Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis.

abstract：:Clinical evaluation of patients with low bone mass attempts to determine which patients should be offered one of the effective therapies for fracture prevention. Current guidelines are primarily based on bone density. Risk factors are used, but their contribution to fracture risk is not easily assessed. The combinatio...

journal_title：Current rheumatology reports

authors： Deal CL

更新日期：2007-04-01 00:00:00

abstract：:While the link between malignancy and vasculitis has been known for some time, the association of vasculitis and myelodysplastic syndrome (MDS) has only recently been reported. This article reviews the most current and landmark publications regarding MDS, as well as malignancy-associated vasculitis. We include theorie...

journal_title：Current rheumatology reports

authors： Agha A,Bateman H,Sterrett A,Valeriano-Marcet J

更新日期：2012-12-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a devastating complication of systemic sclerosis (SSc). Although there are screening tests for PAH, such as carbon monoxide diffusing capacity and Doppler echocardiography, these tests are far from perfect, patients are still identified late in the course of disease, and the un...

journal_title：Current rheumatology reports

authors： Shah SJ

更新日期：2009-04-01 00:00:00

abstract：:Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...

journal_title：Current rheumatology reports

authors： Brune K,Hinz B,Otterness I

更新日期：2009-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic disease affecting the physical, social, and psychological well-being of patients. Different instruments have been developed to measure health-related quality of life, some of which are SLE-specific. Contributors to poor quality of life in patients with SLE include fatigu...

journal_title：Current rheumatology reports

authors： Kiani AN,Petri M

更新日期：2010-08-01 00:00:00

abstract：:Many lines of evidence suggest that autoimmune diseases result from chronic immune activation following environmental exposures in genetically susceptible individuals. A genetic basis for autoimmunity is supported by twin and family studies, candidate gene investigations, animal models, and whole genome microsatellite...

journal_title：Current rheumatology reports

authors： Shamim EA,Miller FW

更新日期：2000-06-01 00:00:00

abstract：:Urate is the major inert end product of purine degradation in higher primates in contrast to most other mammals because of the genetic silencing of hepatic oxidative enzyme uricase. The kidney plays a dominant role in urate elimination. The kidney excretes 70% of the daily urate production. Therefore, it is important ...

journal_title：Current rheumatology reports

authors： Anzai N,Enomoto A,Endou H

更新日期：2005-06-01 00:00:00

abstract：:Our growing understanding of the immune response mechanism has created a wave of novel biologic agents for the treatment of rheumatoid arthritis. The domain of biologic agents includes: 1) Recombinant regulatory cytokines; 2) engineered molecules and monoclonal antibodies that target proinflammatory cytokines; 3) mono...

journal_title：Current rheumatology reports

authors： Bulpitt KJ

更新日期：1999-12-01 00:00:00

abstract：:TNF-blocking biologics have revolutionized the care of patients with spondyloarthritis, a group of clinically overlapping conditions that includes ankylosing spondylitis and psoriatic arthritis. However, incomplete response rates speak to the need for alternative therapeutic approaches. Over the last decade, animal mo...

journal_title：Current rheumatology reports

authors： Smith JA

更新日期：2016-06-01 00:00:00

abstract：:To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apop...

journal_title：Current rheumatology reports

authors： Del Carlo M Jr,Loeser RF

更新日期：2008-01-01 00:00:00

abstract：:Sleep disturbance is one of the most common comorbid problems for chronic pain patients. The association between the two phenomena has long been recognized, but the nature of the relationship is not well-understood. Many agree that the relationship is likely bidirectional. In this review, we focus on one side of the r...

journal_title：Current rheumatology reports

authors： Okifuji A,Hare BD

更新日期：2011-12-01 00:00:00

abstract：:Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...

journal_title：Current rheumatology reports

authors： Eppinga H,Konstantinov SR,Peppelenbosch MP,Thio HB

更新日期：2014-03-01 00:00:00

abstract：:Uric acid nephrolithiasis is typically found in individuals with a low urine pH and a normal concentration of urinary uric acid. Patients with a history of gout are at greater risk of forming uric acid stones, as are patients with obesity, diabetes, or the complete metabolic syndrome. The unifying renal tubular abnorm...

journal_title：Current rheumatology reports

authors： Liebman SE,Taylor JG,Bushinsky DA

更新日期：2007-06-01 00:00:00

abstract：:Neonatal lupus is a disease characterized by one or more of the following findings: congenital heart block, cardiomyopathy, cutaneous lupus lesions, hepatobiliary disease, and thrombocytopenia. Accumulating evidence indicates that the disease is probably caused by maternal autoantibodies, particularly autoantibodies o...

journal_title：Current rheumatology reports

authors： Lee LA

更新日期：2001-10-01 00:00:00

abstract：:The classification of Spondyloarthritis (SpA) has been revised with the introduction of the ASAS classification criteria. Although this has best been described in ankylosing spondylitis and psoriatic arthritis, there are population studies evaluating the epidemiology of the different subgroups of SpA. In this paper, w...

