Abstract：
PURPOSE OF REVIEW:The purpose of the study is to briefly review the molecular mechanisms that leads to structural damage in ankylosing spondylitis (AS), defined as new bone formation resulting in complete or incomplete ankylosis of the spine, and the impact of treatment with biologics to retard this process. RECENT FINDINGS:The understanding of molecular mechanisms leading to new bone formation in AS has significantly improved but is still incomplete. Availability of biologics has greatly enhanced the treatment of patients with AS, but its impact on slowing the structural damage is still a matter of debate, although a few observational studies have shown that long term use of TNF-α blockers may slow radiographic progression. The availability of newer biologics targeting IL-17/1L23 has shown some promising results in slowing radiographic progression in AS. Although the availability of TNF-inhibitors has greatly enhanced the treatment options for patients with AS, their impact on slowing the structural damage is still not clearly established. However, preliminary results using newer biologics targeting IL-17/1L23 axis are more encouraging but longer follow-up is needed.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Magrey MN,Khan MAdoi
10.1007/s11926-017-0644-xsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
17issue
4eissn
1523-3774issn
1534-6307pii
10.1007/s11926-017-0644-xjournal_volume
19pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Optimal management of anxiety and mood disorders in patients with systemic lupus erythematosus (SLE) is limited by an incomplete understanding of their pathophysiology and a lack of treatment guidelines. This review aims to critically synthesize recent literature on these conditions in adults with SLE...
journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
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更新日期：2020-11-24 00:00:00
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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更新日期：2010-04-01 00:00:00
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
abstract：:Osteoarthritis (OA) is a major health problem in urgent need of better treatment. Gene therapy offers to meet this need. Of the different strategies for using gene therapy in OA, local gene transfer to synovium is in the most advanced stage of development. Local gene transfer brings several advantages, including a foc...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2004-02-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0285-z
更新日期：2012-12-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0204-8
更新日期：2011-12-01 00:00:00
abstract：:Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-999-0013-5
更新日期：1999-12-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-006-0020-8
更新日期：2006-02-01 00:00:00
abstract：:Bone is not structurally normal in osteoarthritis (OA). Periarticular bone in OA has increased turnover, decreased bone mineral content and stiffness, and decreased trabecular numbers. The increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of proces...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-003-0078-5
更新日期：2003-02-01 00:00:00
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journal_title：Current rheumatology reports
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更新日期：2005-10-01 00:00:00
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abstract：PURPOSE OF REVIEW:Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gen...
journal_title：Current rheumatology reports
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pub_type： 杂志文章,评审
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更新日期：2005-08-01 00:00:00
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journal_title：Current rheumatology reports
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更新日期：2012-04-01 00:00:00
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2010-08-01 00:00:00
abstract：:Congenital heart block (CHB) can occur in association with structural heart disease, such as atrioventricular septal defects, left atrial isomerism, and abnormalities of the great arteries, with tumors, such as mesotheliomas, or as an isolated defect. In 1928, Aylward reported the occurrence of CHB in two children who...
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pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2013-12-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2019-07-24 00:00:00
