Abstract：
:Uric acid nephrolithiasis is typically found in individuals with a low urine pH and a normal concentration of urinary uric acid. Patients with a history of gout are at greater risk of forming uric acid stones, as are patients with obesity, diabetes, or the complete metabolic syndrome. The unifying renal tubular abnormality of these disorders appears to be the excretion of abnormally acidic urine. This article focuses on the relationship of these disorders to the development of uric acid stones. The diagnosis of uric acid stones can be elusive, because pure uric acid stones are radiolucent on plain radiographs. Ultrasound, or preferably noncontrast helical CT scanning, is required for their detection. The treatment of uric acid stones should focus on alkalinization of the urine with citrate or bicarbonate salts. Additional interventions such as increase in fluid intake and decrease in animal protein ingestion are often beneficial. Patients with documented hyperuricemia often require specific therapy to lower serum uric acid concentration and subsequent excretion.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Liebman SE,Taylor JG,Bushinsky DAdoi
10.1007/s11926-007-0040-zsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
251-7issue
3eissn
1523-3774issn
1534-6307journal_volume
9pub_type
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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更新日期：2015-10-01 00:00:00
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2002-02-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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更新日期：2013-03-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2010-08-01 00:00:00
abstract：:Bone is not structurally normal in osteoarthritis (OA). Periarticular bone in OA has increased turnover, decreased bone mineral content and stiffness, and decreased trabecular numbers. The increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of proces...
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2003-10-01 00:00:00
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journal_title：Current rheumatology reports
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更新日期：2002-06-01 00:00:00
