B Cell Therapies, Approved and Emerging: a Review of Infectious Risk and Prevention During Use.

abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...

journal_title：Current rheumatology reports

authors： Smith GP,Chan ES

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Medical treatment with urate-lowering therapy (ULT) is efficacious. A recent publication suggested that surgery in gout is more prevalent than previously reported. This revelation led us to review what is known about surgical treatment of gout. RECENT FINDINGS:The Google Scholar database (January 1, ...

journal_title：Current rheumatology reports

authors： Carcione J,Bodofsky S,LaMoreaux B,Schlesinger N

更新日期：2020-11-24 00:00:00

abstract：:Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylit...

journal_title：Current rheumatology reports

authors： O'Rielly DD,Rahman P

更新日期：2013-08-01 00:00:00

abstract：:Although the pathogenesis of SLE remains poorly understood, there is consensus that it involves a combination of genetic, hormonal, and environmental factors. New technologies applied to genomic and gene expression studies have revealed novel gene mutations and cytokine alterations in this disease. Recently, advances ...

journal_title：Current rheumatology reports

authors： Stichweh D,Pascual V

更新日期：2005-12-01 00:00:00

abstract：:Clinical evaluation of patients with low bone mass attempts to determine which patients should be offered one of the effective therapies for fracture prevention. Current guidelines are primarily based on bone density. Risk factors are used, but their contribution to fracture risk is not easily assessed. The combinatio...

journal_title：Current rheumatology reports

authors： Deal CL

更新日期：2007-04-01 00:00:00

abstract：:Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...

journal_title：Current rheumatology reports

authors： Brune K,Hinz B,Otterness I

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Pain is an intense experience that can place a heavy burden on peoples' lives. The identification of psychosocial risk factors led to the development of effective pain treatments. However, effect sizes are modest. Accumulating evidence suggests that enhancing protective factors might also impact on (w...

journal_title：Current rheumatology reports

authors： Hanssen MM,Peters ML,Boselie JJ,Meulders A

更新日期：2017-11-09 00:00:00

abstract：:Resistive exercise is controversial for patients with idiopathic inflammatory myopathies. This paper provides an update on exercise and clinical assessment in these patients. The few published studies on this topic report unchanged disease activity from a variety of exercise regimens in patients in all stages of disea...

journal_title：Current rheumatology reports

authors： Alexanderson H

更新日期：2005-04-01 00:00:00

abstract：:Although exercise in the form of stretching, strength maintenance, and aerobic conditioning is generally considered beneficial to patients with fibromyalgia (FM), there is no reliable evidence to explain why exercise should help alleviate the primary symptom of FM, namely pain. Study results are varied and do not prov...

journal_title：Current rheumatology reports

authors： Clark SR,Jones KD,Burckhardt CS,Bennett R

更新日期：2001-04-01 00:00:00

abstract：:Exercise is an important part of treatment in patients with idiopathic inflammatory myopathies. Improved functioning, ability to perform activities of daily living, and health-related quality of life have been reported in adult polymyositis, dermatomyositis, and also recently inclusion body myositis following differen...

journal_title：Current rheumatology reports

authors： Alexanderson H

更新日期：2012-06-01 00:00:00

abstract：:Hereditary hemochromatosis is a frequent disease in Caucasian populations. It leads to progressive iron overload in a variety of organs. The most common cause is the C282Y homozygous mutation in the HFE gene. The classical triad of skin hyperpigmentation, diabetes, and liver cirrhosis is nowadays rare but musculoskele...

journal_title：Current rheumatology reports

authors： Husar-Memmer E,Stadlmayr A,Datz C,Zwerina J

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:One justification for using expensive biologic therapy in rheumatoid arthritis (RA) has been that it can reduce future healthcare utilization such as joint surgeries and physician visits. However, the evidence to support this assertion is unclear. We conducted a review of the literature for studies wh...

journal_title：Current rheumatology reports

authors： Bansback N,Fu E,Sun H,Guh D,Zhang W,Lacaille D,Milbers K,Anis AH

更新日期：2017-09-01 00:00:00

abstract：:The pathogenic mechanisms in Behçet's syndrome are largely unknown. An autoantigen role for human leukocyte antigen B51 has been proposed. The reasons behind the thrombophilia are also not clear. Endothelial pathology could be the main culprit. The recently proposed association between familial Mediterranean fever and...

journal_title：Current rheumatology reports

authors： Yazici H

更新日期：2003-06-01 00:00:00

abstract：:Bone is not structurally normal in osteoarthritis (OA). Periarticular bone in OA has increased turnover, decreased bone mineral content and stiffness, and decreased trabecular numbers. The increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of proces...

journal_title：Current rheumatology reports

authors： Hunter DJ,Spector TD

更新日期：2003-02-01 00:00:00

abstract：:Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) is the first-ever international network created to design and conduct large-scale, multicenter clinical trials and research in persistently antiphospholipid antibody (aPL)-positive patients. Since its inception in 2010, th...

journal_title：Current rheumatology reports

authors： Barbhaiya M,Andrade D,Erkan D,APS ACTION.

