Abstract：
:To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apoptosis, necrosis, or some combination of the two. Chondrocyte death can be induced by mechanical injury, loss of extracellular matrix, loss of growth factors, or excessive levels of reactive oxygen species. Although therapy specifically targeting cell death in human OA has not been reported, preclinical studies in animal models have provided early evidence that inhibition of caspases might slow OA-like changes in articular cartilage. Because of potential unwanted side effects from agents systemically inhibiting cell death, treatments specifically targeting cell death in OA will likely need to be delivered locally and in a manner that prevents systemic absorption. Inhibition of cell death in OA likely will not be a sole therapeutic target but rather a desired effect of interventions designed to reverse the catabolic-anabolic imbalance occurring in OA joint tissues.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Del Carlo M Jr,Loeser RFdoi
10.1007/s11926-008-0007-8subject
Has Abstractpub_date
2008-01-01 00:00:00pages
37-42issue
1eissn
1523-3774issn
1534-6307journal_volume
10pub_type
杂志文章,评审abstract：:Urate is the major inert end product of purine degradation in higher primates in contrast to most other mammals because of the genetic silencing of hepatic oxidative enzyme uricase. The kidney plays a dominant role in urate elimination. The kidney excretes 70% of the daily urate production. Therefore, it is important ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-996-0044-0
更新日期：2005-06-01 00:00:00
abstract：:Transforming growth factor-beta (TGF beta) plays a critical role in the development of tissue fibrosis. Its expression is consistently elevated in affected organs and correlates with increased extracellular matrix deposition. During the last few years, tremendous progress has been made in understanding the molecular a...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0010-4
更新日期：2002-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this study was to provide the most up-to-date scientific evidence of the potential analgesic effects, or lack thereof, of the marijuana plant (cannabis) or cannabinoids, and of safety or tolerability of their long-term use. RECENT FINDINGS:We found that inhaled (smoked or vaporized) ca...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0693-1
更新日期：2017-10-05 00:00:00
abstract：PURPOSE OF REVIEW:The effect of urate lowering treatment (ULT) on cardiovascular (CV) risk and mortality in gout has been a topic of interest. This review discusses the CV effect of ULT and comparative CV safety among ULT agents. RECENT FINDINGS:The mechanism linking gout with CV risk is not fully understood but seems...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0843-8
更新日期：2019-07-24 00:00:00
abstract：:Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). Attention has, therefore, been paid to regenerative therapeutic procedures for the early treatment of cartilagi...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-014-0452-5
更新日期：2014-10-01 00:00:00
abstract：:Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of th...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0253-7
更新日期：2012-06-01 00:00:00
abstract：:Recent clinical development programs for new therapeutic agents in rheumatoid arthritis have included assessment of radiographic progression comparing changes with treatment to placebo and active controls. Studies now use reliable methods of assessment and sufficient study length to detect radiographic changes. Althou...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0050-1
更新日期：2001-02-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic debilitating condition with significant impact on the musculoskeletal system. Arthroplasty may be indicated for damage related to active lupus or its treatment. As therapies for SLE have advanced, morbidity and mortality have declined, while the rate of joint replacement...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0608-6
更新日期：2016-09-01 00:00:00
abstract：:β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms b...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-010-0151-9
更新日期：2011-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0831-z
更新日期：2019-05-23 00:00:00
abstract：:Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Although there are screening tests for PAH, such as carbon monoxide diffusing capacity and Doppler echocardiography, these tests are far from perfect, patients are still identified late in the course of disease, and the un...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-009-0013-5
更新日期：2009-04-01 00:00:00
abstract：:Teriparatide (recombinant human parathyroid hormone ) is an anabolic agent approved for the treatment of patients at high risk for fracture. The Fracture Prevention Trial administered teriparatide to treatment-naïve patients, leading to its US Food and Drug Administration approval in 2002. Clinical trial data using an...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-009-0023-3
更新日期：2009-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Childhood arthritis is in need of a new system of classification, owing to deficiencies in the International League of Associations for Rheumatology (ILAR) criteria. We briefly review the history of classification of childhood arthritis, discuss the major criticisms of the current system, and highligh...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-020-0880-3
更新日期：2020-01-11 00:00:00
