Abstract：
:Sleep disturbance is one of the most common comorbid problems for chronic pain patients. The association between the two phenomena has long been recognized, but the nature of the relationship is not well-understood. Many agree that the relationship is likely bidirectional. In this review, we focus on one side of the relationship: whether and how disordered sleep adversely impacts pain. We discuss the available evidence from the epidemiologic, clinical, and human, as well as infrahuman laboratory studies. Generally, the literature supports the positive relationship between poor sleep and increased pain. Sleep deprivation also seems to attenuate analgesic effects of medications. Research delineating the causal or associative relationship between sleep and pain is still preliminary at this time. Continuing efforts in both experimental and clinical research are needed to develop a translationally meaningful understanding of how poor sleep impacts pain.
journal_name
Curr Rheumatol Repjournal_title
Current rheumatology reportsauthors
Okifuji A,Hare BDdoi
10.1007/s11926-011-0204-8subject
Has Abstractpub_date
2011-12-01 00:00:00pages
528-34issue
6eissn
1523-3774issn
1534-6307journal_volume
13pub_type
杂志文章,评审abstract：:Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0215-5
更新日期：2012-02-01 00:00:00
abstract：:Juvenile idiopathic arthritis (JIA) is in a majority of the cases of self-limiting, and sometimes even a self-remitting, disease. A growing amount of data suggests that active T cell regulation determines, at least partly, the clinical outcome of JIA. In experimental models of arthritis, a group of highly conserved mi...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0052-7
更新日期：2002-12-01 00:00:00
abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-009-0080-7
更新日期：2010-02-01 00:00:00
abstract：:Interest in imaging ankylosing spondylitis (AS) and related spondyloarthropathies has increased in recent years. MRI is regarded as the most sensitive imaging modality to detect early inflammatory lesions in the sacroiliac joints and in the spine. Standard radiography plays a major role in evaluating potential disease...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-007-0057-3
更新日期：2007-10-01 00:00:00
abstract：:Neonatal lupus is a disease characterized by one or more of the following findings: congenital heart block, cardiomyopathy, cutaneous lupus lesions, hepatobiliary disease, and thrombocytopenia. Accumulating evidence indicates that the disease is probably caused by maternal autoantibodies, particularly autoantibodies o...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-996-0009-3
更新日期：2001-10-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is associated with a heightened risk of cardiovascular disease (CVD) events, presumably related to a greater burden of atherosclerosis, as well as atherosclerotic plaques that tend to be inflamed and rupture prone. Many of the inflammatory pathways underlying the pathobiology of RA are also r...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0578-8
更新日期：2016-05-01 00:00:00
abstract：:There have been few studies examining whether persons with chronic widespread pain or fibromyalgia are at increased risk for dying prematurely. Among the studies conducted there is little consistency in results. If there is an increased mortality risk, it is of the order of a 30% excess and it may be related to the li...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-005-0017-8
更新日期：2005-10-01 00:00:00
abstract：:Traditional nonsteroidal anti-inflammatory drugs block cyclooxygenase (COX). They are the most widely used drugs for pain relief. They are indispensable for their effects but are condemned for their adverse drug reactions. Two COX inhibitors, acetaminophen and aspirin, are the most widely used over-the-counter drugs. ...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-009-0006-4
更新日期：2009-02-01 00:00:00
abstract：:Antiphospholipid syndrome (APS) is characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. However, there is a range of other manifestations associated with APS, called non-criteria manifestations that add significant morbidity to this syndrome and, some of them, repre...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-015-0502-7
更新日期：2015-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability worldwide. OA-associated pain is usually refractory to classically used analgesics, and disease-modifying therapies are still lacking. Therefore, a better understanding of mechanisms and mediators contri...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-018-0716-6
更新日期：2018-02-26 00:00:00
abstract：:Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). Attention has, therefore, been paid to regenerative therapeutic procedures for the early treatment of cartilagi...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-014-0452-5
更新日期：2014-10-01 00:00:00
abstract：:Wegener's granulomatosis (WG) is a complex autoimmune disorder that has been transformed from a uniformly lethal process to a chronic disease with a relapsing-remitting course. In the setting of frequent relapses, the need to manage cumulative disease damage and drug toxicities has spurred the identification and devel...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-006-0014-6
更新日期：2006-08-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Idiopathic acute and recurrent pericarditis are rare diseases of unknown origin. Here, we review trigger factors, pathomechanism, and treatment options for acute and recurrent pericarditis. RECENT FINDINGS:Acute pericarditis can be triggered by viral infections, myocardial ischemia, heart cathete...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0820-2
