Pathogenesis of cartilage calcification: mechanisms of crystal deposition in cartilage.

abstract：:While the most obvious manifestations of rheumatoid arthritis (RA) involve inflammation and damage in the synovial joints, the systemic effects of the condition are widespread and life-threatening. Of particular interest is the 'lipid paradox' of RA, where patients with a numerically equivocal starting lipid profile h...

journal_title：Current rheumatology reports

authors： McGrath CM,Young SP

更新日期：2015-09-01 00:00:00

abstract：:The pathogenic mechanisms in Behçet's syndrome are largely unknown. An autoantigen role for human leukocyte antigen B51 has been proposed. The reasons behind the thrombophilia are also not clear. Endothelial pathology could be the main culprit. The recently proposed association between familial Mediterranean fever and...

journal_title：Current rheumatology reports

authors： Yazici H

更新日期：2003-06-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Although there are screening tests for PAH, such as carbon monoxide diffusing capacity and Doppler echocardiography, these tests are far from perfect, patients are still identified late in the course of disease, and the un...

journal_title：Current rheumatology reports

authors： Shah SJ

更新日期：2009-04-01 00:00:00

abstract：:Osteoporosis and related fractures represent a major, and growing, public health concern for the United States and worldwide. The pathogenesis of osteoporosis is complex, requiring attention to the different life phases involved in growth, maintenance, and loss of bone, in addition to non-skeletal factors associated w...

journal_title：Current rheumatology reports

authors： Samelson EJ,Hannan MT

更新日期：2006-02-01 00:00:00

abstract：:Spondyloarthritis (SpA) is characterized by inflammation and new bone formation in the spine and entheses. The disease is the result of a complex interplay among susceptibility genes, microbial triggers, inflammation of bone marrow, and the enthesial structures and new bone formation. This article gives a conceptual o...

journal_title：Current rheumatology reports

authors： Ronneberger M,Schett G

更新日期：2011-10-01 00:00:00

abstract：:Genetic defects of collagen formation (the collagenopathies) affect almost every organ system and tissue in the body. They can be grouped by clinical phenotype, which usually correlates with the tissue distribution of the affected collagen subtype. Many of these conditions present in childhood; however, milder phenoty...

journal_title：Current rheumatology reports

authors： Jobling R,D'Souza R,Baker N,Lara-Corrales I,Mendoza-Londono R,Dupuis L,Savarirayan R,Ala-Kokko L,Kannu P

更新日期：2014-01-01 00:00:00

abstract：:β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms b...

journal_title：Current rheumatology reports

authors： Giannakopoulos B,Mirarabshahi P,Krilis SA

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. With the global spread of CHIKV infection, practitioners should know its epidemiol...

journal_title：Current rheumatology reports

authors： Hua C,Combe B

更新日期：2017-10-05 00:00:00

abstract：:Upregulated adhesion molecule and cytokine expression on endothelial cells and infiltrating inflammatory cells occur in most vasculitis syndromes. These observations suggest that vasculitis is associated with pathologic activation of normal immune cell cytokine cascades. Abnormal expression of adhesion molecules and c...

journal_title：Current rheumatology reports

authors： Sundy JS,Haynes BF

更新日期：2000-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic disease affecting the physical, social, and psychological well-being of patients. Different instruments have been developed to measure health-related quality of life, some of which are SLE-specific. Contributors to poor quality of life in patients with SLE include fatigu...

journal_title：Current rheumatology reports

authors： Kiani AN,Petri M

更新日期：2010-08-01 00:00:00

abstract：:Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of th...

journal_title：Current rheumatology reports

authors： Deal C

更新日期：2012-06-01 00:00:00

abstract：:Synovitis is the characteristic feature of inflammatory joint disease. If synovitis is localized to interphalangeal joints, rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis are among the most common differential diagnoses. The absence of pain, tenderness, and limitation of function despite ...

journal_title：Current rheumatology reports

authors： Dallos T,Oppl B,Kovács L,Zwerina J

更新日期：2014-01-01 00:00:00

abstract：:Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more t...

journal_title：Current rheumatology reports

authors： Plenge RM

更新日期：2009-10-01 00:00:00

abstract：:Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic...

journal_title：Current rheumatology reports

authors： Lu TT

更新日期：2012-02-01 00:00:00

abstract：:The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...

journal_title：Current rheumatology reports

authors： Ruperto N,Meiorin S,Iusan SM,Ravelli A,Pistorio A,Martini A

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory respo...

journal_title：Current rheumatology reports

authors： Kalaitzoglou E,Griffin TM,Humphrey MB

更新日期：2017-08-01 00:00:00

abstract：:Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...

