Abstract:
:Scleroderma renal crisis (SRC) is characterized by malignant hypertension, oliguric/anuric acute renal failure, and important mortality, with a 5-year survival rate of 65%. SRC occurs in 2% to 5% of patients with systemic sclerosis (SSc), particularly those with diffuse cutaneous SSc in the first years of disease evolution. Several retrospective studies have found high-dose corticosteroid therapy to be associated with increased risk of SRC, and anti-RNA-polymerase III antibodies have been detected in one third of patients with SRC. Treatment relies on the early control of blood pressure with increasing doses of angiotensin-converting enzyme inhibitors, eventually associated with calcium channel blockers together with dialysis if necessary. After 2 years on dialysis, eligible patients should be considered for renal transplantation. The strategy for prevention of SRC lacks consensus. However, corticosteroids and/or nephrotoxic drugs should be avoided in patients with diffuse cutaneous SSc.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Bussone G,Bérezné A,Pestre V,Guillevin L,Mouthon Ldoi
10.1007/s11926-010-0145-7subject
Has Abstractpub_date
2011-02-01 00:00:00pages
37-43issue
1eissn
1523-3774issn
1534-6307journal_volume
13pub_type
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