更新日期：2019-03-09 00:00:00
abstract：PURPOSE OF REVIEW:The effect of urate lowering treatment (ULT) on cardiovascular (CV) risk and mortality in gout has been a topic of interest. This review discusses the CV effect of ULT and comparative CV safety among ULT agents. RECENT FINDINGS:The mechanism linking gout with CV risk is not fully understood but seems...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0843-8
更新日期：2019-07-24 00:00:00
abstract：:Gout is the most common inflammatory arthropathy and occurs in the setting of elevated serum urate levels. Gout is also known to be associated with multiple comorbidities including cardiovascular disease and the metabolic syndrome. Recent advances in research have increased our understanding and improved our knowledge...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0309-8
更新日期：2013-02-01 00:00:00
abstract：:Transforming growth factor-beta (TGF beta) plays a critical role in the development of tissue fibrosis. Its expression is consistently elevated in affected organs and correlates with increased extracellular matrix deposition. During the last few years, tremendous progress has been made in understanding the molecular a...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-002-0010-4
更新日期：2002-04-01 00:00:00
abstract：:Acute and chronic gout are common complications following organ transplantation. Risk factors include those shared with the general population (eg, diuretic use) and transplant-specific risk factors (eg, cyclosporine). Clinical features of gout are similar to those seen in the general population, although tophi may be...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-012-0235-9
更新日期：2012-04-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory respo...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-017-0672-6
更新日期：2017-08-01 00:00:00
abstract：:This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Syst...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-016-0600-1
更新日期：2016-08-01 00:00:00
abstract：:Systemic vasculitis can affect practically any structure in or around the eye. Although the ocular presentations of vasculitic disease are highly variable and may be quite subtle, it is important for physicians to understand some of the basic concepts, critical findings, and potential significance of ocular signs and ...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-003-0037-1
更新日期：2003-04-01 00:00:00
abstract：:Until recently, imaging evaluation of osteoarthritis has relied primarily on conventional radiography. Using radiography in clinical practice or clinical research, however, has been fraught with difficulty. Techniques for reproducibly acquiring serial radiographs of joints have improved considerably over the past seve...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-006-0020-8
更新日期：2006-02-01 00:00:00
abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-011-0183-9
更新日期：2011-08-01 00:00:00
abstract：:Erosive osteoarthritis (OA) is a subcategory of OA in which destructive changes occur in the joints, probably as a result of a combination of inflammatory inciters and phenomena. The major changes occur in the distal and proximal interphalangeal joints, root joints of the thumb, and less commonly other hand and centri...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-001-0062-x
更新日期：2001-12-01 00:00:00
abstract：:To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apop...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-008-0007-8
更新日期：2008-01-01 00:00:00
abstract：:Large epidemiologic studies of gout can improve insight into the etiology, pathology, impact, and management of the disease. Identification of monosodium urate monohydrate crystals is considered the gold standard for diagnosis, but its application is often not possible in large studies. Therefore, under such circumsta...
journal_title：Current rheumatology reports
pub_type： 杂志文章
doi：10.1007/s11926-010-0157-3
更新日期：2011-04-01 00:00:00
abstract：PURPOSE OF THE REVIEW:Osteoarthritis (OA) is an aging-associated and injury-induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent low-grade inflammation in the joint. Aging and injury are triggers of joint pathological changes mediated by pro-inflammatory factors, some of which ar...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0868-z
更新日期：2019-12-07 00:00:00
abstract：:While the most obvious manifestations of rheumatoid arthritis (RA) involve inflammation and damage in the synovial joints, the systemic effects of the condition are widespread and life-threatening. Of particular interest is the 'lipid paradox' of RA, where patients with a numerically equivocal starting lipid profile h...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-015-0534-z
更新日期：2015-09-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review paper is to provide an overview of the relationship between obesity, osteoarthritis, arthroplasty outcomes, and the potential use of bariatric surgery to improve these outcomes. RECENT FINDINGS:Unfortunately, the findings in the currently available literature evaluating the...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-018-0717-5
更新日期：2018-02-21 00:00:00
abstract：:Genetic defects of collagen formation (the collagenopathies) affect almost every organ system and tissue in the body. They can be grouped by clinical phenotype, which usually correlates with the tissue distribution of the affected collagen subtype. Many of these conditions present in childhood; however, milder phenoty...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-013-0394-3
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately...
journal_title：Current rheumatology reports
pub_type： 杂志文章,评审
doi：10.1007/s11926-019-0831-z
更新日期：2019-05-23 00:00:00