abstract：:The frequency of Takayasu's arteritis (TA) has been estimated to be 2.9 cases per 1 million people, with a female preponderance, although female-to-male ratio varies from different geographic areas. A high frequency of haplotype A24-B52-DR2 has been found in Japanese patients, without this association in other populat...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0021-1
更新日期：2002-02-01 00:00:00
abstract：:Childhood systemic lupus erythematosus (SLE) is known to have a worse prognosis than adult-onset disease, and monitoring and treatment of the disease are still a challenge. Thus, there is an urgent need for highly reliable, non-invasive biomarkers for early detection of relapses, to avoid long-term complications and t...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0312-0
更新日期：2013-03-01 00:00:00
abstract：:Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) is the first-ever international network created to design and conduct large-scale, multicenter clinical trials and research in persistently antiphospholipid antibody (aPL)-positive patients. Since its inception in 2010, th...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0611-y
更新日期：2016-10-01 00:00:00
abstract：:Neonatal lupus is a disease characterized by one or more of the following findings: congenital heart block, cardiomyopathy, cutaneous lupus lesions, hepatobiliary disease, and thrombocytopenia. Accumulating evidence indicates that the disease is probably caused by maternal autoantibodies, particularly autoantibodies o...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-996-0009-3
更新日期：2001-10-01 00:00:00
abstract：:The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not b...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0172-z
更新日期：2011-06-01 00:00:00
abstract：:Several entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural progression of osteoarthritis has been obtained with glucosamine sulfate, while some preliminary results also suggest that chondro...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0023-9
更新日期：2000-12-01 00:00:00
abstract：:Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-013-0407-2
更新日期：2014-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Arthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical characteristics, and autoantibody associations of joint involvement in various forms of IIM. RECENT FINDINGS:Arthritis is reported in 18-55% ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0878-x
更新日期：2019-12-07 00:00:00
abstract：:The World Health Organization criteria for classification of bone mineral density (BMD) cannot be applied to premenopausal women because the relationship between BMD and fracture risk is not the same as in postmenopausal women. Approximately 2.5% of premenopausal women have BMD that is more than 2.0 standard deviation...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-005-0008-9
更新日期：2005-03-01 00:00:00
abstract：:Large epidemiologic studies of gout can improve insight into the etiology, pathology, impact, and management of the disease. Identification of monosodium urate monohydrate crystals is considered the gold standard for diagnosis, but its application is often not possible in large studies. Therefore, under such circumsta...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-010-0157-3
更新日期：2011-04-01 00:00:00
abstract：:Psoriatic arthritis is a chronic, disabling disease for which therapies have been borrowed from rheumatoid arthritis and spondylitis. Traditional disease-modifying antirheumatic drugs (DMARDs) remain the first choice for the treatment of peripheral arthritis despite scarce evidence of their efficacy or ability to halt...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-009-0038-9
更新日期：2009-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Chikungunya virus (CHIKV) infection has become increasingly prevalent in the last decade not only across the southern hemisphere but also, because of a recently documented viral mutation, in southern Europe and the USA. With the global spread of CHIKV infection, practitioners should know its epidemiol...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0694-0
更新日期：2017-10-05 00:00:00
abstract：:This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0600-1
更新日期：2016-08-01 00:00:00
abstract：:The pathogenic mechanisms in Behçet's syndrome are largely unknown. An autoantigen role for human leukocyte antigen B51 has been proposed. The reasons behind the thrombophilia are also not clear. Endothelial pathology could be the main culprit. The recently proposed association between familial Mediterranean fever and...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-003-0066-9
更新日期：2003-06-01 00:00:00
abstract：:Behçet's syndrome is a systemic vasculitis with an unknown etiology affecting the small and large vessels of the venous and arterial systems. At least two clusters of disease expression have been described. The first includes superficial vein thrombosis, deep vein thrombosis, and dural sinus thrombi. The second includ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-010-0132-z
更新日期：2010-12-01 00:00:00
abstract：:Upregulated adhesion molecule and cytokine expression on endothelial cells and infiltrating inflammatory cells occur in most vasculitis syndromes. These observations suggest that vasculitis is associated with pathologic activation of normal immune cell cytokine cascades. Abnormal expression of adhesion molecules and c...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-000-0040-8
更新日期：2000-10-01 00:00:00
abstract：:Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0021-6
更新日期：2001-06-01 00:00:00