journal_title：Current rheumatology reports

authors： Bakland G,Nossent HC

更新日期：2013-09-01 00:00:00

abstract：:Ayurvedic medicine is the traditional medicine of India, which originated over 5,000 years ago. Parts of this alternative medical system have become increasingly popular worldwide as patients seek approaches to medical care that they perceive as more holistic and less toxic than those offered by conventional Western m...

journal_title：Current rheumatology reports

authors： Basnyat S,Kolasinski SL

更新日期：2014-08-01 00:00:00

abstract：:There have been few studies examining whether persons with chronic widespread pain or fibromyalgia are at increased risk for dying prematurely. Among the studies conducted there is little consistency in results. If there is an increased mortality risk, it is of the order of a 30% excess and it may be related to the li...

journal_title：Current rheumatology reports

authors： Macfarlane GJ

更新日期：2005-10-01 00:00:00

abstract：:Resistive exercise is controversial for patients with idiopathic inflammatory myopathies. This paper provides an update on exercise and clinical assessment in these patients. The few published studies on this topic report unchanged disease activity from a variety of exercise regimens in patients in all stages of disea...

journal_title：Current rheumatology reports

authors： Alexanderson H

更新日期：2005-04-01 00:00:00

abstract：:Advanced imaging has become essential for recognition of clinically suspected early spondyloarthritis. This report summarizes recent progress towards a data-driven comprehensive definition of a positive sacroiliac joint MRI in axial spondyloarthritis, which incorporates contextual information provided by structural le...

journal_title：Current rheumatology reports

authors： Weber U,Jurik AG,Lambert RG,Maksymowych WP

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review progress in the field of clinical trials for SLE. RECENT FINDINGS:Treatment development for SLE has been marked by failures of many later phase studies, representing billions of dollars of lost research and development funding. Recently, more successful Phase II trials have tested reduction...

journal_title：Current rheumatology reports

authors： Thanou A,Merrill JT

更新日期：2018-05-03 00:00:00

abstract：:Optimal management for scleroderma (systemic sclerosis) is likely to require treatment of the underlying disease process, which remains incompletely understood, and also of the organ-based complications of this heterogeneous condition. Clinical trials evaluating several potential agents have been completed recently, i...

journal_title：Current rheumatology reports

authors： Denton CP,Black CM

更新日期：1999-10-01 00:00:00

abstract：:The pathogenic mechanisms in Behçet's syndrome are largely unknown. An autoantigen role for human leukocyte antigen B51 has been proposed. The reasons behind the thrombophilia are also not clear. Endothelial pathology could be the main culprit. The recently proposed association between familial Mediterranean fever and...

journal_title：Current rheumatology reports

authors： Yazici H

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Arthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical characteristics, and autoantibody associations of joint involvement in various forms of IIM. RECENT FINDINGS:Arthritis is reported in 18-55% ...

journal_title：Current rheumatology reports

authors： Klein M,Mann H,Vencovský J

更新日期：2019-12-07 00:00:00

abstract：:Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...

journal_title：Current rheumatology reports

authors： Sammaritano LR

更新日期：2001-06-01 00:00:00

abstract：:Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of th...

journal_title：Current rheumatology reports

authors： Deal C

更新日期：2012-06-01 00:00:00

abstract：:Although exercise in the form of stretching, strength maintenance, and aerobic conditioning is generally considered beneficial to patients with fibromyalgia (FM), there is no reliable evidence to explain why exercise should help alleviate the primary symptom of FM, namely pain. Study results are varied and do not prov...

journal_title：Current rheumatology reports

authors： Clark SR,Jones KD,Burckhardt CS,Bennett R

更新日期：2001-04-01 00:00:00

abstract：:Biomarkers in psoriatic arthritis (PsA) may serve as surrogate end points for disease outcome and can provide insights into disease susceptibility and natural history. Biomarkers could relate to diagnosis, pathogenesis, prognosis, therapeutic response, and comorbidities. The "felt need" is, however, in the development...

journal_title：Current rheumatology reports

authors： Chandran V,Gladman DD

更新日期：2010-08-01 00:00:00

abstract：:Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role ...

journal_title：Current rheumatology reports

authors： Roldan JF,Brey RL

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study was to provide the most up-to-date scientific evidence of the potential analgesic effects, or lack thereof, of the marijuana plant (cannabis) or cannabinoids, and of safety or tolerability of their long-term use. RECENT FINDINGS:We found that inhaled (smoked or vaporized) ca...

journal_title：Current rheumatology reports

authors： Romero-Sandoval EA,Kolano AL,Alvarado-Vázquez PA

更新日期：2017-10-05 00:00:00

abstract：:Interest in imaging ankylosing spondylitis (AS) and related spondyloarthropathies has increased in recent years. MRI is regarded as the most sensitive imaging modality to detect early inflammatory lesions in the sacroiliac joints and in the spine. Standard radiography plays a major role in evaluating potential disease...

journal_title：Current rheumatology reports

authors： Weber U,Kissling RO,Hodler J

更新日期：2007-10-01 00:00:00