Abstract：
PURPOSE OF THE REVIEW:An increased prevalence of cardiovascular risk factors in rheumatoid arthritis (RA) is reported. The absolute cardiovascular risk in RA patients is higher than in the general population, and although the RA prognosis has gradually improved, premature cardiovascular (CV) mortality remains a matter of fact. The purpose of this review is to shed light on CV and metabolic involvement in RA, with the aim of defining its best management. RECENT FINDINGS:Multiple lines of evidence have revealed common mechanisms behind inflammatory and CV diseases and clarified the metabolic and CV pathways involved in RA and the effects of different pharmacological treatments. CV risk assessment should be mandatory in all RA patients, taking into account the impact of both diseases on patient's prognosis. Therefore, a multidisciplinary approach is the best management, and rheumatologists, cardiologists, and general practitioners must work together to significantly improve outcome and quality of life in RA patients. Future research could investigate the potential beneficial effects of a more aggressive pharmacological treatment of CV and metabolic risk factors.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Romano S,Salustri E,Ruscitti P,Carubbi F,Penco M,Giacomelli Rdoi
10.1007/s11926-018-0790-9subject
Has Abstractpub_date
2018-11-05 00:00:00pages
81issue
12eissn
1523-3774issn
1534-6307pii
10.1007/s11926-018-0790-9journal_volume
20pub_type
杂志文章,评审abstract：:Optimal management for scleroderma (systemic sclerosis) is likely to require treatment of the underlying disease process, which remains incompletely understood, and also of the organ-based complications of this heterogeneous condition. Clinical trials evaluating several potential agents have been completed recently, i...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-999-0020-6
更新日期：1999-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Pain is an intense experience that can place a heavy burden on peoples' lives. The identification of psychosocial risk factors led to the development of effective pain treatments. However, effect sizes are modest. Accumulating evidence suggests that enhancing protective factors might also impact on (w...
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abstract：PURPOSE OF THE REVIEW:Polymyalgia rheumatica (PMR) is one of the most common inflammatory rheumatologic condition occurring in older adults. It is characterized by proximal pain and stiffness in the shoulders, neck, and/or pelvic girdle in individuals over 50 years of age along with evidence of an intense systemic infl...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-020-00919-2
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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abstract：:The World Health Organization criteria for classification of bone mineral density (BMD) cannot be applied to premenopausal women because the relationship between BMD and fracture risk is not the same as in postmenopausal women. Approximately 2.5% of premenopausal women have BMD that is more than 2.0 standard deviation...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-005-0008-9
更新日期：2005-03-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-999-0013-5
更新日期：1999-12-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-008-0079-5
更新日期：2008-12-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0868-z
更新日期：2019-12-07 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2016-06-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2000-08-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic debilitating condition with significant impact on the musculoskeletal system. Arthroplasty may be indicated for damage related to active lupus or its treatment. As therapies for SLE have advanced, morbidity and mortality have declined, while the rate of joint replacement...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0183-9
更新日期：2011-08-01 00:00:00
abstract：:Psoriatic arthritis is a chronic, disabling disease for which therapies have been borrowed from rheumatoid arthritis and spondylitis. Traditional disease-modifying antirheumatic drugs (DMARDs) remain the first choice for the treatment of peripheral arthritis despite scarce evidence of their efficacy or ability to halt...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-009-0038-9
更新日期：2009-08-01 00:00:00
abstract：:Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-007-0004-3
更新日期：2007-05-01 00:00:00
abstract：:Transforming growth factor-beta (TGF beta) plays a critical role in the development of tissue fibrosis. Its expression is consistently elevated in affected organs and correlates with increased extracellular matrix deposition. During the last few years, tremendous progress has been made in understanding the molecular a...
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pub_type： 杂志文章,评审
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更新日期：2002-04-01 00:00:00
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journal_title：Current rheumatology reports
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更新日期：2016-05-01 00:00:00
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journal_title：Current rheumatology reports
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pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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abstract：:Sleep disturbance is one of the most common comorbid problems for chronic pain patients. The association between the two phenomena has long been recognized, but the nature of the relationship is not well-understood. Many agree that the relationship is likely bidirectional. In this review, we focus on one side of the r...
journal_title：Current rheumatology reports
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更新日期：2011-12-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
abstract：:Biomarkers in psoriatic arthritis (PsA) may serve as surrogate end points for disease outcome and can provide insights into disease susceptibility and natural history. Biomarkers could relate to diagnosis, pathogenesis, prognosis, therapeutic response, and comorbidities. The "felt need" is, however, in the development...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
abstract：:Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Although there are screening tests for PAH, such as carbon monoxide diffusing capacity and Doppler echocardiography, these tests are far from perfect, patients are still identified late in the course of disease, and the un...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-009-0013-5
更新日期：2009-04-01 00:00:00
