially preventable condition frequently encountered in patients with systemic lupus erythematosus (SLE). Bone loss in SLE is likely a multi- factorial process involving traditional osteoporosis risk factors along with lupus-related factors. Recognizing potential contributors to bone loss in pati...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-005-0056-1

    authors: Lee C,Ramsey-Goldman R

    更新日期:2005-12-01 00:00:00

  • Large epidemiologic studies of gout: challenges in diagnosis and diagnostic criteria.

    abstract::Large epidemiologic studies of gout can improve insight into the etiology, pathology, impact, and management of the disease. Identification of monosodium urate monohydrate crystals is considered the gold standard for diagnosis, but its application is often not possible in large studies. Therefore, under such circumsta...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章

    doi:10.1007/s11926-010-0157-3

    authors: Wijnands JM,Boonen A,Arts IC,Dagnelie PC,Stehouwer CD,van der Linden S

    更新日期:2011-04-01 00:00:00

  • Therapeutic approaches in myositis.

    abstract::The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not b...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-011-0172-z

    authors: Aggarwal R,Oddis CV

    更新日期:2011-06-01 00:00:00

  • Genetics of systemic sclerosis-associated pulmonary arterial hypertension: recent progress and current concepts.

    abstract::Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Although there are screening tests for PAH, such as carbon monoxide diffusing capacity and Doppler echocardiography, these tests are far from perfect, patients are still identified late in the course of disease, and the un...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-009-0013-5

    authors: Shah SJ

    更新日期:2009-04-01 00:00:00

  • Ayurvedic medicine for rheumatoid arthritis.

    abstract::Ayurvedic medicine is the traditional medicine of India, which originated over 5,000 years ago. Parts of this alternative medical system have become increasingly popular worldwide as patients seek approaches to medical care that they perceive as more holistic and less toxic than those offered by conventional Western m...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-014-0435-6

    authors: Basnyat S,Kolasinski SL

    更新日期:2014-08-01 00:00:00

  • Familial autoimmunity and the idiopathic inflammatory myopathies.

    abstract::Many lines of evidence suggest that autoimmune diseases result from chronic immune activation following environmental exposures in genetically susceptible individuals. A genetic basis for autoimmunity is supported by twin and family studies, candidate gene investigations, animal models, and whole genome microsatellite...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-000-0080-0

    authors: Shamim EA,Miller FW

    更新日期:2000-06-01 00:00:00

  • Cardiovascular Safety of Urate Lowering Therapies.

    abstract:PURPOSE OF REVIEW:The effect of urate lowering treatment (ULT) on cardiovascular (CV) risk and mortality in gout has been a topic of interest. This review discusses the CV effect of ULT and comparative CV safety among ULT agents. RECENT FINDINGS:The mechanism linking gout with CV risk is not fully understood but seems...

    journal_title:Current rheumatology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11926-019-0843-8

    authors: Kang EH,Kim SC

    更新日期:2019-07-24 00:00:00