journal_title：Current rheumatology reports

authors： Hayat S,Berney SM

更新日期：2005-08-01 00:00:00

abstract：:Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...

journal_title：Current rheumatology reports

authors： Eppinga H,Konstantinov SR,Peppelenbosch MP,Thio HB

更新日期：2014-03-01 00:00:00

abstract：:Psoriatic arthritis is a chronic, disabling disease for which therapies have been borrowed from rheumatoid arthritis and spondylitis. Traditional disease-modifying antirheumatic drugs (DMARDs) remain the first choice for the treatment of peripheral arthritis despite scarce evidence of their efficacy or ability to halt...

journal_title：Current rheumatology reports

authors： Soriano ER,Rosa J

更新日期：2009-08-01 00:00:00

abstract：:The human microbiome, which represents the total collection of microorganisms (and their genes) inhabiting the human body, has increasingly been recognized as a potential key factor in the development of autoimmune disease. Multiple studies suggest that the microbiome has significant influence on immune homeostasis, w...

journal_title：Current rheumatology reports

authors： Manasson J,Scher JU

更新日期：2015-02-01 00:00:00

abstract：:Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role ...

journal_title：Current rheumatology reports

authors： Roldan JF,Brey RL

更新日期：2007-05-01 00:00:00

abstract：:The investigations used to diagnose an inflammatory muscle disease include history and physical examination, evaluation of serum levels of enzymes derived from skeletal muscle, electromyography, magnetic resonance imaging, and muscle histology. The evaluation of patients who may have noninflammatory myopathy includes,...

journal_title：Current rheumatology reports

authors： Wortmann RL,Vladutiu GD

更新日期：2001-08-01 00:00:00

abstract：:Antiphospholipid antibodies are associated with a hypercoagulable state leading to a wide variety of systemic manifestations and obstetric complications. The different pathologic manifestations can be a result of arterial and venous thrombosis, microthrombotic angiopathy, embolization, obstetric disease, and non-throm...

journal_title：Current rheumatology reports

authors： DeMarco P,Singh I,Weinstein A

更新日期：2006-04-01 00:00:00

abstract：:Acupuncture has been used for millennia in traditional Chinese medicine as a technique believed to restore the balance of energy in the body caused by disease through the use of needles inserted into specific points or energy channels. This energy is called the de qi. The use of acupuncture for the treatment of pain i...

journal_title：Current rheumatology reports

authors： Amezaga Urruela M,Suarez-Almazor ME

更新日期：2012-12-01 00:00:00

abstract：:The magnitude of placebo analgesia is influenced by environmental and perceptual factors. Environmental factors include past exposure to effective analgesic agents and verbal suggestions and cues that foster a perception of being given an effective treatment. Environmental factors, in turn, influence the proximate psy...

journal_title：Current rheumatology reports

authors： Price DD,Fillingim RB,Robinson ME

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF THE REVIEW:An increased prevalence of cardiovascular risk factors in rheumatoid arthritis (RA) is reported. The absolute cardiovascular risk in RA patients is higher than in the general population, and although the RA prognosis has gradually improved, premature cardiovascular (CV) mortality remains a matter ...

journal_title：Current rheumatology reports

authors： Romano S,Salustri E,Ruscitti P,Carubbi F,Penco M,Giacomelli R

更新日期：2018-11-05 00:00:00

abstract：:The World Health Organization criteria for classification of bone mineral density (BMD) cannot be applied to premenopausal women because the relationship between BMD and fracture risk is not the same as in postmenopausal women. Approximately 2.5% of premenopausal women have BMD that is more than 2.0 standard deviation...

journal_title：Current rheumatology reports

authors： Lewiecki EM

更新日期：2005-03-01 00:00:00

abstract：:Scleroderma renal crisis (SRC) is characterized by malignant hypertension, oliguric/anuric acute renal failure, and important mortality, with a 5-year survival rate of 65%. SRC occurs in 2% to 5% of patients with systemic sclerosis (SSc), particularly those with diffuse cutaneous SSc in the first years of disease evol...

journal_title：Current rheumatology reports

authors： Bussone G,Bérezné A,Pestre V,Guillevin L,Mouthon L

更新日期：2011-02-01 00:00:00

abstract：:TNF-blocking biologics have revolutionized the care of patients with spondyloarthritis, a group of clinically overlapping conditions that includes ankylosing spondylitis and psoriatic arthritis. However, incomplete response rates speak to the need for alternative therapeutic approaches. Over the last decade, animal mo...

journal_title：Current rheumatology reports

authors： Smith JA

更新日期：2016-06-01 00:00:00

abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...

journal_title：Current rheumatology reports

authors： Smith GP,Chan ES

更新日期：2010-02-01 00:00:00