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Positron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with...

journal_title：Current rheumatology reports

authors： Selva-O'Callaghan A,Gil-Vila A,Simó-Perdigó M,Trallero-Araguás E,Alvarado-Cárdenas M,Pinal-Fernandez I

更新日期：2019-11-21 00:00:00

abstract：:This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...

journal_title：Current rheumatology reports

authors： Jones C,Payne K,Gannon B,Verstappen S

更新日期：2016-08-01 00:00:00

abstract：:Uric acid nephrolithiasis is typically found in individuals with a low urine pH and a normal concentration of urinary uric acid. Patients with a history of gout are at greater risk of forming uric acid stones, as are patients with obesity, diabetes, or the complete metabolic syndrome. The unifying renal tubular abnorm...

journal_title：Current rheumatology reports

authors： Liebman SE,Taylor JG,Bushinsky DA

更新日期：2007-06-01 00:00:00

abstract：:Biomarkers in psoriatic arthritis (PsA) may serve as surrogate end points for disease outcome and can provide insights into disease susceptibility and natural history. Biomarkers could relate to diagnosis, pathogenesis, prognosis, therapeutic response, and comorbidities. The "felt need" is, however, in the development...

journal_title：Current rheumatology reports

authors： Chandran V,Gladman DD

更新日期：2010-08-01 00:00:00

abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...

journal_title：Current rheumatology reports

authors： Leung YY,Tam LS,Li EK

更新日期：2011-08-01 00:00:00

abstract：:The recent increase in the number of patients taking opioids chronically for pain has not yielded the expected benefits in reduction of symptoms and improved function. Chronic pain patients typically respond well initially to opioid medications, but regular use is associated with adverse psychological and physical eff...

journal_title：Current rheumatology reports

authors： Krashin D,Sullivan M,Ballantyne J

更新日期：2013-03-01 00:00:00

abstract：:Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...

journal_title：Current rheumatology reports

authors： Bulpitt KJ

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiphospholipid syndrome (APS) is a chronic autoimmune disease that can be seen as a burden, with consequences on patients' daily life. Health has traditionally been measured using measures of morbidity or mortality. Health-related quality of life (HRQoL) is a concept that includes quality of life th...

journal_title：Current rheumatology reports

authors： Desnoyers M,Dufrost V,Wahl D,Zuily S

更新日期：2020-05-13 00:00:00

abstract：:Spondyloarthritis (SpA) is characterized by inflammation and new bone formation in the spine and entheses. The disease is the result of a complex interplay among susceptibility genes, microbial triggers, inflammation of bone marrow, and the enthesial structures and new bone formation. This article gives a conceptual o...

journal_title：Current rheumatology reports

authors： Ronneberger M,Schett G

更新日期：2011-10-01 00:00:00

abstract：:Synovitis is the characteristic feature of inflammatory joint disease. If synovitis is localized to interphalangeal joints, rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis are among the most common differential diagnoses. The absence of pain, tenderness, and limitation of function despite ...

journal_title：Current rheumatology reports

authors： Dallos T,Oppl B,Kovács L,Zwerina J

更新日期：2014-01-01 00:00:00

abstract：:The vasculitides are a group of protean diseases, some of which are caused by conditions including infections, other autoimmune diseases, or neoplasias. They are a challenge to the clinician, in terms of both diagnosis and therapy. No diagnostic criteria exist, although a multinational effort to develop them is in pro...

journal_title：Current rheumatology reports

authors： Flores-Suárez LF,Contreras-Rodríguez Fde J

更新日期：2014-06-01 00:00:00

abstract：:Scleroderma renal crisis (SRC) is characterized by malignant hypertension, oliguric/anuric acute renal failure, and important mortality, with a 5-year survival rate of 65%. SRC occurs in 2% to 5% of patients with systemic sclerosis (SSc), particularly those with diffuse cutaneous SSc in the first years of disease evol...

journal_title：Current rheumatology reports

authors： Bussone G,Bérezné A,Pestre V,Guillevin L,Mouthon L

更新日期：2011-02-01 00:00:00

abstract：:Teriparatide (recombinant human parathyroid hormone ) is an anabolic agent approved for the treatment of patients at high risk for fracture. The Fracture Prevention Trial administered teriparatide to treatment-naïve patients, leading to its US Food and Drug Administration approval in 2002. Clinical trial data using an...

journal_title：Current rheumatology reports

authors： File E,Deal C

更新日期：2009-07-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. TIO is usually induced by small, slowly growing tumors of mesenchymal origin (phosphaturic mesenchymal tumor mixed connective tissue variant [PMTMCT]). Nonspecific symptoms including fa...

journal_title：Current rheumatology reports

authors： Hautmann AH,Hautmann MG,Kölbl O,Herr W,Fleck M

更新日期：2015-06-01 00:00:00

abstract：:Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of p...

journal_title：Current rheumatology reports

authors： Yokose C,Chen M,Berhanu A,Pillinger MH,Krasnokutsky S

更新日期：2016-10-01 00:00:00