Abstract:
:Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is still debated. During this same timespan, knowledge of the complement system has exploded, with identification of more than 30 proteins, an abundance of newly recognized functions, and even a third pathway of activation. These advances suggest that it is appropriate to revisit the complement system as a potential source of biomarkers for SLE. This paper reviews briefly the role of complement in SLE and other inflammatory diseases, discusses conventional methods for complement measurement and their drawbacks, and focuses on recent advancements in harnessing the complement system for monitoring SLE. Specifically, novel assays that measure cell-bound complement activation products are introduced and their utility as biomarkers of SLE disease activity is discussed.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Liu CC,Manzi S,Danchenko N,Ahearn JMdoi
10.1007/s11926-004-0012-5keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
375-81issue
5eissn
1523-3774issn
1534-6307journal_volume
6pub_type
杂志文章,评审abstract::Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
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abstract::Sjögren's syndrome is a chronic inflammatory process involving primarily the exocrine glands. Its association with lymphoma is well documented. A low-grade marginal-zone lymphoma related to mucosa-associated lymphoid tissue is the most common lymphoid neoplasia in Sjögren's syndrome. Among all autoimmune diseases, Sjö...
journal_title:Current rheumatology reports
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abstract::The distribution of the anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) is not uniform across geographical regions and ethnic and racial groups, suggesting that genetic and environmental factors affect the pathogenesis of these diseases. In addition, genetic factors affect not only the clin...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-014-0428-5
更新日期:2014-07-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-996-0028-0
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journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-010-0157-3
更新日期:2011-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-011-0215-5
更新日期:2012-02-01 00:00:00
abstract::Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and t...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
abstract::Several entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural progression of osteoarthritis has been obtained with glucosamine sulfate, while some preliminary results also suggest that chondro...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-000-0023-9
更新日期:2000-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study was to highlight recent findings on evaluation for lung transplantation and outcomes after transplantation in patients with systemic sclerosis (scleroderma). RECENT FINDINGS:The recognition that extra-pulmonary disease manifestations can seriously compromise post-transplant ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0650-z
更新日期:2017-05-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0008-9
更新日期:2005-03-01 00:00:00
abstract::The frequency of Takayasu's arteritis (TA) has been estimated to be 2.9 cases per 1 million people, with a female preponderance, although female-to-male ratio varies from different geographic areas. A high frequency of haplotype A24-B52-DR2 has been found in Japanese patients, without this association in other populat...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-002-0021-1
更新日期:2002-02-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-996-0044-0
更新日期:2005-06-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-011-0202-x
更新日期:2011-10-01 00:00:00
abstract::The Delphi Technique and Nominal Group Technique are two well-recognized consensus-formation methodologies specifically designed to combine judgments from a group of experts. The Delphi Technique utilizes a series of well-defined questionnaire-based surveys, whereas Nominal Group Technique is a structured face-to-face...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-008-0025-6
更新日期:2008-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-015-0539-7
更新日期:2015-10-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-006-0020-8
更新日期:2006-02-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-003-0078-5
更新日期:2003-02-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-016-0578-8
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review paper is to provide an overview of the relationship between obesity, osteoarthritis, arthroplasty outcomes, and the potential use of bariatric surgery to improve these outcomes. RECENT FINDINGS:Unfortunately, the findings in the currently available literature evaluating the...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-018-0717-5
更新日期:2018-02-21 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-012-0285-z
更新日期:2012-12-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-005-0027-6
更新日期:2005-10-01 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Although there are screening tests for PAH, such as carbon monoxide diffusing capacity and Doppler echocardiography, these tests are far from perfect, patients are still identified late in the course of disease, and the un...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-009-0013-5
更新日期:2009-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-001-0050-1
更新日期:2001-02-01 00:00:00
abstract::Many lines of evidence suggest that autoimmune diseases result from chronic immune activation following environmental exposures in genetically susceptible individuals. A genetic basis for autoimmunity is supported by twin and family studies, candidate gene investigations, animal models, and whole genome microsatellite...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-000-0080-0
更新日期:2000-06-01 00:00:00
abstract:PURPOSE OF THE REVIEW:Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory respo...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0672-6
更新日期:2017-08-01 00:00:00
abstract::Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-999-0013-5
更新日期:1999-12-01 00:00:00
abstract::Seronegative spondyloarthropathies comprise a group of inflammatory arthritides, which consists of ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic arthritis, and undifferentiated spondyloarthropathy. All of them share common laboratory, clinical, and imaging findings, ...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-004-0054-8
更新日期:2004-04-01 00:00:00
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journal_title:Current rheumatology reports
pub_type: 杂志文章
doi:10.1007/s11926-009-0038-9
更新日期:2009-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. With the global spread of CHIKV infection, practitioners should know its epidemiol...
journal_title:Current rheumatology reports
pub_type: 杂志文章,评审
doi:10.1007/s11926-017-0694-0
更新日期:2017-10-05 00:00:00